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ENTRY	nt06268
Name	Melanoma
Category	Disease view; Cancer
Pathway	hsa05218 Melanoma
Disease	H00038 Melanoma
Display	drug-target relation   disease type

ERK signaling                           D1,D2,D3  |         N00001    EGF → EGFR → GRB2 → SOS → RAS → RAF → MEK → ERK → CCND1                           D1,D2,D3  |         N00012                    (KRAS*,NRAS*) → RAF → MEK → ERK → CCND1                       D4,D5,D6  |   D1,D2,D3  |     N00013                        BRAF* → MEK → ERK PI3K signaling N00220    PTEN ⊣ PIP3 → AKT N00051    PTEN* ⌿ PIP3 → AKT N00052    PTEN* ⌿ PIP3 → AKT N00030    EGF → EGFR → GRB2 → SOS → RAS → PI3K → PIP3 → AKT ⊣ BAD N00032                    (KRAS*,NRAS*) → PI3K → PIP3 → AKT ⊣ BAD Cell cycle N00066    CDKN2A ⊣ MDM2 ⊣ TP53 ⇒ CDKN1A ⊣ (CCND+CDK4/6) → RB1 ⌿ E2F N00067    CDKN2A* ⌿ MDM2 ⊣ TP53 ⇒ CDKN1A ⊣ (CCND+CDK4/6) → RB1 ⌿ E2F N00076    CDKN2A* ⌿ MDM2 ⊣ TP53 ⇒ CDKN1A ⊣ (CCND+CDK4/6) → RB1 ⌿ E2F N00069                CDKN2A ⊣ (CCND+CDK4/6) → RB1 ⌿ E2F N00070                CDKN2A* ⌿ (CCND+CDK4/6) → RB1 ⌿ E2F N00071                CDKN2A* ⌿ (CCND+CDK4/6) → RB1 ⌿ E2F N00073                    (CCND+CDK4*) → RB1 ⌿ E2F Transcription N00115    TP53* ⌿ (CDKN1A,GADD45,BAX..

		Drug name
D1	D10176	Trametinib dimethyl sulfoxide (JAN/USAN)
D2	D10604	Binimetinib (JAN/USAN/INN)
D3	D10615	Cobimetinib fumarate (USAN)
D4	D09996	Vemurafenib (JAN/USAN/INN)
D5	D10104	Dabrafenib mesylate (USAN)
D6	D11053	Encorafenib (JAN/USAN/INN)