# OC Root 2nd 3rd 4th 5th 6th PC Gene/Definition OC.571340 Bacteria.397047 Proteobacteria.266210 Deltaproteobacteria.2208 Anaeromyxobacter.1222 Anaeromyxobacter_dehalogenans.2121 ade.755 ade:Adeh_0750 Beta-lactamase-like protein OC.571340 Bacteria.397047 Proteobacteria.266210 Deltaproteobacteria.2208 Anaeromyxobacter.1222 Anaeromyxobacter_dehalogenans.2121 acp.797 acp:A2cp1_0801 beta-lactamase domain protein OC.571340 Bacteria.397047 Proteobacteria.266210 Deltaproteobacteria.2208 Anaeromyxobacter.1222 Anaeromyxobacter_sp_.1573 afw.825 afw:Anae109_0787 beta-lactamase domain protein OC.571340 Bacteria.397047 Proteobacteria.266210 Deltaproteobacteria.2208 Anaeromyxobacter.1222 Anaeromyxobacter_sp_.5015 ank.806 ank:AnaeK_0797 beta-lactamase domain protein OC.571340 Bacteria.397051 Proteobacteria.560082 Deltaproteobacteria.54070 - - hmr.189 hmr:Hipma_0171 beta-lactamase domain protein OC.571340 Bacteria.397051 Proteobacteria.560082 Deltaproteobacteria.54070 - - dav.1580 dav:DESACE_08620 beta-lactamase OC.571340 Bacteria.456562 Firmicutes.129874 Firmicutes___Clostridia.72321 Desulfotomaculum.1348 - drm.2816 drm:Dred_2993 beta-lactamase domain protein OC.571340 Bacteria.456562 Firmicutes.129874 Firmicutes___Clostridia.72321 Desulfotomaculum.1348 - dca.2364 dca:Desca_2516 beta-lactamase domain protein OC.571340 Bacteria.456562 Firmicutes.129874 Firmicutes___Clostridia.72321 Desulfotomaculum.1348 - dru.3439 dru:Desru_3601 beta-lactamase domain-containing protein OC.571340 Bacteria.456562 Firmicutes.129874 Firmicutes___Clostridia.72321 Desulfotomaculum.1348 - dfg.2727 dfg:B0537_15155 MBL fold metallo-hydrolase OC.571340 Bacteria.456562 Firmicutes.129874 Firmicutes___Clostridia.72321 - - tjr.2547 tjr:TherJR_2714 conserved hypothetical protein OC.571340 Bacteria.456562 Firmicutes.129874 Firmicutes___Clostridia.72321 - - cthm.542 cthm:CFE_0542 Ribonuclease BN, tRNA processing enzyme OC.571340 Bacteria.456562 Firmicutes.129874 Firmicutes___Clostridia.72321 - - chy.312 chy:CHY_0276 conserved hypothetical protein OC.571340 Bacteria.397047 Chloroflexi.5015 Dehalococcoides.1162 Dehalococcoides_mccartyi.3146 - det.1486 det:DET1628 metallo-beta-lactamase family protein OC.571340 Bacteria.397047 Chloroflexi.5015 Dehalococcoides.1162 Dehalococcoides_mccartyi.766 - deh.643 deh:cbdbA1725 metallo-beta-lactamase family protein OC.571340 Bacteria.397047 Chloroflexi.5015 Dehalococcoides.1162 Dehalococcoides_mccartyi.766 - deb.1341 deb:DehaBAV1_1373 beta-lactamase domain protein OC.571340 Bacteria.397047 Chloroflexi.5015 Dehalococcoides.1162 Dehalococcoides_mccartyi.3146 - dev.539 dev:DhcVS_1510 beta-lactamase domain protein OC.571340 Bacteria.397047 Chloroflexi.5015 Dehalococcoides.1162 Dehalococcoides_mccartyi.766 - deg.1363 deg:DehalGT_1421 metallo-beta-lactamase family protein OC.571340 Bacteria.397047 Chloroflexi.5015 Dehalococcoides.1162 Dehalococcoides_mccartyi.766 - dmc.613 dmc:btf_1568 metallo-beta-lactamase family protein OC.571340 Bacteria.397047 Chloroflexi.5015 