[ Network menu | Network entry | Help ]

ENTRY	nt06528
Name	Calcium signaling
Category	Pathway view; Signal transduction
Pathway	hsa04020 Calcium signaling pathway
Disease	H00720 Long QT syndrome H00728 Brugada syndrome H01019 Catecholaminergic polymorphic ventricular tachycardia H00293 Arrhythmogenic right ventricular cardiomyopathy H00606 Early infantile epileptic encephalopathy H00063 Spinocerebellar ataxia
Display	drug-target relation   disease type

N01638                    CAV1.1 → (RYR1+TRDN+JCN+CAS.. → Ca2+(cyto)     HOKPP1                 CACNA1S*     CMYP1B                     RYR1*     VMCQA                     CASQ1* N01282                STAC3 → CAV1.1     CMYP13             STAC3* N01639            Ca2+(extracellular.. − CAV1.2 → Ca2+(cyto) → (RYR2+TRDN+JCN+CAS.. → Ca2+(cyto)     LQT8             CACNA1C* ↗     BRGDA3/NEDHLSS             CACNA1C*     CPVT1                     RYR2* ↗     ARVD2                     RYR2*     CPVT5                     TRDN*     CPVT2                     CASQ2* N01637                    Ca2+(extracellular.. − CAV → Ca2+(cyto)     SCA6/FHM1/SHM1                     CACNA1A* ↗     PASNA                     CACNA1D* ↗     DEE69                     CACNA1E* ↗     SCA42                     CACNA1G* ↗     HALD4/EIG6                     CACNA1H* ↗     NEDSIS                     CACNA1I* ↗     DEE42/EA2                     CACNA1A*     NEDNEH                     CACNA1B*     SANDD                     CACNA1D*     CSNB2A/CORDX3/AIED                     CACNA1F* N01642                    Ca2+(extracellular.. − LGCC → Ca2+(cyto)     DEE46                     GRIN2D* ↗     LKS                     GRIN2A*     DEE27/MRD6                     GRIN2B*     DEE101/MRD8/NDHMSR                     GRIN1*     DFNA41                     P2RX2* N01643                Ca2+(er/sr) ⊣ STIM → ORAI → Ca2+(cyto)     TAM1/STRMK                 STIM1* ↗     IMD10                 STIM1*     TAM2                     ORAI1* ↗     IMD9                     ORAI1* N01640        GPCR → GNAQ → PLCB → IP3 → ITPR → Ca2+(cyto)     SCA44/SCAR13     GRM1* ↗     DEE58     NTRK2*     DEE12             PLCB1*     SCA29                     ITPR1* ↗     SCA15                     ITPR1* N01641        GF → RTK → PLCG → IP3 → ITPR → Ca2+(cyto)     HCC     GF* ↗     Glioma/NSCLC         RTK* ↗     DFNB97         MET*     DFNB39         HGF*     ANHD                     ITPR2* N01655            Ca2+(cyto) → PLCD → IP3 → ITPR → Ca2+(cyto)     NDNC3             PLCD1* N01644                    PI(3.5)P2 → MCOLN1 → Ca2+(cyto) → CALM = CN → TFEB     MLIV                     MCOLN1* N01645                            Ca2+(cyto) − ATP2A → Ca2+(er/sr)     BROD                             ATP2A1*     DAR/AKV                             ATP2A2* N01646                            (PLN,SLN,MLN,ELN,A.. ⊣ ATP2A     CMH18                         PLN* ↗     CMD1P                         PLN* N01429                            Ca2+(cyto) − ATP2B → Ca2+(extracellular..     