# OC Root 2nd 3rd 4th 5th 6th PC Gene/Definition OC.226727 Bacteria.397930 Proteobacteria.262407 Gammaproteobacteria.118882 Francisella.1926 Francisella_sp_.840 frf.357 frf:LO80_01865 radical SAM protein OC.226727 Bacteria.397930 Proteobacteria.262407 Gammaproteobacteria.118882 Francisella.1926 Francisella_sp_.2728 frm.898 frm:BBG19_0921 Radical SAM domain heme biosynthesis protein OC.226727 Bacteria.397930 Proteobacteria.262407 Gammaproteobacteria.118882 Francisella.1926 Francisella_sp_.4770 frt.1471 frt:F7308_1471 Radical SAM domain heme biosynthesis protein OC.226727 Bacteria.397930 Proteobacteria.262407 Gammaproteobacteria.118882 Francisella.1926 Francisella_sp_.6127 frx.1159 frx:F7310_06050 radical SAM/SPASM domain-containing protein OC.226727 Bacteria.397930 Proteobacteria.262407 Gammaproteobacteria.118882 Francisella.1926 Francisella_cf_.852 fcf.757 fcf:FNFX1_0764 Radical SAM domain heme biosynthesis protein OC.226727 Bacteria.397930 Proteobacteria.262407 Gammaproteobacteria.118882 Francisella.1926 Francisella_cf_.2817 fcn.1113 fcn:FN3523_1115 Radical SAM domain heme biosynthesis protein OC.226727 Bacteria.397930 Proteobacteria.262407 Gammaproteobacteria.118882 Francisella.1926 Francisella_tularensis.3089 ftn.741 ftn:FTN_0761 radical SAM family protein OC.226727 Bacteria.397930 Proteobacteria.262407 Gammaproteobacteria.118882 Francisella.1926 Francisella_tularensis.3089 ftx.291 ftx:AW25_1260 radical SAM additional 4Fe4S-binding SPASM domain protein OC.226727 Bacteria.397930 Proteobacteria.262407 Gammaproteobacteria.118882 Francisella.1926 Francisella_tularensis.3089 ftd.825 ftd:AS84_1779 radical SAM additional 4Fe4S-binding SPASM domain protein OC.226727 Bacteria.397930 Proteobacteria.262407 Gammaproteobacteria.118882 Francisella.1926 Francisella_tularensis.3089 fty.284 fty:CH70_1281 radical SAM additional 4Fe4S-binding SPASM domain protein OC.226727 Bacteria.397930 Proteobacteria.262407 Gammaproteobacteria.118882 Francisella.1926 Francisella_philomiragia.718 fph.1610 fph:Fphi_1658 radical SAM family protein OC.226727 Bacteria.397930 Proteobacteria.262407 Gammaproteobacteria.118882 Francisella.1926 Francisella_philomiragia.718 fpi.967 fpi:BF30_1936 radical SAM additional 4Fe4S-binding SPASM domain protein OC.226727 Bacteria.397930 Proteobacteria.262407 Gammaproteobacteria.118882 Francisella.1926 Francisella_philomiragia.718 fpm.1297 fpm:LA56_513 radical SAM additional 4Fe4S-binding SPASM domain protein OC.226727 Bacteria.397930 Proteobacteria.262407 Gammaproteobacteria.118882 Francisella.1926 Francisella_philomiragia.718 fpx.682 fpx:KU46_1639 radical SAM additional 4Fe4S-binding SPASM domain protein OC.226727 Bacteria.397930 Proteobacteria.262407 Gammaproteobacteria.118882 Francisella.1926 Francisella_philomiragia.718 fpj.368 fpj:LA02_1355 radical SAM additional 4Fe4S-binding SPASM domain protein OC.226727 Bacteria.397930 Proteobacteria.262407 Gammaproteobacteria.118882 Francisella.1926 Francisella_philomiragia.2616 fpt.1170 fpt:BZ13_338 radical SAM additional 4Fe4S-binding SPASM domain protein OC.226727 Bacteria.397930 Proteobacteria.262407 Gammaproteobacteria.118882 Francisella.1926 Francisella_philomiragia.2701 fpz.161 fpz:LA55_1131 radical SAM additional 4Fe4S-binding SPASM domain protein OC.226727 Bacteria.397930 Proteobacteria.262407 Gammaproteobacteria.118882 Francisella.1926 - fhi.872 fhi:FSC454_04745 radical SAM/SPASM domain-containing protein OC.226727 Bacteria.397930 Proteobacteria.262407 Deltaproteobacteria.14742 - - dps.1293 dps:DP1281 related to coenzyme PQQ synthesis protein OC.226727 Bacteria.397930 Proteobacteria.262407 Deltaproteobacteria.14742 - - dak.1863 dak:DaAHT2_1941 Radical SAM domain protein OC.226727 Bacteria.397930 Proteobacteria.262407 Deltaproteobacteria.14742 Desulfobulbus.1046 - dpr.859 dpr:Despr_0852 Radical SAM domain protein OC.226727 Bacteria.397930 Proteobacteria.262407 Deltaproteobacteria.14742 Desulfobulbus.1046 - deo.932 deo:CAY53_05000 radical SAM/SPASM domain-containing protein OC.226727 Bacteria.397930 Proteobacteria.262407 Deltaproteobacteria.14742 - - dsf.149 dsf:UWK_00074 radical SAM additional 4Fe4S-binding domain-containing protein OC.226727 Bacteria.397930 Proteobacteria.262408 Deltaproteobacteria.14743 - - dav.341 dav:DESACE_01530 radical SAM protein OC.226727 Bacteria.397930 Proteobacteria.262408 Deltaproteobacteria.14744 - - hmr.290 hmr:Hipma_0282 Radical SAM domain protein OC.226727 Bacteria.397930 Proteobacteria.271948 Deltaproteobacteria.32456 Geobacter.1069 Geobacter_sp_.1643 geb.80 geb:GM18_0014 Radical SAM domain protein OC.226727 Bacteria.397930 Proteobacteria.271948 Deltaproteobacteria.32456 Geobacter.1069 