Dehalococcoides.1162 Dehalococcoides_mccartyi.766 - dmd.558 dmd:dcmb_1514 metallo-beta-lactamase family protein OC.571340 Bacteria.397047 Chloroflexi.5015 Dehalococcoides.1162 Dehalococcoides_mccartyi.3146 - dmg.1480 dmg:GY50_1522 beta-lactamase domain-containing protein OC.571340 Bacteria.397047 Chloroflexi.5015 Dehalococcoides.1162 Dehalococcoides_mccartyi.3146 - dmx.1548 dmx:X792_08150 metallo-beta-lactamase OC.571340 Bacteria.397047 Chloroflexi.5015 Dehalococcoides.1162 Dehalococcoides_mccartyi.3146 - dmy.1434 dmy:X793_07510 metallo-beta-lactamase OC.571340 Bacteria.397047 Chloroflexi.5015 Dehalococcoides.1162 Dehalococcoides_mccartyi.766 - dmz.1414 dmz:X794_07400 metallo-beta-lactamase OC.571340 Bacteria.397047 Chloroflexi.5015 Dehalococcoides.1162 - - duc.1480 duc:UCH007_14960 hypothetical protein OC.571340 Bacteria.397047 Chloroflexi.5015 Dehalogenimonas.572 - - dly.1245 dly:Dehly_1333 beta-lactamase domain-containing protein OC.571340 Bacteria.397047 Chloroflexi.5015 Dehalogenimonas.572 - - dew.1661 dew:DGWBC_1791 metallo-beta-lactamase family protein OC.571340 Bacteria.397047 Chloroflexi.5015 Dehalogenimonas.572 - - dfo.181 dfo:Dform_00055 Ribonuclease BN, tRNA processing enzyme OC.571340 Bacteria.397047 Planctomycetes.31494 - - - kst.2058 kst:KSMBR1_2230 hypothetical protein OC.571340 Bacteria.397049 Synergistetes.1407 - - - tai.797 tai:Taci_0809 beta-lactamase domain-containing protein OC.571340 Bacteria.397049 Synergistetes.1407 - - - tli.1190 tli:Tlie_1230 beta-lactamase domain protein OC.571340 Bacteria.397049 Synergistetes.1407 - - - amo.1387 amo:Anamo_1472 metal-dependent hydrolase, beta-lactamase superfamily III OC.571340 Bacteria.397049 Synergistetes.1407 - - - cpor.1318 cpor:BED41_07140 hypothetical protein OC.571340 Bacteria.397050 Aquificae.2203 - - - aae.552 aae:aq_1625 hypothetical protein OC.571340 Bacteria.397050 Aquificae.2203 Hydrogenobaculum.1435 - - hya.919 hya:HY04AAS1_0922 conserved hypothetical protein OC.571340 Bacteria.397050 Aquificae.2203 Hydrogenobaculum.1435 - - hho.893 hho:HydHO_0917 metallo-beta-lactamase family protein OC.571340 Bacteria.397050 Aquificae.2203 Hydrogenobaculum.1435 - - hys.888 hys:HydSN_0940 metal-dependent hydrolase, beta-lactamase superfamily I OC.571340 Bacteria.397050 Aquificae.2203 Hydrogenobacter.914 - - hth.1864 hth:HTH_1889 metallo-beta-lactamase family protein OC.571340 Bacteria.397050 Aquificae.2203 Hydrogenobacter.914 - - hte.1838 hte:Hydth_1871 conserved hypothetical protein OC.571340 Bacteria.397050 Aquificae.2203 Thermocrinis.90 - - tal.1144 tal:Thal_1159 beta-lactamase domain protein OC.571340 Bacteria.397050 Aquificae.2203 Thermocrinis.90 - - trd.1265 trd:THERU_06675 metallo-beta-lactamase OC.571340 Bacteria.397050 Aquificae.2203 Sulfurihydrogenibium.760 - - sul.716 sul:SYO3AOP1_0751 beta-lactamase domain protein OC.571340 Bacteria.397050 Aquificae.2203 Sulfurihydrogenibium.760 - - saf.293 saf:SULAZ_0293 metallo-beta-lactamase family protein OC.571340 Bacteria.397050 