# OC Root 2nd 3rd 4th 5th 6th PC Gene/Definition OC.455597 Bacteria.263289 Proteobacteria.646925 Gammaproteobacteria.198324 Pseudomonas.44471 - pazo.581 pazo:AYR47_02975 cyclase OC.455597 Bacteria.263289 Proteobacteria.646925 Gammaproteobacteria.198324 Pseudomonas.44471 Pseudomonas_sp_.37795 psk.5385 psk:U771_27685 cyclase OC.455597 Bacteria.263289 Proteobacteria.723573 Gammaproteobacteria.331470 Nitrosococcus.3322 - nhl.1725 nhl:Nhal_1888 cyclase family protein OC.455597 Bacteria.263289 Proteobacteria.133865 Gammaproteobacteria.414664 - - gai.5700 gai:IMCC3135_30715 kynB_2; Kynurenine formamidase OC.455597 Bacteria.263289 Proteobacteria.646925 Gammaproteobacteria.198324 - - hch.1572 hch:HCH_01555 predicted metal-dependent hydrolase OC.455597 Bacteria.263289 Proteobacteria.280966 Deltaproteobacteria.46458 - - age.4755 age:AA314_04804 Metal-dependent hydrolase OC.455597 Bacteria.263289 Proteobacteria.280966 Deltaproteobacteria.46458 Sorangium.5737 - scl.8516 scl:sce8783 hypothetical protein OC.455597 Bacteria.263289 Proteobacteria.280966 Deltaproteobacteria.46458 Sorangium.5737 - scu.9524 scu:SCE1572_50225 hypothetical protein OC.455597 Bacteria.263289 Proteobacteria.611916 Deltaproteobacteria.127162 - - llu.5353 llu:AKJ09_05788 hypothetical protein OC.455597 Bacteria.263289 Proteobacteria.133865 Alphaproteobacteria.40773 Mesorhizobium.9267 Mesorhizobium_sp_.1370 meso.1200 meso:BSQ44_05970 cyclase OC.455597 Bacteria.263289 Proteobacteria.133865 Alphaproteobacteria.40773 Aminobacter.6497 - amih.211 amih:CO731_00107 kynB; Kynurenine formamidase OC.455597 Bacteria.263289 Proteobacteria.133865 Alphaproteobacteria.40773 Sinorhizobium.2541 Sinorhizobium_meliloti.3419 sme.4074 sme:SMc01459 hypothetical protein OC.455597 Bacteria.263289 Proteobacteria.133865 Alphaproteobacteria.40773 Sinorhizobium.2541 Sinorhizobium_meliloti.3419 smk.2121 smk:Sinme_2120 cyclase family protein OC.455597 Bacteria.263289 Proteobacteria.133865 Alphaproteobacteria.40773 Sinorhizobium.2541 Sinorhizobium_meliloti.3419 smq.1925 smq:SinmeB_1964 cyclase family protein OC.455597 Bacteria.263289 Proteobacteria.133865 Alphaproteobacteria.40773 Sinorhizobium.2541 Sinorhizobium_meliloti.3419 smx.1225 smx:SM11_chr1176 hypothetical protein OC.455597 Bacteria.263289 Proteobacteria.133865 Alphaproteobacteria.40773 Sinorhizobium.2541 Sinorhizobium_meliloti.3419 smi.1991 smi:BN406_01964 hypothetical protein OC.455597 Bacteria.263289 Proteobacteria.133865 Alphaproteobacteria.40773 Sinorhizobium.2541 Sinorhizobium_meliloti.3419 smeg.2162 smeg:C770_GR4Chr2197 putative metal-dependent hydrolase OC.455597 Bacteria.263289 Proteobacteria.133865 Alphaproteobacteria.40773 Sinorhizobium.2541 Sinorhizobium_meliloti.3419 smel.4119 smel:SM2011_c01459 putative transmembrane protein OC.455597 Bacteria.263289 