PCIDB

KNApSAcK Metabolite C00002568

Metabolite

KNApSAcK Entry

id C00002568
Name Rotenone / Tubotoxin / Nicouline
CAS RN 83-79-4
Standard InChI InChI=1S/C23H22O6/c1-11(2)16-8-14-15(28-16)6-5-12-22(24)21-13-7-18(25-3)19(26-4)9-17(13)27-10-20(21)29-23(12)14/h5-7,9,16,20-21H,1,8,10H2,2-4H3/t16-,20-,21+/m1/s1
Standard InChI (Main Layer) InChI=1S/C23H22O6/c1-11(2)16-8-14-15(28-16)6-5-12-22(24)21-13-7-18(25-3)19(26-4)9-17(13)27-10-20(21)29-23(12)14/h5-7,9,16,20-21H,1,8,10H2,2-4H3

Cluster

Phytochemical cluster No. 15
KCF-S cluster No. 281

Link

ChEMBL

By standard InChI CHEMBL429023
By standard InChI Main Layer CHEMBL429023 CHEMBL267461 CHEMBL418710 CHEMBL1518927

KEGG

By LinkDB C07593

CTD

By CAS RN D012402

Human Protein / Gene in interaction

129 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL429023 CHEMBL1518927 CHEMBL1741321 (1) CHEMBL1909136 (2)
1 / 0
P42345 Serine/threonine-protein kinase mTOR Enzyme CHEMBL429023 CHEMBL1613805 (1) CHEMBL1614293 (1)
CHEMBL1913840 (1) CHEMBL1913842 (1)
CHEMBL1913844 (1) CHEMBL1913898 (1)
CHEMBL1913900 (1) CHEMBL1913902 (1)
CHEMBL1913904 (1) CHEMBL1913906 (1)
CHEMBL1913908 (1) CHEMBL1913910 (1)
0 / 0
P04637 Cellular tumor antigen p53 Transcription Factor CHEMBL429023 CHEMBL1518927 CHEMBL1226577 (1) CHEMBL1613995 (1)
CHEMBL2114895 (1)
7 / 44
Q16637 Survival motor neuron protein Unclassified protein CHEMBL429023 CHEMBL418710 CHEMBL1613842 (2)
4 / 2
Q99700 Ataxin-2 Unclassified protein CHEMBL429023 CHEMBL1794367 (1) CHEMBL2114784 (1)
1 / 1
P49798 Regulator of G-protein signaling 4 Unclassified protein CHEMBL429023 CHEMBL1794499 (1)
2 / 0
P21728 D(1A) dopamine receptor Dopamine receptor CHEMBL429023 CHEMBL1909139 (2)
0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase CHEMBL429023 CHEMBL1909131 (2)
0 / 3
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) CHEMBL429023 CHEMBL1794573 (1) CHEMBL1909190 (2)
2 / 2
P08246 Neutrophil elastase S1A CHEMBL429023 CHEMBL1909195 (2)
2 / 1
P33765 Adenosine receptor A3 Adenosine receptor CHEMBL429023 CHEMBL1909215 (2)
0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 CHEMBL429023 CHEMBL1909201 (2)
0 / 0
P06746 DNA polymerase beta Enzyme CHEMBL429023 CHEMBL1614079 (1)
0 / 0
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor CHEMBL429023 CHEMBL1909176 (2)
0 / 0
P29466 Caspase-1 C14 CHEMBL429023 CHEMBL1909193 (2)
0 / 0
P17252 Protein kinase C alpha type Alpha CHEMBL429023 CHEMBL1909198 (2)
0 / 0
P27361 Mitogen-activated protein kinase 3 Erk CHEMBL429023 CHEMBL1909199 (2)
0 / 0
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 CHEMBL429023 CHEMBL1794552 (1)
0 / 0
P14780 Matrix metalloproteinase-9 M10A CHEMBL429023 CHEMBL1909197 (2)
2 / 2
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme CHEMBL418710 CHEMBL1614331 (1)
0 / 0
P02545 Prelamin-A/C Unclassified protein CHEMBL429023 CHEMBL418710 CHEMBL1614310 (1) CHEMBL1614544 (3)
11 / 10
P16473 Thyrotropin receptor Glycohormone receptor CHEMBL429023 CHEMBL1518927 CHEMBL1614281 (2) CHEMBL1614361 (2)
3 / 2
P10828 Thyroid hormone receptor beta NR1A2 CHEMBL429023 CHEMBL1794399 (1)
3 / 1
P19793 Retinoic acid receptor RXR-alpha NR2B1 CHEMBL429023 CHEMBL1794371 (1) CHEMBL1794471 (1)
0 / 0
P00918 Carbonic anhydrase 2 Lyase CHEMBL429023 CHEMBL1909123 (2)
1 / 2
P07550 Beta-2 adrenergic receptor Adrenergic receptor CHEMBL429023 CHEMBL1909092 (2)
0 / 1
P21397 Amine oxidase [flavin-containing] A Oxidoreductase CHEMBL429023 CHEMBL1909169 (2)
1 / 1
P25021 Histamine H2 receptor Histamine receptor CHEMBL429023 CHEMBL1909157 (2)
0 / 0
P35367 Histamine H1 receptor Histamine receptor CHEMBL429023 CHEMBL1909156 (2)
0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine CHEMBL429023 CHEMBL1909143 (2)
1 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor CHEMBL429023 CHEMBL1909174 (2)
0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor CHEMBL429023 CHEMBL1909090 (2)
0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor CHEMBL429023 CHEMBL1909093 (2)
0 / 0
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor CHEMBL429023 CHEMBL1909127 (2)
0 / 0
P06241 Tyrosine-protein kinase Fyn Src CHEMBL429023 CHEMBL1909204 (2)
0 / 0
P06493 Cyclin-dependent kinase 1 Cdc2 CHEMBL429023 CHEMBL1226575 (1) CHEMBL1226576 (1)
0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr CHEMBL429023 CHEMBL1909202 (2)
0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL429023 CHEMBL1518927 CHEMBL1614027 (2) CHEMBL1741325 (1)
CHEMBL1909135 (2)
0 / 1
P54132 Bloom syndrome protein Enzyme CHEMBL429023 CHEMBL1614522 (1) CHEMBL1614067 (1)
1 / 2
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily CHEMBL429023 CHEMBL1909203 (2)
1 / 11
P14416 D(2) dopamine receptor Dopamine receptor CHEMBL429023 CHEMBL1909140 (2)
2 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase CHEMBL429023 CHEMBL1909130 (2)
0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor CHEMBL429023 CHEMBL1909120 (2)
0 / 0
P41145 Kappa-type opioid receptor Opioid receptor CHEMBL429023 CHEMBL1909181 (2)
0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor CHEMBL429023 CHEMBL1909164 (2)
0 / 0
P29274 Adenosine receptor A2a Adenosine receptor CHEMBL429023 CHEMBL1909214 (2)
0 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor CHEMBL429023 CHEMBL1909175 (2)
0 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor CHEMBL429023 CHEMBL1909096 (2)
1 / 1
P17948 Vascular endothelial growth factor receptor 1 Vegfr CHEMBL429023 CHEMBL1909118 (2)
0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor CHEMBL429023 CHEMBL1909166 (2)
1 / 0
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL429023 CHEMBL418710 CHEMBL1614458 (2)
0 / 0
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 CHEMBL429023 CHEMBL1909133 (2)
0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor CHEMBL1518927 CHEMBL1614456 (1) CHEMBL1613803 (1)
0 / 0
O75496 Geminin Unclassified protein CHEMBL429023 CHEMBL1613941 (1) CHEMBL1738370 (1)
CHEMBL1738636 (1) CHEMBL1737957 (1)
CHEMBL2114843 (1) CHEMBL2114780 (2)
0 / 0
P51151 Ras-related protein Rab-9A Unclassified protein CHEMBL429023 CHEMBL1613838 (1)
0 / 0
P23528 Cofilin-1 Unclassified protein CHEMBL429023 CHEMBL1226579 (1)
0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase CHEMBL429023 CHEMBL1909158 (2)
0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor CHEMBL429023 CHEMBL1909088 (2)
0 / 0
P21917 D(4) dopamine receptor Dopamine receptor CHEMBL429023 CHEMBL1909142 (2)