Geobacter_sp_.4337 gem.32 gem:GM21_0014 Radical SAM domain protein OC.226727 Bacteria.397930 Proteobacteria.271948 Deltaproteobacteria.32456 Geobacter.1069 Geobacter_sulfurreducens.2350 gsu.3257 gsu:GSU3454 radical SAM domain-containing iron-sulfur cluster-binding oxidoreductase OC.226727 Bacteria.397930 Proteobacteria.271948 Deltaproteobacteria.32456 Geobacter.1069 Geobacter_sulfurreducens.2350 gsk.3193 gsk:KN400_3399 radical SAM domain iron-sulfur cluster-binding oxidoreductase OC.226727 Bacteria.397930 Proteobacteria.271948 Deltaproteobacteria.32456 Geobacter.1069 - gme.43 gme:Gmet_0015 radical SAM domain iron-sulfur cluster-binding oxidoreductase OC.226727 Bacteria.397930 Proteobacteria.271948 Deltaproteobacteria.32456 Geobacter.1069 - gur.122 gur:Gura_0014 Radical SAM domain protein OC.226727 Bacteria.397930 Proteobacteria.271948 Deltaproteobacteria.32456 Geobacter.1069 - glo.2954 glo:Glov_3122 Radical SAM domain protein OC.226727 Bacteria.397930 Proteobacteria.271948 Deltaproteobacteria.32456 Geobacter.1069 - gbm.44 gbm:Gbem_0015 radical SAM domain iron-sulfur cluster-binding oxidoreductase OC.226727 Bacteria.397930 Proteobacteria.271948 Deltaproteobacteria.32456 Geobacter.1069 - geo.56 geo:Geob_0014 radical SAM domain iron-sulfur cluster-binding oxidoreductase OC.226727 Bacteria.397930 Proteobacteria.271948 Deltaproteobacteria.32456 Geobacter.1069 - gpi.43 gpi:GPICK_00065 radical SAM protein OC.226727 Bacteria.397930 Proteobacteria.271948 Deltaproteobacteria.32456 Geobacter.1069 - gao.2650 gao:A2G06_16320 radical SAM/SPASM domain-containing protein OC.226727 Bacteria.397930 Proteobacteria.271948 Deltaproteobacteria.32456 - - gsb.662 gsb:GSUB_03715 radical SAM protein OC.226727 Bacteria.397930 Proteobacteria.271948 Deltaproteobacteria.32456 Pelobacter.888 - pca.3025 pca:Pcar_3149 radical SAM domain iron-sulfur cluster-binding oxidoreductase OC.226727 Bacteria.397930 Proteobacteria.271948 Deltaproteobacteria.32456 Pelobacter.888 - pace.2166 pace:A6070_11730 radical SAM/SPASM domain-containing protein OC.226727 Bacteria.397930 Proteobacteria.271948 Deltaproteobacteria.32456 Pelobacter.888 - pef.1338 pef:A7E78_07110 radical SAM/SPASM domain-containing protein OC.226727 Bacteria.397930 Proteobacteria.271948 Deltaproteobacteria.32456 Pelobacter.7635 - ppd.2771 ppd:Ppro_2942 Radical SAM domain protein OC.226727 Bacteria.397930 Proteobacteria.271948 Deltaproteobacteria.32456 Desulfuromonas.834 - des.2579 des:DSOUD_2664 radical SAM/SPASM domain-containing protein OC.226727 Bacteria.397930 Proteobacteria.271948 Deltaproteobacteria.32456 Desulfuromonas.834 - deu.994 deu:DBW_1050 radical SAM domain-containing iron-sulfur cluster-binding oxidoreductase OC.226727 Bacteria.397930 Aquificae.3895 - - - tam.1234 tam:Theam_1244 Radical SAM domain protein OC.226727 Bacteria.397930 Aquificae.3895 - - - dte.273 dte:Dester_0271 Radical SAM domain protein OC.226727 Bacteria.397930 Aquificae.8104 - - - ttk.1414 ttk:TST_1454 radical SAM domain protein OC.226727 Bacteria.397930 - - - - din.2194 din:Selin_2336 Radical SAM domain protein OC.226727 Bacteria.397930 Deferribacteres.39 - - - ddf.1401 ddf:DEFDS_1457 radical SAM domain protein OC.226727 Bacteria.397930 Deferribacteres.39 - - - dap.1195 dap:Dacet_1278 Radical SAM domain protein OC.226727 Bacteria.397930 Deferribacteres.39 - - - cni.1035 cni:Calni_1044 Radical SAM domain protein OC.226727 Bacteria.397930 Deferribacteres.39 - - - fsi.1152 fsi:Flexsi_1248 Radical SAM domain protein OC.226727 Bacteria.397930 Nitrospirae.12481 - - - tye.844 tye:THEYE_A0807 radical SAM protein OC.226728 Bacteria.921082 Planctomycetes.32600 - - - kst.3271 kst:KSMBR1_3784 nirJ_4; hypothetical protein; K22227 heme synthase OC.226729 Bacteria.887520 Firmicutes.278803 Firmicutes___Clostridia.147088 - - adg.353 adg:Adeg_0324 Radical SAM domain protein OC.226730 Bacteria.367879 Actinobacteria.153632 - - - ccu.1171 ccu:Ccur_12330 predicted Fe-S oxidoreductase OC.226730 Bacteria.367879 Actinobacteria.153632 - - - shi.1120 shi:Shel_11650 predicted Fe-S oxidoreductase OC.226730 Bacteria.367879 Chloroflexi.6346 Dehalogenimonas.225 - - dly.417 dly:Dehly_0450 Radical SAM domain protein; K22227 heme synthase OC.226730 Bacteria.367879 Chloroflexi.6346 Dehalogenimonas.225 - - dew.1230 dew:DGWBC_1298 radical SAM domain heme biosynthesis protein; K22227 heme synthase OC.226730 Bacteria.367879 Chloroflexi.6346 Dehalogenimonas.225 - - dfo.1292 dfo:Dform_01373 heme b synthase; K22227 heme synthase OC.226731 Bacteria.529534 Proteobacteria.553464 Deltaproteobacteria.20178 - - dao.454 dao:Desac_0397 Radical SAM domain protein; K22227 heme synthase OC.226732 Bacteria.1103104 Proteobacteria.604583 