KEGG Amyotrophic lateral sclerosis - Reference pathway
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    • nt06410 Calcium signaling
      • N01151 Mutation-inactivated SIGMAR1 to Ca2+ -apoptotic pathway
    • nt06420 Ubiquitin-proteasome system
      • N01144 Mutation-caused aberrant SOD1 to 26S proteasome-mediated protein degradation
      • N01145 Mutation-inactivated VCP to 26S proteasome-mediated protein degradation
      • N01146 Mutation-inactivated UBQLN2 to 26S proteasome-mediated protein degradation
    • nt06412 Unfolded protein response (UPR) signaling
      • N01149 Mutation-caused aberrant SOD1 to PERK-ATF4 signaling pathway
      • N01148 Mutation-caused aberrant SOD1 to IRE1a-XBP1 signaling pathway
      • N01150 Mutation-inactivated VAPB to ATF6-mediated transcription
      • N01147 Mutation-caused aberrant SOD1 to ATF6-mediated transcription
    • nt06413 Autophagy
      • N01143 Mutation-inactivated C9orf72 to C9orf72-mediated autophagy initiation
    • nt06421 Mitophagy
      • N01138 Mutation-inactivated OPTN to PINK-Parkin-mediated autophagosome formation
      • N01139 Mutation-inactivated p62 to PINK-Parkin-mediated autophagosome formation
      • N01141 Mutation-inactivated TBK1 to TBK1-mediated autophagosome formation
    • nt06414 Apoptosis
      • N01135 Mutation-caused aberrant SOD1 to intrinsic apoptotic pathway
    • nt06415 PI3K signaling
      • N01164 Mutation-inactivated ERBB4 to NRG-ERBB4-PI3K signaling pathway
    • nt06418 Oxidative phosphorylation
      • N01136 Mutation-caused aberrant TDP43 to electron transfer in Complex I
    • nt06419 Microtubule-based transport
      • N01160 Mutation-caused aberrant SOD1 to retrograde axonal transport
      • N01158 Mutation-caused aberrant DCTN1 to retrograde axonal transport
      • N01159 Mutation-caused aberrant TUBA4A to retrograde axonal transport
    • nt06423 Cytoskeletal regulation
      • N01162 Mutation-caused aberrant PFN1 to actin polymerization
    • nt06424 RNA processing
      • N01155 Mutation-caused aberrant TDP43 to TDP-43-regulated splicing
      • N01157 Mutation-caused aberrant FUS to FUS-regulated splicing
      • N01153 Mutation-caused aberrant GLE1 to nuclear export of mRNA