# OC Root 2nd 3rd 4th 5th PC Gene/Definition OC.336193 Archaea.100593 - - - loki.2700 loki:Lokiarch_31190 hypothetical protein; K17993 sulfhydrogenase subunit alpha [EC:1.12.1.3 1.12.1.5] OC.336194 Archaea.101371 - - - loki.3656 loki:Lokiarch_52050 vhcA; F420-non-reducing hydrogenase vhc subunit A; K14126 F420-non-reducing hydrogenase large subunit [EC:1.12.99.- 1.8.98.5] OC.336195 Archaea.43757 Crenarchaeota.15077 Ignicoccus.1512 - iis.440 iis:EYM_02305 hypothetical protein OC.336196 Archaea.8274 Crenarchaeota.1504 Acidianus.1683 - aman.866 aman:B6F84_04305 Ni,Fe-hydrogenase I large subunit; K06281 hydrogenase large subunit [EC:1.12.99.6] OC.336196 Archaea.8274 Crenarchaeota.1504 Acidianus.1683 - abri.669 abri:DFR85_03575 Ni,Fe-hydrogenase I large subunit; K06281 hydrogenase large subunit [EC:1.12.99.6] OC.336196 Archaea.8274 Crenarchaeota.1504 Acidianus.1683 - asul.765 asul:DFR86_03955 Ni,Fe-hydrogenase I large subunit; K06281 hydrogenase large subunit [EC:1.12.99.6] OC.336197 Archaea.25574 Euryarchaeota.28327 Methanosarcina.4193 Methanosarcina_sp_.1307 mef.2280 mef:MSWH1_2364 Methanophenazine hydrogenase large subunit; K14068 methanophenazine hydrogenase, large subunit [EC:1.12.98.3] OC.336197 Archaea.25574 Euryarchaeota.28327 Methanosarcina.4193 Methanosarcina_sp_.1307 meq.2647 meq:MSWHS_2736 Methanophenazine hydrogenase large subunit; K14068 methanophenazine hydrogenase, large subunit [EC:1.12.98.3] OC.336197 Archaea.25574 Euryarchaeota.28327 Methanosarcina.4193 Methanosarcina_sp_.1312 mef.2285 mef:MSWH1_2369 Methanophenazine hydrogenase large subunit; K14068 methanophenazine hydrogenase, large subunit [EC:1.12.98.3] OC.336197 Archaea.25574 Euryarchaeota.28327 Methanosarcina.4193 Methanosarcina_sp_.1312 meq.2652 meq:MSWHS_2741 Methanophenazine hydrogenase large subunit; K14068 methanophenazine hydrogenase, large subunit [EC:1.12.98.3] OC.336197 Archaea.25574 Euryarchaeota.28327 Methanosarcina.4193 Methanosarcina_sp_.5742 mek.2584 mek:MSKOL_2602 Methanophenazine hydrogenase large subunit; K14068 methanophenazine hydrogenase, large subunit [EC:1.12.98.3] OC.336197 Archaea.25574 Euryarchaeota.28327 Methanosarcina.4193 Methanosarcina_sp_.5748 mek.2590 mek:MSKOL_2608 Methanophenazine hydrogenase large subunit; K14068 methanophenazine hydrogenase, large subunit [EC:1.12.98.3] OC.336197 Archaea.25574 Euryarchaeota.28327 Methanosarcina.4193 Methanosarcina_sp_.9038 metm.2371 metm:MSMTP_2425 Methanophenazine hydrogenase large subunit; K14068 methanophenazine hydrogenase, large subunit [EC:1.12.98.3] OC.336197 Archaea.25574 Euryarchaeota.28327 Methanosarcina.4193 Methanosarcina_sp_.9042 metm.2376 metm:MSMTP_2430 Methanophenazine hydrogenase large subunit; K14068 methanophenazine hydrogenase, large subunit [EC:1.12.98.3] OC.336197 Archaea.25574 Euryarchaeota.28327 Methanosarcina.4193 - mac.1128 mac:MA_1142 vhtA; F420-nonreducing hydrogenase; K14068 methanophenazine hydrogenase, large subunit [EC:1.12.98.3] OC.336197 Archaea.25574 Euryarchaeota.28327 Methanosarcina.4193 - mac.1133 mac:MA_1147 vhtA; F420-nonreducing hydrogenase; K14068 methanophenazine hydrogenase, large subunit [EC:1.12.98.3] OC.336197 Archaea.25574 Euryarchaeota.28327 Methanosarcina.4193 Methanosarcina_barkeri.883 mba.1787 mba:Mbar_A1840 methanophenazine-reducing hydrogenase, large