# OC Root 2nd 3rd 4th 5th 6th PC Gene/Definition OC.37820 Bacteria.17241 Firmicutes.67145 Firmicutes___Clostridia.48932 Clostridium.12512 Clostridium_perfringens.539 cpe.1560 cpe:CPE1560 conserved hypothetical protein OC.37820 Bacteria.17241 Firmicutes.67145 Firmicutes___Clostridia.48932 Clostridium.12512 Clostridium_perfringens.539 cpf.1761 cpf:CPF_1811 GGDEF/HD domain protein OC.37820 Bacteria.17241 Firmicutes.67145 Firmicutes___Clostridia.48932 Clostridium.12512 Clostridium_perfringens.539 cpr.1446 cpr:CPR_1530 GGDEF/HD domain protein OC.37820 Bacteria.17241 Firmicutes.67145 Firmicutes___Clostridia.48932 Clostridium.12512 Clostridium_botulinum.2745 cbo.331 cbo:CBO0333 diguanylate cyclase OC.37820 Bacteria.17241 Firmicutes.67145 Firmicutes___Clostridia.48932 Clostridium.12512 Clostridium_botulinum.2745 cba.334 cba:CLB_0376 GGDEF/HD domain protein OC.37820 Bacteria.17241 Firmicutes.67145 Firmicutes___Clostridia.48932 Clostridium.12512 Clostridium_botulinum.2745 cbh.320 cbh:CLC_0391 diguanylate cyclase OC.37820 Bacteria.17241 Firmicutes.67145 Firmicutes___Clostridia.48932 Clostridium.12512 Clostridium_botulinum.2745 cby.367 cby:CLM_0401 GGDEF/HD domain protein OC.37820 Bacteria.17241 Firmicutes.67145 Firmicutes___Clostridia.48932 Clostridium.12512 Clostridium_botulinum.2745 cbl.3371 cbl:CLK_3521 GGDEF/HD domain protein OC.37820 Bacteria.17241 Firmicutes.67145 Firmicutes___Clostridia.48932 Clostridium.12512 Clostridium_botulinum.2745 cbb.416 cbb:CLD_0419 GGDEF/HD domain protein OC.37820 Bacteria.17241 Firmicutes.67145 Firmicutes___Clostridia.48932 Clostridium.12512 Clostridium_botulinum.2745 cbi.656 cbi:CLJ_B0389 GGDEF/HD domain protein OC.37820 Bacteria.17241 Firmicutes.67145 Firmicutes___Clostridia.48932 Clostridium.12512 Clostridium_botulinum.12750 cbt.1302 cbt:CLH_1356 ggdef/hd domain protein OC.37820 Bacteria.17241 Firmicutes.67145 Firmicutes___Clostridia.48932 Clostridium.12512 Clostridium_botulinum.2745 cbf.332 cbf:CLI_0404 GGDEF/HD domain protein OC.37820 Bacteria.17241 Firmicutes.67145 Firmicutes___Clostridia.48932 Clostridium.12512 Clostridium_botulinum.2745 cbj.351 cbj:H04402_00342 two-component response regulator OC.37820 Bacteria.17241 Firmicutes.67145 Firmicutes___Clostridia.48932 Clostridium.12512 - csr.2295 csr:Cspa_c22600 hypothetical protein OC.37820 Bacteria.17241 Firmicutes.67145 Firmicutes___Clostridia.48932 Clostridium.12512 Clostridium_pasteurianum.1864 cpas.3091 cpas:Clopa_3623 diguanylate cyclase (GGDEF) domain-containing protein OC.37820 Bacteria.17241 Firmicutes.67145 Firmicutes___Clostridia.48932 Clostridium.12512 Clostridium_pasteurianum.1864 cpat.2695 cpat:CLPA_c28070 diguanylate cyclase (GGDEF) domain-containing protein OC.37820 Bacteria.17241 Firmicutes.67145 Firmicutes___Clostridia.48932 Clostridium.12512 Clostridium_pasteurianum.1864 cpae.2695 cpae:CPAST_c28070 diguanylate cyclase (GGDEF) domain-containing protein OC.37820 Bacteria.17241 Firmicutes.67145 Firmicutes___Clostridia.48932 Clostridium.12512 - cbv.1476 cbv:U729_2381 diguanylate cyclase domain protein OC.37820 Bacteria.17241 Firmicutes.67145 Firmicutes___Clostridia.48932 Clostridium.12512 - cld.342 cld:CLSPO_c03630 diguanylate cyclase (GGDEF) domain-containing protein OC.37820 Bacteria.17241 Firmicutes.67145 Firmicutes___Clostridia.48932 Clostridium.12513 - cace.1153 cace:CACET_c11970 GGDEF/HD domain