# OC Root 2nd 3rd 4th 5th PC Gene/Definition OC.338124 Archaea.89528 Euryarchaeota.75832 - - srub.719 srub:C2R22_03525 metal-dependent hydrolase OC.338125 Archaea.17335 Euryarchaeota.16910 Halobacterium.1915 - hdl.2137 hdl:HALDL1_11115 hydrolase OC.338125 Archaea.17335 Euryarchaeota.16910 Halobacterium.1915 - hhb.1241 hhb:Hhub_2247 UPF0173 family metal-dependent hydrolase OC.338125 Archaea.17335 Euryarchaeota.16910 Halobacterium.2893 Halobacterium_salinarum.2197 hal.941 hal:VNG_1038C conserved hypothetical protein OC.338125 Archaea.17335 Euryarchaeota.16910 Halobacterium.2893 Halobacterium_salinarum.2197 hsl.913 hsl:OE_2513F UPF0173 family metal-dependent hydrolase OC.338125 Archaea.17335 Euryarchaeota.16910 - - hje.1581 hje:HacjB3_07440 hypothetical protein OC.338125 Archaea.17335 Euryarchaeota.16910 Halodesulfurarchaeum.1776 - halh.867 halh:HTSR_0894 metallo-beta-lactamase family protein OC.338125 Archaea.17335 Euryarchaeota.16910 Halodesulfurarchaeum.1776 - hhsr.890 hhsr:HSR6_0910 metallo-beta-lactamase family protein OC.338125 Archaea.17335 Euryarchaeota.16910 Halanaeroarchaeum.558 - hsu.1506 hsu:HLASF_1546 metallo-beta-lactamase family protein OC.338125 Archaea.17335 Euryarchaeota.16910 Halanaeroarchaeum.558 - hsf.1501 hsf:HLASA_1533 metallo-beta-lactamase family protein OC.338125 Archaea.17335 Euryarchaeota.16910 Haloarcula.1858 - hma.1068 hma:rrnAC0300 unknown OC.338125 Archaea.17335 Euryarchaeota.16910 Haloarcula.1858 Haloarcula_hispanica.28 hhi.1023 hhi:HAH_1040 conserved hypothetical protein OC.338125 Archaea.17335 Euryarchaeota.16910 Haloarcula.1858 Haloarcula_hispanica.28 hhn.1052 hhn:HISP_05345 hydrolase OC.338125 Archaea.17335 Euryarchaeota.16910 Haloarcula.1858 - hab.2494 hab:SG26_13015 hydrolase OC.338125 Archaea.17335 Euryarchaeota.16910 Haloarcula.1858 - hta.996 hta:BVU17_05090 metal-dependent hydrolase OC.338125 Archaea.17335 Euryarchaeota.16910 Natronomonas.579 - nph.1095 nph:NP_2132A metal-dependent hydrolase domain protein OC.338125 Archaea.17335 Euryarchaeota.16910 Natronomonas.579 - nmo.1964 nmo:Nmlp_3175 UPF0173 family metal-dependent hydrolase OC.338125 Archaea.17335 Euryarchaeota.16910 Halorhabdus.1148 - hut.2690 hut:Huta_2750 beta-lactamase domain protein OC.338125 Archaea.17335 Euryarchaeota.16910 Halorhabdus.1148 - hti.2433 hti:HTIA_2497 metal-dependent hydrolase OC.338125 Archaea.17335 Euryarchaeota.16910 - - hmu.2677 hmu:Hmuk_2759 beta-lactamase domain protein OC.338125 Archaea.17335 Euryarchaeota.16910 - - hali.125 hali:BV210_00250 metal-dependent hydrolase OC.338125 Archaea.17335 Euryarchaeota.16910 - - harc.1950 harc:HARCEL1_10265 metal-dependent hydrolase OC.338125 Archaea.17335 Euryarchaeota.16910 Haloquadratum.1218 - hwa.2212 hwa:HQ_3368A metal-dependent hydrolase domain protein OC.338125 Archaea.17335 Euryarchaeota.16910 Haloquadratum.1218 - hwc.2322 hwc:Hqrw_3893 metal-dependent hydrolase domain protein OC.338125 Archaea.17335 Euryarchaeota.16910 Haloferax.250 - hvo.1302 hvo:HVO_1290 UPF0173 family metal-dependent hydrolase OC.338125 Archaea.17335 Euryarchaeota.16910 Haloferax.250 - hme.1325 hme:HFX_1354 hypothetical protein OC.338125 Archaea.17335 Euryarchaeota.16910 Haloferax.250 - hgi.1243 hgi:ABY42_06295 hydrolase OC.338125 Archaea.17335 Euryarchaeota.16910 - - hbo.1884 hbo:Hbor_19360 predicted Zn-dependent hydrolase of beta-lactamase fold family OC.338125 Archaea.17335 Euryarchaeota.16910 Haloplanus.723 - haq.1691 