Deltaproteobacteria.117657 - - dti.2736 dti:Desti_2956 putative heme d1 biosynthesis radical SAM protein NirJ2; K22227 heme synthase OC.226733 Bacteria.590067 Acidobacteria.12537 - - - aba.2638 aba:Acid345_2710 Fe-S protein, radical SAM family OC.226734 Bacteria.529533 Proteobacteria.265160 Deltaproteobacteria.20176 Desulfovibrio.1585 Desulfovibrio_vulgaris.2860 dvu.844 dvu:DVU0855 radical SAM domain-containing protein; K22227 heme synthase OC.226734 Bacteria.529533 Proteobacteria.265160 Deltaproteobacteria.20176 Desulfovibrio.1585 Desulfovibrio_vulgaris.2860 dvl.2116 dvl:Dvul_2128 Radical SAM domain protein; K22227 heme synthase OC.226734 Bacteria.529533 Proteobacteria.265160 Deltaproteobacteria.20176 Desulfovibrio.1585 Desulfovibrio_vulgaris.2860 dvm.2858 dvm:DvMF_2901 Radical SAM domain protein; K22227 heme synthase OC.226734 Bacteria.529533 Proteobacteria.265160 Deltaproteobacteria.20176 Desulfovibrio.1585 Desulfovibrio_vulgaris.2860 dvg.780 dvg:Deval_0785 Radical SAM domain protein; K22227 heme synthase OC.226734 Bacteria.529533 Proteobacteria.265160 Deltaproteobacteria.20176 Desulfovibrio.1585 Desulfovibrio_desulfuricans.3723 dds.288 dds:Ddes_0287 Radical SAM domain protein; K22227 heme synthase OC.226734 Bacteria.529533 Proteobacteria.265160 Deltaproteobacteria.20176 Desulfovibrio.1585 - dfi.2288 dfi:AXF13_12310 heme b synthase; K22227 heme synthase OC.226734 Bacteria.529533 Proteobacteria.265160 Deltaproteobacteria.20176 Desulfovibrio.1585 - dpg.1517 dpg:DESPIGER_1625 Radical SAM domain heme biosynthesis protein; K22227 heme synthase OC.226734 Bacteria.529533 Proteobacteria.265160 Deltaproteobacteria.20176 Desulfovibrio.1585 - def.2362 def:CNY67_13555 ahbD; heme b synthase; K22227 heme synthase OC.226734 Bacteria.529533 Proteobacteria.265160 Deltaproteobacteria.20176 Desulfovibrio.1585 - dtr.962 dtr:RSDT_0965 ahbD; alternative heme biosynthesis protein AhbD; K22227 heme synthase OC.226734 Bacteria.529533 Proteobacteria.265160 Deltaproteobacteria.20176 Desulfovibrio.1586 - dgg.2364 dgg:DGI_2628 putative radical SAM domain-containing protein; K22227 heme synthase OC.226734 Bacteria.529533 Proteobacteria.265160 Deltaproteobacteria.20176 Desulfovibrio.1587 - dde.2182 dde:Dde_2577 Radical SAM domain protein; K22227 heme synthase OC.226734 Bacteria.529533 Proteobacteria.265160 Deltaproteobacteria.20176 Desulfovibrio.9734 - dsa.1234 dsa:Desal_1240 Radical SAM domain protein; K22227 heme synthase OC.226734 Bacteria.529533 Proteobacteria.265160 Deltaproteobacteria.20176 Desulfovibrio.9734 - dhy.3174 dhy:DESAM_22934 Radical SAM domain protein; K22227 heme synthase OC.226734 Bacteria.529533 Proteobacteria.265160 Deltaproteobacteria.20176 Desulfovibrio.13188 Desulfovibrio_desulfuricans.3423 ddn.3421 ddn:DND132_3455 Radical SAM domain protein; K22227 heme synthase OC.226734 Bacteria.529533 Proteobacteria.265160 Deltaproteobacteria.20176 Desulfovibrio.16040 - daf.2523 daf:Desaf_2642 Radical SAM domain protein; K22227 heme synthase OC.226734 Bacteria.529533 Proteobacteria.265160 Deltaproteobacteria.20176 Desulfovibrio.21526 - dma.614 dma:DMR_04480 hypothetical protein; K22227 heme synthase OC.226734 Bacteria.529533 Proteobacteria.265160 Deltaproteobacteria.20176 Pseudodesulfovibrio.1037 - das.2159 das:Daes_2206 Radical SAM domain protein; K22227 heme synthase OC.226734 Bacteria.529533 Proteobacteria.265160 Deltaproteobacteria.20176 Pseudodesulfovibrio.1037 - dpi.3298 dpi:BN4_20515 Radical SAM domain protein; K22227 heme synthase OC.226734 Bacteria.529533 Proteobacteria.265160 Deltaproteobacteria.20176 Pseudodesulfovibrio.1037 - dej.2754 dej:AWY79_14415 heme b synthase; K22227 heme synthase OC.226734 Bacteria.529533 Proteobacteria.265160 Deltaproteobacteria.20176 Pseudodesulfovibrio.1037 - pprf.3689 pprf:DPRO_4012 albA; Antilisterial bacteriocin subtilosin biosynthesis protein AlbA; K22227 heme synthase OC.226734 Bacteria.529533 Proteobacteria.265160 Deltaproteobacteria.20176 Lawsonia.408 - lip.205 lip:LI0206 predicted Fe-S oxidoreductases; K22227 heme synthase OC.226734 Bacteria.529533 Proteobacteria.265160 Deltaproteobacteria.20176 Lawsonia.408 - lir.208 lir:LAW_00209 radical SAM domain-containing protein; K22227 heme synthase OC.226734 Bacteria.529533 Proteobacteria.265160 Deltaproteobacteria.20176 Desulfomicrobium.543 - dba.2297 dba:Dbac_2393 Radical SAM domain protein; K22227 heme synthase OC.226734 Bacteria.529533 Proteobacteria.265160 Deltaproteobacteria.20176 Desulfomicrobium.543 - doa.865 doa:AXF15_04760 heme b synthase; K22227 heme synthase OC.226734 Bacteria.529533 Proteobacteria.265160 Deltaproteobacteria.20176 - - drt.1901 drt:Dret_1955 Radical SAM domain protein; K22227 