DFNA82/DFNB12                             ATP2B2*     SCAX1                             ATP2B3* N01647                            Ca2+(cyto) → CALM = CN → NFAT     ACCIID                                 PPP3CA* ↗     DEE91/IECEE1                                 PPP3CA* N01648                            Ca2+(cyto) → CALM = CAMK     MRD53                             CAMK2A* ↗     MRD54                             CAMK2B* ↗     MRD59                             CAMK2G* ↗     MRT63                             CAMK2A*     AAT7/MMIHS1                             MYLK*     CMH1                             MYLK2* ↗ N01649                            Ca2+(cyto) = CALM = (CAV,RYR)     LQT14/CPVT4                             CALM1*     LQT15                             CALM2*     LQT16/CPVT6                             CALM3* N01741                            Ca2+(cyto) → PKC ⊣ TRPC3 → Ca2+(cyto)     SCA14                             PRKCG*     SCA41                                 TRPC3* ↗ N00953    Glutamate → GRM1 → GNAQ → PLCB → IP3 → ITPR → Ca2+ → PKC ⊣ TRPC3 → Ca2+ N00984    Glutamate → GRM5 → GNAQ → PLCB → IP3 → ITPR → Ca2+ − MCU → Ca2+(mito) − MPTP → CYCS = APAF1 → CASP9 → (CASP3,CASP7) N01000    ACh → mAChR → GNAQ → PLCB → IP3 → ITPR → Ca2+ − MCU → Ca2+(mito) − MPTP → CYCS

		Disease name	Disease category
HOKPP1	H00215	Periodic paralysis	Nervous system disease
CMYP1B	H01810	Congenital myopathy	Nervous system disease
VMCQA	H02320	Vacuolar myopathy with CASQ1 aggregates	Musculoskeletal disease
CMYP13	H01810	Congenital myopathy	Nervous system disease
LQT8	H00720	Long QT syndrome	Cardiovascular disease
BRGDA3/NEDHLSS	H00728	Brugada syndrome	Cardiovascular disease
	H02397	Neurodevelopmental disorder with movement abnormalities or hypotonia	Congenital malformation
CPVT1	H01019	Catecholaminergic polymorphic ventricular tachycardia	Cardiovascular disease
ARVD2	H00293	Arrhythmogenic right ventricular cardiomyopathy	Cardiovascular disease
CPVT5	H01019	Catecholaminergic polymorphic ventricular tachycardia	Cardiovascular disease
CPVT2	H01019	Catecholaminergic polymorphic ventricular tachycardia	Cardiovascular disease
SCA6/FHM1/SHM1	H00063	Spinocerebellar ataxia (SCA)	Neurodegenerative disease
	H00775	Hemiplegic migraine	Nervous system disease
PASNA	H01603	Primary aldosteronism	Endocrine and metabolic disease
DEE69	H00606	Early infantile epileptic encephalopathy	Nervous system disease
SCA42	H00063	Spinocerebellar ataxia (SCA)	Neurodegenerative disease
HALD4/EIG6	H01603	Primary aldosteronism	Endocrine and metabolic disease
	H00808	Idiopathic generalized epilepsies	Nervous system disease
NEDSIS	H02397	Neurodevelopmental disorder with movement abnormalities or hypotonia	Congenital malformation
DEE42/EA2	H00606	Early infantile epileptic encephalopathy	Nervous system disease
	H00749	Episodic ataxias	Nervous system disease
NEDNEH	H02397	Neurodevelopmental disorder with movement abnormalities or hypotonia	Congenital malformation
SANDD	H02636	Sinoatrial node dysfunction and deafness	Cardiovascular disease
CSNB2A/CORDX3/AIED	H00787	Congenital stationary night blindness	Nervous system disease
	H00481	Cone-rod dystrophy and cone dystrophy	Nervous system disease
	H00690	Aland Island eye disease	Nervous system disease
DEE46	H00606	Early infantile epileptic encephalopathy	Nervous system disease
LKS	H01514	Landau-Kleffner syndrome	Nervous system disease
DEE27/MRD6	H00606	Early infantile epileptic encephalopathy	Nervous system disease
	H00773	Autosomal dominant intellectual developmental disorder	Mental and behavioural disorder
DEE101/MRD8/NDHMSR	H00606	Early infantile epileptic encephalopathy	Nervous system disease
