# OC Root 2nd 3rd 4th 5th 6th PC Gene/Definition OC.250916 Bacteria.570076 Proteobacteria.48297 Gammaproteobacteria.450097 - - slim.845 slim:SCL_0832 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase OC.250916 Bacteria.570076 Proteobacteria.48298 Gammaproteobacteria.408907 - - enm.1331 enm:EBS_1465 hpaF; 5-carboxymethyl-2-hydroxymuconate isomerase OC.250916 Bacteria.570076 Proteobacteria.48297 Betaproteobacteria.86288 Ralstonia.13301 Ralstonia_pickettii.11818 rpj.5856 rpj:N234_30260 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase OC.250916 Bacteria.570076 Proteobacteria.48297 Betaproteobacteria.86288 Cupriavidus.6296 - reu.4628 reu:Reut_B4668 Fumarylacetoacetate (FAA) hydrolase OC.250916 Bacteria.570076 Proteobacteria.48297 Betaproteobacteria.86288 Cupriavidus.6296 Cupriavidus_necator.3875 reh.5325 reh:H16_B1716 h16_B1716; 2-Keto-4-pentenoatehydratase/2-oxohepta-3-ene-1-dioic acid hydratase (catechol pathway) OC.250916 Bacteria.570076 Proteobacteria.48297 Betaproteobacteria.86288 Cupriavidus.6296 Cupriavidus_necator.3875 cnc.5316 cnc:CNE_2c16910 2-keto-4-pentenoatehydratase/2-oxohepta-3-ene-1-dioic acid hydratase OC.250916 Bacteria.570076 Proteobacteria.48297 Betaproteobacteria.86288 Cupriavidus.6296 Cupriavidus_necator.3875 cuh.5718 cuh:BJN34_30150 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase OC.250916 Bacteria.570076 Proteobacteria.48297 Betaproteobacteria.86288 Cupriavidus.6296 - rme.4230 rme:Rmet_4363 fumarylacetoacetate (FAA) hydrolase OC.250916 Bacteria.570076 Proteobacteria.48297 Betaproteobacteria.86288 Cupriavidus.6296 - cti.4622 cti:RALTA_B1514 Fumarylacetoacetate (FAA) hydrolase OC.250916 Bacteria.570076 Proteobacteria.48297 Betaproteobacteria.86288 Cupriavidus.6296 - cbw.6290 cbw:RR42_s2205 Fumarylacetoacetate hydrolase family protein OC.250916 Bacteria.570076 Proteobacteria.48297 Betaproteobacteria.86288 Cupriavidus.6296 - cgd.4012 cgd:CR3_4120 mhpD; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) OC.250916 Bacteria.570076 Proteobacteria.48297 Betaproteobacteria.86288 Burkholderia.63580 Burkholderia_sp_.30613 bug.5119 bug:BC1001_5185 fumarylacetoacetate (FAA) hydrolase OC.250916 Bacteria.570076 Proteobacteria.48297 Betaproteobacteria.86288 Burkholderia.55734 Burkholderia_sp_.20681 bge.3326 bge:BC1002_3376 fumarylacetoacetate (FAA) hydrolase OC.250916 Bacteria.570076 Proteobacteria.48297 Betaproteobacteria.86288 Burkholderia.50600 Burkholderia_sp_.2688 bgf.4219 bgf:BC1003_4297 fumarylacetoacetate (FAA) hydrolase OC.250916 Bacteria.570076 Proteobacteria.48297 Betaproteobacteria.86288 Burkholderia.51742 Burkholderia_sp_.10265 byi.1456 byi:BYI23_A013890 fumarylacetoacetate hydrolase, putative OC.250916 Bacteria.570076 Proteobacteria.48297 Betaproteobacteria.86288 Burkholderia.31871 Burkholderia_sp_.12990 byi.3847 byi:BYI23_B010380 fumarylacetoacetate hydrolase, putative OC.250916 Bacteria.570076 Proteobacteria.48297 Betaproteobacteria.86288 Burkholderia.31871 - buo.3167 buo:BRPE64_BCDS02520 fumarylacetoacetate (FAA) hydrolase OC.250916 Bacteria.570076 Proteobacteria.48297 Betaproteobacteria.86288 Burkholderia.51742 Burkholderia_sp_.10265 bue.1557 bue:BRPE67_ACDS14310 fumarylacetoacetate hydrolase, putative OC.250916 Bacteria.570076 Proteobacteria.48297 Betaproteobacteria.86288 Burkholderia.31871 Burkholderia_sp_.12990 bue.4347 bue:BRPE67_BCDS14510 fumarylacetoacetate hydrolase, putative OC.250916 Bacteria.570076 Proteobacteria.48297 Betaproteobacteria.86288 Burkholderia.50600 