heme synthase OC.226734 Bacteria.529533 Proteobacteria.265160 Deltaproteobacteria.20176 Desulfococcus.1754 - dml.1248 dml:Dmul_12470 pqqE; PqqE: predicted coenzyme PQQ synthesis protein E; K22227 heme synthase OC.226734 Bacteria.529533 Proteobacteria.265160 Deltaproteobacteria.20176 Desulfococcus.4775 - dol.1246 dol:Dole_1223 Radical SAM domain protein; K22227 heme synthase OC.226734 Bacteria.529533 Proteobacteria.265160 Deltaproteobacteria.20176 - - dal.3661 dal:Dalk_3856 Radical SAM domain protein; K22227 heme synthase OC.226734 Bacteria.529533 Proteobacteria.265160 Deltaproteobacteria.20176 - - dat.2712 dat:HRM2_28000 ppqE2; PpqE2; K22227 heme synthase OC.226734 Bacteria.529533 Proteobacteria.265160 Deltaproteobacteria.20176 - - dto.2110 dto:TOL2_C22120 ppqE; PqqE: predicted coenzyme PQQ synthesis protein E; K22227 heme synthase OC.226734 Bacteria.529533 Proteobacteria.265160 Deltaproteobacteria.20176 - - sfu.2901 sfu:Sfum_3058 Radical SAM domain protein; K22227 heme synthase OC.226734 Bacteria.529533 Proteobacteria.265160 Deltaproteobacteria.20176 - - dbr.826 dbr:Deba_0779 Radical SAM domain protein; K22227 heme synthase OC.226734 Bacteria.529533 Proteobacteria.553463 Deltaproteobacteria.20177 - - sat.2061 sat:SYN_02266 radical SAM superfamily protein; K22227 heme synthase OC.226734 Bacteria.529533 Thermodesulfobacteria.271 - - - tid.748 tid:Thein_0772 Radical SAM domain protein; K22227 heme synthase OC.226734 Bacteria.529533 Thermodesulfobacteria.271 Thermodesulfobacterium.1574 - - top.417 top:TOPB45_0421 Radical SAM domain protein; K22227 heme synthase OC.226734 Bacteria.529533 Thermodesulfobacteria.271 - - - cthi.1173 cthi:THC_1234 radical SAM protein; K22227 heme synthase OC.226735 Bacteria.1257619 Verrucomicrobia.5339 Akkermansia.516 - - amu.796 amu:Amuc_0792 Radical SAM domain protein OC.226735 Bacteria.1257619 Verrucomicrobia.5339 Akkermansia.516 - - agl.1746 agl:PYTT_1939 aldolase-type tim barrel OC.226736 Bacteria.468109 Firmicutes.44750 Firmicutes___Clostridia.24516 Halanaerobium.2704 - hpk.1285 hpk:Hprae_1334 Radical SAM domain protein OC.226736 Bacteria.468109 Planctomycetes.31084 - - - kst.1614 kst:KSMBR1_1711 moaA_nirJ_pqqE_2; hypothetical protein; K22226 Fe-coproporphyrin III synthase OC.226737 Bacteria.894490 Firmicutes.291839 Firmicutes___Clostridia.166523 - - gfe.1250 gfe:Gferi_06080 hypothetical protein OC.226738 Bacteria.1079850 Proteobacteria.554106 Deltaproteobacteria.23227 - - dat.2710 dat:HRM2_27980 ppqE1; PpqE1; K22226 Fe-coproporphyrin III synthase OC.226739 Bacteria.346088 Actinobacteria.123127 - - - ccu.1173 ccu:Ccur_12350 predicted Fe-S oxidoreductase; K22226 Fe-coproporphyrin III synthase OC.226739 Bacteria.346088 Actinobacteria.123127 - - - shi.1118 shi:Shel_11630 predicted Fe-S oxidoreductase; K22226 Fe-coproporphyrin III synthase OC.226739 Bacteria.346088 Actinobacteria.123127 Eggerthella.2437 - - ele.1989 ele:Elen_2068 Radical SAM domain protein; K22226 Fe-coproporphyrin III synthase OC.226739 Bacteria.346088 Actinobacteria.123127 - - - ddt.753 ddt:AAY81_04370 Fe-S oxidoreductase; K22226 Fe-coproporphyrin III synthase OC.226740 Bacteria.529846 Proteobacteria.266816 Deltaproteobacteria.23223 Desulfovibrio.1589 Desulfovibrio_vulgaris.2862 dvu.846 dvu:DVU0857 12,18-didecarboxysiroheme deacetylase; K22226 Fe-coproporphyrin III synthase OC.226740 Bacteria.529846 Proteobacteria.266816 Deltaproteobacteria.23223 Desulfovibrio.1589 Desulfovibrio_vulgaris.2862 dvl.2114 dvl:Dvul_2126 Radical SAM domain protein; K22226 Fe-coproporphyrin III synthase OC.226740 Bacteria.529846 Proteobacteria.266816 Deltaproteobacteria.23223 Desulfovibrio.1589 Desulfovibrio_vulgaris.2862 dvm.2860 dvm:DvMF_2903 Radical SAM domain protein; K22226 Fe-coproporphyrin III synthase OC.226740 Bacteria.529846 Proteobacteria.266816 Deltaproteobacteria.23223 Desulfovibrio.1589 Desulfovibrio_vulgaris.2862 dvg.782 dvg:Deval_0787 Radical SAM domain protein; K22226 Fe-coproporphyrin III synthase OC.226740 Bacteria.529846 Proteobacteria.266816 Deltaproteobacteria.23223 Desulfovibrio.1589 - dde.2180 dde:Dde_2575 Radical SAM domain protein; K22226 Fe-coproporphyrin III synthase OC.226740 Bacteria.529846 Proteobacteria.266816 Deltaproteobacteria.23223 Desulfovibrio.1589 Desulfovibrio_desulfuricans.3725 dds.290 dds:Ddes_0289 Radical SAM domain protein; K22226 Fe-coproporphyrin III synthase OC.226740 Bacteria.529846 Proteobacteria.266816 Deltaproteobacteria.23223 Desulfovibrio.1589 - dsa.1236 dsa:Desal_1242 Radical SAM domain protein; K22226 Fe-coproporphyrin III synthase OC.226740 Bacteria.529846 Proteobacteria.266816 Deltaproteobacteria.23223 Desulfovibrio.1589 - dhy.3172 dhy:DESAM_22932 