	H00773	Autosomal dominant intellectual developmental disorder	Mental and behavioural disorder
	H02705	Neurodevelopmental disorder with glutamatergic synapse dysfunction	Nervous system disease
DFNA41	H00604	Deafness, autosomal dominant	Nervous system disease
TAM1/STRMK	H02258	Tubular aggregate myopathy	Musculoskeletal disease
	H02259	Stormorken syndrome	Hematologic disease
IMD10	H00093	Combined immunodeficiency	Primary immunodeficiency
TAM2	H02258	Tubular aggregate myopathy	Musculoskeletal disease
IMD9	H00093	Combined immunodeficiency	Primary immunodeficiency
SCA44/SCAR13	H00063	Spinocerebellar ataxia (SCA)	Neurodegenerative disease
	H01891	Autosomal recessive spinocerebellar ataxias	Neurodegenerative disease
DEE58	H00606	Early infantile epileptic encephalopathy	Nervous system disease
DEE12	H00606	Early infantile epileptic encephalopathy	Nervous system disease
SCA29	H00063	Spinocerebellar ataxia (SCA)	Neurodegenerative disease
SCA15	H00063	Spinocerebellar ataxia (SCA)	Neurodegenerative disease
HCC	H00048	Hepatocellular carcinoma	Cancer
Glioma/NSCLC	H00042	Glioma	Cancer
	H00014	Non-small cell lung cancer	Cancer
DFNB97	H00605	Deafness, autosomal recessive	Nervous system disease
DFNB39	H00605	Deafness, autosomal recessive	Nervous system disease
ANHD	H02281	Isolated anhidrosis with normal sweat glands	Skin disease
NDNC3	H01307	Nonsyndromic congenital nail disorder	Skin disease
MLIV	H00144	Mucolipidosis IV	Inherited metabolic disorder, Lysosomal disease
BROD	H01129	Brody myopathy	Nervous system disease
DAR/AKV	H00715	Darier disease	Congenital malformation
	H00755	Acrokeratosis verruciformis	Congenital malformation
CMH18	H00292	Hypertrophic cardiomyopathy	Cardiovascular disease
CMD1P	H00294	Dilated cardiomyopathy	Cardiovascular disease
DFNA82/DFNB12	H00604	Deafness, autosomal dominant	Nervous system disease
	H00605	Deafness, autosomal recessive	Nervous system disease
SCAX1	H00063	Spinocerebellar ataxia (SCA)	Neurodegenerative disease
ACCIID	H02641	Arthrogryposis, cleft palate, craniosynostosis, and impaired intellectual development	Congenital malformation
DEE91/IECEE1	H00606	Early infantile epileptic encephalopathy	Nervous system disease
	H02150	Infantile or early childhood epileptic encephalopathy	Nervous system disease
MRD53	H00773	Autosomal dominant intellectual developmental disorder	Mental and behavioural disorder
MRD54	H00773	Autosomal dominant intellectual developmental disorder	Mental and behavioural disorder
MRD59	H00773	Autosomal dominant intellectual developmental disorder	Mental and behavioural disorder
MRT63	H00768	Autosomal recessive intellectual developmental disorder	Mental and behavioural disorder
AAT7/MMIHS1	H00801	Familial thoracic aortic aneurysm and dissection	Cardiovascular disease
	H01869	Megacystis microcolon intestinal hypoperistalsis syndrome	Congenital malformation
CMH1	H00292	Hypertrophic cardiomyopathy	Cardiovascular disease
LQT14/CPVT4	H00720	Long QT syndrome	Cardiovascular disease
	H01019	Catecholaminergic polymorphic ventricular tachycardia	Cardiovascular disease
LQT15	H00720	Long QT syndrome	Cardiovascular disease
LQT16/CPVT6	H00720	Long QT syndrome	Cardiovascular disease
	H01019	Catecholaminergic polymorphic ventricular tachycardia	Cardiovascular disease
SCA14	H00063	Spinocerebellar ataxia (SCA)	Neurodegenerative disease
SCA41	H00063	Spinocerebellar ataxia (SCA)	Neurodegenerative disease