haq:DU484_08995 metal-dependent hydrolase OC.338125 Archaea.17335 Euryarchaeota.16910 Haloplanus.723 - haj.1763 haj:DU500_09245 metal-dependent hydrolase OC.338125 Archaea.17335 Euryarchaeota.16910 - - hla.1359 hla:Hlac_1347 beta-lactamase domain protein OC.338125 Archaea.17335 Euryarchaeota.16910 - - hae.2688 hae:halTADL_2938 L-ascorbate metabolism protein UlaG (beta-lactamase superfamily) OC.338125 Archaea.17335 Euryarchaeota.16910 - - hah.1302 hah:Halar_1441 UPF0173 metal-dependent hydrolase OC.338125 Archaea.17335 Euryarchaeota.16910 Haloterrigena.2342 - hda.1810 hda:BB347_09265 metal-dependent hydrolase OC.338125 Archaea.17335 Euryarchaeota.16910 Haloterrigena.5706 - htu.2724 htu:Htur_2724 beta-lactamase domain protein OC.338125 Archaea.17335 Euryarchaeota.16910 - - nmg.878 nmg:Nmag_0878 UPF0173 family metal-dependent hydrolase OC.338125 Archaea.17335 Euryarchaeota.16910 - - hxa.2338 hxa:Halxa_2417 UPF0173 metal-dependent hydrolase OC.338125 Archaea.17335 Euryarchaeota.16910 Natrinema.2114 - nat.914 nat:NJ7G_0889 hypothetical protein OC.338125 Archaea.17335 Euryarchaeota.16910 Natrinema.2114 - npe.1429 npe:Natpe_1439 putative Zn-dependent hydrolase of beta-lactamase fold protein OC.338125 Archaea.17335 Euryarchaeota.16910 - - nge.2564 nge:Natgr_2751 putative Zn-dependent hydrolase of beta-lactamase fold protein OC.338125 Archaea.17335 Euryarchaeota.16910 - - hru.1901 hru:Halru_1993 putative Zn-dependent hydrolase of beta-lactamase fold protein OC.338125 Archaea.17335 Euryarchaeota.16910 - - nou.2603 nou:Natoc_2703 putative Zn-dependent hydrolase of beta-lactamase fold protein OC.338125 Archaea.17335 Euryarchaeota.16910 - - sali.623 sali:L593_03075 hypothetical protein OC.338125 Archaea.17335 Euryarchaeota.16910 - - hlr.1523 hlr:HALLA_07465 hydrolase OC.338125 Archaea.17335 Euryarchaeota.16910 - - hlc.1844 hlc:CHINAEXTREME09480 metal-dependent hydrolase OC.338125 Archaea.17335 Euryarchaeota.16910 Natronolimnobius.1761 - nag.2744 nag:AArcMg_2803 hypothetical protein OC.338125 Archaea.17335 Euryarchaeota.16910 Natronolimnobius.1761 - nan.902 nan:AArc1_0904 Zn-dependent hydrolase of the beta-lactamase fold OC.338125 Archaea.17335 Euryarchaeota.16910 - - naj.820 naj:B1756_04095 metal-dependent hydrolase OC.338126 Archaea.2461 - - - kcr.79 kcr:Kcr_0055 Zn-dependent hydrolase of the beta-lactamase fold OC.338126 Archaea.2461 Bathyarchaeota.255 - - barc.1974 barc:AOA65_2096 metal-dependent hydrolase OC.338126 Archaea.2461 Bathyarchaeota.255 - - barb.1475 barb:AOA66_1554 metal-dependent hydrolase OC.338127 Eukaryotes.788382 Protists.129969 Amoebozoa.19621 Entamoeba.6460 ehi.2395 ehi:EHI_054690 133.t00014; metal dependent hydrolase OC.338127 Archaea.7058 Crenarchaeota.12142 Thermofilum.402 - tpe.168 tpe:Tpen_0154 conserved hypothetical protein OC.338127 Archaea.7058 Crenarchaeota.12142 Thermofilum.402 - thb.339 thb:N186_01695 metal dependent hydrolase OC.338127 Archaea.7058 Crenarchaeota.12142 Thermofilum.402 - tcb.1389 tcb:TCARB_1423 hypothetical protein OC.338127 Archaea.7058 Crenarchaeota.12142 Thermofilum.402 - thf.126 thf:MA03_00655 Zn-dependent hydrolase OC.338127 Archaea.7058 - - - agw.1276 agw:QT03_C0001G1368 hypothetical protein OC.338128 Archaea.12664 Crenarchaeota.8772 Ignicoccus.1071 - iho.85 iho:Igni_0079 Zn-dependent hydrolase of the beta-lactamase fold-like protein OC.338128 Archaea.12664 Crenarchaeota.8772 Ignicoccus.1071 - iis.930 