0 / 0
P30988 Calcitonin receptor Calcitonin receptor CHEMBL429023 CHEMBL1909101 (2)
0 / 0
P35462 D(3) dopamine receptor Dopamine receptor CHEMBL429023 CHEMBL1909141 (2)
1 / 0
P41143 Delta-type opioid receptor Opioid receptor CHEMBL429023 CHEMBL1909180 (2)
0 / 0
Q92731 Estrogen receptor beta NR3A2 CHEMBL429023 CHEMBL1909146 (2)
0 / 1
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor CHEMBL429023 CHEMBL1909104 (2)
0 / 0
P25101 Endothelin-1 receptor Endothelin receptor CHEMBL429023 CHEMBL1909144 (2)
0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor CHEMBL429023 CHEMBL1909100 (2)
0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor CHEMBL429023 CHEMBL1909167 (2)
1 / 0
P32238 Cholecystokinin receptor type A Cholecystokinin receptor CHEMBL429023 CHEMBL1909129 (2)
0 / 0
P08311 Cathepsin G S1A CHEMBL429023 CHEMBL1909194 (2)
0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor CHEMBL429023 CHEMBL1909110 (2)
1 / 0
P03956 Interstitial collagenase M10A CHEMBL429023 CHEMBL1909196 (2)
0 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor CHEMBL429023 CHEMBL1909119 (2)
0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein CHEMBL429023 CHEMBL1738610 (1)
0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme CHEMBL429023 CHEMBL1794467 (2)
0 / 0
P04150 Glucocorticoid receptor NR3C1 CHEMBL429023 CHEMBL1794382 (1) CHEMBL1909150 (2)
0 / 1
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor CHEMBL429023 CHEMBL1909171 (2)
2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor CHEMBL429023 CHEMBL1909170 (2)
0 / 0
P21554 Cannabinoid receptor 1 Cannabinoid receptor CHEMBL429023 CHEMBL1909122 (2)
0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin CHEMBL429023 CHEMBL1909109 (2)
2 / 0
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 CHEMBL429023 CHEMBL1794293 (1) CHEMBL1794510 (1)
5 / 3
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily CHEMBL429023 CHEMBL1909205 (2)
5 / 10
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor CHEMBL429023 CHEMBL1909172 (2)
1 / 0
P21452 Substance-K receptor Neurokinin receptor CHEMBL429023 CHEMBL1909114 (2)
0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor CHEMBL429023 CHEMBL1909125 (2)
0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor CHEMBL429023 CHEMBL1909126 (2)
3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor CHEMBL429023 CHEMBL1909108 (2)
0 / 0
P41597 C-C chemokine receptor type 2 CC chemokine receptor CHEMBL429023 CHEMBL1909124 (2)
1 / 0
P28482 Mitogen-activated protein kinase 1 Erk CHEMBL429023 CHEMBL418710 CHEMBL1613808 (1) CHEMBL1909200 (2)
0 / 0
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme CHEMBL429023 CHEMBL1909207 (2)
2 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL429023 CHEMBL1518927 CHEMBL1741322 (1) CHEMBL1909132 (2)
0 / 0
P03905 NADH-ubiquinone oxidoreductase chain 4 Oxidoreductase CHEMBL429023 CHEMBL747976 (1)
3 / 1
Q92887 Canalicular multispecific organic anion transporter 1 Unclassified protein CHEMBL429023 CHEMBL1006005 (1)
1 / 1
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme CHEMBL418710 CHEMBL1614038 (1)
2 / 2
O15118 Niemann-Pick C1 protein Unclassified protein CHEMBL429023 CHEMBL1614342 (1)
1 / 1
Q01453 Peripheral myelin protein 22 Unclassified protein CHEMBL429023 CHEMBL1614171 (1)
5 / 2
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein CHEMBL429023 CHEMBL1738675 (1)
0 / 0
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A CHEMBL429023 CHEMBL1909186 (2)
0 / 0
P03372 Estrogen receptor NR3A1 CHEMBL429023 CHEMBL1794542 (1) CHEMBL1909145 (2)
1 / 1
P08588 Beta-1 adrenergic receptor Adrenergic receptor CHEMBL429023 CHEMBL1909091 (2)
1 / 0
P22303 Acetylcholinesterase Hydrolase CHEMBL429023 CHEMBL1909212 (2)
1 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor CHEMBL429023 CHEMBL1909211 (2)
0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor CHEMBL429023 CHEMBL1909105 (2)
0 / 0
P35372 Mu-type opioid receptor Opioid receptor CHEMBL429023 CHEMBL1909182 (2)
0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor CHEMBL429023 CHEMBL1909173 (2)
0 / 0
P25103 Substance-P receptor Neurokinin receptor CHEMBL429023 CHEMBL1909113 (2)
0 / 0
P25105 Platelet-activating factor receptor PAF receptor CHEMBL429023 CHEMBL1909187 (2)
0 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor CHEMBL429023 CHEMBL1909168 (2)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL429023 CHEMBL1518927 CHEMBL1613777 (2) CHEMBL1741323 (1)
CHEMBL1909134 (2)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL429023 CHEMBL418710 CHEMBL1518927 CHEMBL1614108 (3) CHEMBL1613886 (3)
CHEMBL1741324 (1) CHEMBL1909138 (2)
0 / 1
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 CHEMBL429023 CHEMBL1909137 (2)
0 / 0
Q9UNA4 DNA polymerase iota Enzyme CHEMBL429023 CHEMBL1794483 (1)
0 / 0
Q6W5P4 Neuropeptide S receptor Neuropeptide receptor CHEMBL429023 CHEMBL1614052 (1)
1 / 0
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL429023 CHEMBL418710 CHEMBL1614421 (2)
4 / 3
Q99549 M-phase phosphoprotein 8 Unclassified protein CHEMBL429023 CHEMBL1738402 (2)
0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL429023 CHEMBL1737980 (1) CHEMBL2114890 (1)
0 / 0
P10275 Androgen receptor NR3C4 CHEMBL429023 CHEMBL1794321 (1)
3 / 4
P23975 Sodium-dependent noradrenaline transporter Norepinephrine CHEMBL429023 CHEMBL1909094 (2)
1 / 1
P25100 Alpha-1D adrenergic receptor Adrenergic receptor CHEMBL429023 CHEMBL1909087 (2)
0 / 0
P30542 Adenosine receptor A1 Adenosine receptor CHEMBL429023 CHEMBL1909213 (2)
0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor CHEMBL429023 CHEMBL1909089 (2)
0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 CHEMBL429023 CHEMBL1909116 (2)
1 / 1
P05412 Transcription factor AP-1 Transcription Factor CHEMBL429023 CHEMBL1226578 (1)
0 / 0
P06239 Tyrosine-protein kinase Lck Src CHEMBL429023 CHEMBL1909206 (2)
0 / 1
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor CHEMBL429023 CHEMBL1909128 (2)
0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL429023 CHEMBL418710 CHEMBL1613914 (2)
0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme CHEMBL429023 CHEMBL1613829 (1)
0 / 0
P40225 Thrombopoietin Unclassified protein CHEMBL1518927 CHEMBL1614086 (1) CHEMBL1614034 (1)
1 / 1
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL429023 CHEMBL1738442 (1)
0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme CHEMBL429023 CHEMBL1614364 (1)
1 / 1

