# OC Root 2nd 3rd 4th 5th PC Gene/Definition OC.226478 Bacteria.319687 Actinobacteria.45425 Cutibacterium.1275 Cutibacterium_acnes.221 pac.1135 pac:PPA1172 activator of 2-hydroxyglutaryl-CoA dehydratase fused to uncharacterized conserved protein OC.226478 Bacteria.319687 Actinobacteria.45425 Cutibacterium.1275 Cutibacterium_acnes.221 pak.1201 pak:HMPREF0675_4233 putative CoA-substrate-specific enzyme activase OC.226478 Bacteria.319687 Actinobacteria.45425 Cutibacterium.1275 Cutibacterium_acnes.221 pav.1130 pav:TIA2EST22_05825 hypothetical protein OC.226478 Bacteria.319687 Actinobacteria.45425 Cutibacterium.1275 Cutibacterium_acnes.221 pax.1134 pax:TIA2EST36_05795 hypothetical protein OC.226478 Bacteria.319687 Actinobacteria.45425 Cutibacterium.1275 Cutibacterium_acnes.221 paz.1119 paz:TIA2EST2_05735 hypothetical protein OC.226478 Bacteria.319687 Actinobacteria.45425 Cutibacterium.1275 Cutibacterium_acnes.221 paw.1179 paw:PAZ_c12210 hgdC; activator of (R)-2-hydroxyglutaryl-CoA dehydratase OC.226478 Bacteria.319687 Actinobacteria.45425 Cutibacterium.1275 Cutibacterium_acnes.221 pad.1679 pad:TIIST44_08775 putative CoA-substrate-specific enzyme activase OC.226478 Bacteria.319687 Actinobacteria.45425 Cutibacterium.1275 Cutibacterium_acnes.221 pcn.1181 pcn:TIB1ST10_06015 hypothetical protein OC.226478 Bacteria.319687 Actinobacteria.45425 Cutibacterium.1275 Cutibacterium_acnes.221 pacc.1190 pacc:PAC1_06125 activator of (R)-2-hydroxyglutaryl-CoA dehydratase OC.226478 Bacteria.319687 Actinobacteria.45425 Cutibacterium.1275 Cutibacterium_acnes.221 pach.950 pach:PAGK_0981 activator of 2-hydroxyglutaryl-CoA dehydratase OC.226478 Bacteria.319687 Actinobacteria.45425 Cutibacterium.1275 Cutibacterium_acnes.221 pacn.1130 pacn:TIA1EST1_05780 activase OC.226478 Bacteria.319687 Actinobacteria.45425 Cutibacterium.1275 Cutibacterium_acnes.221 cacn.1197 cacn:RN83_06230 activase OC.226478 Bacteria.319687 Actinobacteria.45425 Cutibacterium.4789 - pra.999 pra:PALO_05110 activator of (R)-2-hydroxyglutaryl-CoA dehydratase OC.226478 Bacteria.319687 Actinobacteria.45425 Cutibacterium.4072 - cgrn.1280 cgrn:4412665_01339 hgdC; 2-hydroxyglutaryl-CoA dehydratase component A OC.226478 Bacteria.319687 Actinobacteria.45425 Propionibacterium.1071 Propionibacterium_freudenreichii.1029 pfr.2056 pfr:PFREUD_21700 Hypothetical fusion protein OC.226478 Bacteria.319687 Actinobacteria.45425 Propionibacterium.1071 Propionibacterium_freudenreichii.1029 pfre.1969 pfre:RM25_2041 Putative CoA-substrate-specific enzyme activase OC.226478 Bacteria.319687 Actinobacteria.45425 Propionibacterium.2973 - prl.471 prl:BCB70_02450 activase OC.226478 Bacteria.319687 Actinobacteria.45425 Acidipropionibacterium.458 Acidipropionibacterium_acidipropionici.1475 pbo.1723 pbo:PACID_17910 CoA-substrate-specific enzyme activase OC.226478 Bacteria.319687 Actinobacteria.45425 Acidipropionibacterium.458 Acidipropionibacterium_acidipropionici.1475 aaci.2387 aaci:ASQ49_12605 activase OC.226478 Bacteria.319687 Actinobacteria.45425 Acidipropionibacterium.458 - acij.1577 acij:JS278_01618 hadI; 2-hydroxyisocaproyl-CoA dehydratase activator OC.226478 Bacteria.319687 Actinobacteria.45425 Tessaracoccus.3447 - tes.2231 tes:BW730_12410 activase OC.226478 Bacteria.319687 Actinobacteria.45425 - - mgg.425 mgg:MPLG2_0366 putative CoA-substrate-specific enzyme activase OC.226478 Bacteria.319687 Actinobacteria.45425 - - mcu.500 