# OC Root 2nd 3rd 4th 5th 6th PC Gene/Definition OC.226481 Bacteria.887485 Firmicutes.278735 Firmicutes___Clostridia.146995 - - aar.2104 aar:Acear_2297 CoA-substrate-specific enzyme activase OC.226482 Bacteria.345093 Firmicutes.109209 Firmicutes___Clostridia.12420 Desulfitobacterium.1104 Desulfitobacterium_hafniense.2174 dsy.2305 dsy:DSY2314 hypothetical protein OC.226482 Bacteria.345093 Firmicutes.109209 Firmicutes___Clostridia.12420 Desulfitobacterium.1104 Desulfitobacterium_hafniense.2174 dhd.3368 dhd:Dhaf_3452 CoA-substrate-specific enzyme activase OC.226482 Bacteria.345093 Firmicutes.109209 Firmicutes___Clostridia.12420 Desulfitobacterium.1104 - ddh.2644 ddh:Desde_2888 (R)-2-hydroxyisocaproyl-CoA dehydratase activator protein OC.226482 Bacteria.345093 Firmicutes.109209 Firmicutes___Clostridia.12420 Desulfosporosinus.609 - dor.1643 dor:Desor_1725 CoA-substrate-specific enzyme activase, putative OC.226482 Bacteria.345093 Firmicutes.109209 Firmicutes___Clostridia.12420 Desulfosporosinus.609 - dai.2088 dai:Desaci_2301 CoA-substrate-specific enzyme activase, putative OC.226482 Bacteria.345093 Firmicutes.109209 Firmicutes___Clostridia.12420 Desulfosporosinus.609 - dmi.1542 dmi:Desmer_1676 CoA-substrate-specific enzyme activase, putative OC.226482 Bacteria.345093 Firmicutes.109209 Firmicutes___Clostridia.12420 - - chy.852 chy:CHY_0848 hgdC; (R)-2-hydroxyglutaryl-CoA dehydratase activator OC.226483 Bacteria.345092 Proteobacteria.598584 Deltaproteobacteria.109761 - - dat.4088 dat:HRM2_43020 hgdC1; HgdC1 OC.226484 Bacteria.345084 Proteobacteria.595060 Deltaproteobacteria.105202 - - dal.480 dal:Dalk_0251 CoA-substrate-specific enzyme activase OC.226484 Bacteria.345084 Firmicutes.134071 Firmicutes___Clostridia.83509 - - dau.806 dau:Daud_0885 putative CoA-substrate-specific enzyme activase OC.226484 Bacteria.345084 Firmicutes.134071 Firmicutes___Clostridia.83509 - - mta.972 mta:Moth_1005 CoA enzyme activase OC.226484 Bacteria.345084 Firmicutes.134071 Firmicutes___Clostridia.83509 - - adg.1526 adg:Adeg_1706 CoA-substrate-specific enzyme activase OC.226484 Bacteria.345084 Firmicutes.134071 Firmicutes___Clostridia.83509 - - tpz.940 tpz:Tph_c09670 hgdC1; activator of (R)-2-hydroxyglutaryl-CoA dehydratase HgdC OC.226484 Bacteria.345084 Firmicutes.134071 Firmicutes___Clostridia.83509 - - nth.1722 nth:Nther_1773 CoA-substrate-specific enzyme activase OC.226485 Bacteria.345086 Proteobacteria.599107 Deltaproteobacteria.110422 - - dav.827 dav:DESACE_04335 2-hydroxyglutaryl-CoA dehydratase OC.226486 Bacteria.345096 Proteobacteria.98188 Alphaproteobacteria.157413 Rhodopseudomonas.8764 - rpc.2029 rpc:RPC_2057 CoA enzyme activase OC.226486 Bacteria.345096 Proteobacteria.98188 Alphaproteobacteria.157413 - - bvr.1991 bvr:BVIR_2849 R-phenyllactate dehydratase activator OC.226487 Bacteria.345091 - - - - caci.832 caci:CLOAM0918 hgdC; Activator of (R)-2-hydroxyglutaryl-CoA dehydratase OC.226488 Bacteria.345094 Proteobacteria.566789 Deltaproteobacteria.65129 Desulfococcus.6173 - dol.3035 dol:Dole_3161 putative CoA-substrate-specific enzyme activase OC.226488 Bacteria.345094 Proteobacteria.599694 Deltaproteobacteria.111103 - - dbr.611 dbr:Deba_0558 CoA-substrate-specific enzyme activase OC.226488 Bacteria.345094 Firmicutes.117356 