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ENTRY	nt06465
Name	Prion disease
Category	Disease view; Neurodegenerative disease
Pathway	hsa05020 Prion disease
Disease	H00061 Prion disease
Display	drug-target relation   disease type

Calcium signaling N00984    Glutamate → GRM5 → GNAQ → PLCB → IP3 → ITPR → Ca2+ − MCU → Ca2+(mito) − MPTP → CYCS = APAF1 → CASP9 → (CASP3,CASP7) N01199                    PRNP* → (RYR,ITPR) → Ca2+ − MCU → Ca2+(mito) − MPTP → CYCS = APAF1 → CASP9 → CASP3 N00967                    Ca2+(extracellular.. − VGCC → Ca2+ − MCU → Ca2+(mito) − MPTP → CYCS = APAF1 → CASP9 → (CASP3,CASP7) N01201                    PRNP* ⊣ VGCC(N,L-type) → Ca2+ N00970                    Glutamate → NMDAR → Ca2+ N01200                    PRNP* → NMDAR → Ca2+ − MCU → Ca2+(mito) − MPTP → CYCS = APAF1 → CASP9 → CASP3 Ubiquitin-proteasome system N01029    (Protein+UB) − 26S → Peptide N01197    PRNP* ⊣ 26S Unfolded protein response (UPR) signaling N01009            EIF2AK3 → EIF2S1 → ATF4 ⇒ DDIT3 N01198    PRNP* ⊣ BIP ⊣ EIF2AK3 → EIF2S1 → ATF4 ⇒ DDIT3 PI3K signaling N01204    PRNP → CAV → FYN → PI3K → PRKCD → NOX2 → ERK → CREB ⇒ EGR1 N01205    PRNP* → CAV → FYN → PI3K → PRKCD → NOX2 → ROS Microtubule-based transport N00978            (KIF5+KLC) = (TUBA+TUBB) N01202    PRNP* → (GSK3B,CK2) ⊣ (KIF5+KLC) NOTCH signaling N00086    (DLL,JAG) → NOTCH → (NICD+RBPJ) ⇒ (HES1,HEY1) N01203    PRNP* → NOTCH1