# OC Root 2nd 3rd 4th 5th PC Gene/Definition OC.276642 Archaea.35386 Euryarchaeota.8722 Methanocaldococcus.1211 - mja.512 mja:MJ_0503 2-isopropylmalate synthase (leuA); K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8722 Methanocaldococcus.1211 - mfe.686 mfe:Mefer_0710 isopropylmalate/citramalate/homocitrate synthase; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8722 Methanocaldococcus.1211 - mvu.1547 mvu:Metvu_1576 isopropylmalate/citramalate/homocitrate synthase; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8722 Methanocaldococcus.1211 - mfs.1744 mfs:MFS40622_1791 isopropylmalate/citramalate/homocitrate synthase; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8722 Methanocaldococcus.1211 - mif.1321 mif:Metin_1354 isopropylmalate/citramalate/homocitrate synthase; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8722 Methanocaldococcus.1211 - mjh.1398 mjh:JH146_1425 trans-homoaconitate synthase; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8722 - - mig.675 mig:Metig_0696 isopropylmalate/citramalate/homocitrate synthase; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8722 Methanococcus.1486 Methanococcus_maripaludis.645 mmp.153 mmp:MMP0153 aksA; 2-oxosuberate synthase, first step; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8722 Methanococcus.1486 Methanococcus_maripaludis.645 mmq.1491 mmq:MmarC5_1522 2-isopropylmalate synthase; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8722 Methanococcus.1486 Methanococcus_maripaludis.645 mmx.777 mmx:MmarC6_0797 isopropylmalate/citramalate/homocitrate synthase; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8722 Methanococcus.1486 Methanococcus_maripaludis.645 mmz.1147 mmz:MmarC7_1153 isopropylmalate/citramalate/homocitrate synthase; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8722 Methanococcus.1486 Methanococcus_maripaludis.645 mmd.159 mmd:GYY_00785 aksA; trans-homoaconitate synthase; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8722 Methanococcus.3256 - mae.971 mae:Maeo_0994 isopropylmalate/citramalate/homocitrate synthase; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8722 Methanococcus.1486 - mvn.1118 mvn:Mevan_1158 isopropylmalate/citramalate/homocitrate synthase; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8722 Methanococcus.1486 - mvo.1470 mvo:Mvol_1568 isopropylmalate/citramalate/homocitrate synthase; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8722 - - mok.619 mok:Metok_0640 isopropylmalate/citramalate/homocitrate synthase; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8722 Methanothermobacter.1203 - mth.682 mth:MTH_1630 2-isopropylmalate synthase; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8722 Methanothermobacter.1203 - mmg.214 mmg:MTBMA_c02150 leuA2; predicted 2-isopropylmalate synthase; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8722 Methanothermobacter.1203 Methanothermobacter_sp_.434 metc.1483 metc:MTCT_1489 trans-homoaconitate synthase; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8722 Methanothermobacter.1203 - mwo.175 mwo:MWSIV6_0176 aksA; Homocitrate synthase AksA; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8722 Methanothermobacter.1203 Methanothermobacter_sp_.434 mete.1549 mete:tca_01580 leuA_3; 2-isopropylmalate synthase; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8722 Methanosphaera.749 - mst.1021 mst:Msp_1099 leuA2; LeuA2; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8722 Methanosphaera.749 - metb.1807 metb:AW729_10320 aksA; homoaconitate hydratase; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8722 Methanobrevibacter.997 - msi.720 msi:Msm_0722 2-isopropylmalate synthase, LeuA; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8722 Methanobrevibacter.997 - mru.416 mru:mru_0385 aksA; homocitrate synthase AksA; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8722 Methanobrevibacter.997 Methanobrevibacter_sp_.329 meb.201 meb:Abm4_0181 aksA; homocitrate synthase AksA; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8722 Methanobrevibacter.997 - mmil.1980 mmil:sm9_2160 aksA; homocitrate synthase AksA; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8722 Methanobrevibacter.997 Methanobrevibacter_sp_.1855 meye.245 meye:TL18_01070 aksA; trans-homoaconitate synthase; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8722 