Aquificae.2203 - - - pmx.966 pmx:PERMA_0965 metallo-beta-lactamase family protein OC.571340 Bacteria.397050 Aquificae.2203 - - - ttk.1660 ttk:TST_1718 metallo-beta-lactamase family protein OC.571340 Bacteria.397047 Aquificae.4058 - - - tam.620 tam:Theam_0619 metallo-beta-lactamase family protein OC.571340 Bacteria.397047 Aquificae.4058 - - - dte.540 dte:Dester_0568 metallo-beta-lactamase family protein OC.571340 Bacteria.397048 - - - - cex.1299 cex:CSE_13410 hypothetical protein OC.571340 Bacteria.397048 Thermodesulfobacteria.301 - - - tid.909 tid:Thein_0946 metallo-beta-lactamase family protein OC.571340 Bacteria.397048 Thermodesulfobacteria.301 Thermodesulfobacterium.1618 - - top.547 top:TOPB45_0555 beta-lactamase domain-containing protein OC.571340 Bacteria.397048 Thermodesulfobacteria.301 - - - cthi.519 cthi:THC_0524 metallo-beta-lactamase OC.571340 Bacteria.397048 - - - - bana.179 bana:BARAN1_0164 conserved protein of unknown function OC.571340 Archaea.3913 Euryarchaeota.3697 Methanocaldococcus.239 - - mja.1393 mja:MJ_1374 conserved hypothetical protein OC.571340 Archaea.3913 Euryarchaeota.3697 Methanocaldococcus.239 - - mfe.12 mfe:Mefer_0010 beta-lactamase domain-containing protein OC.571340 Archaea.3913 Euryarchaeota.3697 Methanocaldococcus.239 - - mvu.717 mvu:Metvu_0732 conserved hypothetical protein OC.571340 Archaea.3913 Euryarchaeota.3697 Methanocaldococcus.239 - - mfs.552 mfs:MFS40622_0555 conserved hypothetical protein OC.571340 Archaea.3913 Euryarchaeota.3697 Methanocaldococcus.239 - - mif.116 mif:Metin_0109 beta-lactamase domain-containing protein OC.571340 Archaea.3913 Euryarchaeota.3697 Methanocaldococcus.239 - - mjh.407 mjh:JH146_0407 hypothetical protein OC.571340 Archaea.3913 Euryarchaeota.3697 - - - mig.48 mig:Metig_0009 beta-lactamase domain-containing protein OC.571340 Archaea.3913 Euryarchaeota.3697 Methanococcus.1329 Methanococcus_maripaludis.510 - mmp.1343 mmp:MMP1343 conserved hypothetical protein OC.571340 Archaea.3913 Euryarchaeota.3697 Methanococcus.1329 Methanococcus_maripaludis.510 - mmq.247 mmq:MmarC5_0235 conserved hypothetical protein OC.571340 Archaea.3913 Euryarchaeota.3697 Methanococcus.1329 Methanococcus_maripaludis.510 - mmx.1306 mmx:MmarC6_1330 conserved hypothetical protein OC.571340 Archaea.3913 Euryarchaeota.3697 Methanococcus.1329 Methanococcus_maripaludis.510 - mmz.589 mmz:MmarC7_0588 conserved hypothetical protein OC.571340 Archaea.3913 Euryarchaeota.3697 Methanococcus.1329 Methanococcus_maripaludis.510 - mmd.1466 mmd:GYY_07540 hypothetical protein OC.571340 Archaea.3913 Euryarchaeota.3697 Methanococcus.3370 - - mae.1108 mae:Maeo_1134 conserved hypothetical protein OC.571340 Archaea.3913 Euryarchaeota.3697 Methanococcus.1329 - - mvn.645 mvn:Mevan_0654 conserved hypothetical protein OC.571340 Archaea.3913 Euryarchaeota.3697 Methanococcus.1329 - - mvo.40 mvo:Mvol_0048 Metal-dependent hydrolase of the beta-lactamase superfamily I-like protein OC.571340 Archaea.3913 Euryarchaeota.3697 Methanococcus.1329 - - mvo.40 