Proteobacteria.133865 Alphaproteobacteria.40773 Sinorhizobium.2541 Sinorhizobium_meliloti.3419 smer.2247 smer:DU99_12030 cyclase OC.455597 Bacteria.263289 Proteobacteria.133865 Alphaproteobacteria.40773 Sinorhizobium.2541 - smd.2049 smd:Smed_2035 cyclase family protein OC.455597 Bacteria.263289 Proteobacteria.133865 Alphaproteobacteria.40773 Sinorhizobium.2541 Sinorhizobium_fredii.2689 rhi.4607 rhi:NGR_c20750 cyclase family protein OC.455597 Bacteria.263289 Proteobacteria.133865 Alphaproteobacteria.40773 Sinorhizobium.2541 Sinorhizobium_fredii.2689 sfh.2009 sfh:SFHH103_01975 hypothetical protein OC.455597 Bacteria.263289 Proteobacteria.133865 Alphaproteobacteria.40773 Sinorhizobium.2541 Sinorhizobium_fredii.2689 sfd.4334 sfd:USDA257_c44670 putative transmembrane protein OC.455597 Bacteria.263289 Proteobacteria.133865 Alphaproteobacteria.40773 Sinorhizobium.22667 Sinorhizobium_sp_.12245 six.5845 six:BSY16_691 cyclase family protein OC.455597 Bacteria.263289 Proteobacteria.133865 Alphaproteobacteria.40773 Sinorhizobium.2541 - same.2402 same:SAMCFNEI73_Ch2429 cyclase family protein OC.455597 Bacteria.263289 Proteobacteria.133865 Alphaproteobacteria.40773 Sinorhizobium.2541 Sinorhizobium_sp_.4466 sino.4392 sino:SS05631_c22130 hypothetical protein OC.455597 Bacteria.263289 Proteobacteria.133865 Alphaproteobacteria.40773 Ensifer.42 Ensifer_adhaerens.1456 ead.2696 ead:OV14_3540 putative cyclase family protein OC.455597 Bacteria.263289 Proteobacteria.133865 Alphaproteobacteria.40773 Ensifer.42 Ensifer_adhaerens.1456 eah.2135 eah:FA04_10725 cyclase OC.455597 Bacteria.263289 Proteobacteria.133865 Alphaproteobacteria.40773 Ensifer.42 - esj.4415 esj:SJ05684_c22250 hypothetical protein OC.455597 Bacteria.263289 Proteobacteria.133865 Alphaproteobacteria.40774 Agrobacterium.4655 - atu.4342 atu:Atu4769 hypothetical protein OC.455597 Bacteria.263289 Proteobacteria.133865 Alphaproteobacteria.40774 Agrobacterium.4655 Agrobacterium_tumefaciens.7677 atf.2777 atf:Ach5_27760 cyclase OC.455597 Bacteria.263289 Proteobacteria.133865 Alphaproteobacteria.40774 Agrobacterium.4655 Agrobacterium_tumefaciens.408 ata.342 ata:AWN88_01805 cyclase OC.455597 Bacteria.263289 Proteobacteria.133865 Alphaproteobacteria.40774 Agrobacterium.4655 Agrobacterium_sp_.7708 agr.3075 agr:AGROH133_10041 putative cyclase protein OC.455597 Bacteria.263289 Proteobacteria.133865 Alphaproteobacteria.40774 Agrobacterium.10609 Agrobacterium_sp_.3588 agc.3546 agc:BSY240_4245 cyclase family protein OC.455597 Bacteria.263289 Proteobacteria.133865 Alphaproteobacteria.40774 Rhizobium.29934 Rhizobium_sp_.26210 rir.4746 rir:BN877_II1891 putative cyclase protein OC.455597 Bacteria.263289 Proteobacteria.133865 Alphaproteobacteria.40774 Rhizobium.24994 Rhizobium_sp_.20500 rht.2406 rht:NT26_2401 conserved