iis:EYM_04990 metal dependent hydrolase OC.338128 Archaea.12664 Crenarchaeota.8772 - - pfm.1070 pfm:Pyrfu_1090 hypothetical protein OC.338128 Archaea.12664 Crenarchaeota.8772 Pyrobaculum.1358 - pai.2169 pai:PAE3189 conserved hypothetical protein OC.338128 Archaea.12664 Crenarchaeota.8772 Pyrobaculum.1358 - pis.557 pis:Pisl_0545 conserved hypothetical protein OC.338128 Archaea.12664 Crenarchaeota.8772 Pyrobaculum.1358 - pcl.1763 pcl:Pcal_1819 conserved hypothetical protein OC.338128 Archaea.12664 Crenarchaeota.8772 Pyrobaculum.1358 - pas.1574 pas:Pars_1645 conserved hypothetical protein OC.338128 Archaea.12664 Crenarchaeota.8772 Pyrobaculum.1358 - pyr.1326 pyr:P186_1378 Zn-dependent hydrolase of the beta-lactamase fold-like protein OC.338128 Archaea.12664 Crenarchaeota.8772 Pyrobaculum.1358 - pog.530 pog:Pogu_0491 putative Zn-dependent hydrolases of the beta-lactamase fold protein OC.338128 Archaea.12664 Crenarchaeota.8772 Pyrobaculum.1358 - tne.1578 tne:Tneu_1628 conserved hypothetical protein OC.338128 Archaea.12664 Crenarchaeota.8772 Pyrobaculum.1358 - pyw.1677 pyw:PYWP30_01783 putative Zn-dependent hydrolase of the beta-lactamase fold OC.338128 Archaea.12664 Thaumarchaeota.3022 Nitrososphaera.1762 - nga.662 nga:Ngar_c05840 Zn-dependent hydrolase of the beta-lactamase fold protein OC.338128 Archaea.12664 Thaumarchaeota.3022 Nitrososphaera.1762 - nvn.2412 nvn:NVIE_025280 Zn-dependent hydrolase of the beta-lactamase fold OC.338128 Archaea.12664 Thaumarchaeota.3022 Nitrososphaera.1762 - nev.2893 nev:NTE_03037 putative Zn-dependent hydrolase of beta-lactamase fold OC.338128 Archaea.12664 Thaumarchaeota.3022 - - taa.593 taa:NMY3_00407 metal-dependent hydrolase OC.338128 Archaea.12664 Thaumarchaeota.3022 - - ncv.1561 ncv:NCAV_1637 Zn-dependent hydrolase OC.338128 Archaea.12664 Thaumarchaeota.3022 - - ndv.181 ndv:NDEV_0102 Zn-dependent hydrolase of the beta-lactamase fold protein OC.338128 Archaea.12664 Thaumarchaeota.7237 - - csu.27 csu:CSUB_C0006 conserved hypothetical protein OC.338129 Archaea.98511 - - - arg.365 arg:QT11_C0001G0371 Metal dependent hydrolase OC.338130 Archaea.26907 Euryarchaeota.30085 Methanosarcina.2514 Methanosarcina_sp_.1422 mef.240 mef:MSWH1_0207 putative metal dependent hydrolase OC.338130 Archaea.26907 Euryarchaeota.30085 Methanosarcina.2514 Methanosarcina_sp_.1422 meq.259 meq:MSWHS_0218 putative metal dependent hydrolase OC.338130 Archaea.26907 Euryarchaeota.30085 Methanosarcina.2514 Methanosarcina_sp_.3508 mek.280 mek:MSKOL_0257 putative metal dependent hydrolase OC.338130 Archaea.26907 Euryarchaeota.30085 Methanosarcina.2514 Methanosarcina_sp_.9519 metm.2922 metm:MSMTP_3006 putative metal dependent hydrolase OC.338130 Archaea.26907 Euryarchaeota.30085 Methanosarcina.2514 - mac.352 mac:MA_0289 conserved hypothetical protein OC.338130 Archaea.26907 Euryarchaeota.30085 Methanosarcina.2514 Methanosarcina_barkeri.287 mba.1249 mba:Mbar_A1271 conserved hypothetical protein OC.338130 Archaea.26907 Euryarchaeota.30085 Methanosarcina.2514 Methanosarcina_barkeri.287 mbw.3422 mbw:MSBRW_3453 putative metal dependent hydrolase OC.338130 Archaea.26907 Euryarchaeota.30085 Methanosarcina.2514 Methanosarcina_barkeri.3996 mby.379 mby:MSBRM_0368 putative metal dependent hydrolase OC.338130 Archaea.26907 Euryarchaeota.30085 Methanosarcina.2514 Methanosarcina_barkeri.3996 mbar.1997 mbar:MSBR2_2014 putative metal dependent hydrolase OC.338130 Archaea.26907 