mvo:Mvol_0108 Metal-dependent hydrolase of the beta-lactamase superfamily I-like protein OC.571340 Archaea.3913 Euryarchaeota.3697 - - - mok.672 mok:Metok_0696 hypothetical protein OC.571340 Archaea.3913 Euryarchaeota.3695 Methanothermobacter.1675 - - mth.1601 mth:MTH_751 conserved protein OC.571340 Archaea.3913 Euryarchaeota.3695 Methanothermobacter.1675 - - mmg.1128 mmg:MTBMA_c11460 predicted metal-dependent hydrolase OC.571340 Archaea.3913 Euryarchaeota.3695 Methanothermobacter.1675 Methanothermobacter_sp_.864 - metc.671 metc:MTCT_0671 conserved hypothetical protein OC.571340 Archaea.3913 Euryarchaeota.3695 Methanothermobacter.1675 - - mwo.1107 mwo:MWSIV6_1125 putative protein MJ1374 OC.571340 Archaea.3913 Euryarchaeota.3695 Methanothermobacter.1675 Methanothermobacter_sp_.864 - mete.715 mete:tca_00719 rbn_1; Ribonuclease BN OC.571340 Archaea.3913 Euryarchaeota.3695 Methanosphaera.1067 - - mst.561 mst:Msp_0575 predicted metal-dependent hydrolase OC.571340 Archaea.3913 Euryarchaeota.3695 Methanosphaera.1067 - - metb.767 metb:AW729_04260 MBL fold metallo-hydrolase OC.571340 Archaea.3913 Euryarchaeota.3695 Methanobrevibacter.271 - - msi.1453 msi:Msm_1473 metal-dependent hydrolase, beta-lactamase superfamily OC.571340 Archaea.3913 Euryarchaeota.3695 Methanobrevibacter.271 - - mru.1505 mru:mru_1562 metallo-beta-lactamase superfamily protein OC.571340 Archaea.3913 Euryarchaeota.3695 Methanobrevibacter.271 Methanobrevibacter_sp_.1194 - meb.1109 meb:Abm4_1182 metallo-beta-lactamase superfamily protein OC.571340 Archaea.3913 Euryarchaeota.3695 Methanobrevibacter.271 - - mmil.1465 mmil:sm9_1594 metallo-beta-lactamase superfamily protein OC.571340 Archaea.3913 Euryarchaeota.3695 Methanobrevibacter.271 Methanobrevibacter_sp_.2821 - meye.1252 meye:TL18_07030 beta-lactamase OC.571340 Archaea.3913 Euryarchaeota.3695 Methanobrevibacter.271 - - mol.1029 mol:YLM1_1048 metallo-beta-lactamase superfamily protein OC.571340 Archaea.3913 Euryarchaeota.3695 Methanobacterium.1994 - - mel.1115 mel:Metbo_1096 metal-dependent hydrolase OC.571340 Archaea.3913 Euryarchaeota.3695 Methanobacterium.1994 - - mew.1052 mew:MSWAN_1066 beta-lactamase superfamily hydrolase OC.571340 Archaea.3913 Euryarchaeota.3695 Methanobacterium.1994 Methanobacterium_sp_.1222 - meth.1178 meth:MBMB1_1203 beta-lactamase superfamily hydrolase OC.571340 Archaea.3913 Euryarchaeota.3695 Methanobacterium.1994 Methanobacterium_formicicum.379 - mfc.1378 mfc:BRM9_1409 metallo-beta-lactamase superfamily protein OC.571340 Archaea.3913 Euryarchaeota.3695 Methanobacterium.1994 Methanobacterium_formicicum.379 - mfi.2047 mfi:DSM1535_2107 beta-lactamase superfamily hydrolase OC.571340 Archaea.3913 Euryarchaeota.3695 Methanobacterium.1994 - - mcub.1068 mcub:MCBB_1101 putative protein MJ1374 OC.571340 Archaea.3913 Euryarchaeota.3695 Methanobacterium.1994 - - msub.452 msub:BK009_02265 MBL fold metallo-hydrolase OC.571340 Archaea.3913 Euryarchaeota.3695 Methanobacterium.1994 Methanobacterium_sp_.3818 - metn.1877 