exported protein of unknown function OC.455597 Bacteria.263289 Proteobacteria.133865 Alphaproteobacteria.40774 Rhizobium.27821 Rhizobium_sp_.23511 rhv.3175 rhv:BA939_16880 cyclase OC.455597 Bacteria.263289 Proteobacteria.133865 Alphaproteobacteria.40773 - - shz.2205 shz:shn_11150 cyclase OC.455597 Bacteria.263289 Proteobacteria.133865 Alphaproteobacteria.164191 - - sno.1116 sno:Snov_1101 cyclase family protein OC.455597 Bacteria.263289 Proteobacteria.133865 Alphaproteobacteria.40774 - - aua.3387 aua:M673_17095 hypothetical protein OC.455597 Bacteria.263289 Proteobacteria.133865 Alphaproteobacteria.164193 - - brn.2114 brn:D1F64_11760 cyclase family protein OC.455597 Bacteria.263289 Proteobacteria.133865 Alphaproteobacteria.40774 Ruegeria.11669 - sil.767 sil:SPO0761 cyclase family protein OC.455597 Bacteria.263289 Proteobacteria.133865 Alphaproteobacteria.40774 Ruegeria.3356 Ruegeria_sp_.2762 rua.2565 rua:D1823_13140 cyclase family protein OC.455597 Bacteria.263289 Proteobacteria.133865 Alphaproteobacteria.40773 Rhodobacter.1283 Rhodobacter_sphaeroides.2167 rsp.3159 rsp:RSP_3383 putative metal-dependent hydrolase OC.455597 Bacteria.263289 Proteobacteria.133865 Alphaproteobacteria.40773 Rhodobacter.1283 Rhodobacter_sphaeroides.2167 rsh.2994 rsh:Rsph17029_3029 cyclase family protein OC.455597 Bacteria.263289 Proteobacteria.133865 Alphaproteobacteria.40773 Rhodobacter.1283 Rhodobacter_sphaeroides.2167 rsq.3645 rsq:Rsph17025_3859 hypothetical protein OC.455597 Bacteria.263289 Proteobacteria.133865 Alphaproteobacteria.40773 Rhodobacter.1283 Rhodobacter_sphaeroides.2167 rsk.3502 rsk:RSKD131_3549 Cyclase family protein precursor OC.455597 Bacteria.263289 Proteobacteria.133865 Alphaproteobacteria.40774 - - jan.1752 jan:Jann_1749 Twin-arginine translocation pathway signal OC.455597 Bacteria.263289 Proteobacteria.133865 Alphaproteobacteria.40774 Roseobacter.2420 - rde.3506 rde:RD1_3797 cyclase, putative OC.455597 Bacteria.263289 Proteobacteria.133865 Alphaproteobacteria.40774 Roseobacter.2420 - rli.664 rli:RLO149_c006460 hypothetical protein OC.455597 Bacteria.263289 Proteobacteria.133865 Alphaproteobacteria.40774 Paracoccus.4306 - pami.2410 pami:JCM7686_2533 hypothetical protein OC.455597 Bacteria.263289 Proteobacteria.133865 Alphaproteobacteria.40774 Paracoccus.4306 - pye.2737 pye:A6J80_14880 cyclase family protein OC.455597 Bacteria.263289 Proteobacteria.133865 Alphaproteobacteria.40774 Paracoccus.4306 - pzh.2823 pzh:CX676_14395 cyclase OC.455597 Bacteria.263289 Proteobacteria.133865 Alphaproteobacteria.40774 Paracoccus.4306 - pmut.1656 pmut:DPM13_13625 cyclase family protein OC.455597 Bacteria.263289 Proteobacteria.133864 Alphaproteobacteria.164192 - - psf.5039 psf:PSE_p0143 cyclase family protein OC.455597 Bacteria.263289 Proteobacteria.133865 