Firmicutes___Clostridia.38174 Clostridium.12520 - csr.3768 csr:Cspa_c38570 CoA-substrate-specific enzyme activase OC.226488 Bacteria.345094 Firmicutes.117356 Firmicutes___Clostridia.38174 Clostridium.12520 - csq.469 csq:CSCA_0429 CoA-substrate-specific enzyme activase OC.226488 Bacteria.345094 Firmicutes.117356 Firmicutes___Clostridia.38174 Clostridium.12520 - cck.2415 cck:Ccar_12345 3-hydroxyacyl-ACP dehydratase OC.226488 Bacteria.345094 Firmicutes.117356 Firmicutes___Clostridia.38174 Clostridium.12520 - ctyk.2355 ctyk:CTK_C24910 R-2-hydroxyglutaryl-CoA dehydratase subunit/R-2-hydroxyglutaryl-CoA dehydratase activase OC.226488 Bacteria.345094 Firmicutes.117356 Firmicutes___Clostridia.38174 Clostridium.12520 - cdrk.3117 cdrk:B9W14_16350 3-hydroxyacyl-ACP dehydratase OC.226488 Bacteria.345094 Firmicutes.117356 Firmicutes___Clostridia.38174 Clostridium.12521 Clostridium_botulinum.1277 cbo.2141 cbo:CBO2202 bifunctional 2-hydroxyacyl-CoA dehydratase/activator domain-containing protein OC.226488 Bacteria.345094 Firmicutes.117356 Firmicutes___Clostridia.38174 Clostridium.12521 Clostridium_botulinum.1277 cba.2054 cba:CLB_2140 bcrA; benzoyl-CoA reductase, subunit A OC.226488 Bacteria.345094 Firmicutes.117356 Firmicutes___Clostridia.38174 Clostridium.12521 Clostridium_botulinum.1277 cby.2245 cby:CLM_2403 bcrA; benzoyl-CoA reductase, subunit A OC.226488 Bacteria.345094 Firmicutes.117356 Firmicutes___Clostridia.38174 Clostridium.12521 Clostridium_botulinum.1277 cbl.1635 cbl:CLK_1641 bcrA; benzoyl-CoA reductase, subunit A OC.226488 Bacteria.345094 Firmicutes.117356 Firmicutes___Clostridia.38174 Clostridium.12521 Clostridium_botulinum.1277 cbb.2239 cbb:CLD_2377 bcrA; benzoyl-CoA reductase, subunit A OC.226488 Bacteria.345094 Firmicutes.117356 Firmicutes___Clostridia.38174 Clostridium.12521 Clostridium_botulinum.1277 cbi.2516 cbi:CLJ_B2410 putative CoA-substrate-specific enzyme activase OC.226488 Bacteria.345094 Firmicutes.117356 Firmicutes___Clostridia.38174 Clostridium.12521 Clostridium_botulinum.1277 cbf.2130 cbf:CLI_2246 benzoyl-CoA reductase, subunit A family OC.226488 Bacteria.345094 Firmicutes.117356 Firmicutes___Clostridia.38174 Clostridium.12521 Clostridium_botulinum.1277 cbm.2047 cbm:CBF_2232 benzoyl-CoA reductase, subunit A family OC.226488 Bacteria.345094 Firmicutes.117356 Firmicutes___Clostridia.38174 Clostridium.12521 Clostridium_botulinum.1277 cbj.2171 cbj:H04402_02213 benzoyl-CoA reductase subunit BadF OC.226488 Bacteria.345094 Firmicutes.117356 Firmicutes___Clostridia.38174 Clostridium.12521 - cbv.1559 cbv:U729_2460 putative CoA-substrate-specific enzyme activase domain protein OC.226488 Bacteria.345094 Firmicutes.117356 Firmicutes___Clostridia.38174 Clostridium.12521 - cld.2190 cld:CLSPO_c22340 activator of 2-hydroxyglutaryl-CoA dehydratase OC.226488 Bacteria.345094 Firmicutes.117356 Firmicutes___Clostridia.38174 Clostridium.35410 Clostridium_sp_.4727 cls.880 cls:CXIVA_08560 activator of 2-hydroxyglutaryl-CoA dehydratase OC.226488 Bacteria.345094 Firmicutes.117356 Firmicutes___Clostridia.38174 - - rbp.1232 rbp:B6259_06655 2-hydroxyglutaryl-CoA dehydratase OC.226488 Bacteria.345094 Firmicutes.117356 Firmicutes___Clostridia.38174 - - fpla.344 fpla:A4U99_01220 2-hydroxyglutaryl-CoA dehydratase OC.226488 Bacteria.345094 