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KofamKOALA - KEGG Orthology Search

K number assignment based on KO-dependent scoring criteria

BlastKOALA GhostKOALA KofamKOALA

KOALA job status 2025/04/30 09:59:47 (GMT+9)
BlastGhostKofam
Number of jobs in the queue100
Submission of last completed job 2025/04/30 09:11:43  2025/04/30 08:39:10  2025/04/30 03:57:44 

KofamKOALA assigns K numbers to the user's sequence data by HMMER/HMMSEARCH against KOfam (a customized HMM database of KEGG Orthologs (KOs)). K number assignments with scores above the predefined thresholds for individual KOs are more reliable than other proposed assignments. Such high score assignments are highlighted with asterisks '*' in the output. The K number assignments facilitate the interpretation of the annotation results by linking the user's sequence data to the KEGG pathways and EC numbers.



Enter FASTA Sequences

or upload a sequence file

E-value
Hits with scores above the predefined adaptive thresholds and E-values
lower than or equal to the specified threshold will be reported with '*'.

E-mail


Current release
  • ver. 2025-02-01
    • KEGG release 113.0
Version history  

2025  

2024  

2023  

2022  

2021  

2020  

2019  

Download
  • KOfam - HMM profiles for KEGG/KO with predefined score thresholds (download by [FTP][HTTPS])
  • KofamScan - Software to search KOfam (download by [FTP][HTTPS])
Reference
  • Aramaki T., Blanc-Mathieu R., Endo H., Ohkubo K., Kanehisa M., Goto S., Ogata H.
    KofamKOALA: KEGG ortholog assignment based on profile HMM and adaptive score threshold.
    Bioinformatics. 2019 Nov 19. pii: btz859. doi: 10.1093/bioinformatics/btz859.
Last updated: November 25, 2019
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