containing protein OC.37820 Bacteria.17241 Firmicutes.67145 Firmicutes___Clostridia.48932 Clostridium.12512 - cbut.1196 cbut:ATN24_06435 diguanylate cyclase OC.37820 Bacteria.17241 Firmicutes.67145 Firmicutes___Clostridia.48932 Clostridium.12512 - ceu.873 ceu:A7L45_04425 diguanylate cyclase OC.37820 Bacteria.17241 Firmicutes.67145 Firmicutes___Clostridia.48932 Clostridium.12512 - ctae.623 ctae:BGI42_03350 diguanylate cyclase OC.37820 Bacteria.17241 Firmicutes.67145 Firmicutes___Clostridia.48932 Clostridium.12512 - cchv.1903 cchv:BTM20_10395 diguanylate cyclase OC.37820 Bacteria.17241 Firmicutes.67145 Firmicutes___Clostridia.48932 - - gfe.1097 gfe:Gferi_05270 diguanylate cyclase OC.37820 Bacteria.17241 Firmicutes.67145 Firmicutes___Clostridia.48933 Hungateiclostridium.1638 Hungateiclostridium_thermocellum.434 cth.144 cth:Cthe_0129 diguanylate cyclase and metal dependent phosphohydrolase OC.37820 Bacteria.17241 Firmicutes.67145 Firmicutes___Clostridia.48933 Hungateiclostridium.1638 Hungateiclostridium_thermocellum.532 cth.156 cth:Cthe_0142 diguanylate cyclase and metal dependent phosphohydrolase OC.37820 Bacteria.16479 Firmicutes.232141 Firmicutes___Clostridia.48936 Hungateiclostridium.2896 Hungateiclostridium_thermocellum.1662 cth.279 cth:Cthe_0273 diguanylate cyclase and metal dependent phosphohydrolase OC.37820 Bacteria.16479 Firmicutes.232141 Firmicutes___Clostridia.48936 Hungateiclostridium.2896 Hungateiclostridium_thermocellum.1662 ctx.1888 ctx:Clo1313_1956 diguanylate cyclase and metal dependent phosphohydrolase OC.37820 Bacteria.17241 Firmicutes.67145 Firmicutes___Clostridia.48933 Hungateiclostridium.1638 Hungateiclostridium_thermocellum.532 ctx.2014 ctx:Clo1313_2091 diguanylate cyclase and metal dependent phosphohydrolase OC.37820 Bacteria.17241 Firmicutes.67145 Firmicutes___Clostridia.48933 Hungateiclostridium.1638 Hungateiclostridium_thermocellum.434 ctx.2026 ctx:Clo1313_2103 diguanylate cyclase and metal dependent phosphohydrolase OC.37820 Bacteria.17241 Firmicutes.67145 Firmicutes___Clostridia.48933 Hungateiclostridium.1638 - ccl.98 ccl:Clocl_2079 diguanylate cyclase (GGDEF) domain-containing protein OC.37820 Bacteria.17241 Firmicutes.67145 Firmicutes___Clostridia.48933 Hungateiclostridium.1638 - ccl.2760 ccl:Clocl_3245 diguanylate cyclase (GGDEF) domain-containing protein OC.37820 Bacteria.17241 Firmicutes.67145 Firmicutes___Clostridia.48933 Hungateiclostridium.1638 - ccl.98 ccl:Clocl_3312 diguanylate cyclase (GGDEF) domain-containing protein OC.37820 Bacteria.17241 Firmicutes.67145 Firmicutes___Clostridia.48933 Hungateiclostridium.1638 - ccl.3320 ccl:Clocl_3951 diguanylate cyclase (GGDEF) domain-containing protein OC.37820 Bacteria.17241 Firmicutes.67145 Firmicutes___Clostridia.48933 Hungateiclostridium.1638 - hsc.1372 hsc:HVS_08165 rpfG2; Cyclic di-GMP phosphodiesterase response regulator RpfG OC.37820 Bacteria.17241 Firmicutes.67145 Firmicutes___Clostridia.48933 Hungateiclostridium.1638 - hsc.2121 hsc:HVS_12230 rpfG5; Cyclic di-GMP phosphodiesterase response regulator RpfG OC.37820 Bacteria.12668 Firmicutes.127348 Firmicutes___Clostridia.65954 Ruminococcus.8318 - rum.1740 rum:CK1_21370 diguanylate cyclase (GGDEF) domain/uncharacterized domain HDIG OC.37820 Bacteria.12668 Firmicutes.127348 Firmicutes___Clostridia.65954 Roseburia.1067 - rho.297 rho:RHOM_01365 GGDEF domain-containing protein