# OC Root 2nd 3rd 4th 5th 6th PC Gene/Definition OC.419887 Bacteria.333721 Proteobacteria.266537 Deltaproteobacteria.22714 Desulfococcus.5592 - dol.2266 dol:Dole_2330 Methylenetetrahydrofolate reductase (NAD(P)H); K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Proteobacteria.266537 Deltaproteobacteria.22714 - - dal.1865 dal:Dalk_1779 Methylenetetrahydrofolate reductase; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Proteobacteria.266537 Deltaproteobacteria.22714 - - dat.1672 dat:HRM2_16730 metF1; MetF1; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Proteobacteria.266537 Deltaproteobacteria.22714 - - dto.1750 dto:TOL2_C17810 metF3; MetF3: 5,10-methylenetetrahydrofolate reductase; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Proteobacteria.256383 Deltaproteobacteria.10059 Anaeromyxobacter.59 Anaeromyxobacter_dehalogenans.1049 ade.2669 ade:Adeh_2676 5,10-methylenetetrahydrofolate reductase; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Proteobacteria.256383 Deltaproteobacteria.10059 Anaeromyxobacter.59 Anaeromyxobacter_dehalogenans.1049 acp.2829 acp:A2cp1_2862 5,10-methylenetetrahydrofolate reductase; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Proteobacteria.256383 Deltaproteobacteria.10059 Anaeromyxobacter.59 Anaeromyxobacter_sp_.2955 afw.2623 afw:Anae109_2667 5,10-methylenetetrahydrofolate reductase; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Proteobacteria.256383 Deltaproteobacteria.10059 Anaeromyxobacter.59 Anaeromyxobacter_sp_.6537 ank.2752 ank:AnaeK_2769 5,10-methylenetetrahydrofolate reductase; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Proteobacteria.256382 Deltaproteobacteria.10058 Myxococcus.3802 - mxa.2958 mxa:MXAN_3039 metF; 5,10-methylenetetrahydrofolate reductase; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Proteobacteria.256382 Deltaproteobacteria.10058 Myxococcus.3802 - mfu.4517 mfu:LILAB_22945 5,10-methylenetetrahydrofolate reductase; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Proteobacteria.256382 Deltaproteobacteria.10058 Myxococcus.9647 - msd.3454 msd:MYSTI_03501 5,10-methylenetetrahydrofolate reductase; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Proteobacteria.256382 Deltaproteobacteria.10058 Myxococcus.3802 - mym.3956 mym:A176_003966 5,10-methylenetetrahydrofolate reductase; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Proteobacteria.256382 Deltaproteobacteria.10058 Myxococcus.3802 - mmas.2936 mmas:MYMAC_002987 5,10-methylenetetrahydrofolate reductase; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Proteobacteria.256382 Deltaproteobacteria.10058 - - ccx.4849 ccx:COCOR_05004 metF; 5,10-methylenetetrahydrofolate reductase; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Proteobacteria.256382 Deltaproteobacteria.10058 - - sur.4857 sur:STAUR_5050 metF; Methylenetetrahydrofolate reductase; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Proteobacteria.256382 Deltaproteobacteria.10058 - - age.6449 age:AA314_06618 5,10-methylenetetrahydrofolate reductase; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Proteobacteria.256382 Deltaproteobacteria.10058 - - mbd.317 mbd:MEBOL_000135 5,10-methylenetetrahydrofolate reductase; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Proteobacteria.256382 Deltaproteobacteria.10058 - - cfus.6059 cfus:CYFUS_006328 5,10-methylenetetrahydrofolate reductase; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Proteobacteria.607457 Deltaproteobacteria.121451 - - hmr.1364 hmr:Hipma_1430 5,10-methylenetetrahydrofolate reductase; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Proteobacteria.224899 Other_proteobacteria.6681 Mariprofundus.1053 - maes.2169 maes:Ga0123461_2241 5,10-methylenetetrahydrofolate reductase (NAD(P)); K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Proteobacteria.224899 Other_proteobacteria.6681 Mariprofundus.1053 - mfn.262 mfn:Ga0123462_0261 5,10-methylenetetrahydrofolate reductase (NAD(P)); K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Firmicutes.127652 Firmicutes___Clostridia.66812 - - dae.594 dae:Dtox_0534 Methylenetetrahydrofolate reductase (NAD(P)H); K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Firmicutes.127652 Firmicutes___Clostridia.66812 Dehalobacter.1689 Dehalobacter_sp_.487 ded.1441 ded:DHBDCA_p2312 5,10-methylenetetrahydrofolate reductase; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Firmicutes.127652 Firmicutes___Clostridia.66812 Dehalobacter.1689 Dehalobacter_sp_.487 dec.1454 dec:DCF50_p2323 5,10-methylenetetrahydrofolate