Radical SAM domain protein; K22226 Fe-coproporphyrin III synthase OC.226740 Bacteria.529846 Proteobacteria.266816 Deltaproteobacteria.23223 Desulfovibrio.1589 - dfi.2290 dfi:AXF13_12320 12,18-didecarboxysiroheme deacetylase; K22226 Fe-coproporphyrin III synthase OC.226740 Bacteria.529846 Proteobacteria.266816 Deltaproteobacteria.23223 Desulfovibrio.1589 - dpg.1514 dpg:DESPIGER_1622 Radical SAM domain heme biosynthesis protein; K22226 Fe-coproporphyrin III synthase OC.226740 Bacteria.529846 Proteobacteria.266816 Deltaproteobacteria.23223 Desulfovibrio.1589 - def.2360 def:CNY67_13545 ahbC; 12,18-didecarboxysiroheme deacetylase; K22226 Fe-coproporphyrin III synthase OC.226740 Bacteria.529846 Proteobacteria.266816 Deltaproteobacteria.23223 Desulfovibrio.1589 - dtr.964 dtr:RSDT_0967 ahbC; alternative heme biosynthesis protein AhbC; K22226 Fe-coproporphyrin III synthase OC.226740 Bacteria.529846 Proteobacteria.266816 Deltaproteobacteria.23223 Desulfovibrio.1590 - dgg.2366 dgg:DGI_2630 putative radical SAM protein; K22226 Fe-coproporphyrin III synthase OC.226740 Bacteria.529846 Proteobacteria.266816 Deltaproteobacteria.23223 Desulfovibrio.1591 - dma.609 dma:DMR_04410 hypothetical protein; K22226 Fe-coproporphyrin III synthase OC.226740 Bacteria.529846 Proteobacteria.266816 Deltaproteobacteria.23223 Desulfovibrio.1592 - daf.2527 daf:Desaf_2646 Radical SAM domain protein; K22226 Fe-coproporphyrin III synthase OC.226740 Bacteria.529846 Proteobacteria.266816 Deltaproteobacteria.23223 Desulfovibrio.13190 Desulfovibrio_desulfuricans.3425 ddn.3423 ddn:DND132_3457 Radical SAM domain protein; K22226 Fe-coproporphyrin III synthase OC.226740 Bacteria.529846 Proteobacteria.266816 Deltaproteobacteria.23223 Pseudodesulfovibrio.1035 - das.2157 das:Daes_2204 Radical SAM domain protein; K22226 Fe-coproporphyrin III synthase OC.226740 Bacteria.529846 Proteobacteria.266816 Deltaproteobacteria.23223 Pseudodesulfovibrio.1035 - dpi.3300 dpi:BN4_20517 Radical SAM domain protein; K22226 Fe-coproporphyrin III synthase OC.226740 Bacteria.529846 Proteobacteria.266816 Deltaproteobacteria.23223 Pseudodesulfovibrio.1035 - dej.2752 dej:AWY79_14405 12,18-didecarboxysiroheme deacetylase; K22226 Fe-coproporphyrin III synthase OC.226740 Bacteria.529846 Proteobacteria.266816 Deltaproteobacteria.23223 Pseudodesulfovibrio.1035 - pprf.3691 pprf:DPRO_4014 Radical SAM domain protein; K22226 Fe-coproporphyrin III synthase OC.226740 Bacteria.529846 Proteobacteria.266816 Deltaproteobacteria.23223 Lawsonia.406 - lip.203 lip:LI0204 predicted Fe-S oxidoreductases; K22226 Fe-coproporphyrin III synthase OC.226740 Bacteria.529846 Proteobacteria.266816 Deltaproteobacteria.23223 Lawsonia.406 - lir.206 lir:LAW_00207 radical SAM domain-containing protein; K22226 Fe-coproporphyrin III synthase OC.226740 Bacteria.529846 Proteobacteria.266816 Deltaproteobacteria.23223 Desulfomicrobium.541 - dba.2295 dba:Dbac_2391 Radical SAM domain protein; K22226 Fe-coproporphyrin III synthase OC.226740 Bacteria.529846 Proteobacteria.266816 Deltaproteobacteria.23223 Desulfomicrobium.541 - doa.1124 doa:AXF15_06225 12,18-didecarboxysiroheme deacetylase; K22226 Fe-coproporphyrin III synthase OC.226740 Bacteria.529846 Proteobacteria.266816 Deltaproteobacteria.23223 - - drt.1899 drt:Dret_1953 Radical SAM domain protein; K22226 Fe-coproporphyrin III synthase OC.226740 Bacteria.529846 Proteobacteria.266816 Deltaproteobacteria.23223 - - dto.2108 dto:TOL2_C22100 radical SAM domain protein, related to coenzyme PQQ biosynthesis protein E; K22226 Fe-coproporphyrin III synthase OC.226741 Bacteria.939742 Proteobacteria.266818 Deltaproteobacteria.23228 - - sat.2063 sat:SYN_02268 radical SAM superfamily protein; K22226 Fe-coproporphyrin III synthase OC.226741 Bacteria.939742 Proteobacteria.266818 Deltaproteobacteria.23230 - - dbr.2834 dbr:Deba_2955 Radical SAM domain protein; K22226 Fe-coproporphyrin III synthase OC.226742 Bacteria.529847 Proteobacteria.266817 Deltaproteobacteria.23224 - - dal.3663 dal:Dalk_3858 Radical SAM domain protein; K22226 Fe-coproporphyrin III synthase OC.226742 Bacteria.529847 Proteobacteria.266817 Deltaproteobacteria.23225 Desulfococcus.91 - dol.1248 dol:Dole_1225 Radical SAM domain protein; K22226 Fe-coproporphyrin III synthase OC.226742 Bacteria.529847 Proteobacteria.266817 Deltaproteobacteria.23225 Desulfococcus.91 - dml.1250 dml:Dmul_12490 radical SAM domain protein, related to coenzyme PQQ biosynthesis protein E; K22226 Fe-coproporphyrin III synthase OC.226742 Bacteria.529847 Proteobacteria.266817 Deltaproteobacteria.23226 - - dao.129 dao:Desac_0013 Radical SAM domain protein; K22226 Fe-coproporphyrin III synthase OC.226742 Bacteria.529847 