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ENTRY	nt06263
Name	Hepatocellular carcinoma
Category	Disease view; Cancer
Pathway	hsa05225 Hepatocellular carcinoma
Disease	H00048 Hepatocellular carcinoma
Display	drug-target relation   disease type

MAPK signaling N00001    EGF → EGFR → GRB2 → SOS → RAS → RAF → MEK → ERK → CCND1 N00540    X → SRC → GRB2 → SOS → RAS → RAF → MEK → ERK → ELK1 N00274        NS5A ⊣ GRB2 N00518                Core ⊣ YWHA ⊣ RAF → MEK → ERK N00519                        Core → MEK N00229    TGFA → EGFR → GRB2 → SOS → RAS → RAF → MEK → ERK N00230    TGFA* → EGFR → GRB2 → SOS → RAS → RAF → MEK → ERK N00233    IGF → IGF1R → GRB2 → SOS → RAS → RAF → MEK → ERK N00235    IGF2* → IGF1R → GRB2 → SOS → RAS → RAF → MEK → ERK N00237    IGF2 → IGF1R* → GRB2 → SOS → RAS → RAF → MEK → ERK N00216    HGF → MET → GRB2 → SOS → RAS → RAF → MEK → ERK N00246    HGF* → MET → GRB2 → SOS → RAS → RAF → MEK → ERK N00005        MET* → GRB2 → SOS → RAS → RAF → MEK → ERK → CCND1 N00248        MET* → GRB2 → SOS → RAS → RAF → MEK → ERK N00541                X → RAS N00545                            X → ERK → AP1 ⇒ MMP9 N00542    EGF → EGFR → GRB2 → SOS → RAS → MEKK1 → MKK4 → JNK N00543                            X → JNK → JUN N00538            Ca2+ → PTK2B → SRC → GRB2 → SOS → RAS → RAF → MEK → ERK N00539    X → VDAC3 → Ca2+ PI3K signaling N00033    EGF → EGFR → PI3K → PIP3 → AKT ⊣ BAD N00267        X → PI3K N00272        NS5A → PI3K N00049            PI3K* → PIP3 → AKT → MTOR → S6K N00231    TGFA → EGFR → PI3K → PIP3 → AKT → MTOR N00232    TGFA* → EGFR → PI3K → PIP3 → AKT N00234    IGF2 → IGF1R → PI3K → PIP3 → AKT → MTOR → S6K N00238    IGF2 → IGF1R* → PI3K → PIP3 → AKT → MTOR → S6K N00236    IGF2* → IGF1R → PI3K → PIP3 → AKT → MTOR → S6K N00043    HGF → MET → GAB1 → PI3K → PIP3 → AKT ⊣ BAD N00247    HGF* → MET → GAB1 → PI3K → PIP3 → AKT ⊣ BAD N00044    MET* → GAB1 → PI3K → PIP3 → AKT ⊣ BAD N00249    MET* → GAB1 → PI3K → PIP3 → AKT ⊣ BAD N00220                PTEN ⊣ PIP3 → AKT N00052                PTEN* ⌿ PIP3 → AKT WNT signaling N00056    WNT → (FZD+LRP5/6) → (DVL+FRAT) ⊣ (GSK3B+AXIN+APC) ⊣ CTNNB1 → TCF/LEF ⇒ (MYC,CCND1) N00059    WNT → (FZD7*+LRP5/6) → (DVL+FRAT) ⊣ (GSK3B+AXIN+APC) ⊣ CTNNB1 → TCF/LEF ⇒ (MYC,CCND1) N00242            (GSK3B+APC) ⌿ AXIN* ⌿ CTNNB1 → TCF/LEF ⇒ (MYC,CCND1) N00058            (GSK3B+AXIN+APC) ⌿ CTNNB1* → TCF/LEF ⇒ (BIRC5,MYC,CCND1) TGFB signaling N00063            TGFB → (TGFBR2+TGFBR1) → (SMAD2,SMAD3) = SMAD4 N00531        X → TGFB → (TGFBR2+TGFBR1) → (SMAD2,SMAD3) = SMAD4 N00241                (TGFBR2*+TGFBR1) ⌿ (SMAD2,SMAD3) Calcium signaling N00227    TGFA → EGFR → PLCG → IP3 → (Ca2+,DAG) → PKC → ELK1 N00228    TGFA* → EGFR → PLCG → IP3 → (Ca2+,DAG) → PKC → ELK1 JAK-STAT signaling N00053    Cytokine → Receptor → JAK → STAT ⇒ PIM1 N00548            X → STAT3 TLR signaling N00435        (TLR1,TLR2,TLR4) → (TIRAP+MYD88) → (IRAK4+IRAK1) → (TRAF6+TAK1+TAB2) → IKK → NFKBIA → NFKB ⇒ (TNF,IL6,IL12A,IL1.. N00556    C ⊣ TLR2 N00557        C ⊣ TIRAP N00549        C ⊣ MYD88 N00550                            C ⊣ NFKB N00269                    Core → NFKB N00438        (TLR2,TLR4) → (TIRAP+MYD88) → (IRAK4+IRAK1) → (TRAF6+TAK1+TAB2) → (MEK,MKK3/6,MKK4/7.. → (ERK,p38,JNK) → AP1 N00551                        S ⊣ JNK N00553        TLR4 → TICAM2 → TICAM1 → TRAF3 → (IKBKE+TBK1) → (IRF3,IRF7) ⇒ IFNB1 N00554        C ⊣ TICAM2 N00555            C ⊣ TICAM1 N00149            TLR3 → TICAM1 → TRAF3 → (IKBKE+TBK1) → IRF3 → (CREBBP,EP300) ⇒ IFNB1 N00516            (NS3,NS4A) ⊣ TICAM1 N00552                P ⊣ DDX3X = (IKBKE+TBK1) RLR signaling N00469    RNA → RIGI → MAVS → TRAF3 → (TANK+NAP1+SINTBAD.. → (TBK1+IKBKE) → (IRF7,IRF3) ⇒ (IFNA,IFNB1) N00271        (NS3,NS4A) ⊣ MAVS N00268        X ⊣ MAVS NLR signaling N00515        OAS → 2-5A → RNASEL N00273    NS5A ⊣ OAS IFN signaling N00150    (IFNA,IFNB1) → (IFNAR1+IFNAR2) → (JAK1,TYK2) → (STAT1+STAT2+IRF9) ⇒ (IRF7,EIF2AK2) N00270            Core ⊣ (STAT1+STAT2+IRF9) N00558            P ⊣ (STAT1+STAT2) TNF signaling N00151    TNF → TNFRSF1A → (RIPK1+TRADD+TRAF2.. → (TAB1/2/3+TAK1) → IKK → NFKBIA → NFKB N00525        NS5A ⊣ (TRADD+TRAF2) N00269                    Core → NFKB N00145    TNF → TNFRSF1A → (RIPK1+TRADD+TRAF2.. → FADD → CASP8 → (CASP3,CASP7) N00524        NS5A ⊣ TRADD N00528            Core → CFLAR ⊣ CASP8 Chemokine signaling N00546    CXCL12 → CXCR4 → GNAQ → (PLCB,PLCG) → IP3 → Ca2+ → PKC → RAF → MEK → ERK N00547                        S → PKC KEAP1-NRF2 signaling N00243    (O2-,HO2,H2O2,OH,A.. ⊣ KEAP1 ⊣ NRF2 ⇒ (HMOX1,NQO1,GST,TX.. N00244        KEAP1* ⌿ NRF2 ⇒ (HMOX1,NQO1,GST,TX.. N00245        KEAP1 ⌿ NRF2* ⇒ (HMOX1,NQO1,GST,TX.. Cell cycle N00066    CDKN2A ⊣ MDM2 ⊣ TP53 ⇒ CDKN1A ⊣ (CCND+CDK4/6) → RB1 ⌿ E2F N00521        Core ⊣ TP53 N00520        NS5A ⊣ TP53 N00522        NS3 ⊣ TP53 N00523            Core ⊣ CDKN1A N00071                CDKN2A* ⌿ (CCND+CDK4/6) → RB1 ⌿ E2F N00074                        RB1* ⌿ E2F N00536    CDKN2A ⊣ MDM2 ⊣ TP53 ⇒ CDKN1A ⊣ (CCNE+CDK2) → RB1 ⌿ E2F N00537                X → (CCNE+CDK2) → RB1 ⌿ E2F Apoptosis N00146        (FASLG,TNFSF10) → (FAS,TNFRSF10B) → FADD → (CASP8,CASP10) → BID → (BAX,BAK1) → CYCS = APAF1 → CASP9 → (CASP3,CASP7) N00527        Core → FAS N00526                NS3 → CASP8 N00534                        X → BAX N00533                                X → BIRC5 ⊣ CASP9 Telomerase activity N00239    TERC ⌿ DNA N00240    (TERT*+TERC) → DNA Transcription N00115        TP53* ⌿ (CDKN1A,GADD45,BAX.. N00535    X ⊣ TP53 ⇒ (CDKN1A,BAX,FAS) N00532    X → (EGR2,EGR3) = EP300 ⇒ FASLG N00544    X → CREBBP = (CREB+ATF2) ⇒ (CXCL8,PCNA) N00529    Core → (RXRA+PPARA) ⇒ (CCND1,CDK4,MYC) N00530    (Core+PSME3) → (RXRA+NR1H3) ⇒ (CCND1,CDK4,MYC)