[ Network menu | Network entry | Help ]

ENTRY	nt06171
Name	SARS coronavirus 2 (SARS-CoV-2)
Category	Disease view; Viral infection
Pathway	hsa05171 Coronavirus disease - COVID-19
Genome	T40361
Disease	H02398 COVID-19
Display	drug-target relation   disease type

RLR signaling N00469        RNA → RIGI → MAVS → TRAF3 → (TANK+NAP1+SINTBAD.. → (TBK1+IKBKE) → (IRF7,IRF3) ⇒ (IFNA,IFNB1) N01310                        nsp13 ⊣ TBK1 N01320                        nsp3 ⊣ ISG15 = IRF3 N01319                            (nsp6,ORF6) ⊣ IRF3 N01308        RNA → (MDA5,ZNFX1) → MAVS → TRAF3 → (TANK+NAP1+SINTBAD.. → (TBK1+IKBKE) → (IRF7,IRF3) ⇒ (IFNA,IFNB1) N01309    nsp3 ⊣ ISG15 = MDA5 Complement cascade N01491        [C4,C2] − ((MBL2,COLEC10/11,.. → [C4b,C2a] → (C4b+C2a) N01312        S → (MBL2+MASP1/2) N01487        [C4,C2] − ((C1QA,C1QB,C1QC)+.. → [C4b,C2a] → (C4b+C2a) N01314    S → (IgG,IgM) → ((C1QA,C1QB,C1QC)+.. N01315        F2 − ((MBL2,COLEC10/11,.. → F2a N01502            FG − (F2a,((MBL2,COLEC1.. → Fibrin N01316        (S,N) → (MBL2,COLEC10/11,F.. IFN signaling N00150    (IFNA,IFNB1) → (IFNAR1+IFNAR2) → (JAK1,TYK2) → (STAT1+STAT2+IRF9) ⇒ (IRF7,EIF2AK2) N01321            (nsp1,nsp6,nsp13,O.. ⊣ STAT1 N01322            (nsp6,nsp13,ORF7a,.. ⊣ STAT2 Translation N01317        40S = mRNA = 60S N01318    nsp1 ⊣ 40S Angiotensin II signaling N01306            AngII → AGTR1 → NOX2 → ROS → NFKB → (VCAM1,IL6,MMP2,MM.. N01307    S ⊣ ACE2 ⊣ AngII → AGTR1 → NOX2 → ROS → NFKB → (TNF,IL6,IL1B,IL12..