Proteobacteria.266817 Deltaproteobacteria.23229 - - sfu.2899 sfu:Sfum_3056 Radical SAM domain protein; K22226 Fe-coproporphyrin III synthase OC.226743 Bacteria.571870 Proteobacteria.604407 Deltaproteobacteria.117459 - - dti.2421 dti:Desti_2579 putative heme d1 biosynthesis radical SAM protein NirJ1; K22226 Fe-coproporphyrin III synthase OC.226743 Bacteria.571870 Thermodesulfobacteria.81 - - - tid.356 tid:Thein_0362 Radical SAM domain protein; K22226 Fe-coproporphyrin III synthase OC.226743 Bacteria.571870 Thermodesulfobacteria.81 Thermodesulfobacterium.1091 - - tcm.334 tcm:HL41_01935 Fe-S oxidoreductase; K22226 Fe-coproporphyrin III synthase OC.226743 Bacteria.571870 Thermodesulfobacteria.81 Thermodesulfobacterium.1934 - - top.1448 top:TOPB45_1506 Radical SAM domain protein; K22226 Fe-coproporphyrin III synthase OC.226743 Bacteria.571870 Thermodesulfobacteria.81 - - - cthi.1521 cthi:THC_1616 Fe-S oxidoreductase; K22226 Fe-coproporphyrin III synthase OC.226744 Bacteria.428594 Chloroflexi.12835 Dehalogenimonas.2378 - - dfo.1632 dfo:Dform_01790 radical SAM additional 4Fe4S-binding SPASM domain-containing protein; K22226 Fe-coproporphyrin III synthase OC.226745 Bacteria.428593 Verrucomicrobia.5340 Akkermansia.517 - - amu.795 amu:Amuc_0791 Radical SAM domain protein OC.226745 Bacteria.428593 Verrucomicrobia.5340 Akkermansia.517 - - agl.1747 agl:PYTT_1940 aldolase-type tim barrel; K22226 Fe-coproporphyrin III synthase OC.226746 Bacteria.428592 Firmicutes.44749 Firmicutes___Bacilli.133210 Brevibacillus.8139 - blr.2625 blr:BRLA_c027170 albA_2; antilisterial bacteriocin subtilosin biosynthesis protein AlbA OC.226746 Bacteria.428592 Firmicutes.44749 Firmicutes___Clostridia.24513 Clostridium.20559 - cace.3241 cace:CACET_c33640 nirJ1; putative heme d1 biosynthesis radical SAM protein NirJ1 OC.226746 Bacteria.428592 Firmicutes.44749 Firmicutes___Clostridia.24513 Clostridium.20559 - cfm.453 cfm:BJL90_02235 putative heme d1 biosynthesis radical SAM protein NirJ1 OC.226746 Bacteria.428592 Firmicutes.44749 Firmicutes___Clostridia.24513 Desulfotomaculum.486 - drm.2033 drm:Dred_2161 Radical SAM domain protein OC.226746 Bacteria.428592 Firmicutes.44749 Firmicutes___Clostridia.24513 Desulfotomaculum.486 - dca.1466 dca:Desca_1542 Radical SAM domain protein OC.226746 Bacteria.428592 Firmicutes.44749 Firmicutes___Clostridia.24513 Desulfotomaculum.486 - dru.1563 dru:Desru_1623 Radical SAM domain protein OC.226746 Bacteria.428592 Firmicutes.44749 Firmicutes___Clostridia.24513 Desulfotomaculum.486 - dfg.1940 dfg:B0537_10750 putative heme d1 biosynthesis radical SAM protein NirJ1 OC.226746 Bacteria.428592 Firmicutes.44749 Firmicutes___Clostridia.24513 - - dae.1214 dae:Dtox_1253 Radical SAM domain protein OC.226746 Bacteria.428592 Firmicutes.44749 Firmicutes___Clostridia.24513 - - dku.1451 dku:Desku_1519 Radical SAM domain protein OC.226746 Bacteria.428592 Firmicutes.44749 Firmicutes___Clostridia.24513 - - dgi.124 dgi:Desgi_2977 putative heme d1 biosynthesis radical SAM protein NirJ1 OC.226746 Bacteria.428592 Firmicutes.44749 Firmicutes___Clostridia.24513 - - dgi.124 dgi:Desgi_2073 putative heme d1 biosynthesis radical SAM protein NirJ1 OC.226746 Bacteria.428592 Firmicutes.44749 Firmicutes___Clostridia.24513 - - pth.1014 pth:PTH_0974 predicted Fe-S oxidoreductases OC.226746 Bacteria.428592 Firmicutes.44749 Firmicutes___Clostridia.24513 - - tjr.1072 tjr:TherJR_1137 Radical SAM domain protein OC.226746 Bacteria.428592 Firmicutes.44749 Firmicutes___Clostridia.24513 - - nth.1120 nth:Nther_1126 Radical SAM domain protein OC.226746 Bacteria.428592 Firmicutes.44749 Firmicutes___Clostridia.24514 Alkaliphilus.925 - amt.232 amt:Amet_0052 Radical SAM domain protein OC.226746 Bacteria.428592 Firmicutes.44749 Firmicutes___Clostridia.24517 - - hmo.1792 hmo:HM1_1967 elongator protein 3/miab/nifb, putative OC.226746 Bacteria.428592 Firmicutes.44749 Firmicutes___Clostridia.24518 Desulfitobacterium.1004 Desulfitobacterium_hafniense.2077 dsy.2215 dsy:DSY2223 hypothetical protein OC.226746 Bacteria.428592 Firmicutes.44749 Firmicutes___Clostridia.24518 Desulfitobacterium.1004 Desulfitobacterium_hafniense.2077 dhd.3271 dhd:Dhaf_3352 Radical SAM domain protein OC.226746 Bacteria.428592 Firmicutes.44749 Firmicutes___Clostridia.24518 Desulfitobacterium.1004 - ddh.2557 ddh:Desde_2798 putative heme d1 biosynthesis radical SAM protein NirJ1 OC.226746 Bacteria.428592 Firmicutes.44749 Firmicutes___Clostridia.24518 Desulfitobacterium.1004 - ddl.2106 ddl:Desdi_2316 putative heme d1 biosynthesis radical SAM protein NirJ1 OC.226746 Bacteria.428592 Firmicutes.44749 Firmicutes___Clostridia.24518 Desulfitobacterium.1004 - dmt.1748 