subunit; K14068 methanophenazine hydrogenase, large subunit [EC:1.12.98.3] OC.336197 Archaea.25574 Euryarchaeota.28327 Methanosarcina.4193 Methanosarcina_barkeri.883 mby.2520 mby:MSBRM_2566 Methanophenazine hydrogenase large subunit; K14068 methanophenazine hydrogenase, large subunit [EC:1.12.98.3] OC.336197 Archaea.25574 Euryarchaeota.28327 Methanosarcina.4193 Methanosarcina_barkeri.883 mbw.2871 mbw:MSBRW_2895 Methanophenazine hydrogenase large subunit; K14068 methanophenazine hydrogenase, large subunit [EC:1.12.98.3] OC.336197 Archaea.25574 Euryarchaeota.28327 Methanosarcina.4193 Methanosarcina_barkeri.883 mbar.2521 mbar:MSBR2_2540 Methanophenazine hydrogenase large subunit; K14068 methanophenazine hydrogenase, large subunit [EC:1.12.98.3] OC.336197 Archaea.25574 Euryarchaeota.28327 Methanosarcina.4193 Methanosarcina_barkeri.890 mba.1793 mba:Mbar_A1846 methanophenazine-reducing hydrogenase, large subunit; K14068 methanophenazine hydrogenase, large subunit [EC:1.12.98.3] OC.336197 Archaea.25574 Euryarchaeota.28327 Methanosarcina.4193 Methanosarcina_barkeri.890 mby.2514 mby:MSBRM_2560 Methanophenazine hydrogenase large subunit; K14068 methanophenazine hydrogenase, large subunit [EC:1.12.98.3] OC.336197 Archaea.25574 Euryarchaeota.28327 Methanosarcina.4193 Methanosarcina_barkeri.890 mbw.2866 mbw:MSBRW_2890 Methanophenazine hydrogenase large subunit; K14068 methanophenazine hydrogenase, large subunit [EC:1.12.98.3] OC.336197 Archaea.25574 Euryarchaeota.28327 Methanosarcina.4193 Methanosarcina_barkeri.890 mbar.2515 mbar:MSBR2_2534 Methanophenazine hydrogenase large subunit; K14068 methanophenazine hydrogenase, large subunit [EC:1.12.98.3] OC.336197 Archaea.25574 Euryarchaeota.28327 Methanosarcina.4193 Methanosarcina_barkeri.6210 mbak.2535 mbak:MSBR3_2556 Methanophenazine hydrogenase large subunit; K14068 methanophenazine hydrogenase, large subunit [EC:1.12.98.3] OC.336197 Archaea.25574 Euryarchaeota.28327 Methanosarcina.4193 Methanosarcina_barkeri.6215 mbak.2542 mbak:MSBR3_2563 Methanophenazine hydrogenase large subunit; K14068 methanophenazine hydrogenase, large subunit [EC:1.12.98.3] OC.336197 Archaea.25574 Euryarchaeota.28327 Methanosarcina.4193 Methanosarcina_mazei.1180 mma.2143 mma:MM_2170 vhtA; F420-nonreducing hydrogenase II, large subunit; K14068 methanophenazine hydrogenase, large subunit [EC:1.12.98.3] OC.336197 Archaea.25574 Euryarchaeota.28327 Methanosarcina.4193 Methanosarcina_mazei.1180 mma.2281 mma:MM_2313 vhoA; F420-nonreducing hydrogenase I, large subunit; K14068 methanophenazine hydrogenase, large subunit [EC:1.12.98.3] OC.336197 Archaea.25574 Euryarchaeota.28327 Methanosarcina.4193 Methanosarcina_mazei.1180 mmaz.2085 mmaz:MmTuc01_2222 Methanophenazine hydrogenase large subunit; K14068 methanophenazine hydrogenase, large subunit [EC:1.12.98.3] OC.336197 Archaea.25574 Euryarchaeota.28327 Methanosarcina.4193 Methanosarcina_mazei.1180 mmj.2324 mmj:MSMAS_2388 Methanophenazine hydrogenase large subunit; K14068 methanophenazine hydrogenase, large subunit [EC:1.12.98.3] OC.336197 Archaea.25574 Euryarchaeota.28327 Methanosarcina.4193 Methanosarcina_mazei.1180 mmj.2453 mmj:MSMAS_2519 Methanophenazine hydrogenase large subunit; K14068 methanophenazine hydrogenase, large subunit [EC:1.12.98.3] OC.336197 Archaea.25574 Euryarchaeota.28327 Methanosarcina.4193 