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ENTRY	nt06180
Name	Pathogenic Escherichia coli
Category	Disease view; Bacterial infection
Pathway	hsa05130 Pathogenic Escherichia coli infection
Disease	H00277 Enterohemorrhagic Escherichia coli (EHEC) infection H00278 Enteropathogenic Escherichia coli (EPEC) infection
Display	drug-target relation   disease type

TNF signaling N00446    TNF → TNFRSF1A → (RIPK1+TRADD+TRAF2.. → (TAK1+TAB1/2) → MKK4/7 → JNK → AP1 N00930                    NleD ⊣ JNK N00444    TNF → TNFRSF1A → (RIPK1+TRADD+TRAF2.. → (TAK1+TAB1/2) → MKK3/6 → MAPK14 → MSK1/2 → CREB N00931                    NleD ⊣ MAPK14 N00151    TNF → TNFRSF1A → (RIPK1+TRADD+TRAF2.. → (TAB1/2/3+TAK1) → IKK → NFKBIA → NFKB N00928    NleB ⊣ GAPDH → (RIPK1+TRAF2) N00927            NleE ⊣ (TAB2/3) N00932                    NleH1 ⊣ RPS3 → NFKB N00929                        NleC ⊣ RELA   TLR signaling N00438    (TLR2,TLR4) → (TIRAP+MYD88) → (IRAK4+IRAK1) → (TRAF6+TAK1+TAB2) → (MEK,MKK3/6,MKK4/7.. → (ERK,p38,JNK) → AP1 N00926        Tir → SHP1/2 ⊣ (TRAF6+TAK1+TAB2)   NLR signaling N00742        (NLRP3+PYCARD) → CASP1 → (IL1B,IL18,IL33) N00933    NleA ⊣ (NLRP3+PYCARD) N00934    LPS → CASP4/5 → (NLRP3+PYCARD+CASP.. → (IL1B,IL18) N00935    NleF ⊣ CASP4   Cytoskeletal regulation N01287    (OCLN,CLDN) = TJP1 = CTTN = ARP2/3 = (ACTB,ACTG1) N01288    EspF ⊣ TJP1 N01097    LPA → LPAR → GNA12/13 → (ARHGEF12,ARHGEF1,.. → RHOA → ROCK1/2 N01088            EspH ⊣ (ARHGEF12,ARHGEF1) N01095        Map → NHERF1 → EZR → RHOA → ROCK1/2 N01089                EspM → RHOA → ROCK1/2 N01285        (TUBA+TUBB) ⊣ ARHGEF2 → RHOA → ROCK1/2 N01286    (EspG,EspG2) ⊣ (TUBA+TUBB) N01068    FN1 → (ITGA+ITGB) → (SRC,PTK2) → (PXN,CRK+BCAR1) → (DOCK1+ELMO1) → RAC N01086                    EspT → RAC1 → (WASF2+ABI1) → ARP2/3 → (ACTB,ACTG1) N01087                    EspW → RAC1 N01090        IGG → FCGR → CRK → DOCK1 → RAC N01091    EspJ ⊣ SRC → FCGR N01070    FN1 → (ITGA+ITGB) → (SRC,PTK2) → PXN → (GIT2+ARHGEF7) → CDC42 N01096                    Map → CDC42 → WASL → ARP2/3 → (ACTB,ACTG1) N01066    ARNO → ARF6 → ARF1 → (WASF+ABI1+HSPC300.. → ARP2/3 → (ACTB,ACTG1) N01084    (EspG,EspG2) ⊣ ARF6 N01085        (EspG,EspG2) ⊣ ARF1 N01078    EGF → EGFR → SRC → CTTN → NCK → (WASL+WIPF) → ARP2/3 → (ACTB,ACTG1) N01092            Eae → Tir → NCK → (WASL+WIPF) → ARP2/3 → (ACTB,ACTG1) N01093        EspJ ⊣ (FYN,ABL) → Tir → NCK N01094        Eae → Tir → (IRTKS,IRSp53) → TccP → WASL → ARP2/3 → (ACTB,ACTG1)   Membrane trafficking N01293    GBF1 → ARF1 = (KDELR+TMED2+TMED1.. = (COPI+TMED4/9+TMED.. N01294        NleF ⊣ TMED10 N01289    SEC12 → SAR1 = (SEC23+SEC24) = (SEC13+SEC31) N01290        NleA ⊣ SEC24 N01291    TRAPPI → RAB1 N01292    (EspG,EspG2) ⊣ RAB1