PCIDB

KNApSAcK Metabolite C00001036

Metabolite

KNApSAcK Entry

id C00001036
Name Diosmetin / 4'-Methylluteolin / 5,7,3'-Trihydroxy-4'-methoxyflavone
CAS RN 520-34-3
Standard InChI InChI=1S/C16H12O6/c1-21-13-3-2-8(4-10(13)18)14-7-12(20)16-11(19)5-9(17)6-15(16)22-14/h2-7,17-19H,1H3
Standard InChI (Main Layer) InChI=1S/C16H12O6/c1-21-13-3-2-8(4-10(13)18)14-7-12(20)16-11(19)5-9(17)6-15(16)22-14/h2-7,17-19H,1H3

Cluster

Phytochemical cluster No. 15
KCF-S cluster No. 3

Link

ChEMBL

By standard InChI CHEMBL90568
By standard InChI Main Layer CHEMBL90568

KEGG

By LinkDB C10038

CTD

By CAS RN C039602

Species

Summary

Plant class

class name count
asterids 20
rosids 10
eudicotyledons 2
Liliopsida 1

Family (Top 10)

family name count
Asteraceae 9
Fabaceae 9
Lamiaceae 6
Crassulaceae 1
Boraginaceae 1
Convolvulaceae 1
Plantaginaceae 1
Apiaceae 1
Amaranthaceae 1
Cyperaceae 1

List (34)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Acacia farnesiana 72368 Fabaceae rosids Viridiplantae
Aeonium glutinosum 35948 Crassulaceae eudicotyledons Viridiplantae
Agastache aurantiaca 39130 Lamiaceae asterids Viridiplantae
Arnica spp. 4246 Asteraceae asterids Viridiplantae
Artemisia caerulescens 72336 Asteraceae asterids Viridiplantae
Artemisia iwayomogi 265784 Asteraceae asterids Viridiplantae
Artemisia molinieri 72347 Asteraceae asterids Viridiplantae
Brickellia laciniata 102753 Asteraceae asterids Viridiplantae
Cnidium monnieri 94007 Apiaceae asterids Viridiplantae
Cyperus alopecuroides 1234173 Cyperaceae Liliopsida Viridiplantae
Diosma spp. 378921 Rutaceae rosids Viridiplantae
Dubautia arborea 4249 Asteraceae asterids Viridiplantae
Eupatorium altissimum 102769 Asteraceae asterids Viridiplantae
Froelichia floridana 46114 Amaranthaceae eudicotyledons Viridiplantae
Lippia citriodora 320344 Verbenaceae asterids Viridiplantae
Mentha spicata 29719 Lamiaceae asterids Viridiplantae
Merremia tridentata 89667 Convolvulaceae asterids Viridiplantae
Nonea rosea 203745 Boraginaceae asterids Viridiplantae
Ozothamnus scutellifolius 1284902 Asteraceae asterids Viridiplantae
Pentemon gentianoides HBK
Salvia candidissima 268896 Lamiaceae asterids Viridiplantae
Salvia nutans 21880 Lamiaceae asterids Viridiplantae
Salvia pratensis 49216 Lamiaceae asterids Viridiplantae
Salvia tomentosa 1132405 Lamiaceae asterids Viridiplantae
Stemodia viscosa 225102 Plantaginaceae asterids Viridiplantae
Tithonia calva 684019 Asteraceae asterids Viridiplantae
Vicia hybrida 298727 Fabaceae rosids Viridiplantae
Vicia melanops 47765 Fabaceae rosids Viridiplantae
Vicia michauxii 173235 Fabaceae rosids Viridiplantae
Vicia noeana 298729 Fabaceae rosids Viridiplantae
Vicia pannonica 29753 Fabaceae rosids Viridiplantae
Vicia sicula 1276849 Fabaceae rosids Viridiplantae
Vicia truncatu 3904 Fabaceae rosids Viridiplantae
Vicia villosa 3911 Fabaceae rosids Viridiplantae

