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ENTRY	nt06316
Name	Renin-angiotensin-aldosterone signaling
Category	Pathway view; Endocrine system
Pathway	hsa04614 Renin-angiotensin system hsa04924 Renin secretion hsa04925 Aldosterone synthesis and secretion
Display	drug-target relation   disease type

N01743    AGT − REN → AngI − ACE → AngII → AGTR     RTD AGT*     RTD     REN*     RTD             ACE*     RTD                     AGTR1* N00301    AngII → AGTR1 → GNAQ → PLCB → IP3 → Ca2+ → CALM → CAMK → CREB ⇒ CYP11B2 → Aldosterone N00302    Primary aldosteronism                 (CACNA1D*,CACNA1H*.. → Ca2+ → CALM → CAMK → CREB ⇒ CYP11B2 → Aldosterone N00303    Primary aldosteronism         KCNJ5* → Na+ → (CACNA1D,CACNA1H) → Ca2+ → CALM → CAMK → CREB ⇒ CYP11B2 → Aldosterone N00304    Primary aldosteronism         ATP1A1* → Na+ → (CACNA1D,CACNA1H) → Ca2+ → CALM → CAMK → CREB ⇒ CYP11B2 → Aldosterone N00305    Primary aldosteronism                 ATP2B3* → Ca2+ → CALM → CAMK → CREB ⇒ CYP11B2 → Aldosterone

		Disease name	Disease category
RTD	H00575	Renal tubular dysgenesis	Congenital malformation
Primary aldosteronism	H01603	Primary aldosteronism	Endocrine and metabolic disease