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ENTRY	nt06161
Name	Human immunodeficiency virus 1 (HIV-1)
Category	Disease view; Viral infection
Pathway	hsa05170 Human immunodeficiency virus 1 infection
Genome	T40001
Disease	H01563 HIV infection H00406 Acquired immunodeficiency syndrome (AIDS)
Display	drug-target relation   disease type

TLR signaling N00435    (TLR1,TLR2,TLR4) → (TIRAP+MYD88) → (IRAK4+IRAK1) → (TRAF6+TAK1+TAB2) → IKK → NFKBIA → NFKB ⇒ (TNF,IL6,IL12A,IL1.. N00436                        Tat → NFKB ⇒ (TNF,IFNA,IFNB1) N00437                        Vpu ⊣ NFKB N00438    (TLR2,TLR4) → (TIRAP+MYD88) → (IRAK4+IRAK1) → (TRAF6+TAK1+TAB2) → (MEK,MKK3/6,MKK4/7.. → (ERK,p38,JNK) → AP1 N00439                    Nef ⊣ ERK CGAS-STING signaling N00395    DNA → CGAS → cGAMP → STING1 → TBK1 → IRF3 ⇒ (IFNA,IFNB) N00440                    (Vpu,Vif,Vpr) ⊣ IRF3 TNF signaling N00446        TNF → TNFRSF1A → (RIPK1+TRADD+TRAF2.. → (TAK1+TAB1/2) → MKK4/7 → JNK → AP1 N00447                        (Vpr,Tat) → JNK → AP1 N00444        TNF → TNFRSF1A → (RIPK1+TRADD+TRAF2.. → (TAK1+TAB1/2) → MKK3/6 → MAPK14 → MSK1/2 → CREB N00445                        (Tat,Nef) → MAPK14 N00151        TNF → TNFRSF1A → (RIPK1+TRADD+TRAF2.. → (TAB1/2/3+TAK1) → IKK → NFKBIA → NFKB N00441        Env → TNFRSF1A → (RIPK1+TRADD+TRAF2.. → (TAB1/2/3+TAK1) → IKK → NFKBIA → NFKB N00442            Nef → (RIPK1+TRADD+TRAF2.. → (TAB1/2/3+TAK1) → IKK → NFKBIA → NFKB N00443                            (Vpr,Nef,Tat) → NFKB Chemokine signaling N00401    CXCL12 → CXCR4 → GNAQ → (PLCB,PLCG) → IP3 → Ca2+ → CALM = CN → NFAT N00432    Env → (CXCR4,CCR5) → GNAQ N00430    CXCL12 → CXCR4 → GNAI → PI3K → PIP3 → AKT ⊣ BAD N00431    Env → (CXCR4,CCR5) → GNAI N00433    CXCL12 → CXCR4 → GNB/G → RAC → PAK1 → LIMK1 → CFL N00434    Env → (CXCR4,CCR5) → GNB/G MHC presentation N00363    TAP1/2 = TAPBP = (PDIA3+CALR) → (MHCI+B2M) N00461            Nef ⊣ MHCI Cell cycle N00455            (ATM,ATR) → CHEK1/2 ⊣ CDC25B/C → (CCNB+CDK1) N00456    Vpr = (DCAF1+DDB1+CUL4) → ATR → CHEK1 ⊣ CDC25C → (CCNB+CDK1) N00458                Vpr ⊣ CDC25C N00457                    Vpr ⊣ (CCNB+CDK1) N00459            ATR → CHEK1 → WEE1 ⊣ (CCNB+CDK1) N00460                Vpr → WEE1 ⊣ (CCNB+CDK1) Apoptosis N00146        (FASLG,TNFSF10) → (FAS,TNFRSF10B) → FADD → (CASP8,CASP10) → BID → (BAX,BAK1) → CYCS = APAF1 → CASP9 → (CASP3,CASP7) N00448    (Tat,Nef) → FASLG N00449                (Tat,Nef) → CASP8 → BID → (BAX,BAK1) → CYCS = APAF1 → CASP9 → CASP3 N00098                    (PMAIP1,BBC3,BAD,B.. ⊣ (BCL2,BCL2L1) ⊣ (BAX,BAK1) → CYCS = APAF1 → CASP9 → (CASP3,CASP7) N00452                Nef ⊣ BAD N00451                    Tat ⊣ (BCL2,BCL2L1) N00453                    Vpr → BCL2 N00450                        Tat → BAX N00454                        Vpr ⊣ BAX