# OC Root 2nd 3rd 4th 5th PC Gene/Definition OC.338117 Archaea.34693 Euryarchaeota.6620 Archaeoglobus.3193 - apo.66 apo:Arcpr_0036 beta-lactamase domain protein OC.338117 Archaea.34693 Euryarchaeota.6620 Archaeoglobus.4217 - ast.627 ast:Asulf_00619 putative Zn-dependent hydrolases of the beta-lactamase fold protein OC.338117 Archaea.34693 Euryarchaeota.6620 Geoglobus.29 - gac.1025 gac:GACE_1068 hypothetical protein OC.338117 Archaea.34693 Euryarchaeota.6620 Geoglobus.29 - gah.1806 gah:GAH_01905 putative Zn-dependent hydrolases of the beta-lactamase fold OC.338117 Archaea.34693 Euryarchaeota.6620 - - cdiv.1297 cdiv:CPM_1448 metal-dependent hydrolase OC.338117 Archaea.34693 Euryarchaeota.6620 Pyrococcus.2419 Pyrococcus_sp_.326 pyn.261 pyn:PNA2_0259 metal-dependent hydrolase OC.338117 Archaea.34693 Euryarchaeota.6620 Pyrococcus.2419 - pho.1664 pho:PH1671 PH1671; 236aa long hypothetical protein OC.338117 Archaea.34693 Euryarchaeota.6620 Pyrococcus.2419 - pab.235 pab:PAB0339 Predicted Zn-dependent hydrolase of the beta-lactamase fold OC.338117 Archaea.34693 Euryarchaeota.6620 Pyrococcus.2420 Pyrococcus_sp_.3429 pys.1521 pys:Py04_1558 putative metal-dependent hydrolase OC.338117 Archaea.34693 Euryarchaeota.6620 Pyrococcus.2421 Pyrococcus_furiosus.937 pfu.1743 pfu:PF1764 hypothetical protein OC.338117 Archaea.34693 Euryarchaeota.6620 Pyrococcus.2421 Pyrococcus_furiosus.937 pfi.1872 pfi:PFC_09770 metal-dependent hydrolase OC.338117 Archaea.34693 Euryarchaeota.6620 Pyrococcus.6169 - pya.497 pya:PYCH_05180 metal-dependent hydrolase OC.338117 Archaea.34693 Euryarchaeota.6620 Pyrococcus.7583 - pyc.1547 pyc:TQ32_08480 metal-dependent hydrolase OC.338117 Archaea.34693 Euryarchaeota.6620 Thermococcus.2663 Thermococcus_sp_.202 the.1808 the:GQS_09085 metal-dependent hydrolase OC.338117 Archaea.34693 Euryarchaeota.6620 Thermococcus.2663 Thermococcus_sp_.202 thh.1382 thh:CDI07_07120 metal-dependent hydrolase OC.338117 Archaea.34693 Euryarchaeota.6620 Thermococcus.2663 Thermococcus_sp_.549 tha.76 tha:TAM4_1073 metal-dependent hydrolase OC.338117 Archaea.34693 Euryarchaeota.6620 Thermococcus.2663 - tga.429 tga:TGAM_0425 Zn-dependent hydrolase of the beta-lactamase fold family OC.338117 Archaea.34693 Euryarchaeota.6620 Thermococcus.2663 - thm.1397 thm:CL1_1417 putative metal-dependent hydrolase OC.338117 Archaea.34693 Euryarchaeota.6620 Thermococcus.2663 - tnu.1663 tnu:BD01_1706 putative Zn-dependent hydrolases of the beta-lactamase fold OC.338117 Archaea.34693 Euryarchaeota.6620 Thermococcus.2663 - tce.876 tce:A3L02_04625 metal-dependent hydrolase OC.338117 Archaea.34693 Euryarchaeota.6620 Thermococcus.2663 - tbs.1385 tbs:A3L01_07170 metal-dependent hydrolase OC.338117 Archaea.34693 Euryarchaeota.6620 Thermococcus.2663 - tsl.155 tsl:A3L11_00830 metal-dependent hydrolase OC.338117 Archaea.34693 Euryarchaeota.6620 Thermococcus.2663 - ttd.1827 ttd:A3L14_09505 metal-dependent hydrolase OC.338117 Archaea.34693 Euryarchaeota.6620 