KEGG    Network variation - CRH-ACTH-cortisol signaling
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ENTRYnt06310
NameCRH-ACTH-cortisol signaling
CategoryPathway view; Endocrine system
Pathwayhsa04024 cAMP signaling pathway
hsa04927 Cortisol synthesis and secretion
DiseaseH01431 Cushing syndrome
Display drug-target relation   disease type
N00324    CRHCRHRGNASADCYcAMPPKACREBACTH
N00325      RASD1*GNAIADCYcAMPPKACREBACTH
    PITA3     GNAS*
N01542            PRKARPKA
    CNC         PRKAR1A*
 
               D1,D2
 |
  
N00297    ACTH(MC2R+MRAP)GNASADCYcAMPPKA(NR5A1,NR4A1,SP1,P..(STAR,CYP11B1)Cortisol
    FGD   MC2R*
    FGD   MRAP*
        GNAS*
               D1,D2
 |
  
N00323          (PDE11A*,PDE8B*)cAMP(PRKAR1A+PRKACA)(NR5A1,NR4A1,SP1,P..(STAR,CYP11B1)Cortisol
    BMAH           PRKACA*
N00298    GRA ACTH(MC2R+MRAP)GNASADCYcAMPPKA(NR5A1,NR4A1,SP1,P..CYP11B2*Aldosterone
N01542            PRKARPKA
            PRKAR1A*
 
N00924    GCNR3C1=MED14(IGFBP1,IRF8)
    GCCR   NR3C1*
 
N00318      EGFRERK1/2ACTH
N00319    PITA4 USP8*EGFRERK1/2ACTH
 
               D1,D2,D4
 |
N00306              NR0B1NR5A1(CYP11B1,CYP17A1)
    AHC           NR0B1*
    Adrenal insufficiency             NR5A1*

Disease nameDisease category
PITA3H01102Pituitary adenomasNeoplasm
CNCH01102Pituitary adenomasNeoplasm
FGDH00256Familial glucocorticoid deficiencyEndocrine and metabolic disease
PPNADH00260Pigmented micronodular adrenocortical diseaseEndocrine and metabolic disease
PPNAD, BMAHH00260Pigmented micronodular adrenocortical diseaseEndocrine and metabolic disease
H02049Bilateral macronodular adrenal hyperplasiaEndocrine and metabolic disease
BMAHH02049Bilateral macronodular adrenal hyperplasiaEndocrine and metabolic disease
GRAH00602Glucocorticoid-remediable aldosteronism (GRA)Endocrine and metabolic disease
GCCRH01702Glucocorticoid resistance syndromeEndocrine and metabolic disease
PITA4H01102Pituitary adenomasNeoplasm
AHCH01772Adrenal hypoplasia, congenitalEndocrine and metabolic disease
Adrenal insufficiencyH02316Adrenal insufficiency, NR5A1 relatedEndocrine and metabolic disease


Drug name
D1D00410Metyrapone (JP18/USP/INN)
D2D10950Levoketoconazole (USAN/INN)
D3D11062Osilodrostat phosphate (JAN/USAN)
D4D00420Mitotane (JAN/USP/INN)