metn:BK008_09930 MBL fold metallo-hydrolase OC.571340 Archaea.3913 Euryarchaeota.3695 - - - mfv.827 mfv:Mfer_0832 beta-lactamase superfamily hydrolase OC.571340 Archaea.3913 Euryarchaeota.3698 - - - mka.350 mka:MK0284 Metal-dependent hydrolase of the beta-lactamase superfamily OC.571340 Archaea.3913 Euryarchaeota.3696 - - - tar.287 tar:TALC_00279 Metal-dependent hydrolases of the beta-lactamase superfamily I OC.571340 Archaea.3913 Euryarchaeota.3696 - - - max.269 max:MMALV_02620 hypothetical protein OC.571340 Archaea.3913 Euryarchaeota.3697 - - - mer.572 mer:MMINT_05850 hypothetical protein OC.571340 Archaea.3913 Euryarchaeota.3696 - - - mear.1009 mear:Mpt1_c10890 rbn1; ribonuclease BN OC.571340 Archaea.3913 Euryarchaeota.3696 - - - marc.1491 marc:AR505_1582 hydrolase beta-lactamase family OC.571340 Archaea.3913 Euryarchaeota.3697 Aciduliprofundum.1092 - - abi.805 abi:Aboo_0810 conserved hypothetical protein OC.571340 Archaea.3913 Euryarchaeota.3697 Aciduliprofundum.1092 - - acf.232 acf:AciM339_0266 metal-dependent hydrolase, beta-lactamase superfamily III OC.571340 Archaea.3913 Euryarchaeota.3697 Pyrococcus.319 - - pho.1933 pho:PH1945 PH1945; 284aa long hypothetical protein OC.571340 Archaea.3913 Euryarchaeota.3697 Pyrococcus.319 - - pab.822 pab:PAB1219 Metal dependent hydrolase OC.571340 Archaea.3913 Euryarchaeota.3697 Pyrococcus.319 Pyrococcus_furiosus.1227 - pfu.216 pfu:PF0213 hypothetical protein OC.571340 Archaea.3913 Euryarchaeota.3697 Pyrococcus.319 Pyrococcus_furiosus.1227 - pfi.32 pfi:PFC_00125 hypothetical protein OC.571340 Archaea.3913 Euryarchaeota.3697 Pyrococcus.319 Pyrococcus_sp_.896 - pyn.858 pyn:PNA2_0861 hypothetical protein OC.571340 Archaea.3913 Euryarchaeota.3697 Pyrococcus.6790 - - pya.1502 pya:PYCH_15550 metal dependent hydrolase OC.571340 Archaea.3913 Euryarchaeota.3697 Pyrococcus.319 Pyrococcus_sp_.2323 - pys.363 pys:Py04_0369 hypothetical protein containing beta-lactamase-like protein OC.571340 Archaea.3913 Euryarchaeota.3697 Pyrococcus.7071 - - pyc.243 pyc:TQ32_01275 hydrolase OC.571340 Archaea.3913 Euryarchaeota.3697 Thermococcus.2964 - - tko.1756 tko:TK1778 predicted hydrolase, metallo-beta-lactamase superfamily OC.571340 Archaea.3913 Euryarchaeota.3697 Thermococcus.2964 - - ton.1788 ton:TON_1788 Hypothetical hydrolase OC.571340 Archaea.3913 Euryarchaeota.3697 Thermococcus.2964 - - tga.611 tga:TGAM_0607 Metal-dependent hydrolase, beta-lactamase superfamily OC.571340 Archaea.3913 Euryarchaeota.3697 Thermococcus.7126 - - tsi.1750 tsi:TSIB_1775 Metal dependent hydrolase OC.571340 Archaea.3913 Euryarchaeota.3697 Thermococcus.7461 - - tba.1659 tba:TERMP_01661 hypothetical protein OC.571340 Archaea.3913 Euryarchaeota.3697 Thermococcus.2964 Thermococcus_sp_.3617 - the.1245 the:GQS_06250 Metal-dependent hydrolase, beta-lactamase superfamily protein OC.571340 Archaea.3913 Euryarchaeota.3697 Thermococcus.2964 Thermococcus_sp_.2128 - tha.1684 tha:TAM4_492 metal dependent hydrolase OC.571340 Archaea.3913 Euryarchaeota.3697 