Thermococcus.2663 - trl.1279 trl:A3L10_06595 metal-dependent hydrolase OC.338117 Archaea.34693 Euryarchaeota.6620 Thermococcus.2663 - tpaf.87 tpaf:A3L08_00450 metal-dependent hydrolase OC.338117 Archaea.34693 Euryarchaeota.6620 Thermococcus.2664 - tko.159 tko:TK0141 hydrolase, metallo-beta-lactamase superfamily OC.338117 Archaea.34693 Euryarchaeota.6620 Thermococcus.2664 - teu.95 teu:TEU_00485 metal-dependent hydrolase OC.338117 Archaea.34693 Euryarchaeota.6620 Thermococcus.2664 - tgy.1154 tgy:X802_06060 metal-dependent hydrolase OC.338117 Archaea.34693 Euryarchaeota.6620 Thermococcus.2664 - tpep.641 tpep:A0127_03375 metal-dependent hydrolase OC.338117 Archaea.34693 Euryarchaeota.6620 Thermococcus.2664 - tgg.1391 tgg:A3K92_07270 metal-dependent hydrolase OC.338117 Archaea.34693 Euryarchaeota.6620 Thermococcus.2664 - tprf.1943 tprf:A3L09_10075 metal-dependent hydrolase OC.338117 Archaea.34693 Euryarchaeota.6620 Thermococcus.2665 - ton.1314 ton:TON_1314 Hypothetical Zn-dependent hydrolase of the beta-lactamase fold family OC.338117 Archaea.34693 Euryarchaeota.6620 Thermococcus.2666 - tpie.376 tpie:A7C91_02190 metal-dependent hydrolase OC.338117 Archaea.34693 Euryarchaeota.6620 Thermococcus.6823 Thermococcus_sp_.7021 thv.1169 thv:ADU37_CDS11690 Metal-dependent hydrolase OC.338117 Archaea.34693 Euryarchaeota.6620 Thermococcus.6823 - tsi.851 tsi:TSIB_0861 metal-dependent hydrolase OC.338117 Archaea.34693 Euryarchaeota.6620 Thermococcus.6823 - tba.1316 tba:TERMP_01317 hypothetical protein OC.338117 Archaea.34693 Euryarchaeota.6620 Thermococcus.6823 - tlt.308 tlt:OCC_02039 metal-dependent hydrolase OC.338117 Archaea.34693 Euryarchaeota.6620 Thermococcus.6823 - ths.1330 ths:TES1_1346 Hypothetical protein OC.338117 Archaea.34693 Euryarchaeota.6620 Thermococcus.11002 - tch.1858 tch:CHITON_1899 hypothetical protein OC.338117 Archaea.34693 Euryarchaeota.6620 - - ppac.1020 ppac:PAP_05265 metal-dependent hydrolase OC.338118 Archaea.34696 Euryarchaeota.6624 Thermoplasma.913 - tac.747 tac:Ta0764 conserved hypothetical protein OC.338118 Archaea.34696 Euryarchaeota.6624 Thermoplasma.913 - tvo.867 tvo:TVG0885567 TVG0885567; hypothetical protein OC.338118 Archaea.34696 Euryarchaeota.6624 - - pto.1108 pto:PTO1118 metal dependent hydrolase OC.338118 Archaea.34696 Euryarchaeota.6624 Ferroplasma.1025 - fac.366 fac:FACI_IFERC01G0345 metal-dependent hydrolase OC.338118 Archaea.34696 Euryarchaeota.6624 Ferroplasma.1025 - fai.1178 fai:FAD_1264 metal-dependent hydrolase OC.338119 Archaea.34691 Euryarchaeota.6618 Methanothermobacter.797 Methanothermobacter_sp_.1729 metc.1729 metc:MTCT_1735 putative hydrolase OC.338119 Archaea.34691 Euryarchaeota.6618 Methanothermobacter.797 Methanothermobacter_sp_.2442 mete.1797 mete:tca_01840 rnj_2; Ribonuclease J OC.338119 Archaea.34691 Euryarchaeota.6618 Methanothermobacter.797 - mth.970 mth:MTH_1902 conserved protein OC.338119 Archaea.34691 Euryarchaeota.6618 Methanothermobacter.797 - mmg.460 mmg:MTBMA_c04740 predicted hydrolase OC.338119 Archaea.34691 Euryarchaeota.6618 Methanothermobacter.797 - mwo.423 mwo:MWSIV6_0438 UPF0173 metal-dependent hydrolase MTH_1902 {ECO:0000255|HAMAP-Rule:MF_00457} OC.338119 Archaea.34691 Euryarchaeota.6618 Methanosphaera.1010 - mst.506 mst:Msp_0516 predicted Zn-dependent hydrolase of the beta-lactamase superfamily OC.338119 Archaea.34691 Euryarchaeota.6618 Methanosphaera.1010 - metb.686 metb:AW729_03720 metal-dependent hydrolase OC.338119 Archaea.34691 Euryarchaeota.6618 Methanobrevibacter.395 Methanobrevibacter_sp_.1290 meb.1212 meb:Abm4_1288 metallo-beta-lactamase superfamily protein OC.338119 Archaea.34691 Euryarchaeota.6618 Methanobrevibacter.395 Methanobrevibacter_sp_.2911 meye.1347 meye:TL18_07550 metal-dependent hydrolase OC.338119 Archaea.34691 Euryarchaeota.6618 Methanobrevibacter.395 - msi.776 msi:Msm_0779 predicted Zn-dependent hydrolase, metallo-beta-lactamase superfamily OC.338119 Archaea.34691 Euryarchaeota.6618 Methanobrevibacter.395 - mru.828 mru:mru_0834 metallo-beta-lactamase superfamily protein OC.338119 Archaea.34691 Euryarchaeota.6618 Methanobrevibacter.395 - mmil.1565 mmil:sm9_1700 metallo-beta-lactamase superfamily protein OC.338119 Archaea.34691 Euryarchaeota.6618 Methanobrevibacter.395 - mol.433 mol:YLM1_0426 metallo-beta-lactamase superfamily protein OC.338119 Archaea.34691 Euryarchaeota.6618 Methanobrevibacter.3175 - mmil.838 mmil:sm9_0838 metallo-beta-lactamase superfamily protein OC.338119 Archaea.34691 Euryarchaeota.6618 Methanobacterium.872 Methanobacterium_sp_.1254 meth.1212 meth:MBMB1_1238 UPF0173 metal-dependent hydrolase MTH_1902 OC.338119 Archaea.34691 Euryarchaeota.6618 Methanobacterium.872 Methanobacterium_sp_.2112 metn.127 metn:BK008_00570 metal-dependent hydrolase OC.338119 Archaea.34691 Euryarchaeota.6618 Methanobacterium.872 - mel.790 mel:Metbo_0736 UPF0173 metal-dependent hydrolase OC.338119 Archaea.34691 Euryarchaeota.6618 Methanobacterium.872 - mew.1432 mew:MSWAN_1507 UPF0173 metal-dependent hydrolase OC.338119 Archaea.34691 Euryarchaeota.6618 Methanobacterium.872 Methanobacterium_formicicum.1534 mfc.438 mfc:BRM9_0447 metallo-beta-lactamase superfamily protein OC.338119 Archaea.34691 Euryarchaeota.6618 Methanobacterium.872 Methanobacterium_formicicum.1534 mfi.378 mfi:DSM1535_0376 UPF0173 metal-dependent hydrolase MTH_1902 OC.338119 Archaea.34691 Euryarchaeota.6618 Methanobacterium.872 - mcub.1378 mcub:MCBB_1442 UPF0173 metal-dependent hydrolase MTH_1902 {ECO:0000255|HAMAP-Rule:MF_00457} OC.338119 Archaea.34691 Euryarchaeota.6618 Methanobacterium.872 - msub.975 msub:BK009_05050 metal-dependent hydrolase OC.338119 Archaea.34691 Euryarchaeota.6618 - - mfv.710 mfv:Mfer_0714 conserved hypothetical protein OC.338120 Archaea.34695 Euryarchaeota.6623 Methanocaldococcus.646 - mja.1180 mja:MJ_1163 conserved hypothetical protein OC.338120 Archaea.34695 Euryarchaeota.6623 Methanocaldococcus.646 - mfe.163 