CTD interaction (348)

compound gene gene name gene description interaction interaction type form reference
pmid
D012402 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) Rotenone affects the activity of ABCB1 protein affects activity
protein 15796199
D012402 28976 ACAD9
NPD002
acyl-CoA dehydrogenase family, member 9 Rotenone results in decreased expression of ACAD9 protein decreases expression
protein 16565515
D012402 48 ACO1
ACONS
IREB1
IREBP
IREBP1
IRP1
aconitase 1, soluble (EC:4.2.1.3) Rotenone results in decreased activity of ACO1 protein decreases activity
protein 21570952
D012402 48 ACO1
ACONS
IREB1
IREBP
IREBP1
IRP1
aconitase 1, soluble (EC:4.2.1.3) Rotenone results in increased activity of ACO1 protein increases activity
protein 21570952
D012402 50 ACO2
ACONM
ICRD
aconitase 2, mitochondrial (EC:4.2.1.3) Rotenone results in decreased activity of ACO2 protein decreases activity
protein 21570952
D012402 54 ACP5
SPENCDI
TRAP
acid phosphatase 5, tartrate resistant (EC:3.1.3.2) Rotenone inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA] decreases reaction
/ increases expression
mRNA 19900598
D012402 59 ACTA2
AAT6
ACTSA
MYMY5
actin, alpha 2, smooth muscle, aorta Rotenone inhibits the reaction [Aldosterone results in increased expression of ACTA2 mRNA] decreases reaction
/ increases expression
mRNA 17596522
D012402 59 ACTA2
AAT6
ACTSA
MYMY5
actin, alpha 2, smooth muscle, aorta Rotenone inhibits the reaction [Aldosterone results in increased expression of ACTA2 protein] decreases reaction
/ increases expression
protein 17596522
D012402 183 AGT
ANHU
SERPINA8
angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Rotenone inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased phosphorylation of JAK2 protein]] decreases reaction
/ increases phosphorylation
/ increases reaction
protein 15677497
D012402 9131 AIFM1
AIF
CMTX4
COWCK
COXPD6
PDCD8
apoptosis-inducing factor, mitochondrion-associated, 1 Rotenone affects the localization of AIFM1 protein affects localization
protein 12880480
D012402 9131 AIFM1
AIF
CMTX4
COWCK
COXPD6
PDCD8
apoptosis-inducing factor, mitochondrion-associated, 1 Selegiline inhibits the reaction [Rotenone affects the localization of AIFM1 protein] affects localization
/ decreases reaction
protein 12880480
D012402 290 ANPEP
APN
CD13
GP150
LAP1
P150
PEPN
alanyl (membrane) aminopeptidase (EC:3.4.11.2) Rotenone results in increased expression of ANPEP protein increases expression
protein 8833408
D012402 317 APAF1
APAF-1
CED4
apoptotic peptidase activating factor 1 Rotenone results in increased expression of APAF1 mRNA alternative form increases expression
mRNA 17064354
D012402 402 ARL2
ARFL2
ADP-ribosylation factor-like 2 Rotenone results in decreased expression of ARL2 mRNA decreases expression
mRNA 17651460
D012402 468 ATF4
CREB-2
CREB2
TAXREB67
TXREB
activating transcription factor 4 Rotenone results in increased expression of ATF4 mRNA increases expression
mRNA 19233273
D012402 468 ATF4
CREB-2
CREB2
TAXREB67
TXREB
activating transcription factor 4 Rotenone results in increased expression of ATF4 protein increases expression
protein 19233273
D012402 9474 ATG5
APG5
APG5-LIKE
APG5L
ASP
hAPG5
autophagy related 5 ATG5 protein affects the reaction [Sirolimus inhibits the reaction [Rotenone results in increased cleavage of PARP1 protein]] affects reaction
/ decreases reaction
/ increases cleavage
protein 19682553
D012402 9474 ATG5
APG5
APG5-LIKE
APG5L
ASP
hAPG5
autophagy related 5 ATG5 protein affects the susceptibility to Rotenone affects response to substance
protein 18032788
D012402 472 ATM
AT1
ATA
ATC
ATD
ATDC
ATE
TEL1
TELO1
ataxia telangiectasia mutated (EC:2.7.11.1) Rotenone results in increased expression of ATM mRNA increases expression
mRNA 18191903
D012402 514 ATP5E
ATPE
MC5DN3
ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit (EC:3.6.3.14) Rotenone results in increased expression of ATP5E mRNA increases expression
mRNA 18191903
D012402 518 ATP5G3
P3
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9) Rotenone results in increased expression of ATP5G3 mRNA increases expression
mRNA 18191903
D012402 521 ATP5I
ATP5K
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit E (EC:3.6.1.14) Rotenone results in increased expression of ATP5I mRNA increases expression
mRNA 18191903
D012402 522 ATP5J
ATP5
ATP5A
ATPM
CF6
F6
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6 (EC:3.6.1.14) Rotenone results in increased expression of ATP5J mRNA increases expression
mRNA 18191903
D012402 10632 ATP5L
ATP5JG
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit G (EC:3.6.1.14) Rotenone results in increased expression of ATP5L mRNA increases expression
mRNA 18191903
D012402 539 ATP5O
ATPO
OSCP
ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit (EC:3.6.3.14) Rotenone results in increased expression of ATP5O mRNA increases expression
mRNA 18191903
D012402 545 ATR
FCTCS
FRP1
MEC1
SCKL
SCKL1
ataxia telangiectasia and Rad3 related (EC:2.7.11.1) Rotenone results in increased expression of ATR mRNA increases expression
mRNA 18191903
D012402 4287 ATXN3
AT3
ATX3
JOS
MJD
MJD1
SCA3
ataxin 3 (EC:3.4.19.12) Rotenone results in increased expression of ATXN3 mRNA increases expression
mRNA 18191903
D012402 23621 BACE1
ASP2
BACE
HSPC104
beta-site APP-cleaving enzyme 1 (EC:3.4.23.46) Rotenone inhibits the reaction [Oxygen deficiency results in increased expression of BACE1 mRNA] decreases reaction
/ increases expression
mRNA 19196431
D012402 572 BAD
BBC2
BCL2L8
BCL2-associated agonist of cell death Rotenone results in decreased phosphorylation of BAD protein decreases phosphorylation
protein 15280438
D012402 572 BAD
BBC2
BCL2L8
BCL2-associated agonist of cell death Tacrolimus inhibits the reaction [Rotenone results in decreased phosphorylation of BAD protein] decreases phosphorylation
/ decreases reaction
protein 15280438
D012402 580 BARD1
BRCA1 associated RING domain 1 Rotenone results in increased expression of BARD1 mRNA increases expression
mRNA 18191903
D012402 581 BAX
BCL2L4
BCL2-associated X protein Ranitidine inhibits the reaction [Rotenone results in increased expression of BAX protein] decreases reaction
/ increases expression
protein 19723537
D012402 581 BAX
BCL2L4
BCL2-associated X protein Rotenone results in increased expression of BAX protein increases expression
protein 19539006
19723537
19777565
D012402 581 BAX
BCL2L4
BCL2-associated X protein Tranexamic Acid inhibits the reaction [Rotenone results in increased expression of BAX protein] decreases reaction
/ increases expression
protein 19539006
D012402 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 BCL2 protein results in decreased susceptibility to Rotenone decreases response to substance
protein 12730627
D012402 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 PK 11195 inhibits the reaction [BCL2 protein results in decreased susceptibility to Rotenone] decreases reaction
/ decreases response to substance
protein 12730627
D012402 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 Ranitidine inhibits the reaction [Rotenone results in decreased expression of BCL2 protein] decreases expression
/ decreases reaction
protein 19723537
D012402 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 Rotenone results in decreased expression of BCL2 protein decreases expression
