# OC Root 2nd 3rd 4th 5th PC Gene/Definition OC.340236 Archaea.22706 Euryarchaeota.24459 Methanobacterium.1588 Methanobacterium_sp_.1279 meth.1238 meth:MBMB1_1264 UPF0053 protein; K03699 putative hemolysin OC.340236 Archaea.22706 Euryarchaeota.24459 Methanobacterium.1588 Methanobacterium_sp_.2149 metn.165 metn:BK008_00775 hypothetical protein; K03699 putative hemolysin OC.340236 Archaea.22706 Euryarchaeota.24459 Methanobacterium.1588 Methanobacterium_formicicum.2139 mfc.470 mfc:BRM9_0481 hypothetical protein; K03699 putative hemolysin OC.340236 Archaea.22706 Euryarchaeota.24459 Methanobacterium.1588 - msub.1008 msub:BK009_05230 hypothetical protein; K03699 putative hemolysin OC.340237 Archaea.27500 Euryarchaeota.30812 Methanoculleus.1186 - mem.1289 mem:Memar_1314 protein of unknown function DUF21; K03699 putative hemolysin OC.340237 Archaea.27500 Euryarchaeota.30812 Methanoculleus.1186 - mbg.2083 mbg:BN140_2212 putative hemolysin; K03699 putative hemolysin OC.340237 Archaea.27500 Euryarchaeota.30812 Methanoculleus.1186 - mema.2831 mema:MMAB1_2934 conserved membrane protein of unknown function; K03699 putative hemolysin OC.340238 Eukaryotes.468220 Animals.235410 Arthropods.101604 Insects.118633 pxy.13314 pxy:105397637 putative DUF21 domain-containing protein At3g13070, chloroplastic OC.340238 Archaea.64142 Euryarchaeota.49128 Methanocella.2054 - mpd.1336 mpd:MCP_1320 conserved hypothetical protein; K03699 putative hemolysin OC.340238 Archaea.64142 Euryarchaeota.49128 Methanocella.2054 - rci.786 rci:RCIX1155 conserved hypothetical protein; K03699 putative hemolysin OC.340238 Archaea.68379 Euryarchaeota.53494 Methanosaeta.1309 - mcj.563 mcj:MCON_0532 conserved hypothetical protein; K03699 putative hemolysin OC.340238 Archaea.68379 Euryarchaeota.53494 Methanosaeta.1309 - mhi.1908 mhi:Mhar_2023 hypothetical protein; K03699 putative hemolysin OC.340239 Archaea.86938 Euryarchaeota.73083 - - mpl.116 mpl:Mpal_0021 protein of unknown function DUF21; K03699 putative hemolysin OC.340240 Archaea.84484 Euryarchaeota.70452 - - mhu.450 mhu:Mhun_0343 protein of unknown function DUF21; K03699 putative hemolysin OC.340241 Archaea.30794 Euryarchaeota.34754 Methanosarcina.984 Methanosarcina_barkeri.1519 mba.2386 mba:Mbar_A2480 probable hemolysin; K03699 putative hemolysin OC.340241 Archaea.30794 Euryarchaeota.34754 Methanosarcina.984 Methanosarcina_barkeri.1519 mby.1177 mby:MSBRM_1193 Hemolysins and related protein containing CBS domains; K03699 putative hemolysin OC.340241 Archaea.30794 Euryarchaeota.34754 Methanosarcina.984 Methanosarcina_barkeri.1519 mbw.2254 mbw:MSBRW_2272 Hemolysins and related protein containing CBS domains; K03699 putative hemolysin OC.340241 Archaea.30794 Euryarchaeota.34754 Methanosarcina.984 Methanosarcina_barkeri.1519 mbar.1218 mbar:MSBR2_1217 Hemolysins and related protein containing CBS domains; K03699 putative hemolysin OC.340241 Archaea.30794 Euryarchaeota.34754 Methanosarcina.984 Methanosarcina_barkeri.1519 mbak.334 mbak:MSBR3_0291 Hemolysins and related protein containing CBS domains; K03699 putative hemolysin OC.340241 Archaea.30794 Euryarchaeota.34754 Methanosarcina.984 Methanosarcina_mazei.2249 mma.3200 mma:MM_3275 conserved protein; K03699 putative hemolysin OC.340241 Archaea.30794 Euryarchaeota.34754 Methanosarcina.984 Methanosarcina_mazei.2249 