reductase; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Firmicutes.127652 Firmicutes___Clostridia.66812 Dehalobacter.1689 - drs.804 drs:DEHRE_04380 methylenetetrahydrofolate reductase; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Actinobacteria.270519 - - - cwo.1298 cwo:Cwoe_1081 5,10-methylenetetrahydrofolate reductase; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Deinococcus_Thermus.5080 Thermus.2324 Thermus_thermophilus.723 - tth.1646 tth:TT_C1656 methylenetetrahydrofolate reductase; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Deinococcus_Thermus.5080 Thermus.2324 Thermus_thermophilus.723 - ttj.327 ttj:TTHA0327 5,10-methylenetetrahydrofolate reductase; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Deinococcus_Thermus.5080 Thermus.2324 Thermus_thermophilus.723 - tts.68 tts:Ththe16_0050 5,10-methylenetetrahydrofolate reductase; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Deinococcus_Thermus.5080 Thermus.2324 Thermus_thermophilus.723 - ttl.65 ttl:TtJL18_0054 5,10-methylenetetrahydrofolate reductase; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Deinococcus_Thermus.5080 Thermus.2324 - - tsc.181 tsc:TSC_c01680 metF; 5,10-methylenetetrahydrofolate reductase; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Deinococcus_Thermus.5080 Thermus.2324 - - thc.1227 thc:TCCBUS3UF1_21210 5,10-methylenetetrahydrofolate reductase; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Deinococcus_Thermus.5080 Thermus.2324 - - tos.1860 tos:Theos_1957 5,10-methylenetetrahydrofolate reductase; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Deinococcus_Thermus.5080 Thermus.2324 - - taq.101 taq:TO73_0070 5,10-methylenetetrahydrofolate reductase; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Deinococcus_Thermus.5080 Thermus.2324 - - tbc.1250 tbc:A0O31_01362 5,10-methylenetetrahydrofolate reductase; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Deinococcus_Thermus.5080 Meiothermus.1389 Meiothermus_ruber.2389 - mrb.482 mrb:Mrub_0482 5,10-methylenetetrahydrofolate reductase; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Deinococcus_Thermus.5080 Meiothermus.1389 Meiothermus_ruber.2389 - mre.409 mre:K649_02035 5,10-methylenetetrahydrofolate reductase; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Deinococcus_Thermus.5080 Meiothermus.1389 - - msv.696 msv:Mesil_0674 5,10-methylenetetrahydrofolate reductase; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Deinococcus_Thermus.5080 Meiothermus.1389 - - mtai.419 mtai:Mtai_v1c04060 5,10-methylenetetrahydrofolate reductase; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Deinococcus_Thermus.5080 - - - mhd.1115 mhd:Marky_1160 5,10-methylenetetrahydrofolate reductase; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Verrucomicrobia.1130 - - - ote.4032 ote:Oter_4187 5,10-methylenetetrahydrofolate reductase; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Verrucomicrobia.1130 - - - obg.2266 obg:Verru16b_02362 metF; 5,10-methylenetetrahydrofolate reductase; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Verrucomicrobia.1130 - - - obt.3427 obt:OPIT5_19790 5,10-methylenetetrahydrofolate reductase; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Verrucomicrobia.1130 - - - caa.1298 caa:Caka_1393 5,10-methylenetetrahydrofolate reductase; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Verrucomicrobia.1130 - - - vba.627 vba:IMCC26134_03385 5,10-methylenetetrahydrofolate reductase; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Verrucomicrobia.1130 - - - vbh.868 vbh:CMV30_04060 metF; methylenetetrahydrofolate reductase [NAD(P)H]; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Planctomycetes.9110 - - - rba.5621 rba:RB7546 metF; 5,10-methylenetetrahydrofolate reductase; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Planctomycetes.9111 Pirellula.793 - - psl.1741 psl:Psta_1766 5,10-methylenetetrahydrofolate reductase; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Planctomycetes.9111 Pirellula.793 - - pir.4169 pir:VN12_22560 metF; 5,10-methylenetetrahydrofolate reductase; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Planctomycetes.9110 - - - plm.3883 plm:Plim_3996 5,10-methylenetetrahydrofolate reductase; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Planctomycetes.9110 - - - pbs.2220 pbs:Plabr_2291 5,10-methylenetetrahydrofolate reductase; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Planctomycetes.9110 Planctomyces.7064 - - pls.1939 pls:VT03_09325 metF; 5,10-methylenetetrahydrofolate reductase; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Planctomycetes.9110 - - - fmr.977 fmr:Fuma_00841 metF; 5,10-methylenetetrahydrofolate reductase; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Spirochaetes.5632 Leptospira.2587 Leptospira_interrogans.2543 - lil.3360 lil:LB_002 metF; 5,10-methylenetetrahydrofolate reductase; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Spirochaetes.5632 Leptospira.2587 Leptospira_interrogans.2543 - lie.3383 lie:LIF_B002 metF; 5,10 methylene tetrahydrofolate reductase; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Spirochaetes.5632 Leptospira.2587 Leptospira_interrogans.2543 - lic.3368 lic:LIC_20002 metF; 5,10 methylene tetrahydrofolate reductase; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Spirochaetes.5632 Leptospira.2587 Leptospira_interrogans.2543 - lis.3500 lis:LIL_20002 metF; 5,10-methylenetetrahydrofolate reductase; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Spirochaetes.5632 Leptospira.2587 Leptospira_borgpetersenii.1711 - lbj.2568 lbj:LBJ_4004 metF; 5,10-methylenetetrahydrofolate reductase; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Spirochaetes.5632 Leptospira.2587 Leptospira_borgpetersenii.1711 - lbl.2606 lbl:LBL_4004 metF; 5,10-methylenetetrahydrofolate reductase; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Spirochaetes.5632 Leptospira.2587 - - lst.1604 lst:LSS_08619 5,10-methylenetetrahydrofolate reductase; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Spirochaetes.5632 Leptospira.2587 - - laj.3743 laj:A0128_19365 methylenetetrahydrofolate reductase [NAD(P)H]; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Spirochaetes.5632 Leptospira.2587 - - lmay.3303 lmay:DPV73_19230 metF; methylenetetrahydrofolate reductase [NAD(P)H]; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Bacteroidetes.135934 - - - blq.3338 blq:L21SP5_03805 metF; 5,10-methylenetetrahydrofolate reductase; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Aquificae.505 - - - aae.417 aae:aq_1429 metF; 5,10-methylenetetrahydrofolate reductase; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Aquificae.505 Hydrogenobaculum.528 - - hya.1550 hya:HY04AAS1_1567 5,10-methylenetetrahydrofolate reductase; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Aquificae.505 Hydrogenobaculum.528 - - hho.1476 hho:HydHO_1511 5,10-methylenetetrahydrofolate reductase (NAD(P)); K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Aquificae.505 Hydrogenobaculum.528 - - hys.1473 hys:HydSN_1554 5,10-methylenetetrahydrofolate reductase; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Aquificae.505 Hydrogenobacter.1396 - - hth.611 hth:HTH_0616 metF; 5,10-methylenetetrahydrofolate reductase; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Aquificae.505 Hydrogenobacter.1396 - - hte.602 hte:Hydth_0615 5,10-methylenetetrahydrofolate reductase; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Aquificae.505 Thermocrinis.1151 - - tal.527 tal:Thal_0525 5,10-methylenetetrahydrofolate reductase; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Aquificae.505 Thermocrinis.2141 - - trd.1251 trd:THERU_06595 5,10-methylenetetrahydrofolate reductase; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Aquificae.505 Sulfurihydrogenibium.1135 - - sul.463 sul:SYO3AOP1_0477 5,10-methylenetetrahydrofolate reductase; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Aquificae.505 Sulfurihydrogenibium.1135 - - saf.744 saf:SULAZ_0776 metF; 5,10-methylenetetrahydrofolate reductase; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Aquificae.505 - - - pmx.98 pmx:PERMA_0068 metF; 5,10-methylenetetrahydrofolate reductase; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Aquificae.8199 - - - ttk.1525 ttk:TST_1570 metF; methylenetetrahydrofolate reductase (NADPH); K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Deferribacteres.293 - - - ddf.1099 ddf:DEFDS_1143 metF; 5,10-methylenetetrahydrofolate reductase; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Deferribacteres.293 - - - dap.1794 dap:Dacet_1936 5,10-methylenetetrahydrofolate reductase; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Deferribacteres.293 - - - cni.1347 cni:Calni_1364 5,10-methylenetetrahydrofolate reductase; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 Deferribacteres.293 - - - fsi.1301 fsi:Flexsi_1430 5,10-methylenetetrahydrofolate reductase; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] OC.419887 Bacteria.333721 - - - - mox.1288 mox:DAMO_1364 metF; 5,10-methylenetetrahydrofolate reductase; K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20]