Methanosarcina_mazei.1180 mmac.42 mmac:MSMAC_1926 Methanophenazine hydrogenase large subunit; K14068 methanophenazine hydrogenase, large subunit [EC:1.12.98.3] OC.336197 Archaea.25574 Euryarchaeota.28327 Methanosarcina.4193 Methanosarcina_mazei.1180 mmac.42 mmac:MSMAC_2058 Methanophenazine hydrogenase large subunit; K14068 methanophenazine hydrogenase, large subunit [EC:1.12.98.3] OC.336197 Archaea.25574 Euryarchaeota.28327 Methanosarcina.4193 Methanosarcina_mazei.1186 mma.2149 mma:MM_2176 F420-nonreducing hydrogenase III, large subunit; K14068 methanophenazine hydrogenase, large subunit [EC:1.12.98.3] OC.336197 Archaea.25574 Euryarchaeota.28327 Methanosarcina.4193 Methanosarcina_mazei.1186 mmaz.2091 mmaz:MmTuc01_2228 Methanophenazine hydrogenase large subunit; K14068 methanophenazine hydrogenase, large subunit [EC:1.12.98.3] OC.336197 Archaea.25574 Euryarchaeota.28327 Methanosarcina.4193 Methanosarcina_mazei.1186 mmj.2447 mmj:MSMAS_2513 Methanophenazine hydrogenase large subunit; K14068 methanophenazine hydrogenase, large subunit [EC:1.12.98.3] OC.336197 Archaea.25574 Euryarchaeota.28327 Methanosarcina.4193 Methanosarcina_mazei.1186 mmac.1889 mmac:MSMAC_1932 Methanophenazine hydrogenase large subunit; K14068 methanophenazine hydrogenase, large subunit [EC:1.12.98.3] OC.336197 Archaea.25574 Euryarchaeota.28327 Methanosarcina.4193 - mvc.2570 mvc:MSVAZ_2598 Methanophenazine hydrogenase large subunit; K14068 methanophenazine hydrogenase, large subunit [EC:1.12.98.3] OC.336197 Archaea.25574 Euryarchaeota.28327 Methanosarcina.4193 - mvc.2576 mvc:MSVAZ_2604 Methanophenazine hydrogenase large subunit; K14068 methanophenazine hydrogenase, large subunit [EC:1.12.98.3] OC.336197 Archaea.25574 Euryarchaeota.28327 Methanosarcina.4193 - mls.749 mls:MSLAZ_0690 Methanophenazine hydrogenase large subunit; K14068 methanophenazine hydrogenase, large subunit [EC:1.12.98.3] OC.336197 Archaea.25574 Euryarchaeota.28327 Methanosarcina.4193 - mls.1046 mls:MSLAZ_1005 Methanophenazine hydrogenase large subunit; K14068 methanophenazine hydrogenase, large subunit [EC:1.12.98.3] OC.336197 Archaea.25574 Euryarchaeota.28327 Methanosarcina.4193 Methanosarcina_siciliae.1786 msj.3010 msj:MSSAC_3201 Methanophenazine hydrogenase large subunit; K14068 methanophenazine hydrogenase, large subunit [EC:1.12.98.3] OC.336197 Archaea.25574 Euryarchaeota.28327 Methanosarcina.4193 Methanosarcina_siciliae.1786 msz.1038 msz:MSSIH_1031 Methanophenazine hydrogenase large subunit; K14068 methanophenazine hydrogenase, large subunit [EC:1.12.98.3] OC.336197 Archaea.25574 Euryarchaeota.28327 Methanosarcina.4193 Methanosarcina_siciliae.1786 msw.1095 msw:MSSIT_1078 Methanophenazine hydrogenase large subunit; K14068 methanophenazine hydrogenase, large subunit [EC:1.12.98.3] OC.336197 Archaea.25574 Euryarchaeota.28327 Methanosarcina.4193 Methanosarcina_siciliae.1791 msj.3015 msj:MSSAC_3206 Methanophenazine hydrogenase large subunit; K14068 methanophenazine hydrogenase, large subunit [EC:1.12.98.3] OC.336197 Archaea.25574 Euryarchaeota.28327 Methanosarcina.4193 Methanosarcina_siciliae.1791 msz.1043 msz:MSSIH_1036 Methanophenazine hydrogenase large subunit; K14068 methanophenazine hydrogenase, large subunit [EC:1.12.98.3] OC.336197 Archaea.25574 Euryarchaeota.28327 Methanosarcina.4193 Methanosarcina_siciliae.1791 