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ENTRY	nt06463
Name	Parkinson disease
Category	Disease view; Neurodegenerative disease
Pathway	hsa05012 Parkinson disease
Disease	H00057 Parkinson disease
Display	drug-target relation   disease type

Calcium signaling N00953    Glutamate → GRM1 → GNAQ → PLCB → IP3 → ITPR → Ca2+ → PKC ⊣ TRPC3 → Ca2+ N01032            PRKN* → PLCG1 → IP3 → ITPR → Ca2+ N00967    Ca2+(extracellular.. − VGCC → Ca2+ − MCU → Ca2+(mito) − MPTP → CYCS = APAF1 → CASP9 → (CASP3,CASP7) N01031    Ca2+(extracellular.. − SNCA* → Ca2+ − MCU → Ca2+(mito) − MPTP → CYCS = APAF1 → CASP9 → CASP3 Ubiquitin-proteasome system N01019    UBCH7/8 = PRKN ⊣ alphaSp22 N01020    UBCH7/8 ⌿ PRKN* ⌿ alphaSp22 N01021    UBCH7/8 = PRKN ⊣ PAELR N01022    UBCH7/8 ⌿ PRKN* ⌿ PAELR N01023    UBCH7/8 = PRKN ⊣ CDCREL1 N01024    UBCH7/8 ⌿ PRKN* ⌿ CDCREL1 N01025    UBCH7/8 = PRKN ⊣ SYPH1 N01026    UBCH7/8 ⌿ PRKN* ⌿ SYPH1 N01029    (Protein+UB) − 26S → Peptide N01030    SNCA* ⊣ 26S N01027    UB(chain) − UCHL1 → UB(free) N01028    UB(chain) ⌿ UCHL1* ⌿ UB(free) Unfolded protein response (UPR) signaling N01009            EIF2AK3 → EIF2S1 → ATF4 ⇒ DDIT3 N01035    SNCA* ⊣ BIP ⊣ EIF2AK3 → EIF2S1 → ATF4 ⇒ DDIT3 N01011            ERN1 → XBP1 ⇒ DDIT3 N01034    SNCA* ⊣ BIP ⊣ ERN1 → XBP1 N01015            ATF6 ⇒ (DDIT3,XBP1,HSPA5) N01033    SNCA* ⊣ BIP ⊣ ATF6 ⇒ DDIT3 Mitophagy N01052    PINK1 → PRKN ⊣ MFN1/2 N01053    PINK1* ⌿ PRKN ⌿ MFN1/2 N01054        PRKN* ⌿ MFN1/2 Apoptosis N00098    (PMAIP1,BBC3,BAD,B.. ⊣ (BCL2,BCL2L1) ⊣ (BAX,BAK1) → CYCS = APAF1 → CASP9 → (CASP3,CASP7) N01051    DJ1* ⌿ BCL2L1 ⌿ BAX N01050    PINK1* ⌿ PRKN ⌿ BAX → CYCS = APAF1 → CASP9 → CASP3 N01049        PRKN* ⌿ BAX → CYCS = APAF1 → CASP9 → CASP3 N01048        PINK1* ⌿ (HTRA2,TRAP1) ⌿ CYCS = APAF1 → CASP9 → CASP3 N01047            LRRK2* → CYCS = APAF1 → CASP9 → CASP3 N01056        FASLG → FAS → (DAXX+ASK1) → JNK N01057            DJ1* ⌿ (DAXX+ASK1) → JNK N01417    PQ → ROS ⊣ TRX1 ⊣ ASK1 → JNK Dopamine metabolism N01530    Tyr+BH4 − TH → L-Dopa − DDC → Dopamine − MAO → DOPAL N01037    SNCA* ⌿ TH → L-Dopa N01039                    PRKN* ⌿ MAO → DOPAL N01040    Dopamine − VMAT → Dopamine(SV) N01041    SNCA* ⊣ VMAT2 Oxidative phosphorylation N00995    NADH − CxI → Q N01042    SNCA* ⊣ CxI → Q N01043    PINK1* ⊣ CxI → Q N01044    MPP+ ⊣ CxI → Q N01045    Rotenone ⊣ CxI → Q N00988    Succinate − CxII → QH2 N01402    Mn2+ ⊣ CxII → QH2 N00990    QH2 − CxIII → CytC N01046    Maneb ⊣ CxIII → CytC Microtubule-based transport N00976        (DCTN+DNAH+DNAI+DN.. = (TUBA+TUBB) N01055    SNCA* ⊣ (KIF5+KLC) ⌿ (TUBA+TUBB) Transcription N01058    DJ1* ⌿ TP53 ⇒ DUSP1 N00243    (O2-,HO2,H2O2,OH,A.. ⊣ KEAP1 ⊣ NRF2 ⇒ (HMOX1,NQO1,GST,TX.. N01059        DJ1* ⌿ NRF2 ⌿ TRX1