dmt:DESME_09265 Fe-S oxidoreductase OC.226746 Bacteria.428592 Firmicutes.44749 Firmicutes___Clostridia.24518 - - sgy.1330 sgy:Sgly_1407 Radical SAM domain protein OC.226746 Bacteria.428592 Firmicutes.44749 Firmicutes___Clostridia.24518 Desulfosporosinus.418 - dor.1281 dor:Desor_1311 putative heme d1 biosynthesis radical SAM protein NirJ1 OC.226746 Bacteria.428592 Firmicutes.44749 Firmicutes___Clostridia.24518 Desulfosporosinus.418 - dai.1779 dai:Desaci_1933 putative heme d1 biosynthesis radical SAM protein NirJ1 OC.226746 Bacteria.428592 Firmicutes.44749 Firmicutes___Clostridia.24518 Desulfosporosinus.418 - dmi.1147 dmi:Desmer_1210 putative heme d1 biosynthesis radical SAM protein NirJ1 OC.226746 Bacteria.428592 Firmicutes.44749 Firmicutes___Clostridia.24518 Dehalobacter.702 Dehalobacter_sp_.175 ded.52 ded:DHBDCA_p1026 putative heme d1 biosynthesis radical SAM protein NirJ1 OC.226746 Bacteria.428592 Firmicutes.44749 Firmicutes___Clostridia.24518 Dehalobacter.702 Dehalobacter_sp_.175 dec.116 dec:DCF50_p1082 putative heme d1 biosynthesis radical SAM protein NirJ1 OC.226746 Bacteria.428592 Firmicutes.44749 Firmicutes___Clostridia.24518 Dehalobacter.702 - drs.1757 drs:DEHRE_09600 Fe-S oxidoreductase OC.226746 Bacteria.428592 Firmicutes.44749 Firmicutes___Clostridia.54064 Clostridium.1902 Clostridium_acetobutylicum.1843 cac.2688 cac:CA_C2796 MoaA/NirJ family Fe-S oxidoreductase OC.226746 Bacteria.428592 Firmicutes.44749 Firmicutes___Clostridia.54064 Clostridium.1902 Clostridium_acetobutylicum.1843 cae.2797 cae:SMB_G2832 pqqE; MoaA/NirJ family Fe-S oxidoreductase OC.226746 Bacteria.428592 Firmicutes.44749 Firmicutes___Clostridia.54064 Clostridium.1902 Clostridium_acetobutylicum.1843 cay.2800 cay:CEA_G2804 MoaA/NirJ family Fe-S oxidoreductase OC.226746 Bacteria.428592 Firmicutes.44749 Firmicutes___Clostridia.54064 Clostridium.1902 Clostridium_beijerinckii.1098 cbe.1987 cbe:Cbei_2007 Radical SAM domain protein OC.226746 Bacteria.428592 Firmicutes.44749 Firmicutes___Clostridia.54064 Clostridium.1902 Clostridium_beijerinckii.1098 cbz.1986 cbz:Cbs_2007 radical SAM domain-containing protein OC.226746 Bacteria.428592 Firmicutes.44749 Firmicutes___Clostridia.54064 Clostridium.1902 Clostridium_beijerinckii.1098 cbei.2030 cbei:LF65_02176 radical SAM protein OC.226746 Bacteria.428592 Firmicutes.44749 Firmicutes___Clostridia.54064 Clostridium.1902 Clostridium_kluyveri.2837 ckl.435 ckl:CKL_0375 Predicted Fe-S oxidoreductase OC.226746 Bacteria.428592 Firmicutes.44749 Firmicutes___Clostridia.54064 Clostridium.1902 Clostridium_kluyveri.2837 ckr.341 ckr:CKR_0325 hypothetical protein OC.226746 Bacteria.428592 Firmicutes.44749 Firmicutes___Clostridia.54064 Clostridium.1902 - csr.4589 csr:Cspa_c47290 radical SAM domain protein OC.226746 Bacteria.428592 Firmicutes.44749 Firmicutes___Clostridia.54064 Clostridium.1902 Clostridium_pasteurianum.3225 cpas.630 cpas:Clopa_0538 putative heme d1 biosynthesis radical SAM protein NirJ1 OC.226746 Bacteria.428592 Firmicutes.44749 Firmicutes___Clostridia.54064 Clostridium.1902 Clostridium_pasteurianum.3225 cpat.421 cpat:CLPA_c04430 pqqE; coenzyme PQQ synthesis protein E OC.226746 Bacteria.428592 Firmicutes.44749 Firmicutes___Clostridia.54064 Clostridium.1902 Clostridium_pasteurianum.3225 cpae.421 cpae:CPAST_c04430 pqqE; coenzyme PQQ synthesis protein E OC.226746 Bacteria.428592 Firmicutes.44749 Firmicutes___Clostridia.54064 Clostridium.1902 - csq.2649 csq:CSCA_2641 Radical SAM domain protein OC.226746 Bacteria.428592 Firmicutes.44749 Firmicutes___Clostridia.54064 Clostridium.1902 - cck.335 cck:Ccar_01380 Fe-S oxidoreductase OC.226746 Bacteria.428592 Firmicutes.44749 Firmicutes___Clostridia.54064 Clostridium.1902 - ctyk.2361 ctyk:CTK_C24970 radical SAM domain protein OC.226746 Bacteria.428592 Firmicutes.44749 Firmicutes___Clostridia.54064 Clostridium.1902 - ceu.1116 ceu:A7L45_05710 putative heme d1 biosynthesis radical SAM protein NirJ1 OC.226746 Bacteria.428592 Firmicutes.44749 Firmicutes___Clostridia.54064 Clostridium.1902 - cdrk.1247 cdrk:B9W14_06475 heme d1 biosynthesis radical SAM protein NirJ1 OC.226746 Bacteria.428592 Firmicutes.44749 Firmicutes___Clostridia.172996 - - mta.1207 mta:Moth_1247 radical SAM family protein OC.226746 Bacteria.428592 Firmicutes.44749 Selenomonas.1218 Selenomonas_sp_.36 - sele.1034 sele:ADJ74_05495 Fe-S oxidoreductase OC.226746 Bacteria.428592 Firmicutes.44749 Selenomonas.1218 Selenomonas_sp_.36 - selo.832 selo:AXE86_04370 radical SAM protein OC.226746 Bacteria.428592 Firmicutes.44749 Selenomonas.1218 Selenomonas_sp_.36 - selt.1924 selt:BCS37_10350 putative heme d1 biosynthesis radical SAM protein NirJ1 OC.226746 Bacteria.428592 Firmicutes.44749 