protein 19539006
19723537
19777565
D012402 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 Rotenone results in increased expression of BCL2 mRNA increases expression
mRNA 16679036
16815102
D012402 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 Rotenone results in increased expression of BCL2 protein increases expression
protein 16679036
16815102
D012402 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 Tranexamic Acid inhibits the reaction [Rotenone results in decreased expression of BCL2 protein] decreases expression
/ decreases reaction
protein 19539006
D012402 8678 BECN1
ATG6
VPS30
beclin1
beclin 1, autophagy related 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Rotenone results in increased expression of BECN1 protein] decreases reaction
/ increases expression
protein 18032788
D012402 8678 BECN1
ATG6
VPS30
beclin1
beclin 1, autophagy related BECN1 protein affects the susceptibility to Rotenone affects response to substance
protein 18032788
D012402 8678 BECN1
ATG6
VPS30
beclin1
beclin 1, autophagy related Rotenone results in increased expression of BECN1 protein increases expression
protein 18032788
D012402 8678 BECN1
ATG6
VPS30
beclin1
beclin 1, autophagy related SOD2 protein inhibits the reaction [Rotenone results in increased expression of BECN1 protein] decreases reaction
/ increases expression
protein 18032788
D012402 330 BIRC3
AIP1
API2
CIAP2
HAIP1
HIAP1
MALT2
MIHC
RNF49
c-IAP2
baculoviral IAP repeat containing 3 [Rotenone co-treated with Thenoyltrifluoroacetone] inhibits the reaction [Oxygen deficiency results in increased expression of BIRC3 mRNA] affects cotreatment
/ decreases reaction
/ increases expression
mRNA 17671207
D012402 672 BRCA1
BRCAI
BRCC1
BROVCA1
IRIS
PNCA4
PPP1R53
PSCP
RNF53
breast cancer 1, early onset Rotenone results in increased expression of BRCA1 mRNA increases expression
mRNA 18191903
D012402 675 BRCA2
BRCC2
BROVCA2
FACD
FAD
FAD1
FANCB
FANCD
FANCD1
GLM3
PNCA2
breast cancer 2, early onset Rotenone results in increased expression of BRCA2 mRNA increases expression
mRNA 18191903
D012402 701 BUB1B
BUB1beta
BUBR1
Bub1A
MAD3L
MVA1
SSK1
hBUBR1
BUB1 mitotic checkpoint serine/threonine kinase B (EC:2.7.11.1) Rotenone results in increased expression of and affects the localization of BUB1B protein affects localization
/ increases expression
protein 17697112
D012402 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) 3-Hydroxybutyric Acid inhibits the reaction [Rotenone results in increased activity of CASP3 protein] decreases reaction
/ increases activity
protein 16917840
D012402 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Hydrogen Peroxide promotes the reaction [Rotenone results in increased activity of CASP3 protein] increases activity
/ increases reaction
protein 12177198
D012402 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) MT1B protein inhibits the reaction [Rotenone results in increased activity of CASP3 protein] decreases reaction
/ increases activity
protein 16402917
D012402 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) MT2A protein inhibits the reaction [Rotenone results in increased activity of CASP3 protein] decreases reaction
/ increases activity
protein 16402917
D012402 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Ranitidine inhibits the reaction [Rotenone results in increased cleavage of and results in increased activity of CASP3 protein] decreases reaction
/ increases activity
/ increases cleavage
protein 19723537
D012402 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) ropinirole inhibits the reaction [Rotenone results in increased cleavage of CASP3 protein] decreases reaction
/ increases cleavage
protein 18242171
D012402 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Rotenone inhibits the reaction [TNF protein results in increased cleavage of CASP3 protein] decreases reaction
/ increases cleavage
protein 10973919
D012402 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Rotenone results in increased activity of CASP3 protein increases activity
protein 12177198
12496265
14976342
16402917
16917840
D012402 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Rotenone results in increased cleavage of and results in increased activity of CASP3 protein increases activity
/ increases cleavage
protein 19539006
19723537
D012402 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Rotenone results in increased cleavage of CASP3 protein increases cleavage
protein 18178165
18242171
19682553
D012402 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Sirolimus inhibits the reaction [Rotenone results in increased cleavage of CASP3 protein] decreases reaction
/ increases cleavage
protein 19682553
D012402 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Tranexamic Acid inhibits the reaction [Rotenone results in increased cleavage of and results in increased activity of CASP3 protein] decreases reaction
/ increases activity
/ increases cleavage
protein 19539006
D012402 840 CASP7
CASP-7
CMH-1
ICE-LAP3
LICE2
MCH3
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) MT1B protein inhibits the reaction [Rotenone results in increased activity of CASP7 protein] decreases reaction
/ increases activity
protein 16402917
D012402 840 CASP7
CASP-7
CMH-1
ICE-LAP3
LICE2
MCH3
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) MT2A protein inhibits the reaction [Rotenone results in increased activity of CASP7 protein] decreases reaction
/ increases activity
protein 16402917
D012402 840 CASP7
CASP-7
CMH-1
ICE-LAP3
LICE2
MCH3
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) Rotenone results in increased activity of CASP7 protein increases activity
protein 16402917
D012402 842 CASP9
APAF-3
APAF3
ICE-LAP6
MCH6
PPP1R56
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) 3-Hydroxybutyric Acid inhibits the reaction [Rotenone results in increased activity of CASP9 protein] decreases reaction
/ increases activity
protein 16917840
D012402 842 CASP9
APAF-3
APAF3
ICE-LAP6
MCH6
PPP1R56
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) Ranitidine inhibits the reaction [Rotenone results in increased cleavage of CASP9 protein] decreases reaction
/ increases cleavage
protein 19723537
D012402 842 CASP9
APAF-3
APAF3
ICE-LAP6
MCH6
PPP1R56
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) ropinirole inhibits the reaction [Rotenone results in increased cleavage of CASP9 protein] decreases reaction
/ increases cleavage
protein 18242171
D012402 842 CASP9
APAF-3
APAF3
ICE-LAP6
MCH6
PPP1R56
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) Rotenone results in increased activity of CASP9 protein increases activity
protein 16917840
D012402 842 CASP9
APAF-3
APAF3
ICE-LAP6
MCH6
PPP1R56
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) Rotenone results in increased cleavage of CASP9 protein increases cleavage
protein 18242171
19539006
19723537
D012402 842 CASP9
APAF-3
APAF3
ICE-LAP6
MCH6
PPP1R56
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) Tranexamic Acid inhibits the reaction [Rotenone results in increased cleavage of CASP9 protein] decreases reaction
/ increases cleavage
protein 19539006
D012402 847 CAT