mcu:HMPREF0573_10488 putative CoA-substrate-specific enzyme activase OC.226478 Bacteria.319687 Actinobacteria.45425 Actinotignum.1019 - actt.670 actt:DDD63_03990 activase OC.226478 Bacteria.319687 Actinobacteria.45425 Actinomyces.7166 - amy.1295 amy:ADJ76_06895 activase OC.226478 Bacteria.319687 Actinobacteria.45425 Bifidobacterium.1554 Bifidobacterium_longum.1685 blo.1660 blo:BL1754 hypothetical protein OC.226478 Bacteria.319687 Actinobacteria.45425 Bifidobacterium.1554 Bifidobacterium_longum.2247 blj.1903 blj:BLD_1931 Activator of 2-hydroxyglutaryl-CoA dehydratase OC.226478 Bacteria.319687 Actinobacteria.45425 Bifidobacterium.1554 Bifidobacterium_longum.2246 bln.594 bln:Blon_0614 putative CoA-substrate-specific enzyme activase OC.226478 Bacteria.319687 Actinobacteria.45425 Bifidobacterium.1554 Bifidobacterium_longum.2246 blon.623 blon:BLIJ_0619 putative CoA-substrate-specific enzyme activating protein OC.226478 Bacteria.319687 Actinobacteria.45425 Bifidobacterium.1554 Bifidobacterium_longum.4070 blf.1536 blf:BLIF_1564 putative CoA-substrate-specific enzyme activating protein OC.226478 Bacteria.319687 Actinobacteria.45425 Bifidobacterium.1554 Bifidobacterium_longum.2246 bll.1471 bll:BLJ_1542 putative CoA-substrate-specific enzyme activase OC.226478 Bacteria.319687 Actinobacteria.45425 Bifidobacterium.1554 Bifidobacterium_longum.1685 blb.868 blb:BBMN68_1787 Activator of 2-hydroxyglutaryl-CoA dehydratase OC.226478 Bacteria.319687 Actinobacteria.45425 Bifidobacterium.1554 Bifidobacterium_longum.1685 blm.1488 blm:BLLJ_1507 putative CoA-substrate-specific enzyme activating protein OC.226478 Bacteria.319687 Actinobacteria.45425 Bifidobacterium.1554 Bifidobacterium_longum.1685 blk.404 blk:BLNIAS_00593 activator of 2-hydroxyglutaryl-CoA dehydratase OC.226478 Bacteria.319687 Actinobacteria.45425 Bifidobacterium.1554 Bifidobacterium_longum.2246 blg.181 blg:BIL_02270 CoA-substrate-specific enzyme activase, putative OC.226478 Bacteria.319687 Actinobacteria.45425 Bifidobacterium.1554 Bifidobacterium_longum.2246 blz.1531 blz:BLGT_08030 activase OC.226478 Bacteria.319687 Actinobacteria.45425 Bifidobacterium.1554 Bifidobacterium_longum.2246 blx.1433 blx:GS08_08020 activase OC.226478 Bacteria.319687 Actinobacteria.45425 Bifidobacterium.1554 Bifidobacterium_adolescentis.205 bad.1211 bad:BAD_1214 yxcA; hypothetical protein OC.226478 Bacteria.319687 Actinobacteria.45425 Bifidobacterium.1554 Bifidobacterium_adolescentis.205 badl.1629 badl:BADO_1653 CoA-substrate-specific enzyme activase OC.226478 Bacteria.319687 Actinobacteria.45425 Bifidobacterium.1554 Bifidobacterium_adolescentis.205 bado.1386 bado:BBMN23_1387 hypothetical protein OC.226478 Bacteria.319687 Actinobacteria.45425 Bifidobacterium.1554 Bifidobacterium_animalis.256 bla.512 bla:BLA_0516 activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) OC.226478 Bacteria.319687 Actinobacteria.45425 Bifidobacterium.1554 Bifidobacterium_animalis.256 blc.1262 blc:Balac_1310 hypothetical protein OC.226478 Bacteria.319687 Actinobacteria.45425 Bifidobacterium.1554 Bifidobacterium_animalis.256 blt.1261 blt:Balat_1310 hypothetical protein OC.226478 Bacteria.319687 Actinobacteria.45425 Bifidobacterium.1554 Bifidobacterium_animalis.256 bbb.1039 bbb:BIF_01467 Activator of (R)-2-hydroxyglutaryl-CoA dehydratase OC.226478 Bacteria.319687 Actinobacteria.45425 Bifidobacterium.1554 Bifidobacterium_animalis.256 