Burkholderia_sp_.2688 buq.4304 buq:AC233_24145 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase OC.250916 Bacteria.570076 Proteobacteria.48297 Betaproteobacteria.86288 Burkholderia.75836 Burkholderia_sp_.52104 buz.5879 buz:AYM40_32090 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase OC.250916 Bacteria.570076 Proteobacteria.48297 Betaproteobacteria.86288 Burkholderia.67232 Burkholderia_sp_.41550 bum.5781 bum:AXG89_35865 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase OC.250916 Bacteria.570076 Proteobacteria.48297 Betaproteobacteria.86288 Paraburkholderia.3127 Paraburkholderia_xenovorans.3016 bxe.6538 bxe:Bxe_B2266 Putative 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase OC.250916 Bacteria.570076 Proteobacteria.48297 Betaproteobacteria.86288 Paraburkholderia.3127 Paraburkholderia_xenovorans.3016 bxb.3894 bxb:DR64_4597 fumarylacetoacetate (FAA) hydrolase family protein OC.250916 Bacteria.570076 Proteobacteria.48297 Betaproteobacteria.86288 Paraburkholderia.13747 - bph.3613 bph:Bphy_3613 fumarylacetoacetate (FAA) hydrolase OC.250916 Bacteria.570076 Proteobacteria.48297 Betaproteobacteria.86288 Paraburkholderia.33636 - bpx.5296 bpx:BUPH_05896 fumarylacetoacetate (FAA) hydrolase OC.250916 Bacteria.570076 Proteobacteria.48297 Betaproteobacteria.86288 Paraburkholderia.3127 - bpy.5878 bpy:Bphyt_6031 fumarylacetoacetate (FAA) hydrolase OC.250916 Bacteria.570076 Proteobacteria.48297 Betaproteobacteria.86288 Paraburkholderia.26447 - bfn.3971 bfn:OI25_4572 fumarylacetoacetate (FAA) hydrolase family protein OC.250916 Bacteria.570076 Proteobacteria.48297 Betaproteobacteria.86288 Paraburkholderia.13747 - bcai.5618 bcai:K788_0005255 Fumarylacetoacetate hydrolase family protein OC.250916 Bacteria.570076 Proteobacteria.48297 Betaproteobacteria.86288 Paraburkholderia.51519 - pspw.3654 pspw:BJG93_18735 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase OC.250916 Bacteria.570076 Proteobacteria.48297 Betaproteobacteria.86288 Paraburkholderia.41064 - para.5123 para:BTO02_27025 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase OC.250916 Bacteria.570076 Proteobacteria.48297 Betaproteobacteria.86288 Paraburkholderia.3127 - parb.6198 parb:CJU94_32270 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase OC.250916 Bacteria.570076 Proteobacteria.48297 Betaproteobacteria.86288 Paraburkholderia.13747 - phs.5515 phs:C2L64_28530 FAA hydrolase family protein OC.250916 Bacteria.570076 Proteobacteria.48297 Betaproteobacteria.86288 Paraburkholderia.13747 - pter.3933 pter:C2L65_19980 FAA hydrolase family protein OC.250916 Bacteria.570076 Proteobacteria.48297 Betaproteobacteria.86288 Paraburkholderia.3127 - pgp.3739 pgp:CUJ91_19425 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase OC.250916 Bacteria.570076 Proteobacteria.48297 Betaproteobacteria.122424 Polynucleobacter.580 - pnu.208 pnu:Pnuc_0192 fumarylacetoacetate (FAA) hydrolase OC.250916 Bacteria.570076 Proteobacteria.48297 Betaproteobacteria.122424 Polynucleobacter.580 - pne.176 pne:Pnec_0208 fumarylacetoacetate (FAA) hydrolase OC.250916 Bacteria.570076 Proteobacteria.48297 Betaproteobacteria.122424 Polynucleobacter.580 - pdq.204 pdq:CL55_00001960 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) OC.250916 Bacteria.570076 Proteobacteria.48297 Betaproteobacteria.122424 Polynucleobacter.580 - poh.198 poh:DPM16_01035 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase OC.250916 Bacteria.570076 Proteobacteria.48297 Betaproteobacteria.86288 Pandoraea.892 