Methanobrevibacter.997 - mol.78 mol:YLM1_0056 homocitrate synthase AksA; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8722 Methanobacterium.2611 - mel.1970 mel:Metbo_2071 isopropylmalate/citramalate/homocitrate synthase; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8722 Methanobacterium.2611 - mew.605 mew:MSWAN_0569 isopropylmalate/citramalate/homocitrate synthase; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8722 Methanobacterium.2611 Methanobacterium_sp_.375 meth.293 meth:MBMB1_0290 aksA; putative homocitrate synthase AksA; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8722 Methanobacterium.2611 Methanobacterium_formicicum.912 mfc.1936 mfc:BRM9_1985 aksA; homocitrate synthase AksA; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8722 Methanobacterium.2611 Methanobacterium_formicicum.912 mfi.183 mfi:DSM1535_0177 aksA; putative homocitrate synthase AksA; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8722 Methanobacterium.2611 - mcub.585 mcub:MCBB_0566 aksA; putative homocitrate synthase AksA; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8722 Methanobacterium.2611 - msub.2199 msub:BK009_11615 aksA; homoaconitate hydratase; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8722 Methanobacterium.2611 Methanobacterium_sp_.3307 metn.1356 metn:BK008_07190 aksA; homoaconitate hydratase; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8722 - - mfv.949 mfv:Mfer_0964 2-oxosuberate synthase, condensing enzyme; 2-isopropylmalate synthase; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8722 - - mka.1161 mka:MK1209 leuA; Isopropylmalate synthase; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8721 Methanosarcina.625 - mac.3103 mac:MA_3342 leuA; 2-isopropylmalate synthase; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8721 Methanosarcina.625 Methanosarcina_barkeri.1245 mba.2120 mba:Mbar_A2192 2-isopropylmalate synthase; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8721 Methanosarcina.625 Methanosarcina_barkeri.1245 mby.2197 mby:MSBRM_2239 Coenzyme B synthesis from 2-oxoglutarate: steps 1, 6, and 10; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8721 Methanosarcina.625 Methanosarcina_barkeri.1245 mbw.2530 mbw:MSBRW_2549 Coenzyme B synthesis from 2-oxoglutarate: steps 1, 6, and 10; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8721 Methanosarcina.625 Methanosarcina_barkeri.1245 mbar.194 mbar:MSBR2_0170 Coenzyme B synthesis from 2-oxoglutarate: steps 1, 6, and 10; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8721 Methanosarcina.625 Methanosarcina_barkeri.1245 mbak.1069 mbak:MSBR3_1047 Coenzyme B synthesis from 2-oxoglutarate: steps 1, 6, and 10; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8721 Methanosarcina.625 Methanosarcina_mazei.1773 mma.2734 mma:MM_2785 2-isopropylmalate synthase; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8721 Methanosarcina.625 Methanosarcina_mazei.1773 mmaz.2647 mmaz:MmTuc01_2834 Coenzyme B synthesis from 2-oxoglutarate; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8721 Methanosarcina.625 Methanosarcina_mazei.1773 mmj.1889 mmj:MSMAS_1942 Coenzyme B synthesis from 2-oxoglutarate: steps 1, 6, and 10; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8721 Methanosarcina.625 Methanosarcina_mazei.1773 mmac.1185 mmac:MSMAC_1183 Coenzyme B synthesis from 2-oxoglutarate: steps 1, 6, and 10; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8721 Methanosarcina.625 - mvc.2014 mvc:MSVAZ_2030 Coenzyme B synthesis from 2-oxoglutarate: steps 1, 6, and 10; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8721 Methanosarcina.625 Methanosarcina_sp_.5180 mek.2005 mek:MSKOL_2008 Coenzyme B synthesis from 2-oxoglutarate: steps 1, 6, and 10; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8721 Methanosarcina.625 - mls.1523 mls:MSLAZ_1553 Coenzyme B synthesis from 2-oxoglutarate: steps 1, 6, and 10; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8721 Methanosarcina.625 Methanosarcina_sp_.8134 metm.1374 metm:MSMTP_1363 Coenzyme B synthesis from 2-oxoglutarate: steps 1, 6, and 10; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8721 Methanosarcina.625 Methanosarcina_sp_.533 mef.1496 mef:MSWH1_1527 Coenzyme B synthesis from 2-oxoglutarate: steps 1, 6, and 10; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8721 