catalase (EC:1.11.1.6) fraxetin inhibits the reaction [Rotenone results in increased expression of and results in increased activity of CAT protein] decreases reaction
/ increases activity
/ increases expression
protein 15904944
D012402 847 CAT
catalase (EC:1.11.1.6) myricetin inhibits the reaction [Rotenone results in increased activity of CAT protein] decreases reaction
/ increases activity
protein 15904944
D012402 847 CAT
catalase (EC:1.11.1.6) Rotenone results in increased expression of and results in increased activity of CAT protein increases activity
/ increases expression
protein 15904944
D012402 595 CCND1
BCL1
D11S287E
PRAD1
U21B31
cyclin D1 Rotenone inhibits the reaction [Estradiol results in increased expression of CCND1 mRNA] decreases reaction
/ increases expression
mRNA 15897899
D012402 902 CCNH
CAK
p34
p37
cyclin H Rotenone results in increased expression of CCNH mRNA increases expression
mRNA 18191903
D012402 929 CD14
CD14 molecule Rotenone results in increased expression of CD14 mRNA increases expression
mRNA 10491287
D012402 948 CD36
BDPLT10
CHDS7
FAT
GP3B
GP4
GPIV
PASIV
SCARB3
CD36 molecule (thrombospondin receptor) Rotenone inhibits the reaction [[Oxygen deficiency results in increased abundance of Reactive Oxygen Species] which results in increased expression of CD36 mRNA] decreases reaction
/ increases abundance
/ increases expression
mRNA 19640849
D012402 952 CD38
T10
CD38 molecule (EC:3.2.2.5) Rotenone results in increased expression of CD38 mRNA increases expression
mRNA 10491287
D012402 952 CD38
T10
CD38 molecule (EC:3.2.2.5) Rotenone results in increased expression of CD38 protein increases expression
protein 8833408
D012402 999 CDH1
Arc-1
CD324
CDHE
ECAD
LCAM
UVO
cadherin 1, type 1, E-cadherin (epithelial) Rotenone inhibits the reaction [Aldosterone results in decreased expression of CDH1 mRNA] decreases expression
/ decreases reaction
mRNA 17596522
D012402 999 CDH1
Arc-1
CD324
CDHE
ECAD
LCAM
UVO
cadherin 1, type 1, E-cadherin (epithelial) Rotenone inhibits the reaction [Aldosterone results in decreased expression of CDH1 protein] decreases expression
/ decreases reaction
protein 17596522
D012402 1026 CDKN1A
CAP20
CDKN1
CIP1
MDA-6
P21
SDI1
WAF1
p21CIP1
cyclin-dependent kinase inhibitor 1A (p21, Cip1) Rotenone inhibits the reaction [Oxygen deficiency results in increased expression of CDKN1A mRNA] decreases reaction
/ increases expression
mRNA 19091749
D012402 1026 CDKN1A
CAP20
CDKN1
CIP1
MDA-6
P21
SDI1
WAF1
p21CIP1
cyclin-dependent kinase inhibitor 1A (p21, Cip1) Rotenone results in increased expression of CDKN1A protein increases expression
protein 21223980
D012402 1111 CHEK1
CHK1
checkpoint kinase 1 (EC:2.7.11.1) Rotenone results in increased expression of CHEK1 mRNA increases expression
mRNA 18191903
D012402 29883 CNOT7
CAF1
Caf1a
hCAF-1
CCR4-NOT transcription complex, subunit 7 (EC:3.1.13.4) Rotenone results in increased expression of CNOT7 mRNA increases expression
mRNA 18191903
D012402 1270 CNTF
HCNTF
ciliary neurotrophic factor Rotenone inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of JAK1 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 15748169
D012402 1270 CNTF
HCNTF
ciliary neurotrophic factor Rotenone inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of JAK2 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 15748169
D012402 1270 CNTF
HCNTF
ciliary neurotrophic factor Rotenone inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT1 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 15748169
D012402 1270 CNTF
HCNTF
ciliary neurotrophic factor Rotenone inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT3 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 15748169
D012402 1270 CNTF
HCNTF
ciliary neurotrophic factor Rotenone inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein] decreases reaction
/ increases phosphorylation
19635391
D012402 1270 CNTF
HCNTF
ciliary neurotrophic factor Rotenone inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein] decreases reaction
/ increases phosphorylation
19635391
D012402 1270 CNTF
HCNTF
ciliary neurotrophic factor Rotenone promotes the reaction [Nitrofurantoin inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT1 protein]] decreases reaction
/ increases activity
/ increases phosphorylation
/ increases reaction
protein 15748169
D012402 1270 CNTF
HCNTF
ciliary neurotrophic factor Rotenone promotes the reaction [Nitrofurantoin inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT3 protein]] decreases reaction
/ increases activity
/ increases phosphorylation
/ increases reaction
protein 15748169
D012402 1270 CNTF
HCNTF
ciliary neurotrophic factor Rotenone results in decreased activity of CNTF protein decreases activity
protein 15748169
19635391
D012402 1270 CNTF
HCNTF
ciliary neurotrophic factor Thioctic Acid inhibits the reaction [Rotenone inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]] decreases reaction
/ increases phosphorylation
19635391
D012402 1270 CNTF
HCNTF
ciliary neurotrophic factor Thioctic Acid inhibits the reaction [Rotenone inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]] decreases reaction
/ increases phosphorylation
19635391
D012402 1270 CNTF
HCNTF
ciliary neurotrophic factor Thioctic Acid inhibits the reaction [Rotenone results in decreased activity of CNTF protein] decreases activity
/ decreases reaction
protein 19635391
D012402 1293 COL6A3
collagen, type VI, alpha 3 [1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester co-treated with Egtazic Acid] inhibits the reaction [COL6A3 gene mutant form results in increased susceptibility to Rotenone] affects cotreatment
/ decreases reaction
/ increases response to substance
gene 18435905
D012402 1293 COL6A3
collagen, type VI, alpha 3 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [COL6A3 gene mutant form results in increased susceptibility to Rotenone] decreases reaction
/ increases response to substance
gene 18435905
D012402 1293 COL6A3
collagen, type VI, alpha 3 COL6A3 gene mutant form results in increased susceptibility to Rotenone increases response to substance
gene 18435905
D012402 1293 COL6A3
collagen, type VI, alpha 3 [Cyclosporine co-treated with 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester co-treated with Egtazic Acid] inhibits the reaction [COL6A3 gene mutant form results in increased susceptibility to Rotenone] affects cotreatment
/ decreases reaction
/ increases response to substance
gene 18435905
D012402 1293 COL6A3
collagen, type VI, alpha 3 Cyclosporine inhibits the reaction [COL6A3 gene mutant form results in increased susceptibility to Rotenone] decreases reaction
/ increases response to substance
gene 18435905
D012402 1293 COL6A3
collagen, type VI, alpha 3 Thapsigargin promotes the reaction [COL6A3 gene mutant form results in increased susceptibility to Rotenone] increases reaction
/ increases response to substance
gene 18435905
D012402 1327 COX4I1
COX4
COX4-1
COXIV
cytochrome c oxidase subunit IV isoform 1 (EC:1.9.3.1) Rotenone results in increased expression of COX4I1 mRNA increases expression
mRNA 18191903
D012402 9377 COX5A
COX
COX-VA
VA
cytochrome c oxidase subunit Va (EC:1.9.3.1) Rotenone results in increased expression of COX5A mRNA increases expression
mRNA 18191903
D012402 1329 COX5B
COXVB