Pandoraea_pnomenusa.1740 ppk.2669 ppk:U875_16535 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase OC.250916 Bacteria.570076 Proteobacteria.48297 Betaproteobacteria.86288 Pandoraea.892 Pandoraea_pnomenusa.1740 ppno.1576 ppno:DA70_08430 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase OC.250916 Bacteria.570076 Proteobacteria.48297 Betaproteobacteria.86288 Pandoraea.892 Pandoraea_pnomenusa.1740 ppnm.3970 ppnm:LV28_22215 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase OC.250916 Bacteria.570076 Proteobacteria.48297 Betaproteobacteria.86288 Pandoraea.892 Pandoraea_pnomenusa.1740 prb.3315 prb:X636_17940 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase OC.250916 Bacteria.570076 Proteobacteria.48297 Betaproteobacteria.86288 Pandoraea.892 - ppul.2901 ppul:RO07_16630 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase OC.250916 Bacteria.570076 Proteobacteria.48297 Betaproteobacteria.86288 Pandoraea.892 - pspu.3891 pspu:NA29_20570 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase OC.250916 Bacteria.570076 Proteobacteria.48297 Betaproteobacteria.86288 Pandoraea.892 - papi.2733 papi:SG18_15450 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase OC.250916 Bacteria.570076 Proteobacteria.48297 Betaproteobacteria.86288 Pandoraea.892 - pve.1481 pve:UC34_07810 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase OC.250916 Bacteria.570076 Proteobacteria.48297 Betaproteobacteria.86288 Pandoraea.892 - pox.2224 pox:MB84_12180 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase OC.250916 Bacteria.570076 Proteobacteria.48297 Betaproteobacteria.86288 Pandoraea.10786 - ptx.1155 ptx:ABW99_06075 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase OC.250916 Bacteria.570076 Proteobacteria.48297 Betaproteobacteria.86288 Pandoraea.892 - pfg.3447 pfg:AB870_18535 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase OC.250916 Bacteria.570076 Proteobacteria.48297 Betaproteobacteria.86288 Pandoraea.892 - pnr.4976 pnr:AT302_26195 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase OC.250916 Bacteria.570076 Proteobacteria.48297 Betaproteobacteria.99246 Polaromonas.6344 - pol.2771 pol:Bpro_2792 5-carboxymethyl-2-hydroxymuconate delta-isomerase OC.250916 Bacteria.570076 Proteobacteria.48297 Betaproteobacteria.99246 Variovorax.3018 Variovorax_paradoxus.3307 vap.4424 vap:Vapar_4480 5-carboxymethyl-2-hydroxymuconate Delta-isomerase OC.250916 Bacteria.570076 Proteobacteria.48297 Betaproteobacteria.99246 Variovorax.3018 Variovorax_paradoxus.3307 vpe.5069 vpe:Varpa_5194 fumarylacetoacetate (FAA) hydrolase OC.250916 Bacteria.570076 Proteobacteria.48297 Betaproteobacteria.99246 Variovorax.3018 Variovorax_paradoxus.3307 vpd.4577 vpd:VAPA_1c46580 putative fumarylacetoacetate (FAA) hydrolase OC.250916 Bacteria.570076 Proteobacteria.48297 Betaproteobacteria.129254 - - mpt.2252 mpt:Mpe_A2225 5-carboxymethyl-2-hydroxymuconate delta-isomerase OC.250916 Bacteria.570076 Proteobacteria.48297 Betaproteobacteria.99246 - - har.357 har:HEAR0345 putative Fumarylacetoacetate (FAA) hydrolase OC.250916 Bacteria.570076 Proteobacteria.48297 Betaproteobacteria.99246 Janthinobacterium.10494 Janthinobacterium_sp_.11533 mms.422 mms:mma_0392 Faa-hydrolase family protein OC.250916 Bacteria.570076 Proteobacteria.48297 Betaproteobacteria.99246 Collimonas.1298 - cfu.2006 cfu:CFU_2011 hpcE; Fumarylacetoacetate hydrolase family protein OC.250916 Bacteria.570076 Proteobacteria.48297 Betaproteobacteria.99246 Collimonas.1298 - care.2606 