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ENTRY	nt06261
Name	Gastric cancer
Category	Disease view; Cancer
Pathway	hsa05226 Gastric cancer
Disease	H00018 Gastric cancer
Display	drug-target relation   disease type

ERK signaling N00021    EGF → (ERBB2+EGFR) → GRB2 → SOS → RAS → RAF → MEK → ERK N00252    EGF → (ERBB2*+EGFR) → GRB2 → SOS → RAS → RAF → MEK → ERK N00019    FGF → FGFR → GRB2 → SOS → RAS → RAF → MEK → ERK N00020        FGFR* → GRB2 → SOS → RAS → RAF → MEK → ERK N00216    HGF → MET → GRB2 → SOS → RAS → RAF → MEK → ERK N00259        MET* → GRB2 → SOS → RAS → RAF → MEK → ERK N00012                    (KRAS*,NRAS*) → RAF → MEK → ERK → CCND1 PI3K signaling N00284        AREG → EGFR → PI3K → PIP3 → AKT → MTOR → S6K N00253        EGF → (ERBB2*+EGFR) → PI3K → PIP3 → AKT → MTOR → S6K N00037        FGF → FGFR → PI3K → PIP3 → AKT → MTOR → S6K N00038            FGFR* → PI3K → PIP3 → AKT → MTOR N00043    HGF → MET → GAB1 → PI3K → PIP3 → AKT ⊣ BAD N00260        MET* → GAB1 → PI3K → PIP3 → AKT → MTOR WNT signaling N00056    WNT → (FZD+LRP5/6) → (DVL+FRAT) ⊣ (GSK3B+AXIN+APC) ⊣ CTNNB1 → TCF/LEF ⇒ (MYC,CCND1) N00057            (GSK3B+AXIN) ⌿ APC* ⌿ CTNNB1 → TCF/LEF ⇒ (BIRC5,MYC,CCND1) N00257                CDH1* ⌿ CTNNB1 → TCF/LEF ⇒ (MYC,CCND1) N00258                CDH1* ⌿ CTNNB1 → TCF/LEF ⇒ (MYC,CCND1) TGFB signaling N00063    TGFB → (TGFBR2+TGFBR1) → (SMAD2,SMAD3) = SMAD4 N00256        (TGFBR2+TGFBR1*) ⌿ (SMAD2,SMAD3) Cell cycle N00091    (SCF+SKP2) ⊣ CDKN1B ⊣ ((CCNA,CCNE)+CDK2) → RB1 ⌿ E2F N00254        CDKN1B* ⌿ (CCNE+CDK2) → RB1 ⌿ E2F N00255            (CCNE*+CDK2) → RB1 ⌿ E2F Telomerase activity N00239    TERC ⌿ DNA N00240    (TERT*+TERC) → DNA Transcription N00115    TP53* ⌿ (CDKN1A,GADD45,BAX.. N00250    CDX2* ⇒ (MUC2,CDH17,REG4,A.. N00251    CDX2* ⫤ SHH