OC.37820 Bacteria.12668 Firmicutes.127348 Firmicutes___Clostridia.65954 Roseburia.1067 Roseburia_intestinalis.272 rix.3100 rix:RO1_37310 diguanylate cyclase (GGDEF) domain/uncharacterized domain HDIG OC.37820 Bacteria.12668 Firmicutes.127348 Firmicutes___Clostridia.65954 Roseburia.1067 Roseburia_intestinalis.272 rim.1364 rim:ROI_16110 diguanylate cyclase (GGDEF) domain/uncharacterized domain HDIG OC.37820 Bacteria.12668 Firmicutes.127348 Firmicutes___Clostridia.65954 Coprococcus.397 - cct.285 cct:CC1_02840 diguanylate cyclase with GAF sensor OC.37820 Bacteria.12668 Firmicutes.127348 Firmicutes___Clostridia.65954 Lachnoclostridium.324 - lacy.4252 lacy:A4V08_26765 diguanylate cyclase OC.37820 Bacteria.12668 Firmicutes.127348 Firmicutes___Clostridia.65954 Lachnoclostridium.324 - cbol.1437 cbol:CGC65_07180 diguanylate cyclase OC.37820 Bacteria.17241 Firmicutes.67145 Firmicutes___Clostridia.48932 - - psor.2721 psor:RSJ16_14955 hypothetical protein OC.37820 Bacteria.17241 Firmicutes.67145 Firmicutes___Clostridia.48932 Desulfotomaculum.1093 - drm.872 drm:Dred_0910 metal dependent phosphohydrolase OC.37820 Bacteria.17241 Firmicutes.67145 Firmicutes___Clostridia.48932 Desulfotomaculum.1093 - dca.2088 dca:Desca_2208 diguanylate cyclase and metal dependent phosphohydrolase OC.37820 Bacteria.17241 Firmicutes.67145 Firmicutes___Clostridia.48932 Desulfotomaculum.1093 - dfg.798 dfg:B0537_04340 phosphohydrolase OC.37820 Bacteria.17241 Firmicutes.67145 Firmicutes___Clostridia.48932 - - dae.2745 dae:Dtox_3082 diguanylate cyclase and metal dependent phosphohydrolase OC.37820 Bacteria.17241 Firmicutes.67145 Firmicutes___Clostridia.48932 - - dku.2610 dku:Desku_2837 diguanylate cyclase and metal dependent phosphohydrolase OC.37820 Bacteria.17241 Firmicutes.67145 Firmicutes___Clostridia.48932 - - dku.102 dku:Desku_2899 diguanylate cyclase and metal dependent phosphohydrolase OC.37820 Bacteria.17241 Firmicutes.67145 Firmicutes___Clostridia.48932 - - dku.102 dku:Desku_3325 diguanylate cyclase and metal dependent phosphohydrolase OC.37820 Bacteria.17241 Firmicutes.67145 Firmicutes___Clostridia.48932 - - dku.102 dku:Desku_3511 diguanylate cyclase and metal dependent phosphohydrolase OC.37820 Bacteria.17241 Firmicutes.67145 Firmicutes___Clostridia.48932 - - pth.2100 pth:PTH_2130 hypothetical protein OC.37820 Bacteria.17241 Firmicutes.67145 Firmicutes___Clostridia.48932 - - awo.659 awo:Awo_c05730 GGDEF/HD domain protein OC.37820 Bacteria.12668 Firmicutes.127348 Firmicutes___Clostridia.65954 - - awo.3152 awo:Awo_c33750 diguanylate cyclase and metal dependent phosphohydrolase OC.37820 Bacteria.17241 Firmicutes.67145 Firmicutes___Clostridia.48932 - - cthm.311 cthm:CFE_0299 diguanylate cyclase (GGDEF) domain-containing protein OC.37820 Bacteria.12669 Firmicutes.67146 Firmicutes___Clostridia.48935 - - cthm.1589 cthm:CFE_1648 diguanylate cyclase (GGDEF) domain-containing protein/HDIG domain-containing protein OC.37820 Bacteria.17241 Firmicutes.67145 Firmicutes___Clostridia.48932 - - chy.1805 chy:CHY_1875 sensory box protein OC.37820 Bacteria.19825 Firmicutes.67147 Firmicutes___Clostridia.171754 - - mas.1773 mas:Mahau_1838 diguanylate cyclase and metal dependent phosphohydrolase OC.37820 Bacteria.17241 Firmicutes.67145 Firmicutes___Clostridia.48932 - - aar.1799 aar:Acear_1932 diguanylate cyclase and metal dependent phosphohydrolase