care:LT85_2629 Fumarylacetoacetate hydrolase family protein OC.250916 Bacteria.570076 Proteobacteria.48297 Betaproteobacteria.99246 Collimonas.1298 - cpra.2539 cpra:CPter91_2577 fumarylacetoacetate (FAA) hydrolase family protein OC.250916 Bacteria.570076 Proteobacteria.48297 Betaproteobacteria.99246 Massilia.16154 - mtim.1105 mtim:DIR46_05935 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase OC.250916 Bacteria.570076 Proteobacteria.48297 Betaproteobacteria.253560 - - ofo.302 ofo:BRW83_0239 Ureidoglycolate lyase OC.250916 Bacteria.570076 Proteobacteria.48297 Betaproteobacteria.129254 - - rgu.4844 rgu:A4W93_25255 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase OC.250916 Bacteria.570076 Proteobacteria.48297 Betaproteobacteria.267963 - - shd.1013 shd:SUTH_01022 fumarylacetoacetate (FAA) hydrolase OC.250916 Bacteria.570076 Proteobacteria.48297 Betaproteobacteria.129254 - - metr.1444 metr:BSY238_2307 fumarylacetoacetate (FAA) hydrolase family protein OC.250916 Bacteria.570076 Proteobacteria.48297 Betaproteobacteria.122424 - - bprc.221 bprc:D521_0193 Fumarylacetoacetate (FAA) hydrolase OC.250916 Bacteria.570076 Proteobacteria.48297 Alphaproteobacteria.109459 Bradyrhizobium.5686 - bja.1396 bja:bll3146 hypothetical protein OC.250916 Bacteria.570076 Proteobacteria.48297 Alphaproteobacteria.109459 Bradyrhizobium.5686 Bradyrhizobium_japonicum.5507 bju.6552 bju:BJ6T_66160 hypothetical protein OC.250916 Bacteria.570076 Proteobacteria.48297 Alphaproteobacteria.109459 Bradyrhizobium.5686 Bradyrhizobium_japonicum.5507 bjp.6143 bjp:RN69_32075 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase OC.250916 Bacteria.570076 Proteobacteria.48297 Alphaproteobacteria.109459 Bradyrhizobium.5686 Bradyrhizobium_sp_.34462 brs.4802 brs:S23_48550 hypothetical protein OC.250916 Bacteria.570076 Proteobacteria.48297 Alphaproteobacteria.109459 Bradyrhizobium.5686 Bradyrhizobium_sp_.20185 brc.2778 brc:BCCGELA001_14140 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase OC.250916 Bacteria.570076 Proteobacteria.48297 Alphaproteobacteria.109459 Bradyrhizobium.5686 Bradyrhizobium_sp_.14306 brad.1717 brad:BF49_1538 Fumarylacetoacetate hydrolase family protein OC.250916 Bacteria.570076 Proteobacteria.48297 Alphaproteobacteria.109459 Bradyrhizobium.5686 - bot.6915 bot:CIT37_37780 FAA hydrolase family protein OC.250916 Bacteria.570076 Proteobacteria.48297 Alphaproteobacteria.109459 Rhodopseudomonas.1204 - rpa.1932 rpa:RPA1942 putative 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase OC.250916 Bacteria.570076 Proteobacteria.48297 Alphaproteobacteria.109459 Rhodopseudomonas.1204 - rpb.3415 rpb:RPB_3432 Fumarylacetoacetate (FAA) hydrolase OC.250916 Bacteria.570076 Proteobacteria.48297 Alphaproteobacteria.109459 Rhodopseudomonas.1204 - rpc.1838 rpc:RPC_1849 fumarylacetoacetate (FAA) hydrolase OC.250916 Bacteria.570076 Proteobacteria.48297 Alphaproteobacteria.109459 Rhodopseudomonas.1204 - rpd.2019 rpd:RPD_2022 5-carboxymethyl-2-hydroxymuconate delta-isomerase OC.250916 Bacteria.570076 Proteobacteria.48297 Alphaproteobacteria.109459 Rhodopseudomonas.1204 - rpe.1940 rpe:RPE_1953 fumarylacetoacetate (FAA) hydrolase OC.250916 Bacteria.570076 Proteobacteria.48297 Alphaproteobacteria.109459 Rhodopseudomonas.1204 - rpt.2118 rpt:Rpal_2152 fumarylacetoacetate (FAA) hydrolase OC.250916 Bacteria.570076 Proteobacteria.48297 Alphaproteobacteria.109459 Rhodopseudomonas.1204 - rpx.3476 rpx:Rpdx1_3560 fumarylacetoacetate (FAA) hydrolase OC.250916 Bacteria.570076 