cytochrome c oxidase subunit Vb (EC:1.9.3.1) Rotenone results in increased expression of COX5B mRNA increases expression
mRNA 18191903
D012402 1347 COX7A2
COX7AL
COX7AL1
COXVIIAL
COXVIIa-L
VIIAL
cytochrome c oxidase subunit VIIa polypeptide 2 (liver) (EC:1.9.3.1) Rotenone results in increased expression of COX7A2 mRNA increases expression
mRNA 18191903
D012402 1349 COX7B
APLCC
cytochrome c oxidase subunit VIIb (EC:1.9.3.1) Rotenone results in increased expression of COX7B mRNA increases expression
mRNA 18191903
D012402 1356 CP
CP-2
ceruloplasmin (ferroxidase) (EC:1.16.3.1) Rotenone results in decreased expression of CP mRNA decreases expression
mRNA 19019832
D012402 1356 CP
CP-2
ceruloplasmin (ferroxidase) (EC:1.16.3.1) Rotenone results in decreased expression of CP protein decreases expression
protein 19019832
D012402 1356 CP
CP-2
ceruloplasmin (ferroxidase) (EC:1.16.3.1) Rotenone results in increased degradation of CP mRNA increases degradation
mRNA 19019832
D012402 1588 CYP19A1
ARO
ARO1
CPV1
CYAR
CYP19
CYPXIX
P-450AROM
cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1) Rotenone results in decreased activity of CYP19A1 protein decreases activity
protein 15319488
D012402 1649 DDIT3
CEBPZ
CHOP
CHOP-10
CHOP10
GADD153
DNA-damage-inducible transcript 3 Rotenone results in increased expression of DDIT3 mRNA increases expression
mRNA 19233273
D012402 1649 DDIT3
CEBPZ
CHOP
CHOP-10
CHOP10
GADD153
DNA-damage-inducible transcript 3 Rotenone results in increased expression of DDIT3 protein increases expression
protein 19233273
D012402 1677 DFFB
CAD
CPAN
DFF-40
DFF2
DFF40
DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) DFFB protein affects the susceptibility to Rotenone affects response to substance
protein 17239993
D012402 10072 DPP3
DPPIII
dipeptidyl-peptidase 3 (EC:3.4.14.4) DPP3 protein results in decreased susceptibility to Rotenone decreases response to substance
protein 17360324
D012402 9451 EIF2AK3
PEK
PERK
WRS
eukaryotic translation initiation factor 2-alpha kinase 3 (EC:2.7.11.1) Rotenone results in increased phosphorylation of EIF2AK3 protein increases phosphorylation
protein 19233273
D012402 1965 EIF2S1
EIF-2
EIF-2A
EIF-2alpha
EIF2
EIF2A
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa Rotenone results in increased expression of EIF2S1 protein increases expression
protein 19233273
D012402 1965 EIF2S1
EIF-2
EIF-2A
EIF-2alpha
EIF2
EIF2A
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa Rotenone results in increased phosphorylation of EIF2S1 protein increases phosphorylation
protein 19233273
D012402 9156 EXO1
HEX1
hExoI
exonuclease 1 Rotenone results in increased expression of EXO1 mRNA increases expression
mRNA 18191903
D012402 2175 FANCA
FA
FA-H
FA1
FAA
FACA
FAH
FANCH
Fanconi anemia, complementation group A Rotenone results in increased expression of FANCA mRNA increases expression
mRNA 18191903
D012402 2176 FANCC
FA3
FAC
FACC
Fanconi anemia, complementation group C Rotenone results in increased expression of FANCC mRNA increases expression
mRNA 18191903
D012402 2177 FANCD2
FA-D2
FA4
FACD
FAD
FAD2
FANCD
Fanconi anemia, complementation group D2 Rotenone results in increased expression of FANCD2 mRNA increases expression
mRNA 18191903
D012402 2178 FANCE
FACE
FAE
Fanconi anemia, complementation group E Rotenone results in increased expression of FANCE mRNA increases expression
mRNA 18191903
D012402 2188 FANCF
FAF
Fanconi anemia, complementation group F Rotenone results in increased expression of FANCF mRNA increases expression
mRNA 18191903
D012402 2189 FANCG
FAG
XRCC9
Fanconi anemia, complementation group G Rotenone results in increased expression of FANCG mRNA increases expression
mRNA 18191903
D012402 355 FAS
ALPS1A
APO-1
APT1
CD95
FAS1
FASTM
TNFRSF6
Fas cell surface death receptor Rotenone results in decreased expression of FAS mRNA decreases expression
mRNA 8902626
D012402 2335 FN1
CIG
ED-B
FINC
FN
FNZ
GFND
GFND2
LETS
MSF
fibronectin 1 Rotenone inhibits the reaction [Glucose results in increased secretion of FN1 protein] decreases reaction
/ increases secretion
protein 15086456
D012402 2335 FN1
CIG
ED-B
FINC
FN
FNZ
GFND
GFND2
LETS
MSF
fibronectin 1 Rotenone results in decreased expression of FN1 mRNA decreases expression
mRNA 17651460
D012402 2335 FN1
CIG
ED-B
FINC
FN
FNZ
GFND
GFND2
LETS
MSF
fibronectin 1 Rotenone results in decreased secretion of FN1 protein decreases secretion
protein 17651460
D012402 2353 FOS
AP-1
C-FOS
p55
FBJ murine osteosarcoma viral oncogene homolog Rotenone inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA] decreases reaction
/ increases expression
mRNA 19900598
D012402 2353 FOS
AP-1
C-FOS
p55
FBJ murine osteosarcoma viral oncogene homolog Rotenone inhibits the reaction [TNFSF11 protein results in increased expression of FOS protein] decreases reaction
/ increases expression
protein 19900598
D012402 2495 FTH1
FHC
FTH
FTHL6
PIG15
PLIF
ferritin, heavy polypeptide 1 (EC:1.16.3.1) Rotenone results in increased expression of FTH1 mRNA increases expression
mRNA 18325346
D012402 2495 FTH1
FHC
FTH
FTHL6
PIG15
PLIF
ferritin, heavy polypeptide 1 (EC:1.16.3.1) Rotenone results in increased expression of FTH1 protein increases expression
protein 18325346
D012402 2876 GPX1
GPXD
GSHPX1
glutathione peroxidase 1 (EC:1.11.1.9) Rotenone results in increased expression of and results in increased activity of GPX1 protein increases activity
/ increases expression
protein 15904944
D012402 10456 HAX1
HCLSBP1
HS1BP1
SCN3
HCLS1 associated protein X-1 Rotenone affects the expression of HAX1 protein affects expression
protein 19763263
D012402 3091 HIF1A
HIF-1A
HIF-1alpha
HIF1
HIF1-ALPHA
MOP1
PASD8
bHLHe78
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) Rotenone inhibits the reaction [Oxygen deficiency results in decreased degradation of HIF1A protein] decreases degradation
/ decreases reaction
protein 12376345
D012402 3091 HIF1A
HIF-1A
HIF-1alpha
HIF1
HIF1-ALPHA
MOP1
PASD8
bHLHe78
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) Rotenone inhibits the reaction [Oxygen deficiency results in increased activity of HIF1A protein] decreases reaction
/ increases activity
protein 19091749
19542490
D012402 3091 HIF1A
HIF-1A
HIF-1alpha
HIF1
HIF1-ALPHA
MOP1
PASD8
bHLHe78
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) Rotenone inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein] decreases reaction
/ increases expression
protein 12062197
19091749
D012402 3091 HIF1A
HIF-1A
HIF-1alpha
HIF1
HIF1-ALPHA
MOP1
PASD8
bHLHe78
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) Rotenone results in decreased expression of HIF1A protein decreases expression
protein 20546814
D012402 3162 HMOX1
HMOX1D
HO-1
HSP32
bK286B10
heme oxygenase (decycling) 1 (EC:1.14.99.3) Rotenone inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 protein] decreases reaction
/ increases expression
protein 22659318
D012402 3313 HSPA9
CSA
GRP-75
GRP75
HSPA9B
MOT
MOT2
MTHSP75
PBP74
heat shock 70kDa protein 9 (mortalin) Rotenone results in decreased expression of HSPA9 protein decreases expression
protein 16565515
D012402 27429 HTRA2
OMI
PARK13
PRSS25
HtrA serine peptidase 2 (EC:3.4.21.108) Rotenone results in decreased expression of HTRA2 protein decreases expression
protein 19763263
D012402 27429 HTRA2
OMI
PARK13
PRSS25