mmaz.3153 mmaz:MmTuc01_3370 Hemolysin; K03699 putative hemolysin OC.340241 Archaea.30794 Euryarchaeota.34754 Methanosarcina.984 Methanosarcina_mazei.2249 mmj.1399 mmj:MSMAS_1411 Hemolysins and related protein containing CBS domains; K03699 putative hemolysin OC.340241 Archaea.30794 Euryarchaeota.34754 Methanosarcina.984 Methanosarcina_mazei.2249 mmac.2673 mmac:MSMAC_2772 Hemolysins and related protein containing CBS domains; K03699 putative hemolysin OC.340241 Archaea.30794 Euryarchaeota.34754 Methanosarcina.984 Methanosarcina_thermophila.1875 mthe.492 mthe:MSTHC_0482 Hemolysins and related protein containing CBS domains; K03699 putative hemolysin OC.340241 Archaea.30794 Euryarchaeota.34754 Methanosarcina.984 Methanosarcina_thermophila.1875 mthr.257 mthr:MSTHT_0249 Hemolysins and related protein containing CBS domains; K03699 putative hemolysin OC.340241 Archaea.30794 Euryarchaeota.34754 Methanosarcina.984 - mhor.2015 mhor:MSHOH_2048 Hemolysins and related protein containing CBS domains; K03699 putative hemolysin OC.340241 Archaea.30794 Euryarchaeota.34754 - - mpy.330 mpy:Mpsy_0268 hemolysin; K03699 putative hemolysin OC.340241 Archaea.30794 Euryarchaeota.34754 - - mhz.642 mhz:Metho_0652 CBS domain-containing protein; K03699 putative hemolysin OC.340241 Archaea.30794 Euryarchaeota.34754 - - mpi.922 mpi:Mpet_0903 protein of unknown function DUF21; K03699 putative hemolysin OC.340242 Archaea.24693 Euryarchaeota.27111 Methanobrevibacter.657 Methanobrevibacter_sp_.1507 meb.1443 meb:Abm4_1538 hypothetical protein; K03699 putative hemolysin OC.340242 Archaea.24693 Euryarchaeota.27111 Methanobrevibacter.657 Methanobrevibacter_sp_.3197 meye.1652 meye:TL18_09375 hypothetical protein; K03699 putative hemolysin OC.340242 Archaea.24693 Euryarchaeota.27111 Methanobrevibacter.657 - msi.1019 msi:Msm_1026 hemolysin-related protein, transporter-associated family, TlyC; K03699 putative hemolysin OC.340242 Archaea.24693 Euryarchaeota.27111 Methanobrevibacter.657 - mru.1886 mru:mru_1952 CBS domain-containing protein; K03699 putative hemolysin OC.340242 Archaea.24693 Euryarchaeota.27111 Methanobrevibacter.657 - mmil.1866 mmil:sm9_2038 hypothetical protein; K03699 putative hemolysin OC.340242 Archaea.24693 Euryarchaeota.27111 Methanobrevibacter.657 - mol.1368 mol:YLM1_1402 hypothetical protein; K03699 putative hemolysin OC.340243 Archaea.27699 Euryarchaeota.31051 - - mhu.2628 mhu:Mhun_3011 protein of unknown function DUF21 OC.340243 Archaea.27699 Euryarchaeota.31051 - - mla.1236 mla:Mlab_1278 protein of unknown function DUF21 OC.340243 Archaea.27699 Euryarchaeota.31051 Methanoculleus.1675 - mem.1931 mem:Memar_1977 protein of unknown function DUF21 OC.340243 Archaea.27699 Euryarchaeota.31051 Methanoculleus.1675 - mbg.298 mbg:BN140_0289 hemolysin-related protein OC.340243 Archaea.27699 Euryarchaeota.31051 Methanoculleus.1675 - mema.413 mema:MMAB1_0368 conserved membrane protein of unknown function OC.340243 Archaea.27699 Euryarchaeota.31051 - - mpi.1734 mpi:Mpet_1841 protein of unknown function DUF21 OC.340243 Archaea.27699 Euryarchaeota.31051 Methanoregula.550 - mbn.1811 mbn:Mboo_1891 protein of unknown function DUF21 OC.340243 Archaea.27699 Euryarchaeota.31051 Methanoregula.550 - mfo.1054 mfo:Metfor_1084 CBS domain-containing protein OC.340243 Archaea.27699 Euryarchaeota.31051 - - mpl.563 mpl:Mpal_0531 protein of unknown function DUF21 OC.340244 Archaea.68381 Euryarchaeota.53497 Methanosaeta.1342 - mcj.610 mcj:MCON_0595 integral membrane protein with CBS domains OC.340244 Archaea.68381 Euryarchaeota.53497 Methanosaeta.1342 - mhi.208 mhi:Mhar_0131 Integral membrane protein with CBS domains OC.340245 Archaea.33044 Euryarchaeota.38324 - - tar.1026 tar:TALC_01057 Hemolysins-related protein containing CBS domains OC.340245 Archaea.33044 Euryarchaeota.38324 - - max.1034 max:MMALV_10740 Hemolysin-related protein containing CBS domains OC.340245 Archaea.33044 Euryarchaeota.38324 - - mer.968 mer:MMINT_10650 Hemolysin-related protein containing CBS domains OC.340245 Archaea.33044 Euryarchaeota.38324 - - mear.601 mear:Mpt1_c06320 nhaP2; K(+)/H(+) antiporter NhaP2 OC.340245 Archaea.33044 Euryarchaeota.38324 - - marc.1311 marc:AR505_1357 gliding motility-associated protein GldE OC.340246 Archaea.17353 Euryarchaeota.16934 Halobacterium.2676 Halobacterium_salinarum.1385 hal.2318 hal:VNG_6302C Vng6302c OC.340246 Archaea.17353 Euryarchaeota.16934 Halobacterium.2676 Halobacterium_salinarum.1385 hsl.2304 hsl:OE_5193F DUF21/CBS domain protein OC.340246 Archaea.17353 Euryarchaeota.16934 Halobacterium.4386 - hdl.2643 hdl:HALDL1_13745 cobalt transporter OC.340246 Archaea.17353 Euryarchaeota.16934 Halobacterium.5141 - hhb.1683 hhb:Hhub_2704 DUF21/CBS domain protein OC.340246 Archaea.17353 Euryarchaeota.16934 - - hje.1115 hje:HacjB3_05020 hypothetical protein OC.340246 Archaea.17353 Euryarchaeota.16934 Halodesulfurarchaeum.1319 - halh.418 halh:HTSR_0429 hypothetical protein OC.340246 Archaea.17353 Euryarchaeota.16934 Halodesulfurarchaeum.1319 - hhsr.408 hhsr:HSR6_0414 hypothetical protein OC.340246 Archaea.17353 Euryarchaeota.16934 Halanaeroarchaeum.583 - hsu.1529 hsu:HLASF_1569 hypothetical protein OC.340246 Archaea.17353 Euryarchaeota.16934 Halanaeroarchaeum.583 - hsf.1524 hsf:HLASA_1556 hypothetical protein OC.340246 Archaea.17353 Euryarchaeota.16934 Haloarcula.502 - hma.2478 hma:rrnAC1898 unknown OC.340246 Archaea.17353 Euryarchaeota.16934 Haloarcula.502 Haloarcula_hispanica.1468 hhi.2364 hhi:HAH_2412 conserved hypothetical protein OC.340246 Archaea.17353 Euryarchaeota.16934 Haloarcula.502 Haloarcula_hispanica.1468 hhn.2410 hhn:HISP_12280 cobalt transporter OC.340246 Archaea.17353 Euryarchaeota.16934 Haloarcula.502 - hab.877 hab:SG26_04590 cobalt transporter OC.340246 Archaea.17353 Euryarchaeota.16934 Haloarcula.502 - hta.2290 hta:BVU17_11735 cobalt transporter OC.340246 Archaea.17353 Euryarchaeota.16934 Natronomonas.1950 - nmo.1009 nmo:Nmlp_2088 cbs12; DUF21/CBS domain protein OC.340246 Archaea.17353 Euryarchaeota.16934 Halorhabdus.3205 - hut.926 hut:Huta_0921 protein of unknown function DUF21 OC.340246 Archaea.17353 Euryarchaeota.16934 - - hmu.760 hmu:Hmuk_0760 protein of unknown function DUF21 OC.340246 Archaea.17353 Euryarchaeota.16934 - - hali.2532 hali:BV210_13265 cobalt transporter OC.340246 Archaea.17353 Euryarchaeota.16934 - - harc.1298 harc:HARCEL1_06765 cobalt transporter OC.340246 Archaea.17353 Euryarchaeota.16934 Haloferax.1054 - hvo.3023 hvo:HVO_A0049 DUF21/CBS domain protein OC.340246 Archaea.17353 Euryarchaeota.16934 Haloferax.1054 - hgi.2082 hgi:ABY42_10605 cobalt transporter OC.340246 Archaea.17353 Euryarchaeota.16934 Haloplanus.2310 - haq.1069 haq:DU484_05515 HlyC/CorC family transporter OC.340246 Archaea.17353 Euryarchaeota.16934 Haloplanus.2310 - haj.3371 haj:DU500_17700 HlyC/CorC family transporter OC.340246 Archaea.17353 Euryarchaeota.16934 - - hla.1878 hla:Hlac_1889 protein of unknown function DUF21 OC.340246 Archaea.17353 Euryarchaeota.16934 - - srub.2464 srub:C2R22_13345 cobalt transporter OC.340246 Archaea.17353 Euryarchaeota.16934 - - hae.2380 hae:halTADL_2590 CBS domain containing-hemolysin-like protein OC.340246 Archaea.17353 Euryarchaeota.16934 - - hah.1447 hah:Halar_1594 protein of unknown function DUF21 OC.340246 Archaea.17353 Euryarchaeota.16934 Haloterrigena.4861 - htu.1639 htu:Htur_1588 protein of unknown function DUF21 OC.340246 Archaea.17353 Euryarchaeota.16934 - - hxa.3068 hxa:Halxa_3161 protein of unknown function DUF21 OC.340246 Archaea.17353 Euryarchaeota.16934 Natrinema.2060 - nat.835 nat:NJ7G_0810 Magnesium and cobalt efflux protein corC OC.340246 Archaea.17353 Euryarchaeota.16934 Natrinema.2060 - npe.1543 npe:Natpe_1557 CBS domain-containing protein OC.340246 Archaea.17353 Euryarchaeota.16934 - - hru.2474 hru:Halru_2591 CBS domain-containing protein OC.340246 Archaea.17353 Euryarchaeota.16934 - - sali.2903 sali:L593_14725 hypothetical protein OC.340246 Archaea.17353 Euryarchaeota.16934 - - hlr.794 hlr:HALLA_03595 cobalt transporter OC.340246 Archaea.17353 Euryarchaeota.16934 - - hlc.873 hlc:CHINAEXTREME04390 cobalt transporter OC.340247 Eukaryotes.774072 Protists.108373 Alveolates.54727 - smin.14324 smin:v1.2.004980.t1 symbB.v1.2.004980.t1; - OC.340248 Eukaryotes.467565 Animals.234698 Arthropods.100787 Insects.117805 pxy.11884 pxy:105395312 DUF21 domain-containing protein At1g55930, chloroplastic-like OC.340249 Archaea.36583 Thaumarchaeota.1953 Nitrosopumilus.305 - nir.908 nir:NSED_04590 hypothetical protein OC.340249 Archaea.36583 Thaumarchaeota.1953 Nitrosopumilus.305 - nid.1351 nid:NPIRD3C_1370 conserved membrane protein of unknown function OC.340249 Archaea.36583 Thaumarchaeota.1953 Nitrosopumilus.305 - nin.1213 nin:NADRNF5_1234 conserved membrane protein of unknown function OC.340249 Archaea.36583 Thaumarchaeota.1953 Nitrosopumilus.476 - nir.614 nir:NSED_03070 hypothetical protein OC.340249 Archaea.36583 Thaumarchaeota.1953 Nitrosopumilus.476 - nid.1546 nid:NPIRD3C_1566 conserved membrane protein of unknown function OC.340249 Archaea.36583 Thaumarchaeota.1953 Nitrosopumilus.476 - nin.1113 nin:NADRNF5_1129 conserved membrane protein of unknown function OC.340249 Archaea.36583 Thaumarchaeota.1953 Nitrosopumilus.4185 - nmr.834 nmr:Nmar_0832 protein of unknown function DUF21 OC.340249 Archaea.36583 Thaumarchaeota.1953 Nitrosopumilus.4226 - nmr.1009 nmr:Nmar_1007 protein of unknown function DUF21 OC.340249 Archaea.36583 Thaumarchaeota.1953 - - nkr.881 nkr:NKOR_04590 hypothetical protein OC.340249 Archaea.36583 Thaumarchaeota.1953 - - nct.775 nct:NMSP_0790 hypothetical protein OC.340249 Archaea.36583 Thaumarchaeota.1953 - - csy.890 csy:CENSYa_0971 hemolysin OC.340249 Archaea.36583 Thaumarchaeota.1953 Nitrososphaera.4369 - nga.2890 nga:Ngar_c31340 HlyC/CorC-like protein OC.340249 Archaea.36583 Thaumarchaeota.1953 - - nbv.708 nbv:T478_0732 membrane protein, PF01595 family OC.340249 Archaea.36583 Thaumarchaeota.1953 - - ndv.1044 ndv:NDEV_1046 CBS domain protein