KEGG  Amyotrophic lateral sclerosis - Reference pathway

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  • nt06410 Calcium signaling
    • N01151 Mutation-inactivated SIGMAR1 to Ca2+ -apoptotic pathway
  • nt06420 Ubiquitin-proteasome system
    • N01144 Mutation-caused aberrant SOD1 to 26S proteasome-mediated protein degradation
    • N01145 Mutation-inactivated VCP to 26S proteasome-mediated protein degradation
    • N01146 Mutation-inactivated UBQLN2 to 26S proteasome-mediated protein degradation
  • nt06412 Unfolded protein response (UPR) signaling
    • N01149 Mutation-caused aberrant SOD1 to PERK-ATF4 signaling pathway
    • N01148 Mutation-caused aberrant SOD1 to IRE1a-XBP1 signaling pathway
    • N01150 Mutation-inactivated VAPB to ATF6-mediated transcription
    • N01147 Mutation-caused aberrant SOD1 to ATF6-mediated transcription
  • nt06413 Autophagy
    • N01143 Mutation-inactivated C9orf72 to C9orf72-mediated autophagy initiation
  • nt06421 Mitophagy
    • N01138 Mutation-inactivated OPTN to PINK-Parkin-mediated autophagosome formation
    • N01139 Mutation-inactivated p62 to PINK-Parkin-mediated autophagosome formation
    • N01141 Mutation-inactivated TBK1 to TBK1-mediated autophagosome formation
  • nt06414 Apoptosis
    • N01135 Mutation-caused aberrant SOD1 to intrinsic apoptotic pathway
  • nt06415 PI3K signaling
    • N01164 Mutation-inactivated ERBB4 to NRG-ERBB4-PI3K signaling pathway
  • nt06418 Oxidative phosphorylation
    • N01136 Mutation-caused aberrant TDP43 to electron transfer in Complex I
  • nt06419 Microtubule-based transport
    • N01160 Mutation-caused aberrant SOD1 to retrograde axonal transport
    • N01158 Mutation-caused aberrant DCTN1 to retrograde axonal transport
    • N01159 Mutation-caused aberrant TUBA4A to retrograde axonal transport
  • nt06423 Cytoskeletal regulation
    • N01162 Mutation-caused aberrant PFN1 to actin polymerization
  • nt06424 RNA processing
    • N01155 Mutation-caused aberrant TDP43 to TDP-43-regulated splicing
    • N01157 Mutation-caused aberrant FUS to FUS-regulated splicing
    • N01153 Mutation-caused aberrant GLE1 to nuclear export of mRNA