HtrA serine peptidase 2 (EC:3.4.21.108) Rotenone results in increased expression of HTRA2 protein increases expression
protein 19763263
D012402 3364 HUS1
hHUS1
HUS1 checkpoint homolog (S. pombe) Rotenone results in increased expression of HUS1 mRNA increases expression
mRNA 18191903
D012402 3383 ICAM1
BB2
CD54
P3.58
intercellular adhesion molecule 1 Rotenone inhibits the reaction [N-caproylsphingosine results in increased expression of ICAM1 mRNA] decreases reaction
/ increases expression
mRNA 12952965
D012402 3419 IDH3A
isocitrate dehydrogenase 3 (NAD+) alpha (EC:1.1.1.41) Rotenone results in decreased expression of IDH3A protein decreases expression
protein 19763263
D012402 3419 IDH3A
isocitrate dehydrogenase 3 (NAD+) alpha (EC:1.1.1.41) Rotenone results in increased expression of IDH3A protein increases expression
protein 19763263
D012402 3458 IFNG
IFG
IFI
interferon, gamma Rotenone inhibits the reaction [IFNG protein affects the localization of STAT1 protein] affects localization
/ decreases reaction
protein 15748169
D012402 3458 IFNG
IFG
IFI
interferon, gamma Rotenone inhibits the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of STAT1 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 15748169
D012402 3458 IFNG
IFG
IFI
interferon, gamma Rotenone results in decreased activity of IFNG protein decreases activity
protein 19635391
D012402 3479 IGF1
IGF-I
IGF1A
IGFI
insulin-like growth factor 1 (somatomedin C) Rotenone inhibits the reaction [IGF1 protein results in increased activity of ODC1 protein] decreases reaction
/ increases activity
protein 9834970
D012402 3569 IL6
BSF2
HGF
HSF
IFNB2
IL-6
interleukin 6 (interferon, beta 2) Rotenone inhibits the reaction [Oxygen deficiency results in increased expression of IL6 mRNA] decreases reaction
/ increases expression
mRNA 11950692
D012402 3569 IL6
BSF2
HGF
HSF
IFNB2
IL-6
interleukin 6 (interferon, beta 2) Rotenone inhibits the reaction [Oxygen deficiency results in increased expression of IL6 protein] decreases reaction
/ increases expression
protein 11950692
D012402 3569 IL6
BSF2
HGF
HSF
IFNB2
IL-6
interleukin 6 (interferon, beta 2) Rotenone results in decreased activity of IL6 protein decreases activity
protein 19635391
D012402 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 Rotenone inhibits the reaction [acetylleucyl-leucyl-norleucinal results in increased expression of IL8 mRNA] decreases reaction
/ increases expression
mRNA 12208513
D012402 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 Rotenone inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of IL8 mRNA] decreases reaction
/ increases expression
mRNA 12208513
D012402 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 Rotenone inhibits the reaction [lactacystin results in increased expression of IL8 mRNA] decreases reaction
/ increases expression
mRNA 12208513
D012402 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 Rotenone inhibits the reaction [MG 262 results in increased expression of IL8 mRNA] decreases reaction
/ increases expression
mRNA 12208513
D012402 3716 JAK1
JAK1A
JAK1B
JTK3
Janus kinase 1 (EC:2.7.10.2) Rotenone inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of JAK1 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 15748169
D012402 3716 JAK1
JAK1A
JAK1B
JTK3
Janus kinase 1 (EC:2.7.10.2) Rotenone results in decreased phosphorylation of JAK1 protein decreases phosphorylation
protein 19635391
D012402 3717 JAK2
JTK10
THCYT3
Janus kinase 2 (EC:2.7.10.2) Rotenone inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of JAK2 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 15748169
D012402 3717 JAK2
JTK10
THCYT3
Janus kinase 2 (EC:2.7.10.2) Rotenone inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased phosphorylation of JAK2 protein]] decreases reaction
/ increases phosphorylation
/ increases reaction
protein 15677497
D012402 3717 JAK2
JTK10
THCYT3
Janus kinase 2 (EC:2.7.10.2) Rotenone results in decreased phosphorylation of JAK2 protein decreases phosphorylation
protein 19635391
D012402 3725 JUN
AP-1
AP1
c-Jun
jun proto-oncogene ropinirole inhibits the reaction [Rotenone results in increased phosphorylation of JUN protein] decreases reaction
/ increases phosphorylation
protein 18242171
D012402 3725 JUN
AP-1
AP1
c-Jun
jun proto-oncogene Rotenone results in increased phosphorylation of and results in increased activity of JUN protein increases activity
/ increases phosphorylation
protein 14976342
D012402 3725 JUN
AP-1
AP1
c-Jun
jun proto-oncogene Rotenone results in increased phosphorylation of JUN protein increases phosphorylation
protein 17324951
18242171
D012402 3952 LEP
LEPD
OB
OBS
leptin Rotenone inhibits the reaction [LEP protein results in increased chemical synthesis of Reactive Oxygen Species] decreases reaction
/ increases chemical synthesis
protein 11342529
D012402 3952 LEP
LEPD
OB
OBS
leptin Rotenone results in decreased susceptibility to LEP protein decreases response to substance
protein 11342529
D012402 120892 LRRK2
AURA17
DARDARIN
PARK8
RIPK7
ROCO2
leucine-rich repeat kinase 2 (EC:2.7.11.1) LRRK2 gene polymorphism results in increased susceptibility to Rotenone increases response to substance
gene 19741132
D012402 120892 LRRK2
AURA17
DARDARIN
PARK8
RIPK7
ROCO2
leucine-rich repeat kinase 2 (EC:2.7.11.1) LRRK2 protein results in decreased susceptibility to Rotenone decreases response to substance
protein 19625511
D012402 120892 LRRK2
AURA17
DARDARIN
PARK8
RIPK7
ROCO2
leucine-rich repeat kinase 2 (EC:2.7.11.1) LRRK2 protein results in increased susceptibility to Rotenone increases response to substance
protein 19692353
D012402 120892 LRRK2
AURA17
DARDARIN
PARK8
RIPK7
ROCO2
leucine-rich repeat kinase 2 (EC:2.7.11.1) PARK2 protein inhibits the reaction [LRRK2 gene polymorphism results in increased susceptibility to Rotenone] decreases reaction
/ increases response to substance
gene 19741132
D012402 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) Ranitidine inhibits the reaction [Rotenone results in increased phosphorylation of MAPK1 protein] decreases reaction
/ increases phosphorylation
protein 19723537
D012402 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) Rotenone inhibits the reaction [Aldosterone results in increased phosphorylation of and results in increased activity of MAPK1 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 17596522
D012402 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) Rotenone results in decreased phosphorylation of and results in decreased activity of MAPK1 protein decreases activity
/ decreases phosphorylation
protein 19777565
D012402 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) Rotenone results in increased phosphorylation of MAPK1 protein increases phosphorylation
protein 19723537
D012402 1432 MAPK14
CSBP
CSBP1
CSBP2
CSPB1
EXIP
Mxi2
PRKM14
PRKM15
RK
SAPK2A
p38
p38ALPHA
mitogen-activated protein kinase 14 (EC:2.7.11.24) Rotenone inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK14 protein] decreases reaction
/ increases phosphorylation
protein 15650392
D012402 1432 MAPK14
CSBP
CSBP1
CSBP2
CSPB1
EXIP
Mxi2
PRKM14
PRKM15
RK
SAPK2A
p38
p38ALPHA
mitogen-activated protein kinase 14 (EC:2.7.11.24) Rotenone results in increased phosphorylation of and results in increased activity of MAPK14 protein increases activity