Firmicutes.117356 Firmicutes___Clostridia.38174 Ruminococcus.8639 - rum.2064 rum:CK1_25350 CoA-substrate-specific enzyme activase, putative OC.226488 Bacteria.345094 Firmicutes.117356 Firmicutes___Clostridia.38174 Coprococcus.740 - cct.635 cct:CC1_07060 CoA-substrate-specific enzyme activase, putative OC.226488 Bacteria.345094 Firmicutes.117356 Firmicutes___Clostridia.38174 Blautia.9173 - rob.2697 rob:CK5_31700 CoA-substrate-specific enzyme activase, putative OC.226488 Bacteria.345094 Firmicutes.117356 Firmicutes___Clostridia.38174 - - bprl.445 bprl:CL2_04700 CoA-substrate-specific enzyme activase, putative OC.226488 Bacteria.345094 Firmicutes.117356 Firmicutes___Clostridia.38174 - - ere.1103 ere:EUBREC_1135 putative R-2-hydroxyglutaryl-CoA dehydratase subunit/R-2-hydroxyglutaryl-CoA dehydratase activase, putative OC.226488 Bacteria.345094 Firmicutes.117356 Firmicutes___Clostridia.38174 - - ert.1887 ert:EUR_21420 CoA-substrate-specific enzyme activase, putative OC.226488 Bacteria.345094 Firmicutes.117356 Firmicutes___Clostridia.38174 - - era.1752 era:ERE_20100 CoA-substrate-specific enzyme activase, putative OC.226488 Bacteria.345094 Firmicutes.117356 Firmicutes___Clostridia.38174 - - bprs.571 bprs:CK3_06730 CoA-substrate-specific enzyme activase, putative OC.226488 Bacteria.345094 Firmicutes.117356 Firmicutes___Clostridia.38174 - - tte.1034 tte:TTE1113 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) OC.226488 Bacteria.345094 Firmicutes.117356 Firmicutes___Clostridia.38174 Thermoanaerobacter.2065 Thermoanaerobacter_sp_.869 tex.1833 tex:Teth514_1898 putative CoA-substrate-specific enzyme activase OC.226488 Bacteria.345094 Firmicutes.117356 Firmicutes___Clostridia.38174 Thermoanaerobacter.2065 Thermoanaerobacter_sp_.869 thx.964 thx:Thet_1038 CoA-substrate-specific enzyme activase OC.226488 Bacteria.345094 Firmicutes.117356 Firmicutes___Clostridia.38174 Thermoanaerobacter.2065 - tpd.822 tpd:Teth39_0845 putative CoA-substrate-specific enzyme activase OC.226488 Bacteria.345094 Firmicutes.117356 Firmicutes___Clostridia.38174 Thermoanaerobacter.2065 - tit.1360 tit:Thit_1451 CoA-substrate-specific enzyme activase OC.226488 Bacteria.345094 Firmicutes.117356 Firmicutes___Clostridia.38174 Thermoanaerobacter.2065 - tmt.1362 tmt:Tmath_1442 CoA-substrate-specific enzyme activase OC.226488 Bacteria.345094 Firmicutes.117356 Firmicutes___Clostridia.38174 Thermoanaerobacter.2065 - tbo.819 tbo:Thebr_0866 CoA-substrate-specific enzyme activase OC.226488 Bacteria.345094 Firmicutes.117356 Firmicutes___Clostridia.38174 Thermoanaerobacter.2065 - twi.1407 twi:Thewi_1549 2-hydroxyglutaryl-CoA dehydratase D-component OC.226488 Bacteria.345094 Firmicutes.117356 Firmicutes___Clostridia.38174 Thermoanaerobacter.2065 - tki.1436 tki:TKV_c15090 lcdC; activator of lactoyl-CoA dehydratase LcdC OC.226488 Bacteria.345094 Firmicutes.117356 Firmicutes___Clostridia.38174 - - chy.1175 chy:CHY_1185 putative CoA dehydratase subunit/(R)-2-hydroxyglutaryl-CoA dehydratase activator OC.226488 Bacteria.345094 Firmicutes.117356 Firmicutes___Clostridia.38174 Caldicellulosiruptor.1310 - csc.366 csc:Csac_0381 putative CoA-substrate-specific enzyme activase OC.226488 Bacteria.345094 Firmicutes.117356 Firmicutes___Clostridia.38174 Caldicellulosiruptor.1310 - ate.220 ate:Athe_0200 CoA-substrate-specific enzyme activase OC.226488 Bacteria.345094 Firmicutes.117356 Firmicutes___Clostridia.38174 Caldicellulosiruptor.1310 - chd.2325 chd:Calhy_2427 CoA-substrate-specific enzyme activase OC.226488 Bacteria.345094 Firmicutes.117356 Firmicutes___Clostridia.38174 Caldicellulosiruptor.1310 - cki.166 cki:Calkr_0173 CoA-substrate-specific enzyme activase OC.226488 Bacteria.345094 Firmicutes.117356 Firmicutes___Clostridia.38174 Caldicellulosiruptor.1310 - clc.1954 clc:Calla_2157 CoA-substrate-specific enzyme activase OC.226488 Bacteria.345094 Firmicutes.117356 Firmicutes___Clostridia.38174 - - toc.446 toc:Toce_0456 CoA-substrate-specific enzyme activase OC.226488 Bacteria.345094 Firmicutes.117356 Firmicutes___Clostridia.38174 Thermoanaerobacterium.2639 Thermoanaerobacterium_thermosaccharolyticum.1963 ttm.897 ttm:Tthe_0962 CoA-substrate-specific enzyme activase OC.226488 Bacteria.345094 Firmicutes.117356 Firmicutes___Clostridia.38174 Thermoanaerobacterium.2639 Thermoanaerobacterium_thermosaccharolyticum.1963 tto.830 tto:Thethe_00921 CoA-substrate-specific enzyme activase, putative OC.226488 Bacteria.345094 Actinobacteria.273147 - - - ddt.1247 ddt:AAY81_07420 2-hydroxyglutaryl-CoA dehydratase OC.226488 Bacteria.345094 Planctomycetes.30560 - - - kst.1026 kst:KSMBR1_1001 hypothetical protein OC.226488 Bacteria.345094 Thermotogae.2706 Pseudothermotoga.971 - - tle.1472 tle:Tlet_1488 putative CoA-substrate-specific enzyme activase OC.226488 Bacteria.345094 Thermotogae.2706 Pseudothermotoga.971 - - tta.1373 tta:Theth_1457 CoA-substrate-specific enzyme activase OC.226488 Bacteria.345094 Thermotogae.2706 Pseudothermotoga.971 - - phy.327 phy:AJ81_01705 CoA activase OC.226488 Bacteria.345094 Thermotogae.2706 Kosmotoga.1211 - - kol.895 kol:Kole_0945 CoA-substrate-specific enzyme activase OC.226488 Bacteria.345094 Thermotogae.2706 Kosmotoga.1211 - - kpf.1660 kpf:IX53_09180 hypothetical protein OC.226488 Bacteria.345094 Thermotogae.2706 Mesotoga.1142 - - mpg.1011 mpg:Theba_1005 CoA-substrate-specific enzyme activase, putative OC.226488 Bacteria.345094 Thermotogae.2706 Mesotoga.1142 - - minf.2377 minf:MESINF_2485 putative CoA-substrate-specific enzyme activase OC.226489 Bacteria.345099 Dictyoglomi.562 - - - dth.1548 dth:DICTH_1634 (R)-2-hydroxyglutaryl-CoA dehydratase activator OC.226489 Bacteria.345099 Dictyoglomi.562 - - - dtu.1664 dtu:Dtur_1745 CoA-substrate-specific enzyme activase OC.226490 Bacteria.345081 Proteobacteria.566305 Deltaproteobacteria.64412 Desulfococcus.4524 - dol.936 dol:Dole_0893 putative CoA-substrate-specific enzyme activase OC.226491 Bacteria.345104 Proteobacteria.554831 Deltaproteobacteria.28004 Desulfovibrio.21289 - dhy.3494 dhy:DESAM_23254 conserved protein of unknown function OC.226491 Bacteria.345104 Proteobacteria.554831 Deltaproteobacteria.28004 - - dto.3591 dto:TOL2_C39530 hgdC2; HgdC2: predicted activator of 2-hydroyglutaryl-CoA dehydratase, alpha subunit OC.226492 Bacteria.345106 Proteobacteria.553154 Deltaproteobacteria.18261 Pelobacter.3058 - pace.2613 pace:A6070_14235 benzoyl-CoA reductase OC.226492 Bacteria.345106 Proteobacteria.553154 Deltaproteobacteria.18261 Desulfobulbus.4127 - dpr.2929 dpr:Despr_3095 CoA-substrate-specific enzyme activase