# OC Root 2nd 3rd 4th 5th 6th PC Gene/Definition OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 Clostridium_perfringens.541 cpe.1562 cpe:CPE1562 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 Clostridium_perfringens.541 cpf.1764 cpf:CPF_1814 conserved hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 Clostridium_perfringens.541 cpr.1449 cpr:CPR_1533 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 Clostridium_botulinum.2711 cbo.328 cbo:CBO0331 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 Clostridium_botulinum.2767 cbo.333 cbo:CBO0335 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 Clostridium_botulinum.2790 cbo.335 cbo:CBO0337 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 Clostridium_botulinum.2711 cba.331 cba:CLB_0373 putative membrane protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 Clostridium_botulinum.2767 cba.336 cba:CLB_0378 conserved hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 Clostridium_botulinum.2790 cba.338 cba:CLB_0380 putative membrane protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 Clostridium_botulinum.2711 cbh.317 cbh:CLC_0388 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 Clostridium_botulinum.2767 cbh.322 cbh:CLC_0393 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 Clostridium_botulinum.2790 cbh.324 cbh:CLC_0395 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 Clostridium_botulinum.2711 cby.364 cby:CLM_0398 putative membrane protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 Clostridium_botulinum.2767 cby.369 cby:CLM_0403 conserved hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 Clostridium_botulinum.2790 cby.371 cby:CLM_0405 putative membrane protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 Clostridium_botulinum.2711 cbl.3368 cbl:CLK_3518 putative membrane protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 Clostridium_botulinum.2767 cbl.3373 cbl:CLK_3523 conserved hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 Clostridium_botulinum.2790 cbl.3375 cbl:CLK_3525 putative membrane protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 Clostridium_botulinum.2790 cbb.412 cbb:CLD_0415 putative membrane protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 Clostridium_botulinum.2767 cbb.414 cbb:CLD_0417 conserved hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 Clostridium_botulinum.2711 cbb.419 cbb:CLD_0422 putative membrane protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 Clostridium_botulinum.2711 cbi.653 cbi:CLJ_B0386 putative membrane protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 Clostridium_botulinum.2767 cbi.658 cbi:CLJ_B0391 conserved hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 Clostridium_botulinum.8101 cbi.660 cbi:CLJ_B0393 putative membrane protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 Clostridium_botulinum.12747 cbt.1299 cbt:CLH_1353 conserved hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 Clostridium_botulinum.2711 cbf.329 cbf:CLI_0401 putative membrane protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 Clostridium_botulinum.2767 cbf.334 cbf:CLI_0406 conserved hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 Clostridium_botulinum.2790 cbf.336 cbf:CLI_0408 putative membrane protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 Clostridium_botulinum.2711 cbm.312 cbm:CBF_0369 putative membrane protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 Clostridium_botulinum.2767 cbm.316 cbm:CBF_0374 conserved hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 Clostridium_botulinum.2790 cbm.318 cbm:CBF_0376 putative membrane protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 Clostridium_botulinum.2711 cbj.348 cbj:H04402_00339 no significant homology 4 putative transmembrane regions were found by PSORT OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 Clostridium_botulinum.2767 cbj.353 cbj:H04402_00344 no significant homology 4 putative transmembrane regions were found by PSORT OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 Clostridium_beijerinckii.2304 cbe.3103 cbe:Cbei_3170 conserved hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 Clostridium_beijerinckii.2304 cbz.3102 cbz:Cbs_3170 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 Clostridium_beijerinckii.2304 cbei.3178 cbei:LF65_03571 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 Clostridium_kluyveri.1978 ckl.2960 ckl:CKL_3113 Conserved hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 Clostridium_kluyveri.1978 ckl.2961 ckl:CKL_3114 Conserved hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 Clostridium_kluyveri.1978 ckl.2962 ckl:CKL_3115 Conserved hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 Clostridium_kluyveri.1978 ckr.2732 ckr:CKR_2753 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 Clostridium_kluyveri.1978 ckr.2733 ckr:CKR_2754 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 Clostridium_kluyveri.1978 ckr.2734 ckr:CKR_2755 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 - ccb.3727 ccb:Clocel_4041 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 - csr.311 csr:Cspa_c00940 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 - csr.2292 csr:Cspa_c22570 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 Clostridium_pasteurianum.1867 cpas.3094 cpas:Clopa_3626 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 Clostridium_pasteurianum.2400 cpas.3491 cpas:Clopa_4096 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 Clostridium_pasteurianum.2400 cpas.3492 cpas:Clopa_4097 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 Clostridium_pasteurianum.1867 cpat.2698 cpat:CLPA_c28100 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 Clostridium_pasteurianum.2400 cpat.3190 cpat:CLPA_c33100 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 Clostridium_pasteurianum.2400 cpat.3191 cpat:CLPA_c33110 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 Clostridium_pasteurianum.1867 cpae.2698 cpae:CPAST_c28100 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 Clostridium_pasteurianum.2400 cpae.3190 cpae:CPAST_c33100 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 Clostridium_pasteurianum.2400 cpae.3191 cpae:CPAST_c33110 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 - cbv.1472 cbv:U729_2378 putative membrane protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 - csq.2190 csq:CSCA_2177 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 - csq.2191 csq:CSCA_2178 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 - csq.2947 csq:CSCA_2947 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 - csq.2948 csq:CSCA_2948 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 - cld.339 cld:CLSPO_c03600 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 - cld.344 cld:CLSPO_c03650 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 - cld.346 cld:CLSPO_c03670 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.20774 - cace.351 cace:CACET_c03290 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.37962 - cace.1152 cace:CACET_c11960 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 - cck.64 cck:Ccar_00010 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 - cck.65 cck:Ccar_00015 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 - cbut.1193 cbut:ATN24_06420 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 - cbut.1306 cbut:ATN24_07000 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 - ctyk.4 ctyk:CTK_C02300 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 - ctyk.4 ctyk:CTK_C02320 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 - ceu.870 ceu:A7L45_04410 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 - ctae.5 ctae:BGI42_03325 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 - ctae.5 ctae:BGI42_03330 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 - ctae.5 ctae:BGI42_03335 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.20774 - cfm.1349 cfm:BJL90_07305 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 - cchv.1906 cchv:BTM20_10410 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 - cdrk.923 cdrk:B9W14_04820 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 - cdrk.924 cdrk:B9W14_04825 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 - cdrk.1666 cdrk:B9W14_08695 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 - cdrk.43 cdrk:B9W14_08700 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Clostridium.7880 - cdrk.43 cdrk:B9W14_08705 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Alkaliphilus.831 - amt.859 amt:Amet_0801 conserved hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Alkaliphilus.1808 - amt.1267 amt:Amet_1280 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Alkaliphilus.831 - aoe.2401 aoe:Clos_2475 conserved hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 - - gfe.1098 gfe:Gferi_05275 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 - - gfe.2092 gfe:Gferi_10635 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118445 Firmicutes___Clostridia.4154 - - psor.2723 psor:RSJ16_14970 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Desulfitobacterium.4256 Desulfitobacterium_hafniense.2388 dsy.2519 dsy:DSY2530 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Desulfitobacterium.3232 Desulfitobacterium_hafniense.5526 dsy.4341 dsy:DSY4414 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Desulfitobacterium.4256 Desulfitobacterium_hafniense.2388 dhd.3602 dhd:Dhaf_3689 conserved hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Desulfitobacterium.3232 - ddh.777 ddh:Desde_0791 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Desulfitobacterium.3232 - ddl.649 ddl:Desdi_0669 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Desulfotomaculum.5622 - dru.2732 dru:Desru_2867 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 - - dae.488 dae:Dtox_0384 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 - - dae.2742 dae:Dtox_3078 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 - - dku.2379 dku:Desku_2576 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 - - dku.2607 dku:Desku_2834 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 - - dgi.1422 dgi:Desgi_1516 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 - - dgi.2241 dgi:Desgi_2486 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 - - pth.2099 pth:PTH_2129 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 - - sgy.679 sgy:Sgly_0685 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Desulfosporosinus.1319 - dor.3583 dor:Desor_4007 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Desulfosporosinus.1319 - dai.3076 dai:Desaci_3426 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Desulfosporosinus.1319 - dmi.2850 dmi:Desmer_3114 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 Desulfosporosinus.1319 - dmi.2851 dmi:Desmer_3115 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4151 Dehalobacter.3293 - drs.1044 drs:DEHRE_05655 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118444 Firmicutes___Clostridia.4157 - - awo.657 awo:Awo_c05710 hypothetical protein membrane protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4150 - - tte.546 tte:TTE0560 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4150 Thermoanaerobacter.700 Thermoanaerobacter_sp_.1639 tex.491 tex:Teth514_0497 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4150 Thermoanaerobacter.700 Thermoanaerobacter_sp_.1639 thx.521 thx:Thet_0547 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4150 Thermoanaerobacter.700 - tpd.1674 tpd:Teth39_1736 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4150 Thermoanaerobacter.700 - tit.519 tit:Thit_0546 conserved hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4150 Thermoanaerobacter.700 - tmt.571 tmt:Tmath_0607 conserved hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4150 Thermoanaerobacter.700 - tbo.1669 tbo:Thebr_1780 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4150 Thermoanaerobacter.700 - twi.583 twi:Thewi_0638 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4150 Thermoanaerobacter.700 - tki.540 tki:TKV_c05430 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 - - mta.873 mta:Moth_0901 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 - - mta.1562 mta:Moth_1623 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 - - tpz.81 tpz:Tph_c14720 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 - - tpz.81 tpz:Tph_c17380 putative membrane protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 - - tpz.81 tpz:Tph_c22470 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 - - mas.527 mas:Mahau_0497 hypothetical protein OC.1403388 Bacteria.451792 Firmicutes.118443 Firmicutes___Clostridia.4148 - - aar.1796 aar:Acear_1929 hypothetical protein