mfe:Mefer_0161 beta-lactamase domain protein OC.338120 Archaea.34695 Euryarchaeota.6623 Methanocaldococcus.646 - mvu.295 mvu:Metvu_0290 beta-lactamase domain protein OC.338120 Archaea.34695 Euryarchaeota.6623 Methanocaldococcus.646 - mfs.780 mfs:MFS40622_0794 beta-lactamase domain protein OC.338120 Archaea.34695 Euryarchaeota.6623 Methanocaldococcus.646 - mif.91 mif:Metin_0083 beta-lactamase domain protein OC.338120 Archaea.34695 Euryarchaeota.6623 Methanocaldococcus.646 - mjh.680 mjh:JH146_0683 beta-lactamase domain protein OC.338120 Archaea.34695 Euryarchaeota.6623 - - mig.205 mig:Metig_0183 UPF0173 metal-dependent hydrolase OC.338120 Archaea.34695 Euryarchaeota.6623 - - mok.984 mok:Metok_1019 UPF0173 metal-dependent hydrolase OC.338121 Archaea.34692 Euryarchaeota.6619 - - mpy.494 mpy:Mpsy_0457 metal-dependent hydrolase OC.338121 Archaea.34692 Euryarchaeota.6621 - - mka.1424 mka:MK1542 Predicted Zn-dependent hydrolase of the beta-lactamase superfamily OC.338121 Archaea.34692 Euryarchaeota.6621 Archaeoglobus.941 Archaeoglobus_fulgidus.301 afu.1236 afu:AF_1265 conserved hypothetical protein OC.338121 Archaea.34692 Euryarchaeota.6621 Archaeoglobus.941 Archaeoglobus_fulgidus.301 afg.1280 afg:AFULGI_00013640 putative Zn-dependent hydrolase of the beta-lactamase fold protein OC.338121 Archaea.34692 Euryarchaeota.6621 Archaeoglobus.941 - ave.1497 ave:Arcve_1577 UPF0173 metal-dependent hydrolase OC.338121 Archaea.34692 Euryarchaeota.6621 - - fpl.916 fpl:Ferp_0959 metal-dependent hydrolase OC.338121 Archaea.34692 Euryarchaeota.6621 Aciduliprofundum.615 - abi.315 abi:Aboo_0306 beta-lactamase domain protein OC.338121 Archaea.34692 Euryarchaeota.6621 Aciduliprofundum.615 - acf.699 acf:AciM339_0758 putative Zn-dependent hydrolase of beta-lactamase fold protein OC.338121 Archaea.34692 Euryarchaeota.6621 Methanosarcina.2402 Methanosarcina_sp_.1196 mef.2175 mef:MSWH1_2252 hypothetical protein OC.338121 Archaea.34692 Euryarchaeota.6621 Methanosarcina.2402 Methanosarcina_sp_.1196 meq.2729 meq:MSWHS_2821 hypothetical protein OC.338121 Archaea.34692 Euryarchaeota.6621 Methanosarcina.2402 Methanosarcina_sp_.5652 mek.2492 mek:MSKOL_2508 hypothetical protein OC.338121 Archaea.34692 Euryarchaeota.6621 Methanosarcina.2402 Methanosarcina_sp_.7641 metm.835 metm:MSMTP_0810 hypothetical protein OC.338121 Archaea.34692 Euryarchaeota.6621 Methanosarcina.2402 - mac.1284 mac:MA_1308 conserved hypothetical protein OC.338121 Archaea.34692 Euryarchaeota.6621 Methanosarcina.2402 Methanosarcina_barkeri.2771 mba.3555 mba:Mbar_A3716 conserved hypothetical protein OC.338121 Archaea.34692 Euryarchaeota.6621 Methanosarcina.2402 Methanosarcina_barkeri.2771 mby.1039 mby:MSBRM_1053 hypothetical protein OC.338121 Archaea.34692 Euryarchaeota.6621 Methanosarcina.2402 Methanosarcina_barkeri.2771 mbw.1028 mbw:MSBRW_1020 hypothetical protein OC.338121 Archaea.34692 Euryarchaeota.6621 Methanosarcina.2402 Methanosarcina_barkeri.2771 mbar.1358 