Alphaproteobacteria.40774 - - red.2344 red:roselon_02508 cyclase family protein OC.455597 Bacteria.263289 Proteobacteria.133865 Alphaproteobacteria.40774 Rhodovulum.1936 - rsu.2274 rsu:NHU_02485 cyclase family protein precursor OC.455597 Bacteria.263289 Proteobacteria.133865 Alphaproteobacteria.40774 Rhodovulum.1936 Rhodovulum_sp_.5207 rhm.1391 rhm:B5V46_07205 cyclase OC.455597 Bacteria.263289 Proteobacteria.133865 Alphaproteobacteria.40774 Rhodovulum.5224 Rhodovulum_sp_.3622 rhc.3461 rhc:RGUI_3516 cyclase family protein OC.455597 Bacteria.263289 Proteobacteria.133865 Alphaproteobacteria.40773 - - pphr.1237 pphr:APZ00_06365 cyclase OC.455597 Bacteria.263289 Proteobacteria.133865 Alphaproteobacteria.40773 Labrenzia.6075 Labrenzia_sp_.4473 labr.3840 labr:CHH27_19945 cyclase OC.455597 Bacteria.263289 Proteobacteria.133865 Alphaproteobacteria.40774 - - daa.3708 daa:AKL17_3618 hypothetical protein OC.455597 Bacteria.263289 Proteobacteria.133865 Alphaproteobacteria.40774 Sulfitobacter.6701 Sulfitobacter_sp_.6534 suli.2197 suli:C1J05_11585 cyclase OC.455597 Bacteria.263289 Proteobacteria.133865 Alphaproteobacteria.40773 Sulfitobacter.7085 Sulfitobacter_sp_.6950 suli.2662 suli:C1J05_14165 cyclase OC.455597 Bacteria.263289 Proteobacteria.133865 Alphaproteobacteria.40774 - - tom.2147 tom:BWR18_11025 cyclase OC.455597 Bacteria.263289 Proteobacteria.133865 Alphaproteobacteria.40774 Roseovarius.1540 - rmm.2425 rmm:ROSMUCSMR3_02444 kynB; kynurenine formamidase OC.455597 Bacteria.263289 Proteobacteria.133865 Alphaproteobacteria.40774 Roseovarius.1540 - rok.745 rok:RAK1035_0739 Cyclase family protein OC.455597 Bacteria.263289 Proteobacteria.133865 Alphaproteobacteria.40775 - - lvs.2279 lvs:LOKVESSMR4R_02288 kynB; kynurenine formamidase OC.455597 Bacteria.263289 Proteobacteria.133865 Alphaproteobacteria.40774 - - sagu.1066 sagu:CDO87_05360 cyclase OC.455597 Bacteria.263289 Proteobacteria.133865 Alphaproteobacteria.164194 - - sagu.4499 sagu:CDO87_23105 cyclase OC.455597 Bacteria.263289 Proteobacteria.133865 Alphaproteobacteria.40773 - - pgv.109 pgv:SL003B_0034 Cyclase family protein OC.455597 Bacteria.263289 Actinobacteria.140552 Nocardia.1867 Nocardia_farcinica.2836 - nfa.3870 nfa:NFA_44670 hypothetical protein OC.455597 Bacteria.263289 Actinobacteria.140552 Nocardia.1867 Nocardia_farcinica.2836 - nfr.5363 nfr:ERS450000_05465 kynB_3; Kynurenine formamidase OC.455597 Bacteria.263289 Actinobacteria.140552 Nocardia.1867 - - nno.3932 nno:NONO_c40050 cyclase family protein OC.455597 Bacteria.263289 Actinobacteria.140552 Nocardia.1867 - - nsl.2981 nsl:BOX37_15510 cyclase OC.455597 Bacteria.263289 Actinobacteria.140552 Nocardia.1867 - - ntp.3797 ntp:CRH09_19890 cyclase OC.455597 Bacteria.263289 Actinobacteria.140552 Rhodococcus.4090 - - rha.5703 rha:RHA1_ro05705 