97 Human target Activity

KNApSAcK	activity
C00000206	cause skin rashes in sensitive people
C00000208	used to treat vascular disorders, e.g., chiblains, frostbite, and Menieres disease
C00000208	vasodilator effect
C00000555	moderately cytotoxic in 3 tumour cell lines
C00000576	cause dermatitis
C00000819	toxic, affect the central nervous system
C00001040	inhibit delta5-lipoxygenase of platelets, due to inhibition of cyclo-oxygenase
C00001079	allergenic activity, cause contact allergic skin reactions
C00001105	inhibit proliferation and invasion of malignant tumour cells in vitro, the release of oxidants by neutrophils, and basophil histamine release
C00001196	fatal dose is between 2 and 5 mg/kg body-weight, stop respiration by blocking the tricarboxylic acid cycle
C00001224	regard as a beneficial dietary component for coronary heart disease
C00001250	used in chewing gum
C00001250	used in lipsticks and other cosmetics
C00001294	induce photodermatitis
C00001294	phototoxic
C00001322	cause subepidermal blistering of skin
C00001327	rearrange, in damaged bulbs of Tulipa hybrida, to a lactone, tulipalin A, which is fungitoxic and allergenic
C00001328	rearrange, in damaged bulbs of Tulipa hybrida, to a lactone, tulipalin B, which is fungitoxic and allergenic
C00001339	cause neurolathyrism, a neurotoxic syndrome, may be permanent and death may occur, characterized by paralysis of the legs and, occasionally, the arms, bladder and bowel
C00001340	essential for the growth of infants
C00001347	inhibit placental alkaline phosphatase caused by canavanine acting as an antimetabolite, and thereby blocking arginine uptake
C00001349	cause nausea, flushing and breathing difficalties if alcohol is consumed after eating the mushroom, similar to the disulfiram reaction used to discourage alcoholics from drinking, caused by interference with alcohol metabolism, causing accumulation of acetaldehyde in the blood
C00001363	an essential amino acid for children
C00001437	minimum lethal dose of hydrogen cyanide is 0.5-3.5 mg/kg body-weight
C00001493	toxin, causing severe pain and a reddish oedema on hands and feet, if ingested
C00001550	a deficiency syndrome has been described with symptoms of fatigue, headache and sleep disturbance
C00001657	high cytotoxicity against nasopharyngeal cancer cells
C00001684	used as a children's laxative
C00001695	lethal dose is about 200 mg
C00001734	frequent cause of poisoning
C00001755	strong cytotoxic activity against carcinomas
C00001767	nicotine antagonist, but with no medicinal usage
C00001783	antitumour agent used particularly for acute lymphocytic leukaemia in childhood
C00001819	moderately toxic, LD50 27.5 mg/kg body-weight, causing cardiac damage, dyspnoea, and lowered blood pressure
C00001836	effective against tuberculosis and leprosy, although it has now been superseded by synthetic drugs
C00001847	major use is in dentrifices and mouthwashes because of its antiplaque activity
C00001849	lethal dose is about one gram
C00001860	unconfirmed
C00001873	toxic, LD50 26 mg/kg
C00001878	cytotoxic to naspharyngeal carcinoma cells in vitro
C00001889	lethal dose lies between 1 and 10 mg
C00001917	major use is in dentrifices and mouthwashes because of its antiplaque activity
C00001926	toxic, LD50 500 mg/kg body-weight
C00002057	fatal dose is about 50 mg
C00002094	hepatotoxic, causing veno-occlusive disease
C00002168	inhibit leukocyte elastase
C00002193	one of the bitterest substances known, significantly bitter at a molar concentration of 1*10^(-5)
C00002262	toxicity symptoms include vomiting, diarrhoea, hallucination and coma, oral ingestion of 2.8 mg/kg is toxic
C00002277	highly toxic, with a lethal dose of 100mg
C00002280	metabolite of cocaine
C00002293	toxic
C00002308	hypotensive activity
C00002310	one of the bitterest substances known, significantly bitter at a molar concentration of 1*10^(-5)
C00002314	highly toxic, with a lethal dose of 10mg
C00002327	highly toxic, with a lethal dose of 10mg
C00002331	show potent cytotoxic activity against naspharyngeal cells, however lack antitumour property
C00002366	central nervous system toxicity
C00002395	jointly responsible for milk sickness after comsumption of milk from Bos taurus feeding on Eupatorium urticaefolium
C00002400	reputed to have contraceptive property
C00002410	Haplopappus heterophyllus is claimed to be responsible for milk sickness after comsumption of milk from Bos taurus feeding on Eupatorium urticaefolium
C00002412	jointly responsible for milk sickness after comsumption of milk from Bos taurus feeding on Eupatorium urticaefolium
C00002425	cytotoxic to P-388, KB and cancer cell lines
C00002445	infected Mangifera indica may be toxic
C00002453	inhibit chorionic gonadotrophin
C00002464	inhibit platelet aggregation in vitro
C00002468	vasodilatory agent, used in medicine
C00002485	inhibit platelet aggregation in vitro
C00002486	inhibit platelet aggregation in vitro
C00002502	cause dermatitis
C00002568	more toxic when inhaled than when ingested
C00002635	responsible for the acute dermatitis caused in handling Anacardium occidentale
C00002650	cause contact allergies
C00002664	toxic
C00002673	cause allergic skin reactions
C00002680	induce allergic skin reactions
C00002680	induce dermatitis
C00002689	immunomodulator, inhibiting the generation of reactive oxygen species by neutrophils
C00002744	inhibit formation of 5-lipoxygenase products in leukocytes
C00002753	moderately toxic
C00002771	moderately toxic
C00002781	inhibit formation of 5-lipoxygenase products in leukocytes
C00002783	inhibit formation of 5-lipoxygenase products in leukocytes, indicating anti-inflammatory property
C00002802	moderately active as a phagocytose inhibitor of granulocytes
C00002807	inhibit mobilisation of spermatozoa
C00002823	cause immobilisation of spermatozoa
C00002847	moderately cytotoxic in 3 tumour cell lines
C00002852	enhance in vitro phagocytosis of granulocytes
C00002868	used in the treatment of hypothrombinaemias
C00002935	usea as a gargle
C00003033	cause diarrhoea
C00003033	cause convulsions
C00003033	cause liver and kidney damage
C00003033	cause respiratory paralysis
C00003034	cause diarrhoea
C00003034	cause convulsions
C00003034	cause liver and kidney damage
C00003034	cause respiratory paralysis