# OC Root 2nd 3rd 4th 5th PC Gene/Definition OC.652774 Archaea.85629 Euryarchaeota.71661 - - mka.478 mka:MK0430 Flavoprotein, possibly involved in thiazole biosynthesis; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652775 Archaea.48990 Crenarchaeota.21678 - - pfm.390 pfm:Pyrfu_0366 thiazole biosynthesis enzyme; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652776 Archaea.86097 Euryarchaeota.72228 - - mla.323 mla:Mlab_0277 thiazole biosynthesis enzyme; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652777 Archaea.31307 Euryarchaeota.35442 Pyrococcus.1397 Pyrococcus_sp_.1935 pyn.1934 pyn:PNA2_1941 ribulose-1,5-biphosphate synthetase; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652777 Archaea.31307 Euryarchaeota.35442 Pyrococcus.1397 - pho.1351 pho:PH1357 PH1357; 255aa long hypothetical thiamine biosynthetic enzyme; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652777 Archaea.31307 Euryarchaeota.35442 Pyrococcus.1397 - pab.365 pab:PAB0536 thi1; Putative thiazole biosynthetic enzyme; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652777 Archaea.31307 Euryarchaeota.35442 Pyrococcus.1397 Pyrococcus_furiosus.338 pfu.1511 pfu:PF1530 thiamine biosynthetic enzyme; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652777 Archaea.31307 Euryarchaeota.35442 Pyrococcus.1397 Pyrococcus_furiosus.338 pfi.1312 pfi:PFC_06880 ribulose-1,5-biphosphate synthetase; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652777 Archaea.31307 Euryarchaeota.35442 Pyrococcus.1398 - pyc.1928 pyc:TQ32_10505 ribonucleoside-triphosphate reductase; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652777 Archaea.31307 Euryarchaeota.35442 Pyrococcus.4919 Pyrococcus_sp_.3124 pys.1197 pys:Py04_1231 ribulose-1,5-biphosphate synthetase; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652777 Archaea.31307 Euryarchaeota.35442 Pyrococcus.6243 - pya.601 pya:PYCH_06240 ribulose-1,5-biphosphate synthetase; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652777 Archaea.31307 Euryarchaeota.35442 Thermococcus.4459 Thermococcus_sp_.2960 the.401 the:GQS_02015 ribulose-1,5-biphosphate synthetase; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652777 Archaea.31307 Euryarchaeota.35442 Thermococcus.4459 - tko.432 tko:TK0434 Thiazole biosynthetic enzyme Thi4; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652777 Archaea.31307 Euryarchaeota.35442 Thermococcus.4459 - tga.1269 tga:TGAM_1270 Thiazole biosynthetic enzyme; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652777 Archaea.31307 Euryarchaeota.35442 Thermococcus.4459 - thm.37 thm:CL1_0036 ribulose-1,5-biphosphate synthetase; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652777 Archaea.31307 Euryarchaeota.35442 Thermococcus.4459 - tnu.504 tnu:BD01_0513 Flavoprotein involved in thiazole biosynthesis; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652777 Archaea.31307 Euryarchaeota.35442 Thermococcus.4459 - teu.1700 teu:TEU_09505 ribonucleoside-triphosphate reductase; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652777 Archaea.31307 Euryarchaeota.35442 Thermococcus.4459 - tgy.1923 tgy:X802_10050 ribonucleoside-triphosphate reductase; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652777 Archaea.31307 Euryarchaeota.35442 Thermococcus.4459 - tpep.434 tpep:A0127_02260 ribose 1,5-bisphosphate isomerase; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652777 Archaea.31307 Euryarchaeota.35442 Thermococcus.4459 - ttd.1056 ttd:A3L14_05500 ribose 1,5-bisphosphate isomerase; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652777 Archaea.31307 Euryarchaeota.35442 Thermococcus.4459 - tprf.1232 tprf:A3L09_06395 ribose 1,5-bisphosphate