conserved hypothetical protein OC.455597 Bacteria.263289 Actinobacteria.140552 Rhodococcus.4090 Rhodococcus_erythropolis.3105 - rer.4307 rer:RER_43140 conserved hypothetical protein OC.455597 Bacteria.263289 Actinobacteria.140552 Rhodococcus.4090 Rhodococcus_erythropolis.3105 - rey.3980 rey:O5Y_20220 hypothetical protein OC.455597 Bacteria.263289 Actinobacteria.140552 Rhodococcus.4090 Rhodococcus_erythropolis.3105 - reb.3991 reb:XU06_20375 cyclase OC.455597 Bacteria.263289 Actinobacteria.140552 Rhodococcus.4090 Rhodococcus_opacus.773 - rop.5737 rop:ROP_57740 hypothetical protein OC.455597 Bacteria.263289 Actinobacteria.140552 Rhodococcus.4090 Rhodococcus_opacus.773 - roa.2394 roa:Pd630_LPD02320 Kynurenine formamidase OC.455597 Bacteria.263289 Actinobacteria.140552 Rhodococcus.4090 - - req.3546 req:REQ_37490 putative cyclase OC.455597 Bacteria.263289 Actinobacteria.140552 Rhodococcus.4093 Rhodococcus_sp_.5309 - rhb.4131 rhb:NY08_4762 hypothetical protein OC.455597 Bacteria.263289 Actinobacteria.140552 Rhodococcus.4090 - - rav.3582 rav:AAT18_19240 cyclase OC.455597 Bacteria.263289 Actinobacteria.140552 Rhodococcus.4092 - - rrz.1694 rrz:CS378_08700 cyclase OC.455597 Bacteria.263289 Actinobacteria.140552 Rhodococcus.4090 - - rqi.4177 rqi:C1M55_21720 cyclase family protein OC.455597 Bacteria.263289 Actinobacteria.140552 Rhodococcus.4090 Rhodococcus_sp_.6074 - rhod.394 rhod:AOT96_01770 cyclase OC.455597 Bacteria.263289 Actinobacteria.83058 Nocardiopsis.2973 - - nda.2847 nda:Ndas_2933 cyclase family protein OC.455597 Bacteria.263289 Actinobacteria.83058 Nocardiopsis.2973 - - nal.5270 nal:B005_5473 cyclase family protein OC.455597 Bacteria.263289 Actinobacteria.83058 - - - gob.1416 gob:Gobs_1475 cyclase family protein OC.455597 Bacteria.263289 Actinobacteria.83058 Actinoplanes.17665 - - ams.3752 ams:AMIS_43960 putative cyclase OC.455597 Bacteria.263289 Cyanobacteria.16949 - - - mic.1192 mic:Mic7113_1119 putative metal-dependent hydrolase OC.455597 Bacteria.263289 Cyanobacteria.16949 Oscillatoria.1252 - - oac.636 oac:Oscil6304_0472 putative metal-dependent hydrolase OC.455597 Bacteria.263289 Cyanobacteria.16949 Oscillatoria.7911 - - oni.2663 oni:Osc7112_2881 cyclase family protein OC.455597 Bacteria.263289 Cyanobacteria.16949 - - - cep.898 cep:Cri9333_0976 cyclase family protein OC.455597 Bacteria.263289 Cyanobacteria.16949 Nostoc.8523 Nostoc_sp_.2311 - ana.4245 ana:alr3769 hypothetical protein OC.455597 Bacteria.263289 Cyanobacteria.16949 Nostoc.6917 - - npu.1176 npu:Npun_F1204 cyclase family protein OC.455597 Bacteria.263289 Cyanobacteria.16949 Nostoc.17517 Nostoc_sp_.14267 - nop.2286 nop:Nos7524_2394 putative metal-dependent hydrolase OC.455597 Bacteria.263289 Cyanobacteria.16949 Nostoc.8523 Nostoc_sp_.2311 - non.3760 non:NOS3756_38380 hypothetical