Euryarchaeota.30085 Methanosarcina.2514 Methanosarcina_barkeri.6004 mbak.2152 mbak:MSBR3_2160 putative metal dependent hydrolase OC.338130 Archaea.26907 Euryarchaeota.30085 Methanosarcina.2514 Methanosarcina_mazei.581 mma.1557 mma:MM_1555 putative metal dependent hydrolase OC.338130 Archaea.26907 Euryarchaeota.30085 Methanosarcina.2514 Methanosarcina_mazei.581 mmaz.1510 mmaz:MmTuc01_1616 Metal dependent hydrolase OC.338130 Archaea.26907 Euryarchaeota.30085 Methanosarcina.2514 Methanosarcina_mazei.581 mmj.3030 mmj:MSMAS_3113 putative metal dependent hydrolase OC.338130 Archaea.26907 Euryarchaeota.30085 Methanosarcina.2514 Methanosarcina_mazei.581 mmac.3011 mmac:MSMAC_3132 putative metal dependent hydrolase OC.338130 Archaea.26907 Euryarchaeota.30085 Methanosarcina.2514 - mvc.308 mvc:MSVAZ_0274 putative metal dependent hydrolase OC.338130 Archaea.26907 Euryarchaeota.30085 Methanosarcina.2514 - mls.144 mls:MSLAZ_0055 putative metal dependent hydrolase OC.338130 Archaea.26907 Euryarchaeota.30085 Methanosarcina.2514 Methanosarcina_siciliae.2636 msj.388 msj:MSSAC_0272 putative metal dependent hydrolase OC.338130 Archaea.26907 Euryarchaeota.30085 Methanosarcina.2514 Methanosarcina_siciliae.2636 msz.251 msz:MSSIH_0236 putative metal dependent hydrolase OC.338130 Archaea.26907 Euryarchaeota.30085 Methanosarcina.2514 Methanosarcina_siciliae.2636 msw.274 msw:MSSIT_0241 putative metal dependent hydrolase OC.338130 Archaea.26907 Euryarchaeota.30085 Methanosarcina.2514 Methanosarcina_thermophila.313 mthe.1286 mthe:MSTHC_1280 putative metal dependent hydrolase OC.338130 Archaea.26907 Euryarchaeota.30085 Methanosarcina.2514 Methanosarcina_thermophila.313 mthr.1992 mthr:MSTHT_2005 putative metal dependent hydrolase OC.338130 Archaea.26907 Euryarchaeota.30085 Methanosarcina.2514 - mhor.3736 mhor:MSHOH_3840 putative metal dependent hydrolase OC.338130 Archaea.26907 Euryarchaeota.30085 Methanococcoides.303 - mbu.1338 mbu:Mbur_1509 Hypothetical protein OC.338130 Archaea.26907 Euryarchaeota.30085 Methanococcoides.303 - mmet.1976 mmet:MCMEM_2003 putative metal dependent hydrolase OC.338130 Archaea.26907 Euryarchaeota.30085 Methanohalophilus.1641 - mmh.1746 mmh:Mmah_1800 conserved hypothetical protein OC.338130 Archaea.26907 Euryarchaeota.30085 Methanohalophilus.1641 - mhaz.905 mhaz:BHR79_04665 hydrolase OC.338130 Archaea.26907 Euryarchaeota.30085 - - mev.1549 mev:Metev_1761 conserved hypothetical protein OC.338130 Archaea.26907 Euryarchaeota.30085 - - mzh.1682 mzh:Mzhil_1788 conserved hypothetical protein OC.338130 Archaea.26907 Euryarchaeota.30085 - - mpy.1422 mpy:Mpsy_1493 hypothetical protein OC.338130 Archaea.26907 Euryarchaeota.30085 - - mhz.240 mhz:Metho_0204 putative Zn-dependent hydrolase of beta-lactamase fold protein OC.338131 Archaea.102199 - - - nac.646 nac:AQV86_03450 hypothetical protein OC.338132 Archaea.35382 Euryarchaeota.8700 Archaeoglobus.133 Archaeoglobus_fulgidus.1208 afu.2104 afu:AF_2153 conserved hypothetical protein OC.338132 Archaea.35382 Euryarchaeota.8700 Archaeoglobus.133 Archaeoglobus_fulgidus.1208 afg.2267 afg:AFULGI_00024230 putative Zn-dependent hydrolase of the beta-lactamase fold protein OC.338132 Archaea.35382 Euryarchaeota.8700 Archaeoglobus.133 - ave.1812 ave:Arcve_1914 hypothetical protein OC.338132 Archaea.35382 Euryarchaeota.8700 Archaeoglobus.133 - ast.1178 ast:Asulf_01203 putative Zn-dependent hydrolases of the beta-lactamase fold protein