Thermococcus.2964 - - thm.880 thm:CL1_0893 hypothetical protein OC.571340 Archaea.3913 Euryarchaeota.3697 Thermococcus.7126 - - tlt.294 tlt:OCC_01774 metal dependent hydrolase OC.571340 Archaea.3913 Euryarchaeota.3697 Thermococcus.7461 - - ths.1643 ths:TES1_1666 Hypothetical protein OC.571340 Archaea.3913 Euryarchaeota.3697 Thermococcus.2964 - - tnu.1406 tnu:BD01_1439 Metal-dependent hydrolases of the beta-lactamase superfamily I OC.571340 Archaea.3913 Euryarchaeota.3697 Thermococcus.2964 - - teu.638 teu:TEU_03460 hydrolase OC.571340 Archaea.3913 Euryarchaeota.3697 Thermococcus.2964 - - tgy.1368 tgy:X802_07185 metal dependent hydrolase OC.571340 Archaea.3913 Euryarchaeota.3697 Thermococcus.7126 Thermococcus_sp_.7729 - thv.1880 thv:ADU37_CDS18900 metal dependent hydrolase OC.571340 Archaea.3913 Euryarchaeota.3697 Thermococcus.9956 - - tch.431 tch:CHITON_0434 metal dependent hydrolase OC.571340 Archaea.3913 Euryarchaeota.3697 Thermococcus.2964 - - tpep.1204 tpep:A0127_06320 hydrolase OC.571340 Archaea.3913 Euryarchaeota.3697 Thermococcus.2964 - - tpie.538 tpie:A7C91_03130 hydrolase OC.571340 Archaea.3913 Euryarchaeota.3697 Thermococcus.2964 - - tgg.1199 tgg:A3K92_06250 hydrolase OC.571340 Archaea.3913 Euryarchaeota.3697 Thermococcus.2964 - - tce.1527 tce:A3L02_08095 hydrolase OC.571340 Archaea.3913 Euryarchaeota.3697 Thermococcus.2964 - - tbs.1940 tbs:A3L01_10040 hydrolase OC.571340 Archaea.3913 Euryarchaeota.3697 Thermococcus.2964 Thermococcus_sp_.5836 - thh.1917 thh:CDI07_09875 MBL fold metallo-hydrolase OC.571340 Archaea.3913 Euryarchaeota.3697 Thermococcus.2964 - - tsl.645 tsl:A3L11_03335 hydrolase OC.571340 Archaea.3913 Euryarchaeota.3697 Thermococcus.2964 - - ttd.181 ttd:A3L14_00915 hydrolase OC.571340 Archaea.3913 Euryarchaeota.3697 Thermococcus.2964 - - tprf.1760 tprf:A3L09_09115 hydrolase OC.571340 Archaea.3913 Euryarchaeota.3697 Thermococcus.2964 - - trl.1828 trl:A3L10_09420 hydrolase OC.571340 Archaea.3913 Euryarchaeota.3697 Thermococcus.2964 - - tpaf.536 tpaf:A3L08_02785 hydrolase OC.571340 Archaea.3913 Euryarchaeota.3697 - - - ppac.977 ppac:PAP_05035 metal dependent hydrolase OC.571340 Archaea.25685 Euryarchaeota.28454 Methanocella.1822 - - mpd.569 mpd:MCP_0471 conserved hypothetical protein OC.571340 Archaea.25685 Euryarchaeota.28454 Methanocella.1822 - - mez.783 mez:Mtc_0797 Metal-dependent hydrolases of the beta-lactamase superfamily III OC.571340 Archaea.25685 Euryarchaeota.28454 Methanocella.1822 - - rci.1326 rci:RCIX1895 putative metallo-beta-lactamase OC.571340 Archaea.3913 - - - - nac.539 nac:AQV86_02850 hypothetical protein OC.571340 Archaea.3913 Nanoarchaeota.666 - - - neq.120 neq:NEQ122 NEQ122 OC.571340 Archaea.3913 Bathyarchaeota.515 - - - barc.366 barc:AOA65_0292 ribonuclease Z OC.571340 Archaea.3913 Bathyarchaeota.515 - - - barb.479 barb:AOA66_0446 ribonuclease Z OC.571340 Archaea.38951 - - - - loki.580 loki:Lokiarch_11840 rbn_2; Ribonuclease BN OC.571340 Archaea.38951 - - - - loki.580 loki:Lokiarch_52010 rbn_4; Ribonuclease BN