protein OC.455597 Bacteria.263289 Cyanobacteria.16949 Nostoc.6917 - - nfl.6783 nfl:COO91_07157 Kynurenine formamidase OC.455597 Bacteria.263289 Cyanobacteria.16949 Nostoc.8523 Nostoc_sp_.2311 - noe.1123 noe:CLI64_05685 cyclase OC.455597 Bacteria.263289 Cyanobacteria.16949 Trichormus.1610 - - ava.1570 ava:Ava_1555 Putative cyclase OC.455597 Bacteria.263289 Cyanobacteria.16949 Anabaena.645 Anabaena_sp_.2467 - anb.4146 anb:ANA_C20651 putative cyclase OC.455597 Bacteria.263289 Cyanobacteria.16949 Anabaena.645 - - acy.2238 acy:Anacy_2424 cyclase family protein OC.455597 Bacteria.263289 Cyanobacteria.16949 Anabaena.645 Anabaena_sp_.2467 - awa.1727 awa:AA650_09280 cyclase OC.455597 Bacteria.263289 Cyanobacteria.16949 - - - csg.402 csg:Cylst_0304 putative metal-dependent hydrolase OC.455597 Bacteria.263289 Chloroflexi.3637 Roseiflexus.2677 - - rrs.1175 rrs:RoseRS_1211 cyclase family protein OC.455597 Bacteria.263289 Chloroflexi.3637 Roseiflexus.2677 - - rca.3892 rca:Rcas_4050 cyclase family protein OC.455597 Bacteria.263289 Chloroflexi.3637 Chloroflexus.3599 Chloroflexus_aurantiacus.2478 - cau.3266 cau:Caur_3343 cyclase family protein OC.455597 Bacteria.263289 Chloroflexi.3637 Chloroflexus.3599 Chloroflexus_aurantiacus.2478 - chl.3464 chl:Chy400_3605 cyclase family protein OC.455597 Bacteria.263289 Chloroflexi.20396 - - - cap.2726 cap:CLDAP_27910 hypothetical protein OC.455597 Bacteria.263289 Deinococcus_Thermus.6844 - - - tra.1599 tra:Trad_1650 cyclase family protein OC.455597 Bacteria.263289 Deinococcus_Thermus.6844 Thermus.1778 Thermus_thermophilus.3253 - tts.2061 tts:Ththe16_2143 uncharacterized peroxidase-related enzyme OC.455597 Bacteria.263289 Deinococcus_Thermus.6844 Thermus.1778 Thermus_thermophilus.2918 - ttl.2016 ttl:TtJL18_2109 putative metal-dependent hydrolase OC.455597 Bacteria.263289 Deinococcus_Thermus.6844 Thermus.1778 - - tsc.1041 tsc:TSC_c10680 cyclase family protein OC.455597 Bacteria.263289 Deinococcus_Thermus.6844 Thermus.1778 - - thc.314 thc:TCCBUS3UF1_12820 Cyclase OC.455597 Bacteria.263289 Deinococcus_Thermus.6844 Thermus.1778 - - tos.2309 tos:Theos_2443 putative metal-dependent hydrolase OC.455597 Bacteria.263289 Deinococcus_Thermus.6844 Thermus.1778 - - tbc.2103 tbc:A0O31_02320 kynB; Kynurenine formamidase OC.455597 Bacteria.263289 Deinococcus_Thermus.6844 - - - mhd.742 mhd:Marky_0766 cyclase family protein OC.455597 Bacteria.263289 Verrucomicrobia.10731 - - - min.2225 min:Minf_2358 Kynurenine formamidase OC.455597 Bacteria.263289 Planctomycetes.12288 Planctomyces.9601 - - pls.4514 pls:VT03_24760 kynB; Kynurenine formamidase OC.455597 Bacteria.263289 Planctomycetes.12288 - - - kst.2993 kst:KSMBR1_3423 hypothetical protein OC.455597 Bacteria.263289 Acidobacteria.12492 - - - aba.2539 aba:Acid345_2610 Kynurenine formamidase