isomerase; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652777 Archaea.31307 Euryarchaeota.35442 Thermococcus.4459 - tpaf.1310 tpaf:A3L08_06895 ribose 1,5-bisphosphate isomerase; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652777 Archaea.31307 Euryarchaeota.35442 Thermococcus.4460 - tce.379 tce:A3L02_01985 ribose 1,5-bisphosphate isomerase; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652777 Archaea.31307 Euryarchaeota.35442 Thermococcus.4461 - tlt.1047 tlt:OCC_06556 ribonucleoside-triphosphate reductase; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652777 Archaea.31307 Euryarchaeota.35442 Thermococcus.4462 - tpie.1594 tpie:A7C91_09070 ribose 1,5-bisphosphate isomerase; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652777 Archaea.31307 Euryarchaeota.35442 Thermococcus.4463 Thermococcus_sp_.8054 thv.2207 thv:ADU37_CDS22280 Thiazole biosynthetic protein Thi4; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652777 Archaea.31307 Euryarchaeota.35442 Thermococcus.10739 - tch.1520 tch:CHITON_1554 Thiazole biosynthetic enzyme Thi4 / Ribose 1,5-bisphosphate or 5-ribose-1,2-cyclic phosphate dehydrogenase; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652777 Archaea.31307 Euryarchaeota.35442 Thermococcus.11750 - ths.1951 ths:TES1_1982 ribulose-1,5-biphosphate synthetase; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652778 Archaea.35441 Euryarchaeota.8857 - - mhu.1724 mhu:Mhun_1935 thiazole-adenylate synthase; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652778 Archaea.35441 Euryarchaeota.8859 Methanothermobacter.1192 Methanothermobacter_sp_.424 metc.1473 metc:MTCT_1479 putative thiazole biosynthetic protein; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652778 Archaea.35441 Euryarchaeota.8859 Methanothermobacter.1192 Methanothermobacter_sp_.424 mete.1538 mete:tca_01569 Putative thiazole biosynthetic enzyme; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652778 Archaea.35441 Euryarchaeota.8859 Methanothermobacter.1192 - mth.671 mth:MTH_1620 thiamine biosynthetic enzyme; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652778 Archaea.35441 Euryarchaeota.8859 Methanothermobacter.1192 - mmg.205 mmg:MTBMA_c02060 predicted thiazole biosynthesis protein; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652778 Archaea.35441 Euryarchaeota.8859 Methanothermobacter.1192 - mwo.165 mwo:MWSIV6_0166 Thi4; Ribose 1,5-bisphosphate isomerase; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652778 Archaea.35441 Euryarchaeota.8859 Methanobrevibacter.2877 Methanobrevibacter_sp_.1445 meb.1372 meb:Abm4_1461 thiazole biosynthesis enzyme; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652778 Archaea.35441 Euryarchaeota.8859 Methanobacterium.1174 Methanobacterium_sp_.1488 meth.1455 meth:MBMB1_1486 Ribose 1,5-bisphosphate isomerase; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652778 Archaea.35441 Euryarchaeota.8859 Methanobacterium.1174 Methanobacterium_sp_.2370 metn.394 metn:BK008_01970 ribose 1,5-bisphosphate isomerase; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652778 Archaea.35441 Euryarchaeota.8859 Methanobacterium.1174 - mel.595 mel:Metbo_0536 thiazole biosynthetic enzyme; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652778 Archaea.35441 Euryarchaeota.8859 Methanobacterium.1174 - mew.1757 mew:MSWAN_1853 thiazole biosynthetic enzyme; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652778 Archaea.35441 Euryarchaeota.8859 Methanobacterium.1174 Methanobacterium_formicicum.1779 mfc.695 mfc:BRM9_0713 thiazole biosynthesis protein; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652778 Archaea.35441 Euryarchaeota.8859 Methanobacterium.1174 Methanobacterium_formicicum.1779 mfi.659 