bbc.1224 bbc:BLC1_1268 putative CoA-substrate-specific enzyme activase OC.226478 Bacteria.319687 Actinobacteria.45425 Bifidobacterium.1554 Bifidobacterium_animalis.256 bnm.1286 bnm:BALAC2494_01416 Activator of (R)-2-hydroxyglutaryl-CoA dehydratase OC.226478 Bacteria.319687 Actinobacteria.45425 Bifidobacterium.1554 Bifidobacterium_animalis.256 blv.1267 blv:BalV_1268 hypothetical protein OC.226478 Bacteria.319687 Actinobacteria.45425 Bifidobacterium.1554 Bifidobacterium_animalis.256 blw.1268 blw:W7Y_1315 Activator of (R)-2-hydroxyglutaryl-CoA dehydratase OC.226478 Bacteria.319687 Actinobacteria.45425 Bifidobacterium.1554 Bifidobacterium_animalis.256 bls.1297 bls:W91_1347 Activator of (R)-2-hydroxyglutaryl-CoA dehydratase OC.226478 Bacteria.319687 Actinobacteria.45425 Bifidobacterium.1554 Bifidobacterium_animalis.256 bani.1226 bani:Bl12_1228 putative CoA-substrate-specific enzyme activase OC.226478 Bacteria.319687 Actinobacteria.45425 Bifidobacterium.1554 Bifidobacterium_animalis.256 banl.1256 banl:BLAC_06550 hypothetical protein OC.226478 Bacteria.319687 Actinobacteria.45425 Bifidobacterium.1554 Bifidobacterium_animalis.256 bni.1252 bni:BANAN_06395 hypothetical protein OC.226478 Bacteria.319687 Actinobacteria.45425 Bifidobacterium.1554 Bifidobacterium_animalis.256 banm.1246 banm:EN10_06635 activase OC.226478 Bacteria.319687 Actinobacteria.45425 Bifidobacterium.1554 Bifidobacterium_dentium.2074 bde.1577 bde:BDP_1691 Activator of (R)-2-hydroxyglutaryl-CoA dehydratase OC.226478 Bacteria.319687 Actinobacteria.45425 Bifidobacterium.1554 Bifidobacterium_dentium.2164 bdn.1596 bdn:BBDE_1604 putative CoA-substrate-specific enzyme activating protein OC.226478 Bacteria.319687 Actinobacteria.45425 Bifidobacterium.1554 Bifidobacterium_bifidum.1037 bbi.481 bbi:BBIF_0480 putative CoA-substrate-specific enzyme activase OC.226478 Bacteria.319687 Actinobacteria.45425 Bifidobacterium.1554 Bifidobacterium_bifidum.1037 bbp.416 bbp:BBPR_0457 (R)-2-hydroxyglutaryl-CoA dehydratase activator OC.226478 Bacteria.319687 Actinobacteria.45425 Bifidobacterium.1554 Bifidobacterium_bifidum.1037 bbf.432 bbf:BBB_0433 hgdC; activator of (R)-2-hydroxyglutaryl-CoAdehydratase OC.226478 Bacteria.319687 Actinobacteria.45425 Bifidobacterium.1554 Bifidobacterium_breve.491 bbv.1339 bbv:HMPREF9228_1490 putative CoA-substrate-specific enzyme activase OC.226478 Bacteria.319687 Actinobacteria.45425 Bifidobacterium.1554 Bifidobacterium_breve.490 bbru.1364 bbru:Bbr_1445 Activator of (R)-2-hydroxyglutaryl-CoA dehydratase OC.226478 Bacteria.319687 Actinobacteria.45425 Bifidobacterium.1554 Bifidobacterium_breve.491 bbre.1289 bbre:B12L_1370 Activator of (R)-2-hydroxyglutaryl-CoA dehydratase OC.226478 Bacteria.319687 Actinobacteria.45425 Bifidobacterium.1554 Bifidobacterium_breve.491 bbrv.1366 bbrv:B689b_1475 Activator of (R)-2-hydroxyglutaryl-CoA dehydratase OC.226478 Bacteria.319687 Actinobacteria.45425 Bifidobacterium.1554 Bifidobacterium_breve.490 bbrj.1308 bbrj:B7017_1634 Activator of (R)-2-hydroxyglutaryl-CoA dehydratase OC.226478 Bacteria.319687 Actinobacteria.45425 Bifidobacterium.1554 Bifidobacterium_breve.491 bbrc.1462 bbrc:B7019_1640 Activator of (R)-2-hydroxyglutaryl-CoA dehydratase OC.226478 Bacteria.319687 Actinobacteria.45425 Bifidobacterium.1554 Bifidobacterium_breve.491 bbrn.1346 bbrn:B2258_1424 Activator of (R)-2-hydroxyglutaryl-CoA dehydratase OC.226478 Bacteria.319687 