msw.1100 msw:MSSIT_1083 Methanophenazine hydrogenase large subunit; K14068 methanophenazine hydrogenase, large subunit [EC:1.12.98.3] OC.336197 Archaea.25574 Euryarchaeota.28327 Methanosarcina.4193 Methanosarcina_thermophila.1245 mthe.2182 mthe:MSTHC_2185 Methanophenazine hydrogenase large subunit; K14068 methanophenazine hydrogenase, large subunit [EC:1.12.98.3] OC.336197 Archaea.25574 Euryarchaeota.28327 Methanosarcina.4193 Methanosarcina_thermophila.1245 mthr.1118 mthr:MSTHT_1118 Methanophenazine hydrogenase large subunit; K14068 methanophenazine hydrogenase, large subunit [EC:1.12.98.3] OC.336197 Archaea.25574 Euryarchaeota.28327 Methanosarcina.4193 Methanosarcina_thermophila.1250 mthe.2187 mthe:MSTHC_2190 Methanophenazine hydrogenase large subunit; K14068 methanophenazine hydrogenase, large subunit [EC:1.12.98.3] OC.336197 Archaea.25574 Euryarchaeota.28327 Methanosarcina.4193 Methanosarcina_thermophila.1250 mthr.1113 mthr:MSTHT_1113 Methanophenazine hydrogenase large subunit; K14068 methanophenazine hydrogenase, large subunit [EC:1.12.98.3] OC.336197 Archaea.25574 Euryarchaeota.28327 Methanosarcina.4193 - mhor.3066 mhor:MSHOH_3150 Methanophenazine hydrogenase large subunit; K14068 methanophenazine hydrogenase, large subunit [EC:1.12.98.3] OC.336197 Archaea.25574 Euryarchaeota.28327 Methanosarcina.4193 - mhor.3071 mhor:MSHOH_3155 Methanophenazine hydrogenase large subunit; K14068 methanophenazine hydrogenase, large subunit [EC:1.12.98.3] OC.336197 Archaea.25574 Euryarchaeota.28327 Methanococcoides.2525 - mmet.1324 mmet:MCMEM_1333 Methanophenazine hydrogenase large subunit; K14068 methanophenazine hydrogenase, large subunit [EC:1.12.98.3] OC.336197 Archaea.25574 Euryarchaeota.28327 - - mzh.885 mzh:Mzhil_0914 nickel-dependent hydrogenase large subunit; K14068 methanophenazine hydrogenase, large subunit [EC:1.12.98.3] OC.336197 Archaea.25574 Euryarchaeota.28327 Methanocella.1566 - mpd.2803 mpd:MCP_2935 vhtA; F420-non-reducing hydrogenase large subunit; K14068 methanophenazine hydrogenase, large subunit [EC:1.12.98.3] OC.336197 Archaea.25574 Euryarchaeota.28327 Methanocella.1566 - mez.496 mez:Mtc_0471 vhtA; methanophenazine-reducing NiFe hydrogenase, large subunit; K14068 methanophenazine hydrogenase, large subunit [EC:1.12.98.3] OC.336197 Archaea.25574 Euryarchaeota.28327 Methanocella.1566 - rci.2443 rci:RCIX882 vhtA; F420-nonreducing hydrogenase (membrane-bound),large subunit; K14068 methanophenazine hydrogenase, large subunit [EC:1.12.98.3] OC.336198 Archaea.10407 Crenarchaeota.4074 Sulfolobus.4447 Sulfolobus_islandicus.4106 sih.900 sih:SiH_0921 Ni Fe-hydrogenase I large subunit-like protein OC.336198 Archaea.10407 Crenarchaeota.4074 Sulfolobus.4447 - sula.88 sula:BFU36_00355 Ni Fe-hydrogenase I large subunit OC.336198 Archaea.10407 Crenarchaeota.4074 Metallosphaera.2768 - mse.944 mse:Msed_0945 Ni Fe-hydrogenase I large subunit-like protein OC.336198 Archaea.10407 Crenarchaeota.4074 Acidianus.3381 - abri.2516 abri:DFR85_14225 Ni Fe-hydrogenase I large subunit OC.336199 Archaea.8374 Crenarchaeota.1557 Ignicoccus.343 - iho.1353 iho:Igni_1367 nickel-dependent hydrogenase, large subunit; K06281 hydrogenase large subunit [EC:1.12.99.6] OC.336199 Archaea.8374 Crenarchaeota.1557 Ignicoccus.343 - iis.72 iis:EYM_00290 cytochrome B; K06281 hydrogenase