| ERK signaling |
| N00216 |
HGF | → | MET | → | GRB2 | → | SOS | → | RAS | → | RAF | → | MEK | → | ERK |
| N00160 |
| | | | | | K1 | → | RAS |
| N00188 |
IL1 | → | IL1R | → | MYD88 | → | IRAK1/4 | → | TRAF6 | → | TAB1/2/3 | → | TAK1 | → | MKK4/7 | → | JNK | → | AP1 |
| N00189 |
| | | | | | | | | | | | K15 | → | MKK4/7 |
| N00186 |
IL1 | → | IL1R | → | MYD88 | → | IRAK1/4 | → | TRAF6 | → | TAB1/2/3 | → | TAK1 | → | MKK3/6 | → | MAPK14 | → | MK2 | ⊣ | TTP |
| N00187 |
| | | | | | | | | | | | | | | | MAPK14 | → | (MK2+K12) | ⊣ | TTP |
| PI3K signaling |
| N00182 |
| | | | | | IGF1 | → | IGF1R | → | PI3K | → | PIP3 | → | AKT | → | IKK | → | NFKBIA | → | NFKB |
| N00179 |
| | | | | | | | K1 | → | PI3K |
| N00030 |
EGF | → | EGFR | → | GRB2 | → | SOS | → | RAS | → | PI3K | → | PIP3 | → | AKT | ⊣ | BAD |
| N00159 |
| | | | | | | | K1 | → | PI3K |
| WNT signaling |
| N00056 |
WNT | → | (FZD+LRP5/6) | → | (DVL+FRAT) | ⊣ | (GSK3B+AXIN+APC) | ⊣ | CTNNB1 | → | TCF/LEF | ⇒ | (MYC,CCND1) |
| N00175 |
| | | | LANA | ⊣ | GSK3B | ⊣ | CTNNB1 | → | TCF/LEF | ⇒ | CCND1 |
| JAK-STAT signaling |
| N00053 |
Cytokine | → | Receptor | → | JAK | → | STAT | ⇒ | PIM1 |
| N00181 |
vIL6 | → | IL6ST | → | JAK2 | → | STAT3 |
| Calcium signaling |
| N00147 |
EGF | → | EGFR | → | PLCG | → | IP3 | → | Ca2+ | → | CALM | = | CN | → | NFAT |
| N00180 |
| | K1 | → | PLCG2 |
| N00172 |
| | K15 | → | PLCG1 |
| TLR signaling |
| N00148 |
TLR3 | → | TICAM1 | → | TRAF3 | → | (IKBKE+TBK1) | → | IRF7 | ⇒ | IFNA |
| N00162 |
| | | | | | vIRF3 | ⊣ | IRF7 |
| N00163 |
| | | | | | (KIE1,KIE2) | ⊣ | IRF7 |
| N00149 |
TLR3 | → | TICAM1 | → | TRAF3 | → | (IKBKE+TBK1) | → | IRF3 | → | (CREBBP,EP300) | ⇒ | IFNB1 |
| N00161 |
| | | | | | (IRF1,IRF2,K8) | ⊣ | IRF3 |
| Complement cascade |
| N01487 |
[C4,C2] | − | ((C1QA,C1QB,C1QC)+.. | → | [C4b,C2a] | → | (C4b+C2a) |
| N00213 |
| | KCP | ⊣ | C4b |
| IFN signaling |
| N00150 |
(IFNA,IFNB1) | → | (IFNAR1+IFNAR2) | → | (JAK1,TYK2) | → | (STAT1+STAT2+IRF9) | ⇒ | (IRF7,EIF2AK2) |
| N00261 |
| | | | vIRF2 | ⊣ | (STAT1+STAT2+IRF9) |
| TNF signaling |
| N00151 |
TNF | → | TNFRSF1A | → | (RIPK1+TRADD+TRAF2.. | → | (TAB1/2/3+TAK1) | → | IKK | → | NFKBIA | → | NFKB |
| N00174 |
| | vFLIP | → | TRAF2 | → | IKK | → | NFKBIA | → | NFKB |
| N00173 |
| | K15 | → | TRAF2 | → | TAK1 | → | IKK | → | NFKBIA | → | NFKB |
| N00171 |
| | | | | | vFLIP | → | IKK | → | NFKBIA | → | NFKB |
| Chemokine signaling |
| N00152 |
CXCL8 | → | CXCR2 | → | GNB/G | → | RAS | → | RAF1 | → | MEK | → | ERK |
| N00157 |
| | vGPCR | → | GNB/G |
| N00153 |
(CC,CXC) | → | (CCR,CXCR) | → | GNB/G | → | PI3Kgamma | → | PREX1 | → | RAC1 |
| N00462 |
(vCCL1,vCCL2,vCCL3.. | → | (CCR3,CCR4,CCR8) |
| N00212 |
vCCL2 | ⊣ | (CCR1,CCR5) |
| N00178 |
| | vGPCR | → | GNB/G |
| N00154 |
CXCL8 | → | CXCR2 | → | GNB/G | → | PI3Kgamma | → | PIP3 | → | AKT | → | MTOR |
| N00158 |
| | vGPCR | → | GNB/G |
| MHC presentation |
| N00363 |
TAP1/2 | = | TAPBP | = | (PDIA3+CALR) | → | (MHCI+B2M) |
| N00184 |
| | | | (MIR1,MIR2) | ⊣ | MHCI |
| N00185 |
| | | | MIR2 | ⊣ | (ICAM1,CD86,MICA,M.. |
| Autophagy |
| N00155 |
mTORC1 | → | ULK1_complex | → | PI3KC3-C1 |
| N00177 |
| | vBCL2 | ⊣ | (BECN1+PIK3C3+ATG1.. |
| N00156 |
LC3 | − | ATG4 | ⇉ | ATG7 | ⇉ | ATG3 | ⇉ | (ATG12+ATG5+ATG16L.. | → | LC3-II |
| N00176 |
| | | | vFLIP | ⊣ | ATG3 |
| Cell cycle |
| N00066 |
CDKN2A | ⊣ | MDM2 | ⊣ | TP53 | ⇒ | CDKN1A | ⊣ | (CCND+CDK4/6) | → | RB1 | ⌿ | E2F |
| N00167 |
| | (vIRF1,vIRF3) | ⊣ | TP53 |
| N00169 |
| | LANA | ⊣ | TP53 |
| N00168 |
| | | | | | vCyclin | → | CDK4/6 | → | RB1 | ⌿ | E2F |
| N00170 |
| | | | | | | | LANA | → | RB1 | ⌿ | E2F |
| Apoptosis |
| N00146 |
(FASLG,TNFSF10) | → | (FAS,TNFRSF10B) | → | FADD | → | (CASP8,CASP10) | → | BID | → | (BAX,BAK1) | → | CYCS | = | APAF1 | → | CASP9 | → | (CASP3,CASP7) |
| N00166 |
| | | | vFLIP | ⊣ | CASP8P3 |
| N00164 |
| | | | | | | | vBCL2 | ⊣ | (BAX,BAK1) |
| N00165 |
| | | | | | | | | | | | | | | | vIAP | ⊣ | CASP3 |
|
Network variation - Kaposi sarcoma-associated herpesvirus (KSHV)