Actinobacteria.45425 Bifidobacterium.1554 Bifidobacterium_breve.490 bbrs.1328 bbrs:BS27_1469 Activator of (R)-2-hydroxyglutaryl-CoA dehydratase OC.226478 Bacteria.319687 Actinobacteria.45425 Bifidobacterium.1554 Bifidobacterium_breve.490 bbrd.1479 bbrd:BBBR_1482 putative CoA-substrate-specific enzyme activating protein OC.226478 Bacteria.319687 Actinobacteria.45425 Bifidobacterium.1554 - bast.446 bast:BAST_0467 putative CoA-substrate-specific enzyme activase OC.226478 Bacteria.319687 Actinobacteria.45425 Bifidobacterium.1554 - btp.488 btp:D805_0492 hypothetical protein OC.226478 Bacteria.319687 Actinobacteria.45425 Bifidobacterium.1554 - bcor.384 bcor:BCOR_0390 activator of 2-hydroxyglutaryl-CoA dehydratase OC.226478 Bacteria.319687 Actinobacteria.45425 Bifidobacterium.1554 Bifidobacterium_kashiwanohense.1621 bka.1454 bka:AH68_07995 activase OC.226478 Bacteria.319687 Actinobacteria.45425 Bifidobacterium.1554 Bifidobacterium_kashiwanohense.2741 bks.1508 bks:BBKW_1509 putative CoA-substrate-specific enzyme activating protein OC.226478 Bacteria.319687 Actinobacteria.45425 Bifidobacterium.1554 - bpsp.1280 bpsp:AH67_07110 activase OC.226478 Bacteria.319687 Actinobacteria.45425 Bifidobacterium.1554 - bii.324 bii:BINDI_0328 putative CoA-substrate-specific enzyme activase OC.226478 Bacteria.319687 Actinobacteria.45425 Bifidobacterium.1554 - bang.1214 bang:BBAG_1213 putative CoA-substrate-specific enzyme activating protein OC.226478 Bacteria.319687 Actinobacteria.45425 Bifidobacterium.1554 - bcat.1311 bcat:BBCT_1313 putative CoA-substrate-specific enzyme activating protein OC.226478 Bacteria.319687 Actinobacteria.45425 Bifidobacterium.1554 - bpsc.1408 bpsc:BBPC_1393 putative CoA-substrate-specific enzyme activating protein OC.226478 Bacteria.319687 Actinobacteria.45425 Bifidobacterium.1554 - bsca.1978 bsca:BBSC_2021 conserved hypothetical protein OC.226478 Bacteria.319687 Actinobacteria.45425 - - sij.976 sij:SCIP_0979 putative CoA-substrate-specific enzyme activating protein OC.226478 Bacteria.319687 Actinobacteria.45425 - - pdo.493 pdo:PSDT_0490 putative CoA-substrate-specific enzyme activating protein OC.226478 Bacteria.319687 Actinobacteria.124126 - - ccu.468 ccu:Ccur_04840 CoA-substrate-specific enzyme activase, putative OC.226478 Bacteria.319687 Actinobacteria.124126 - - shi.726 shi:Shel_07240 CoA-substrate-specific enzyme activase, putative OC.226478 Bacteria.319687 Actinobacteria.291775 - - shi.2610 shi:Shel_28100 CoA-substrate-specific enzyme activase, putative OC.226478 Bacteria.319687 Actinobacteria.124126 Eggerthella.908 - ele.2561 ele:Elen_2682 CoA-substrate-specific enzyme activase OC.226478 Bacteria.319687 Actinobacteria.124126 Eggerthella.908 - eyy.523 eyy:EGYY_05710 hypothetical protein OC.226478 Bacteria.319687 Actinobacteria.124126 - - aeq.541 aeq:AEQU_0526 CoA-substrate-specific enzyme activase OC.226478 Bacteria.319687 Actinobacteria.124126 - - apv.154 apv:Apar_0149 CoA-substrate-specific enzyme activase OC.226478 Bacteria.319687 Actinobacteria.124126 Olsenella.894 - ols.418 ols:Olsu_0429 CoA-substrate-specific enzyme activase OC.226478 Bacteria.319687 Actinobacteria.124126 Olsenella.894 - olo.799 olo:ADJ70_04705 CoA activase OC.226478 Bacteria.319687 Actinobacteria.124126 - - cgo.263 cgo:Corgl_0267 CoA-substrate-specific enzyme activase OC.226478 Bacteria.319687 Actinobacteria.124126 - - caer.1104 caer:CSV91_05770 CoA activase