Selenomonas.1218 - - ssg.1684 ssg:Selsp_1769 Radical SAM domain protein OC.226746 Bacteria.428592 Firmicutes.44749 Selenomonas.1218 - - sri.2171 sri:SELR_22450 hypothetical protein OC.226746 Bacteria.428592 Firmicutes.44749 Pelosinus.2638 - - puf.4178 puf:UFO1_4340 Putative heme d1 biosynthesis protein, NirJ1 OC.226746 Bacteria.428592 Firmicutes.44749 Pelosinus.2638 - - pft.579 pft:JBW_00469 Putative heme d1 biosynthesis protein, NirJ1 OC.226746 Bacteria.428592 Firmicutes.44751 Firmicutes___Bacilli.91925 Paenibacillus.17486 Paenibacillus_polymyxa.9935 ppoy.4625 ppoy:RE92_24475 Fe-S oxidoreductase OC.226746 Bacteria.428592 Firmicutes.44751 Firmicutes___Bacilli.91925 Paenibacillus.17486 - psab.2582 psab:PSAB_13050 Radical SAM domain-containing protein OC.226746 Bacteria.428592 Firmicutes.44751 Firmicutes___Bacilli.91925 Paenibacillus.17486 - pdu.2409 pdu:PDUR_14795 Fe-S oxidoreductase OC.226746 Bacteria.428592 Firmicutes.44751 Firmicutes___Bacilli.91925 Paenibacillus.17486 - pste.2221 pste:PSTEL_13800 Fe-S oxidoreductase OC.226746 Bacteria.428592 Firmicutes.44752 Firmicutes___Clostridia.24515 - - dau.1246 dau:Daud_1345 Radical SAM domain protein OC.226746 Bacteria.428592 Firmicutes.44753 Firmicutes___Clostridia.24519 - - adg.1849 adg:Adeg_2076 Radical SAM domain protein OC.226746 Bacteria.428592 Firmicutes.179944 Firmicutes___Bacilli.143954 Kyrpidia.1246 - bts.2386 bts:Btus_2570 Radical SAM domain protein OC.226746 Bacteria.428592 Firmicutes.179944 Firmicutes___Bacilli.143954 Kyrpidia.1246 - kyr.2349 kyr:CVV65_12760 heme d1 biosynthesis radical SAM protein NirJ1 OC.226746 Bacteria.428592 Chloroflexi.13023 Dehalogenimonas.2625 - - dly.416 dly:Dehly_0449 Radical SAM domain protein OC.226746 Bacteria.428592 Fibrobacteres.1680 - - - fsu.2991 fsu:Fisuc_3041 Radical SAM domain protein OC.226746 Bacteria.428592 Fibrobacteres.1680 - - - fsc.272 fsc:FSU_0306 radical SAM domain protein OC.226747 Bacteria.531146 Proteobacteria.271457 Deltaproteobacteria.31506 Geobacter.5271 Geobacter_sulfurreducens.1791 gsu.2736 gsu:GSU2905 radical SAM domain-containing iron-sulfur cluster-binding oxidoreductase OC.226747 Bacteria.531146 Proteobacteria.271457 Deltaproteobacteria.31506 Geobacter.5271 Geobacter_sulfurreducens.1791 gsk.2664 gsk:KN400_2846 radical SAM domain iron-sulfur cluster-binding oxidoreductase OC.226747 Bacteria.531146 Proteobacteria.271457 Deltaproteobacteria.31506 Geobacter.5271 - gme.572 gme:Gmet_0566 radical SAM domain iron-sulfur cluster-binding oxidoreductase OC.226747 Bacteria.531146 Proteobacteria.271457 Deltaproteobacteria.31506 Geobacter.5271 - gur.1722 gur:Gura_1767 Radical SAM domain protein OC.226747 Bacteria.531146 Proteobacteria.271457 Deltaproteobacteria.31506 Geobacter.5271 - geo.3245 geo:Geob_3352 radical SAM domain iron-sulfur cluster-binding oxidoreductase OC.226747 Bacteria.531146 Proteobacteria.271457 Deltaproteobacteria.31506 Geobacter.5271 - gpi.558 gpi:GPICK_03015 radical SAM protein OC.226747 Bacteria.531146 Proteobacteria.271457 Deltaproteobacteria.31506 Geobacter.5271 - gao.2220 gao:A2G06_13685 radical SAM/SPASM domain-containing protein OC.226747 Bacteria.531146 Proteobacteria.271457 Deltaproteobacteria.31506 - - gsb.1107 gsb:GSUB_06410 radical SAM protein OC.226747 Bacteria.531146 Proteobacteria.271457 Deltaproteobacteria.31506 Desulfuromonas.309 - des.1555 des:DSOUD_1578 GeoRSP system radical SAM/SPASM protein OC.226747 Bacteria.531146 Proteobacteria.271457 Deltaproteobacteria.31506 Desulfuromonas.309 - deu.1912 deu:DBW_2060 radical SAM domain-containing iron-sulfur cluster-binding oxidoreductase OC.226748 Bacteria.867167 Firmicutes.243759 Firmicutes___Clostridia.97198 Caldicellulosiruptor.2995 - ate.25 ate:Athe_0913 Radical SAM domain protein OC.226748 Bacteria.867167 Firmicutes.243759 Firmicutes___Clostridia.97198 Caldicellulosiruptor.2995 - ate.25 ate:Athe_0912 Radical SAM domain protein OC.226749 Bacteria.749595 Chlorobi.3199 Chlorobium.3742 Chlorobium_phaeobacteroides.2463 - cph.82 cph:Cpha266_0055 Radical SAM domain protein OC.226749 Bacteria.749595 Chlorobi.3199 Pelodictyon.2174 - - pph.137 pph:Ppha_0071 Radical SAM domain protein OC.226750 Bacteria.872459 Firmicutes.251928 Firmicutes___Clostridia.109787 Clostridium.43009 - ccb.3375 ccb:Clocel_3666 Radical SAM domain protein OC.226751 Bacteria.386160 Firmicutes.264508 Firmicutes___Clostridia.127987 Hungateiclostridium.2430 Hungateiclostridium_thermocellum.246 cth.1263 cth:Cthe_1309 Radical SAM domain protein OC.226751 Bacteria.386160 Firmicutes.264508 Firmicutes___Clostridia.127987 Hungateiclostridium.2430 Hungateiclostridium_thermocellum.246 ctx.920 ctx:Clo1313_0948 Radical SAM domain protein