# OC Root 2nd 3rd 4th 5th PC Gene/Definition OC.378627 Bacteria.283217 Thermotogae.2076 Thermotoga.27 Thermotoga_sp_.1931 thq.681 thq:T2812B_03450 hypothetical protein OC.378627 Bacteria.283217 Thermotogae.2076 Thermotoga.27 Thermotoga_sp_.3063 thr.685 thr:TRQ7_03545 methylenetetrahydrofolate reductase OC.378627 Bacteria.283217 Thermotogae.2076 Thermotoga.27 Thermotoga_sp_.4179 thz.613 thz:CELL2_03405 methylenetetrahydrofolate reductase OC.378627 Bacteria.283217 Thermotogae.2076 Thermotoga.27 Thermotoga_sp_.4611 trq.670 trq:TRQ2_0678 methylenetetrahydrofolate reductase OC.378627 Bacteria.283217 Thermotogae.2076 Thermotoga.27 Thermotoga_maritima.1021 tma.268 tma:TM0270 5,10-methylenetetrahydrofolate reductase OC.378627 Bacteria.283217 Thermotogae.2076 Thermotoga.27 Thermotoga_maritima.1021 tmm.270 tmm:Tmari_0268 5,10-methylenetetrahydrofolate reductase OC.378627 Bacteria.283217 Thermotogae.2076 Thermotoga.27 Thermotoga_maritima.1021 tmi.654 tmi:THEMA_03375 methylenetetrahydrofolate reductase OC.378627 Bacteria.283217 Thermotogae.2076 Thermotoga.27 Thermotoga_maritima.1021 tmw.265 tmw:THMA_0277 methylenetetrahydrofolate reductase OC.378627 Bacteria.283217 Thermotogae.2076 Thermotoga.27 Thermotoga_maritima.1021 tmq.265 tmq:THMB_0277 methylenetetrahydrofolate reductase OC.378627 Bacteria.283217 Thermotogae.2076 Thermotoga.27 Thermotoga_maritima.1021 tmx.264 tmx:THMC_0277 methylenetetrahydrofolate reductase OC.378627 Bacteria.283217 Thermotogae.2076 Thermotoga.27 - tpt.648 tpt:Tpet_0654 methylenetetrahydrofolate reductase OC.378627 Bacteria.283217 Thermotogae.2076 Thermotoga.27 - tna.417 tna:CTN_0415 Methylenetetrahydrofolate reductase OC.378627 Bacteria.283217 Thermotogae.2076 Thermotoga.27 - tnp.881 tnp:Tnap_0900 methylenetetrahydrofolate reductase OC.378627 Bacteria.283217 Thermotogae.2076 Fervidobacterium.635 - fno.1515 fno:Fnod_1578 methylenetetrahydrofolate reductase OC.378627 Bacteria.283217 Thermotogae.2076 Fervidobacterium.635 - fpe.1655 fpe:Ferpe_1824 5,10-methylenetetrahydrofolate reductase OC.378627 Bacteria.283217 Thermotogae.2076 Fervidobacterium.635 - fia.1632 fia:NA23_09065 methylenetetrahydrofolate reductase OC.378628 Eukaryotes.544494 Animals.341919 - - aqu.12947 aqu:109592360 uncharacterized protein LOC109592360 OC.378628 Archaea.26952 Euryarchaeota.30143 Methanosarcina.788 Methanosarcina_sp_.2476 mef.642 mef:MSWH1_0634 5,10-methylenetetrahydrofolate reductase OC.378628 Archaea.26952 Euryarchaeota.30143 Methanosarcina.788 Methanosarcina_sp_.2476 meq.671 meq:MSWHS_0653 5,10-methylenetetrahydrofolate reductase OC.378628 Archaea.26952 Euryarchaeota.30143 Methanosarcina.788 Methanosarcina_sp_.2892 mek.2151 mek:MSKOL_2157 5,10-methylenetetrahydrofolate reductase OC.378628 Archaea.26952 Euryarchaeota.30143 Methanosarcina.788 Methanosarcina_sp_.2892 metm.2302 metm:MSMTP_2356 5,10-methylenetetrahydrofolate reductase OC.378628 Archaea.26952 Euryarchaeota.30143 Methanosarcina.788 - mac.3251 mac:MA_3514 metF; 5,10-methylenetetrahydrofolate reductase (FADH) OC.378628 Archaea.26952 Euryarchaeota.30143 Methanosarcina.788 Methanosarcina_barkeri.1363 mba.2235 mba:Mbar_A2312 methylenetetrahydrofolate reductase OC.378628 Archaea.26952 Euryarchaeota.30143 Methanosarcina.788 Methanosarcina_barkeri.1363 mby.1254 mby:MSBRM_1273 5,10-methylenetetrahydrofolate reductase OC.378628 Archaea.26952 Euryarchaeota.30143 Methanosarcina.788 Methanosarcina_barkeri.1363 mbw.2413 mbw:MSBRW_2432 5,10-methylenetetrahydrofolate reductase OC.378628 Archaea.26952 Euryarchaeota.30143 Methanosarcina.788 Methanosarcina_barkeri.1363 mbar.1147 mbar:MSBR2_1135 5,10-methylenetetrahydrofolate reductase OC.378628 Archaea.26952 Euryarchaeota.30143 Methanosarcina.788 Methanosarcina_barkeri.5647 mbak.1472 mbak:MSBR3_1466 5,10-methylenetetrahydrofolate reductase OC.378628 Archaea.26952 Euryarchaeota.30143 Methanosarcina.788 Methanosarcina_mazei.2480 mma.467 mma:MM_0438 Methylenetetrahydrofolate reductase OC.378628 Archaea.26952 Euryarchaeota.30143 Methanosarcina.788 Methanosarcina_mazei.2480 mmaz.429 mmaz:MmTuc01_0450 5,10-methylenetetrahydrofolate reductase OC.378628 Archaea.26952 Euryarchaeota.30143 Methanosarcina.788 Methanosarcina_mazei.2480 mmj.879 mmj:MSMAS_0865 5,10-methylenetetrahydrofolate reductase OC.378628 Archaea.26952 Euryarchaeota.30143 Methanosarcina.788 Methanosarcina_mazei.2480 mmac.880 mmac:MSMAC_0854 5,10-methylenetetrahydrofolate reductase OC.378628 Archaea.26952 Euryarchaeota.30143 Methanosarcina.788 - mvc.2143 mvc:MSVAZ_2164 5,10-methylenetetrahydrofolate reductase OC.378628 Archaea.26952 Euryarchaeota.30143 Methanosarcina.788 - mls.809 mls:MSLAZ_0753 5,10-methylenetetrahydrofolate reductase OC.378628 Archaea.26952 Euryarchaeota.30143 Methanosarcina.788 Methanosarcina_siciliae.1810 msj.3032 msj:MSSAC_3223 5,10-methylenetetrahydrofolate reductase OC.378628 Archaea.26952 Euryarchaeota.30143 Methanosarcina.788 Methanosarcina_siciliae.1810 msz.1061 msz:MSSIH_1054 5,10-methylenetetrahydrofolate reductase OC.378628 Archaea.26952 Euryarchaeota.30143 Methanosarcina.788 Methanosarcina_siciliae.1810 msw.1118 msw:MSSIT_1101 5,10-methylenetetrahydrofolate reductase OC.378628 Archaea.26952 Euryarchaeota.30143 Methanosarcina.788 Methanosarcina_thermophila.1280 mthe.2214 mthe:MSTHC_2217 5,10-methylenetetrahydrofolate reductase OC.378628 Archaea.26952 Euryarchaeota.30143 Methanosarcina.788 Methanosarcina_thermophila.1280 mthr.1086 mthr:MSTHT_1086 5,10-methylenetetrahydrofolate reductase OC.378628 Archaea.26952 Euryarchaeota.30143 Methanosarcina.788 - mhor.2980 mhor:MSHOH_3061 5,10-methylenetetrahydrofolate reductase OC.378628 Archaea.26952 Euryarchaeota.30143 Methanococcoides.527 - mbu.1639 mbu:Mbur_1847 methylenetetrahydrofolate reductase OC.378628 Archaea.26952 Euryarchaeota.30143 Methanococcoides.527 - mmet.109 mmet:MCMEM_0080 5,10-methylenetetrahydrofolate reductase OC.378628 