mfi:DSM1535_0665 Ribose 1,5-bisphosphate isomerase; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652778 Archaea.35441 Euryarchaeota.8859 Methanobacterium.1174 - mcub.1641 mcub:MCBB_1725 putative ribose 1,5-bisphosphate isomerase {ECO:0000255|HAMAP-Rule:MF_00304}; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652778 Archaea.35441 Euryarchaeota.8859 Methanobacterium.1174 - msub.1231 msub:BK009_06380 ribose 1,5-bisphosphate isomerase; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652778 Archaea.35441 Euryarchaeota.8859 - - mfv.188 mfv:Mfer_0175 thiazole-adenylate synthase; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652779 Archaea.35442 Euryarchaeota.8858 Methanosarcina.448 Methanosarcina_sp_.740 mef.1717 mef:MSWH1_1762 Thiazole biosynthetic enzyme Thi4; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652779 Archaea.35442 Euryarchaeota.8858 Methanosarcina.448 Methanosarcina_sp_.740 meq.1523 meq:MSWHS_1554 Thiazole biosynthetic enzyme Thi4; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652779 Archaea.35442 Euryarchaeota.8858 Methanosarcina.448 Methanosarcina_sp_.4286 mek.1081 mek:MSKOL_1072 Thiazole biosynthetic enzyme Thi4; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652779 Archaea.35442 Euryarchaeota.8858 Methanosarcina.448 Methanosarcina_sp_.7919 metm.1132 metm:MSMTP_1119 Thiazole biosynthetic enzyme Thi4; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652779 Archaea.35442 Euryarchaeota.8858 Methanosarcina.448 - mac.2656 mac:MA_2851 thiamine biosynthetic enzyme; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652779 Archaea.35442 Euryarchaeota.8858 Methanosarcina.448 Methanosarcina_barkeri.1151 mba.2033 mba:Mbar_A2100 thiazole-adenylate synthase; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652779 Archaea.35442 Euryarchaeota.8858 Methanosarcina.448 Methanosarcina_barkeri.1151 mby.2363 mby:MSBRM_2409 Thiazole biosynthetic enzyme Thi4; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652779 Archaea.35442 Euryarchaeota.8858 Methanosarcina.448 Methanosarcina_barkeri.1151 mbw.2623 mbw:MSBRW_2643 Thiazole biosynthetic enzyme Thi4; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652779 Archaea.35442 Euryarchaeota.8858 Methanosarcina.448 Methanosarcina_barkeri.1151 mbar.2358 mbar:MSBR2_2375 Thiazole biosynthetic enzyme Thi4; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652779 Archaea.35442 Euryarchaeota.8858 Methanosarcina.448 Methanosarcina_barkeri.6144 mbak.2412 mbak:MSBR3_2431 Thiazole biosynthetic enzyme Thi4; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652779 Archaea.35442 Euryarchaeota.8858 Methanosarcina.448 Methanosarcina_mazei.1595 mma.255 mma:MM_0222 thiazole biosynthetic enzyme; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652779 Archaea.35442 Euryarchaeota.8858 Methanosarcina.448 Methanosarcina_mazei.1595 mmaz.219 mmaz:MmTuc01_0227 ribulose-1,5-biphosphate synthetase; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652779 Archaea.35442 Euryarchaeota.8858 Methanosarcina.448 Methanosarcina_mazei.1595 mmj.1086 mmj:MSMAS_1078 Thiazole biosynthetic enzyme Thi4; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652779 Archaea.35442 Euryarchaeota.8858 Methanosarcina.448 Methanosarcina_mazei.1595 mmac.2363 mmac:MSMAC_2441 Thiazole biosynthetic enzyme Thi4; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652779 Archaea.35442 Euryarchaeota.8858 Methanosarcina.448 - mvc.1127 mvc:MSVAZ_1117 Thiazole biosynthetic enzyme Thi4; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652779 Archaea.35442 Euryarchaeota.8858 Methanosarcina.448 - mls.1191 mls:MSLAZ_1169 Thiazole biosynthetic enzyme Thi4; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652779 