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ENTRY	nt06507
Name	TGFB signaling
Category	Pathway view; Signal transduction
Pathway	hsa04350 TGF-beta signaling pathway
Disease	H00800 Loeys-Dietz syndrome H00482 Brachydactyly H00211 Hereditary hemochromatosis H00533 Hereditary hemorrhagic telangiectasia
Display	drug-target relation   disease type

N00063        TGFB → (TGFBR2+TGFBR1) → (SMAD2,SMAD3) = SMAD4     CED     TGFB1*     LDS4     TGFB2*     LDS5     TGFB3*     LDS1A/2A/AAT5         TGFBR1*     LDS1B/2BAAT3         TGFBR2*     CRC         TGFBR2*     LDS3             SMAD3*     LDS6             SMAD2* N00531    HBV X → TGFB → (TGFBR2+TGFBR1) → (SMAD2,SMAD3) = SMAD4 N00507    HTLV-1         TAX ⊣ (SMAD2,SMAD3) N01460    PLG → FBN1 = LTBP1/3/4 ⌿ TGFB     GPHYSD2/MFS     FBN1*     GPHYSD3/DASS         LTBP3*   N01456        INHBA → ((ACVR2A,ACVR2B)+(.. → (SMAD2,SMAD3) = SMAD4     FOP         ACVR1* N01459        NODAL → ((ACVR2A,ACVR2B)+(.. → (SMAD2,SMAD3) = SMAD4     HTX5     NODAL*     HTX4         ACVR2B*   N01453        BMP → ((ACVR2A,ACVR2B,BM.. → (SMAD1,SMAD5,SMAD9.. = SMAD4     BDA2     BMP2*     BDA1C/BDA2/AMD2/SYNS2/SYM1B     GDF5*     SYNS4     GDF6*     JPS/HMPS         BMPR1A*     BDA1D/BDA2/AMD3         BMPR1B* N01428    (NOG,GREM,CHRD,NBL.. ⊣ BMP     BDB2/SYNS1/SYM1A/TCC NOG*     STHAG9 GREM2*   N01458        BMP2/6 → ((ACVR2B,BMPR2)+(A.. → (SMAD1,SMAD5,SMAD9.. = SMAD4 ⇒ HAMP     HFE2B                     HAMP* N01461        (HJV,HFE,TFR2) → ((ACVR2B,BMPR2)+(A..     HFE2A     HJV*     HFE1     HFE*     HFE3     TFR2*   N01426        BMP9/10 → ((BMPR2,ACVR2A)+AC.. → (SMAD1,SMAD5,SMAD9.. = SMAD4     HHT5     BMP9*     PPH1         BMPR2*     HHT2         ACVRL1*     PPH2             SMAD9*     JPHT/JPS/MYHRS                 SMAD4* N01462        ENG → ((BMPR2,ACVR2A)+AC..     HHT1     ENG*   N01455        BMP15 → (BMPR2+BMPR1B) → (SMAD1,SMAD5,SMAD9.. = SMAD4     ODG2     BMP15*   N01454        AMH → (AMHR2+(ACVR1,BMPR.. → (SMAD1,SMAD5,SMAD9.. = SMAD4     PMDS1     AMH*     PMDS2         AMHR2*   N01457        MSTN → (ACVR2B+(ACVR1B,TG.. → (SMAD1,SMAD5,SMAD9.. = SMAD4     MSLHP     MSTN*

		Disease name	Disease category
CED	H00434	Camurati-Engelmann disease	Congenital malformation
LDS4	H00800	Loeys-Dietz syndrome	Congenital malformation
LDS5	H00800	Loeys-Dietz syndrome	Congenital malformation
LDS1A/2A/AAT5	H00800	Loeys-Dietz syndrome	Congenital malformation
	H00801	Familial thoracic aortic aneurysm and dissection	Cardiovascular disease
LDS1B/2BAAT3	H00800	Loeys-Dietz syndrome	Congenital malformation
	H00801	Familial thoracic aortic aneurysm and dissection	Cardiovascular disease
CRC	H00020	Colorectal cancer	Cancer
LDS3	H00800	Loeys-Dietz syndrome	Congenital malformation
LDS6	H00800	Loeys-Dietz syndrome	Congenital malformation
HBV	H00048	Hepatocellular carcinoma	Cancer
HTLV-1	H00009	Adult T-cell leukemia	Cancer
GPHYSD2/MFS	H00900	Geleophysic dysplasia	Congenital malformation
	H00653	Marfan syndrome	Congenital malformation
GPHYSD3/DASS	H00900	Geleophysic dysplasia	Congenital malformation
	H00625	Tooth agenesis	Congenital malformation
FOP	H00430	Fibrodysplasia ossificans progressiva	Musculoskeletal disease
HTX5	H00632	Heterotaxy	Congenital malformation
HTX4	H00632	Heterotaxy	Congenital malformation
BDA2	H00482	Brachydactyly	Congenital malformation
BDA1C/BDA2/AMD2/SYNS2/SYM1B	H00482	Brachydactyly	Congenital malformation
	H02543	Acromesomelic dysplasia	Congenital malformation
	H00484	Multiple synostosis syndrome	Congenital malformation
	H00851	Proximal symphalangism	Congenital malformation
SYNS4	H00484	Multiple synostosis syndrome	Congenital malformation
JPS/HMPS	H01023	Juvenile polyposis syndrome	Neoplasm
	H01024	Hereditary mixed polyposis syndrome	Digestive system disease
BDA1D/BDA2/AMD3	H00482	Brachydactyly	Congenital malformation
	H02543	Acromesomelic dysplasia	Congenital malformation
BDB2/SYNS1/SYM1A/TCC	H00482	Brachydactyly	Congenital malformation
	H00484	Multiple synostosis syndrome	Congenital malformation
	H00851	Proximal symphalangism	Congenital malformation
	H00778	Tarsal-carpal coalition syndrome	Congenital malformation
STHAG9	H00625	Tooth agenesis	Congenital malformation
HFE2B	H00211	Hemochromatosis	Inherited metabolic disorder
HFE2A	H00211	Hemochromatosis	Inherited metabolic disorder
HFE1	H00211	Hemochromatosis	Inherited metabolic disorder
HFE3	H00211	Hemochromatosis	Inherited metabolic disorder
HHT5	H00533	Hereditary hemorrhagic telangiectasia	Congenital malformation
PPH1	H01619	Primary pulmonary hypertension	Cardiovascular disease
HHT2	H00533	Hereditary hemorrhagic telangiectasia	Congenital malformation
PPH2	H01619	Primary pulmonary hypertension	Cardiovascular disease
JPHT/JPS/MYHRS	H00533	Hereditary hemorrhagic telangiectasia	Congenital malformation
	H01023	Juvenile polyposis syndrome	Neoplasm
	H02102	Myhre syndrome	Congenital malformation
HHT1	H00533	Hereditary hemorrhagic telangiectasia	Congenital malformation
ODG2	H00599	Ovarian dysgenesis	Reproductive system disease
PMDS1	H00609	Persistent Mullerian duct syndrome	Reproductive system disease
PMDS2	H00609	Persistent Mullerian duct syndrome	Reproductive system disease
MSLHP	H02452	Muscle hypertrophy	Musculoskeletal disease