Human Protein / Gene in interaction

11 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P33527 Multidrug resistance-associated protein 1 drugs CHEMBL90568 CHEMBL1062295 (1)
0 / 0
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 CHEMBL90568 CHEMBL2341203 (1) CHEMBL2341207 (1)
0 / 0
P04798 Cytochrome P450 1A1 Cytochrome P450 1A1 CHEMBL90568 CHEMBL1225717 (1) CHEMBL1780345 (1)
CHEMBL1780385 (1)
0 / 0
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 CHEMBL90568 CHEMBL1059360 (1) CHEMBL1059361 (1)
5 / 3
Q16678 Cytochrome P450 1B1 Cytochrome P450 1B1 CHEMBL90568 CHEMBL1225718 (1) CHEMBL1780346 (1)
4 / 4
P04745 Alpha-amylase 1 Enzyme CHEMBL90568 CHEMBL964479 (2)
0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL90568 CHEMBL1225716 (1)
0 / 0
Q9UNQ0 ATP-binding cassette sub-family G member 2 ATP binding cassette CHEMBL90568 CHEMBL2076243 (1)
2 / 0
Q92887 Canalicular multispecific organic anion transporter 1 Unclassified protein CHEMBL90568 CHEMBL1062296 (1)
1 / 1
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme CHEMBL90568 CHEMBL1614211 (1)
0 / 0
Q07869 Peroxisome proliferator-activated receptor alpha NR1C1 CHEMBL90568 CHEMBL1059364 (1) CHEMBL1059365 (1)
0 / 0

CTD interaction (6)

compound gene gene name gene description interaction interaction type form reference
pmid
C039602 4363 ABCC1
ABC29
ABCC
GS-X
MRP
MRP1
ATP-binding cassette, sub-family C (CFTR/MRP), member 1 diosmetin results in decreased activity of ABCC1 protein decreases activity
protein 15670588
C039602 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) diosmetin results in decreased activity of CYP1A1 protein decreases activity
protein 21482471
C039602 1545 CYP1B1
CP1B
CYPIB1
GLC3A
P4501B1
cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) diosmetin results in decreased activity of CYP1B1 protein decreases activity
protein 21482471
C039602 1576 CYP3A4
CP33
CP34
CYP3A
CYP3A3
CYPIIIA3
CYPIIIA4
HLP
NF-25
P450C3
P450PCN1
cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) diosmetin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam] decreases reaction
/ increases chemical synthesis
protein 18191104
C039602 1576 CYP3A4
CP33
CP34
CYP3A
CYP3A3
CYPIIIA3
CYPIIIA4
HLP
NF-25
P450C3
P450PCN1
cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) diosmetin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 4-hydroxymidazolam] decreases reaction
/ increases chemical synthesis
protein 18191104
C039602 1577 CYP3A5
CP35
CYPIIIA5
P450PCN3
PCN3
cytochrome P450, family 3, subfamily A, polypeptide 5 (EC:1.14.14.1) diosmetin inhibits the reaction [CYP3A5 protein results in increased chemical synthesis of 4-hydroxymidazolam] decreases reaction
/ increases chemical synthesis
protein 18191104

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (12)

OMIM preferred title UniProt
#614490 Blood group, junior system; jr Q9UNQ0
%606641 Body mass index; bmi P37231
#609338 Carotid intimal medial thickness 1 P37231
#237500 Dubin-johnson syndrome; djs Q92887
#137750 Glaucoma 1, open angle, a; glc1a Q16678
#231300 Glaucoma 3, primary congenital, a; glc3a Q16678
#137760 Glaucoma, primary open angle; poag Q16678
#137800 Glioma susceptibility 1; glm1 P37231
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#601665 Obesity P37231
#604229 Peters anomaly Q16678
#138900 Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 Q9UNQ0

KEGG DISEASE (8)

KEGG disease name UniProt
H00032 Thyroid cancer P37231 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00420 Familial partial lipodystrophy (FPL) P37231 (related)
H00612 Primary open angle glaucoma Q16678 (related)
H01075 Peters anomaly Q16678 (related)
H01159 Anterior segment dysgenesis (ASD) Q16678 (related)
H01203 Primary congenital glaucoma (PCG) Q16678 (related)
H00208 Hyperbilirubinemia Q92887 (related)