Archaea.35442 Euryarchaeota.8858 Methanosarcina.448 Methanosarcina_siciliae.1440 msj.2659 msj:MSSAC_2840 Thiazole biosynthetic enzyme Thi4; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652779 Archaea.35442 Euryarchaeota.8858 Methanosarcina.448 Methanosarcina_siciliae.1440 msz.2480 msz:MSSIH_2497 Thiazole biosynthetic enzyme Thi4; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652779 Archaea.35442 Euryarchaeota.8858 Methanosarcina.448 Methanosarcina_siciliae.1440 msw.2501 msw:MSSIT_2540 Thiazole biosynthetic enzyme Thi4; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652779 Archaea.35442 Euryarchaeota.8858 Methanosarcina.448 Methanosarcina_thermophila.2080 mthe.685 mthe:MSTHC_0676 Thiazole biosynthetic enzyme Thi4; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652779 Archaea.35442 Euryarchaeota.8858 Methanosarcina.448 Methanosarcina_thermophila.2080 mthr.63 mthr:MSTHT_0054 Thiazole biosynthetic enzyme Thi4; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652779 Archaea.35442 Euryarchaeota.8858 Methanosarcina.448 - mhor.1312 mhor:MSHOH_1299 Thiazole biosynthetic enzyme Thi4; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652779 Archaea.35442 Euryarchaeota.8858 Methanococcoides.737 - mbu.1883 mbu:Mbur_2109 Thiazole biosynthetic enzyme, Thi4 family; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652779 Archaea.35442 Euryarchaeota.8858 Methanococcoides.737 - mmet.334 mmet:MCMEM_0306 Thiazole biosynthetic enzyme Thi4; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652779 Archaea.35442 Euryarchaeota.8858 Methanohalophilus.1156 - mmh.298 mmh:Mmah_0298 thiazole-adenylate synthase; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652779 Archaea.35442 Euryarchaeota.8858 Methanohalophilus.1156 - mhaz.401 mhaz:BHR79_02030 ribose 1,5-bisphosphate isomerase; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652779 Archaea.35442 Euryarchaeota.8858 - - mev.291 mev:Metev_0188 thiazole biosynthesis enzyme; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652779 Archaea.35442 Euryarchaeota.8858 - - mzh.1290 mzh:Mzhil_1372 thiazole biosynthesis enzyme; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652779 Archaea.35442 Euryarchaeota.8858 Methanosaeta.1009 - mtp.1092 mtp:Mthe_1121 thiazole-adenylate synthase; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652779 Archaea.35442 Euryarchaeota.8858 Methanosaeta.1009 - mcj.2339 mcj:MCON_3229 putative thiazole biosynthesis enzyme; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652779 Archaea.35442 Euryarchaeota.8858 Methanosaeta.1009 - mhi.2222 mhi:Mhar_2378 Ribose 1,5-bisphosphate isomerase; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652779 Archaea.35442 Euryarchaeota.8858 Methanoculleus.422 - mem.2196 mem:Memar_2251 thiazole-adenylate synthase; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652779 Archaea.35442 Euryarchaeota.8858 Methanoculleus.422 - mbg.1382 mbg:BN140_1460 thi1; thiamine biosynthetic enzyme; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652779 Archaea.35442 Euryarchaeota.8858 Methanoculleus.422 - mema.1823 mema:MMAB1_1869 Ribose 1,5-bisphosphate isomerase; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652779 Archaea.35442 Euryarchaeota.8858 - - mpi.217 mpi:Mpet_0116 thiazole biosynthesis enzyme; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652779 Archaea.35442 Euryarchaeota.8858 Methanoregula.2441 - mfo.335 mfo:Metfor_0238 thiazole biosynthesis enzyme; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] OC.652779 Archaea.35442 Euryarchaeota.8858 Methanocella.2684 - mez.2287 mez:Mtc_2398 thi4-2; thiazole biosynthesis enzyme, flavoprotein; K22699 sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59]