KEGG    Network variation - Apoptosis
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ENTRYnt06524
NameApoptosis
CategoryPathway view; Cellular process
Pathwayhsa04210 Apoptosis
Display drug-target relation   disease type
N00145    TNF→TNFRSF1A→(RIPK1+TRADD+TRAF2..→FADD→CASP8→(CASP3,CASP7)
N00524    HCV   NS5A⊣TRADD
N00936    Escherichia     NleB1⊣FADD
N00528    HCV     Core→CFLAR⊣CASP8
N00352    HPV       E6⊣CASP8
N00579    HSV       ICP6⊣CASP8
N00937    Escherichia       NleF⊣CASP8
 
N00146      (FASLG,TNFSF10)→(FAS,TNFRSF10B)→FADD→(CASP8,CASP10)→BID→(BAX,BAK1)→CYCS=APAF1→CASP9→(CASP3,CASP7)
    ALPS1B   FASLG*
    ALPS1A     FAS*
    HNSCC     TNFRSF10B*
    ALPS2B         CASP8*
    ALPS2A         CASP10*
N00448    HIV (Tat,Nef)→FASLG
N00527    HCV   Core→FAS
N00425    HCMV       UL36⊣CASP8
N00166    KSHV       vFLIP⊣CASP8P3
N00526    HCV       NS3→CASP8
N00477    EBV         BHRF1⊣BID
N00164    KSHV           vBCL2⊣(BAX,BAK1)
N00426    HCMV           UL37x1⊣BAX
N00534    HBV           X→BAX
N00950    Shigella       FimA→VDAC1=HK⊣BAX
N00165    KSHV                   vIAP⊣CASP3
N00580    HSV                   ICP0→CASP3
 
N00098      (PMAIP1,BBC3,BAD,B..⊣(BCL2,BCL2L1)⊣(BAX,BAK1)→CYCS=APAF1→CASP9→(CASP3,CASP7)
    SCLC     BCL2*
    CRC       BAX*
    THC4         CYCS*↗
N00262    EBV EBNA3C⊣BCL2L11
N00585    HSV US3⊣BAD
N00452    HIV Nef⊣BAD
N00475    EBV   BHRF1→BCL2
N00453    HIV   Vpr→BCL2
N00383    HPV     (E6+UBE3A)⊣BAK1
N00450    HIV     Tat→BAX
N00938    Escherichia   NleH→TMBIM6⊣BAX
N00745    IAV     PB1F2=(VDAC1+SLC25A6)→CYCS
N00939    Escherichia         EspF⊣ABCF2⊣CASP9
 
N01056    FASLG→FAS→(DAXX+ASK1)→JNK

Disease nameDisease category
HCVH00048Hepatocellular carcinomaCancer
EscherichiaH00277Enterohemorrhagic Escherichia coli (EHEC) infectionBacterial infectious disease
H00278Enteropathogenic Escherichia coli (EPEC) infectionBacterial infectious disease
HPVH00030Cervical cancerCancer
HSVH00365Herpes simplex virus infectionViral infectious disease
ALPS1BH00108Autoimmune lymphoproliferative syndromesPrimary immunodeficiency
ALPS1AH00108Autoimmune lymphoproliferative syndromesPrimary immunodeficiency
HNSCCH02610Head and neck squamous cell carcinomaCancer
ALPS2BH00108Autoimmune lymphoproliferative syndromesPrimary immunodeficiency
ALPS2AH00108Autoimmune lymphoproliferative syndromesPrimary immunodeficiency
HIVH01563HIV infectionViral infectious disease
HCMVH00368Cytomegalovirus infectionViral infectious disease
KSHVH00041Kaposi sarcomaCancer
EBVH00008Burkitt lymphomaCancer
H00007Hodgkin lymphomaCancer
H00054Nasopharyngeal cancerCancer
HBVH00048Hepatocellular carcinomaCancer
ShigellaH00299ShigellosisBacterial infectious disease
SCLCH00013Small cell lung cancerCancer
CRCH00020Colorectal cancerCancer
THC4H00978Thrombocytopenia (THC)Hematologic disease
IAVH00398InfluenzaViral infectious disease