Proteobacteria.48297 Alphaproteobacteria.109459 Oligotropha.1531 - oca.2518 oca:OCAR_6557 fumarylacetoacetate OC.250916 Bacteria.570076 Proteobacteria.48297 Alphaproteobacteria.109459 Oligotropha.1531 - ocg.1489 ocg:OCA5_c15040 fumarylacetoacetate hydrolase family protein OC.250916 Bacteria.570076 Proteobacteria.48297 Alphaproteobacteria.109459 Oligotropha.1531 - oco.1488 oco:OCA4_c15040 fumarylacetoacetate hydrolase family protein OC.250916 Bacteria.570076 Proteobacteria.48297 Alphaproteobacteria.109459 - - xau.630 xau:Xaut_0492 fumarylacetoacetate (FAA) hydrolase OC.250916 Bacteria.570076 Proteobacteria.48297 Alphaproteobacteria.109459 - - azc.518 azc:AZC_0472 putative 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase precursor OC.250916 Bacteria.570076 Proteobacteria.48297 Alphaproteobacteria.109459 - - sno.2890 sno:Snov_2987 fumarylacetoacetate (FAA) hydrolase OC.250916 Bacteria.570076 Proteobacteria.48297 Alphaproteobacteria.141373 Methylorubrum.494 Methylorubrum_extorquens.1218 mex.2081 mex:Mext_2138 fumarylacetoacetate (FAA) hydrolase OC.250916 Bacteria.570076 Proteobacteria.48297 Alphaproteobacteria.141373 Methylorubrum.494 Methylorubrum_extorquens.1218 mea.1987 mea:Mex_1p2128 Fumarylacetoacetate (FAA) hydrolase family OC.250916 Bacteria.570076 Proteobacteria.48297 Alphaproteobacteria.141373 Methylorubrum.494 Methylorubrum_extorquens.1218 mdi.2635 mdi:METDI2910 Fumarylacetoacetate (FAA) hydrolase family OC.250916 Bacteria.570076 Proteobacteria.48297 Alphaproteobacteria.141373 Methylorubrum.494 Methylorubrum_extorquens.1218 mch.2293 mch:Mchl_2415 fumarylacetoacetate (FAA) hydrolase OC.250916 Bacteria.570076 Proteobacteria.48297 Alphaproteobacteria.141373 Methylorubrum.494 - mpo.2083 mpo:Mpop_2098 fumarylacetoacetate (FAA) hydrolase OC.250916 Bacteria.570076 Proteobacteria.48297 Alphaproteobacteria.141373 Methylorubrum.494 - mza.3399 mza:B2G69_18300 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase OC.250916 Bacteria.570076 Proteobacteria.48297 Alphaproteobacteria.141373 Methylobacterium.16393 Methylobacterium_sp_.8904 meta.2013 meta:Y590_10260 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase OC.250916 Bacteria.570076 Proteobacteria.48297 Alphaproteobacteria.141373 Methylobacterium.20124 Methylobacterium_sp_.13571 metd.2239 metd:C0214_12085 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase OC.250916 Bacteria.570076 Proteobacteria.48297 Alphaproteobacteria.324994 - - msl.3032 msl:Msil_3159 fumarylacetoacetate (FAA) hydrolase OC.250916 Bacteria.570076 Proteobacteria.48297 Alphaproteobacteria.109459 - - brn.1117 brn:D1F64_06005 DUF2437 domain-containing protein OC.250916 Bacteria.570076 Proteobacteria.48297 Alphaproteobacteria.109459 - - hdi.4121 hdi:HDIA_4158 hpcE; Homoprotocatechuate catabolism bifunctional isomerase/decarboxylase OC.250916 Bacteria.570076 Proteobacteria.48297 Alphaproteobacteria.109460 Granulobacter.1664 - gbe.294 gbe:GbCGDNIH1_0292 Fumarylacetoacetate hydrolase family protein OC.250916 Bacteria.570076 Proteobacteria.48297 Alphaproteobacteria.109460 Granulobacter.1664 - gbh.290 gbh:GbCGDNIH2_0292 Fumarylacetoacetate hydrolase family protein OC.250916 Bacteria.570076 Proteobacteria.48297 Alphaproteobacteria.109460 Granulobacter.1664 - gbc.289 gbc:GbCGDNIH3_0292 Fumarylacetoacetate hydrolase family protein OC.250916 Bacteria.570076 Proteobacteria.48297 Alphaproteobacteria.109460 Granulobacter.1664 - gbs.289 gbs:GbCGDNIH4_0292 Fumarylacetoacetate hydrolase family protein