large subunit [EC:1.12.99.6] OC.336199 Archaea.8374 Crenarchaeota.1557 - - hbu.1308 hbu:Hbut_1368 Periplasmic hydrogenase large subunit; K06281 hydrogenase large subunit [EC:1.12.99.6] OC.336199 Archaea.8374 Crenarchaeota.1557 - - pfm.113 pfm:Pyrfu_0078 nickel-dependent hydrogenase large subunit; K06281 hydrogenase large subunit [EC:1.12.99.6] OC.336199 Archaea.8374 Crenarchaeota.1557 - - pdl.652 pdl:Pyrde_0647 Ni,Fe-hydrogenase I large subunit; K06281 hydrogenase large subunit [EC:1.12.99.6] OC.336199 Archaea.8374 Crenarchaeota.1557 Sulfolobus.4420 Sulfolobus_islandicus.4077 sih.871 sih:SiH_0892 [NiFe] hydrogenase large subunit, HyaB; K06281 hydrogenase large subunit [EC:1.12.99.6] OC.336199 Archaea.8374 Crenarchaeota.1557 Sulfolobus.4420 - sula.113 sula:BFU36_00485 cytochrome C; K06281 hydrogenase large subunit [EC:1.12.99.6] OC.336199 Archaea.8374 Crenarchaeota.1557 Acidianus.1718 - aman.832 aman:B6F84_04120 hypothetical protein; K06281 hydrogenase large subunit [EC:1.12.99.6] OC.336199 Archaea.8374 Crenarchaeota.1557 Acidianus.1718 - abri.707 abri:DFR85_03785 cytochrome B; K06281 hydrogenase large subunit [EC:1.12.99.6] OC.336199 Archaea.8374 Crenarchaeota.1557 Acidianus.1718 - asul.778 asul:DFR86_04020 cytochrome B; K06281 hydrogenase large subunit [EC:1.12.99.6] OC.336199 Archaea.8374 Crenarchaeota.1557 Pyrobaculum.2507 - pis.220 pis:Pisl_0197 nickel-dependent hydrogenase, large subunit; K06281 hydrogenase large subunit [EC:1.12.99.6] OC.336199 Archaea.8374 Crenarchaeota.1557 Pyrobaculum.2507 - pcl.1525 pcl:Pcal_1578 nickel-dependent hydrogenase, large subunit; K06281 hydrogenase large subunit [EC:1.12.99.6] OC.336199 Archaea.8374 Crenarchaeota.1557 Pyrobaculum.2507 - pas.1238 pas:Pars_1298 nickel-dependent hydrogenase, large subunit; K06281 hydrogenase large subunit [EC:1.12.99.6] OC.336199 Archaea.8374 Crenarchaeota.1557 Pyrobaculum.2507 - pog.914 pog:Pogu_0917 Ni,Fe-hydrogenase I large subunit; K06281 hydrogenase large subunit [EC:1.12.99.6] OC.336199 Archaea.8374 Crenarchaeota.1557 Pyrobaculum.2507 - tne.409 tne:Tneu_0407 nickel-dependent hydrogenase large subunit; K06281 hydrogenase large subunit [EC:1.12.99.6] OC.336199 Archaea.8374 Crenarchaeota.1557 Thermoproteus.966 - tuz.2143 tuz:TUZN_2207 Ni,Fe-hydrogenase I large subunit; K06281 hydrogenase large subunit [EC:1.12.99.6] OC.336199 Archaea.8374 Crenarchaeota.1557 Thermoproteus.966 - ttn.49 ttn:TTX_0033 hynL; Ni,Fe-hydrogenase I large subunit; K06281 hydrogenase large subunit [EC:1.12.99.6] OC.336199 Archaea.8374 Crenarchaeota.1557 Vulcanisaeta.2357 - vdi.2227 vdi:Vdis_2308 nickel-dependent hydrogenase large subunit; K06281 hydrogenase large subunit [EC:1.12.99.6] OC.336199 Archaea.8374 Crenarchaeota.1557 Thermofilum.880 - tpe.576 tpe:Tpen_0592 nickel-dependent hydrogenase, large subunit; K06281 hydrogenase large subunit [EC:1.12.99.6] OC.336199 Archaea.8374 Crenarchaeota.1557 Thermofilum.880 - thb.827 thb:N186_04330 cytochrome B; K06281 hydrogenase large subunit [EC:1.12.99.6] OC.336199 Archaea.8374 Crenarchaeota.1557 Thermofilum.880 - tcb.1844 tcb:TCARB_1894 NiFe hydrogenase, large subunit; K06281 hydrogenase large subunit [EC:1.12.99.6] OC.336199 Archaea.8374 Crenarchaeota.1557 Thermofilum.880 - thf.1139 thf:MA03_06640 cytochrome B; K06281 hydrogenase large subunit [EC:1.12.99.6]