mbar:MSBR2_1358 hypothetical protein OC.338121 Archaea.34692 Euryarchaeota.6621 Methanosarcina.2402 Methanosarcina_barkeri.5603 mbak.1393 mbak:MSBR3_1387 hypothetical protein OC.338121 Archaea.34692 Euryarchaeota.6621 Methanosarcina.2402 Methanosarcina_mazei.1308 mma.2269 mma:MM_2300 metal dependent hydrolase OC.338121 Archaea.34692 Euryarchaeota.6621 Methanosarcina.2402 Methanosarcina_mazei.1308 mmj.2336 mmj:MSMAS_2400 hypothetical protein OC.338121 Archaea.34692 Euryarchaeota.6621 Methanosarcina.2402 Methanosarcina_mazei.1308 mmac.1999 mmac:MSMAC_2047 hypothetical protein OC.338121 Archaea.34692 Euryarchaeota.6621 Methanosarcina.2402 - mvc.2469 mvc:MSVAZ_2496 hypothetical protein OC.338121 Archaea.34692 Euryarchaeota.6621 Methanosarcina.2402 - mls.1036 mls:MSLAZ_0993 hypothetical protein OC.338121 Archaea.34692 Euryarchaeota.6621 Methanosarcina.2402 Methanosarcina_siciliae.39 msj.1055 msj:MSSAC_0986 hypothetical protein OC.338121 Archaea.34692 Euryarchaeota.6621 Methanosarcina.2402 Methanosarcina_siciliae.39 msz.895 msz:MSSIH_0887 hypothetical protein OC.338121 Archaea.34692 Euryarchaeota.6621 Methanosarcina.2402 Methanosarcina_siciliae.39 msw.939 msw:MSSIT_0921 hypothetical protein OC.338121 Archaea.34692 Euryarchaeota.6621 Methanosarcina.2402 Methanosarcina_thermophila.1396 mthe.2327 mthe:MSTHC_2330 hypothetical protein OC.338121 Archaea.34692 Euryarchaeota.6621 Methanosarcina.2402 Methanosarcina_thermophila.1396 mthr.976 mthr:MSTHT_0976 hypothetical protein OC.338121 Archaea.34692 Euryarchaeota.6621 Methanosarcina.2402 - mhor.2962 mhor:MSHOH_3043 hypothetical protein OC.338121 Archaea.34692 Euryarchaeota.6621 - - mhz.930 mhz:Metho_0967 putative Zn-dependent hydrolase of beta-lactamase fold protein OC.338121 Archaea.34692 Euryarchaeota.6621 Methanosaeta.2683 - mhi.265 mhi:Mhar_0194 UPF0173 metal-dependent hydrolase OC.338121 Archaea.34692 Euryarchaeota.6621 Methanoculleus.162 - mem.1391 mem:Memar_1421 beta-lactamase domain protein OC.338121 Archaea.34692 Euryarchaeota.6621 Methanoculleus.162 - mbg.1155 mbg:BN140_1219 metal-dependent hydrolase OC.338121 Archaea.34692 Euryarchaeota.6621 Methanoculleus.162 - mema.1514 mema:MMAB1_1542 conserved protein of unknown function OC.338121 Archaea.34692 Euryarchaeota.6621 - - mpi.835 mpi:Mpet_0796 beta-lactamase domain-containing protein OC.338121 Archaea.34692 Euryarchaeota.6621 Methanoregula.1363 - mbn.833 mbn:Mboo_0816 beta-lactamase domain protein OC.338121 Archaea.34692 Euryarchaeota.6621 Methanoregula.1363 - mfo.2056 mfo:Metfor_2216 putative Zn-dependent hydrolase of beta-lactamase fold protein OC.338121 Archaea.34692 Euryarchaeota.6621 Methanocella.15 - mpd.1353 mpd:MCP_1337 conserved hypothetical protein OC.338121 Archaea.34692 Euryarchaeota.6621 Methanocella.15 - mez.1010 mez:Mtc_1038 putative Zn-dependent hydrolases (beta-lactamase fold) OC.338121 Archaea.34692 Euryarchaeota.6621 Methanocella.15 - rci.2845 rci:RRC50 predicted metallo-beta-lactamase