Archaea.26952 Euryarchaeota.30143 Methanohalophilus.1524 - mmh.1856 mmh:Mmah_1910 methylenetetrahydrofolate reductase OC.378628 Archaea.26952 Euryarchaeota.30143 Methanohalophilus.1524 - mhaz.792 mhaz:BHR79_04090 5,10-methylenetetrahydrofolate reductase OC.378628 Archaea.26952 Euryarchaeota.30143 - - mev.187 mev:Metev_0070 methylenetetrahydrofolate reductase OC.378628 Archaea.26952 Euryarchaeota.30143 - - mzh.116 mzh:Mzhil_0065 methylenetetrahydrofolate reductase OC.378628 Archaea.26952 Euryarchaeota.30143 - - mpy.1714 mpy:Mpsy_1816 methylenetetrahydrofolate reductase OC.378628 Archaea.26952 Euryarchaeota.30143 - - mhz.2213 mhz:Metho_2393 5,10-methylenetetrahydrofolate reductase OC.378628 Archaea.83532 Euryarchaeota.69454 - - mer.109 mer:MMINT_00390 methylenetetrahydrofolate reductase; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.378629 Archaea.38992 - - - loki.63 loki:Lokiarch_01280 yitJ_1; Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase OC.378629 Archaea.38992 - - - loki.63 loki:Lokiarch_01390 yitJ_2; Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase OC.378630 Archaea.58876 Euryarchaeota.43759 Halodesulfurarchaeum.205 - halh.1186 halh:HTSR_1220 methylenetetrahydrofolate reductase (NADPH); K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.378630 Archaea.58876 Euryarchaeota.43759 Halodesulfurarchaeum.205 - hhsr.1255 hhsr:HSR6_1290 metF; methylenetetrahydrofolate reductase (NADPH); K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.378631 Archaea.32547 Euryarchaeota.37352 Thermoplasma.1110 - tac.955 tac:Ta0979 5, 10-methylenetetrahydrofolate reductase related protein OC.378631 Archaea.32547 Euryarchaeota.37352 Thermoplasma.1110 - tvo.1147 tvo:TVG1178481 TVG1178481; hypothetical protein OC.378631 Archaea.32547 Euryarchaeota.37352 - - cdiv.1730 cdiv:CPM_1928 5,10-methylenetetrahydrofolate reductase; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20]; K00547 homocysteine S-methyltransferase [EC:2.1.1.10] OC.378632 Bacteria.283199 Actinobacteria.142401 Nocardiopsis.8423 - ngv.1986 ngv:CDO52_10645 hypothetical protein; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.378632 Bacteria.283199 Actinobacteria.142401 Planktophila.1570 - plim.936 plim:PHILAsVB114_04880 methylenetetrahydrofolate reductase (NADPH); K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.378632 Bacteria.283199 Actinobacteria.142401 Planktophila.1570 - pvn.954 pvn:A7sIIA15_04930 methylenetetrahydrofolate reductase (NADPH); K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.378633 Bacteria.283200 Proteobacteria.583473 Deltaproteobacteria.89980 Sorangium.5861 scl.8713 scl:sce8996 Methylenetetrahydrofolate reductase (NAD(P)H); K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.378633 Bacteria.283200 Proteobacteria.583473 Deltaproteobacteria.89980 Sorangium.5861 scu.9692 scu:SCE1572_51140 hypothetical protein; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20]