Methanosarcina.625 Methanosarcina_sp_.533 meq.1740 meq:MSWHS_1780 Coenzyme B synthesis from 2-oxoglutarate: steps 1, 6, and 10; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8721 Methanosarcina.625 Methanosarcina_siciliae.1255 msj.2443 msj:MSSAC_2553 Coenzyme B synthesis from 2-oxoglutarate: steps 1, 6, and 10; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8721 Methanosarcina.625 Methanosarcina_siciliae.1255 msz.2146 msz:MSSIH_2157 Coenzyme B synthesis from 2-oxoglutarate: steps 1, 6, and 10; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8721 Methanosarcina.625 Methanosarcina_siciliae.1255 msw.2258 msw:MSSIT_2270 Coenzyme B synthesis from 2-oxoglutarate: steps 1, 6, and 10; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8721 Methanosarcina.625 Methanosarcina_thermophila.1672 mthe.299 mthe:MSTHC_0289 Coenzyme B synthesis from 2-oxoglutarate: steps 1, 6, and 10; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8721 Methanosarcina.625 Methanosarcina_thermophila.1672 mthr.439 mthr:MSTHT_0432 Coenzyme B synthesis from 2-oxoglutarate: steps 1, 6, and 10; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8721 Methanosarcina.625 - mhor.1610 mhor:MSHOH_1618 Coenzyme B synthesis from 2-oxoglutarate: steps 1, 6, and 10; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8721 Methanococcoides.1368 - mbu.752 mbu:Mbur_0854 cimA; (R)-citramalate synthase; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8721 Methanococcoides.1368 - mmet.995 mmet:MCMEM_0986 Coenzyme B synthesis from 2-oxoglutarate: steps 1, 6, and 10; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8721 Methanohalophilus.519 - mmh.1124 mmh:Mmah_1162 2-isopropylmalate synthase; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8721 Methanohalophilus.519 - mhaz.1495 mhaz:BHR79_07725 aksA; homoaconitate hydratase; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8721 - - mev.496 mev:Metev_0432 pyruvate carboxyltransferase; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8721 - - mzh.1086 mzh:Mzhil_1141 pyruvate carboxyltransferase; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8721 - - mpy.2725 mpy:Mpsy_2899 2-isopropylmalate synthase; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8721 - - mhz.855 mhz:Metho_0886 isopropylmalate/homocitrate/citramalate synthase; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8721 Methanosaeta.702 - mtp.1463 mtp:Mthe_1533 2-isopropylmalate synthase; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8721 Methanosaeta.702 - mcj.1913 mcj:MCON_2596 leuA; 2-isopropylmalate synthase 1; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8721 Methanosaeta.702 - mhi.1822 mhi:Mhar_1932 2-isopropylmalate synthase; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8721 - - mhu.1638 mhu:Mhun_1801 2-isopropylmalate synthase; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8721 - - mla.280 mla:Mlab_0232 2-isopropylmalate synthase; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8721 Methanoculleus.716 - mem.625 mem:Memar_0633 2-isopropylmalate synthase; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8721 Methanoculleus.716 - mbg.1631 mbg:BN140_1718 aksA; 2-isopropylmalate synthase; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8721 Methanoculleus.716 - mema.2151 mema:MMAB1_2210 aksA; putative homocitrate synthase AksA; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8721 - - mpi.2293 mpi:Mpet_2488 pyruvate carboxyltransferase; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8721 Methanoregula.1215 - mbn.631 mbn:Mboo_0598 pyruvate carboxyltransferase; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8721 Methanoregula.1215 - mfo.2379 mfo:Metfor_2593 isopropylmalate/homocitrate/citramalate synthase; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8721 - - mpl.1929 mpl:Mpal_2142 pyruvate carboxyltransferase; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8721 Methanocella.527 - mpd.1904 mpd:MCP_1960 aksA; homocitrate synthase; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8721 Methanocella.527 - mez.1490 mez:Mtc_1560 aksA; homocitrate synthase; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] OC.276642 Archaea.35386 Euryarchaeota.8721 Methanocella.527 - rci.1911 rci:RCIX2647 leuA-4; 2-isopropylmalate synthase; K10977 methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-]