/ increases phosphorylation
protein 14976342
D012402 1432 MAPK14
CSBP
CSBP1
CSBP2
CSPB1
EXIP
Mxi2
PRKM14
PRKM15
RK
SAPK2A
p38
p38ALPHA
mitogen-activated protein kinase 14 (EC:2.7.11.24) Rotenone results in increased phosphorylation of MAPK14 protein increases phosphorylation
protein 17324951
19777565
D012402 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) Ranitidine inhibits the reaction [Rotenone results in increased phosphorylation of MAPK3 protein] decreases reaction
/ increases phosphorylation
protein 19723537
D012402 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) Rotenone inhibits the reaction [Aldosterone results in increased phosphorylation of and results in increased activity of MAPK3 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 17596522
D012402 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) Rotenone results in decreased phosphorylation of and results in decreased activity of MAPK3 protein decreases activity
/ decreases phosphorylation
protein 19777565
D012402 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) Rotenone results in increased phosphorylation of MAPK3 protein increases phosphorylation
protein 19723537
D012402 5599 MAPK8
JNK
JNK-46
JNK1
JNK1A2
JNK21B1/2
PRKM8
SAPK1
SAPK1c
mitogen-activated protein kinase 8 (EC:2.7.11.24) Rotenone results in increased activity of MAPK8 protein increases activity
protein 10780954
D012402 5599 MAPK8
JNK
JNK-46
JNK1
JNK1A2
JNK21B1/2
PRKM8
SAPK1
SAPK1c
mitogen-activated protein kinase 8 (EC:2.7.11.24) Rotenone results in increased phosphorylation of and results in increased activity of MAPK8 protein increases activity
/ increases phosphorylation
protein 14976342
D012402 5599 MAPK8
JNK
JNK-46
JNK1
JNK1A2
JNK21B1/2
PRKM8
SAPK1
SAPK1c
mitogen-activated protein kinase 8 (EC:2.7.11.24) SLC2A1 protein inhibits the reaction [Rotenone results in increased activity of MAPK8 protein] decreases reaction
/ increases activity
protein 10780954
D012402 4137 MAPT
DDPAC
FTDP-17
MAPTL
MSTD
MTBT1
MTBT2
PPND
TAU
microtubule-associated protein tau Rotenone results in decreased expression of MAPT protein decreases expression
protein 16930453
D012402 4313 MMP2
CLG4
CLG4A
MMP-II
MONA
TBE-1
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) [Rotenone results in increased abundance of Reactive Oxygen Species] which results in increased activity of MMP2 protein increases abundance
/ increases activity
protein 11929863
D012402 4313 MMP2
CLG4
CLG4A
MMP-II
MONA
TBE-1
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) Rotenone results in increased activity of MMP2 protein increases activity
protein 11929863
D012402 4361 MRE11A
ATLD
HNGS1
MRE11
MRE11B
MRE11 meiotic recombination 11 homolog A (S. cerevisiae) Rotenone results in increased expression of MRE11A mRNA increases expression
mRNA 18191903
D012402 64965 MRPS9
MRP-S9
RPMS9
S9mt
mitochondrial ribosomal protein S9 Rotenone results in increased expression of MRPS9 mRNA increases expression
mRNA 18191903
D012402 4481 MSR1
CD204
SCARA1
SR-A
SRA
phSR1
phSR2
macrophage scavenger receptor 1 Rotenone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MSR1 mRNA] decreases reaction
/ increases expression
mRNA 9614211
D012402 4490 MT1B
MT1
MT1Q
MTP
metallothionein 1B MT1B protein inhibits the reaction [Rotenone results in increased activity of CASP3 protein] decreases reaction
/ increases activity
protein 16402917
D012402 4490 MT1B
MT1
MT1Q
MTP
metallothionein 1B MT1B protein inhibits the reaction [Rotenone results in increased activity of CASP7 protein] decreases reaction
/ increases activity
protein 16402917
D012402 4502 MT2A
MT2
metallothionein 2A MT2A protein inhibits the reaction [Rotenone results in increased abundance of Reactive Oxygen Species] decreases reaction
/ increases abundance
protein 16402917
D012402 4502 MT2A
MT2
metallothionein 2A MT2A protein inhibits the reaction [Rotenone results in increased activity of CASP3 protein] decreases reaction
/ increases activity
protein 16402917
D012402 4502 MT2A
MT2
metallothionein 2A MT2A protein inhibits the reaction [Rotenone results in increased activity of CASP7 protein] decreases reaction
/ increases activity
protein 16402917
D012402 4502 MT2A
MT2
metallothionein 2A Rotenone results in increased expression of MT2A mRNA increases expression
mRNA 16402917
D012402 80198 MUS81
SLX3
MUS81 structure-specific endonuclease subunit (EC:3.1.22.-) Rotenone results in increased expression of MUS81 mRNA increases expression
mRNA 18191903
D012402 10135 NAMPT
1110035O14Rik
PBEF
PBEF1
VF
VISFATIN
nicotinamide phosphoribosyltransferase (EC:2.4.2.12) Rotenone results in decreased activity of NAMPT protein decreases activity
protein 18486613
D012402 4541 ND6
MTND6
MT-ND6
NADH dehydrogenase, subunit 6 (complex I) ND6 gene mutant form results in decreased susceptibility to Rotenone decreases response to substance
gene 15248896
D012402 4705 NDUFA10
CI-42KD
CI-42k
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa (EC:1.6.5.3 1.6.99.3) Rotenone results in increased expression of NDUFA10 mRNA increases expression
mRNA 18191903
D012402 4696 NDUFA3
B9
CI-B9
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa Rotenone results in increased expression of NDUFA3 mRNA increases expression
mRNA 18191903
D012402 4697 NDUFA4
CI-9k
CI-MLRQ
MLRQ
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9kDa (EC:1.6.5.3 1.6.99.3) Rotenone results in increased expression of NDUFA4 mRNA increases expression
mRNA 18191903
D012402 4700 NDUFA6
B14
CI-B14
LYRM6
NADHB14
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, 14kDa Rotenone results in increased expression of NDUFA6 mRNA increases expression
mRNA 18191903
D012402 4704 NDUFA9
CC6
CI-39k
CI39k
NDUFS2L
SDR22E1
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa Rotenone results in increased expression of NDUFA9 mRNA increases expression
mRNA 18191903
D012402 4707 NDUFB1
CI-MNLL
CI-SGDH
MNLL
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa Rotenone results in increased expression of NDUFB1 mRNA increases expression
mRNA 18191903
D012402 4708 NDUFB2
AGGG
CI-AGGG
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa (EC:1.6.5.3 1.6.99.3) Rotenone results in increased expression of NDUFB2 mRNA increases expression
mRNA 18191903
D012402 4709 NDUFB3
B12
CI-B12
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa Rotenone results in increased expression of NDUFB3 mRNA increases expression
mRNA 18191903
D012402 4710 NDUFB4
B15
CI-B15
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa (EC:1.6.5.3 1.6.99.3) Rotenone results in increased expression of NDUFB4 mRNA increases expression
mRNA 18191903
D012402 4711 NDUFB5
CISGDH
SGDH
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa (EC:1.6.5.3 1.6.99.3) Rotenone results in increased expression of NDUFB5 mRNA increases expression
mRNA 18191903
D012402 4712 NDUFB6
B17
CI
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa (EC:1.6.5.3 1.6.99.3) Rotenone results in increased expression of NDUFB6 mRNA increases expression
mRNA 18191903
D012402 4713 NDUFB7
B18
CI-B18
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa (EC:1.6.5.3 1.6.99.3) Rotenone results in increased expression of NDUFB7 mRNA increases expression
mRNA 18191903
D012402 4714 NDUFB8
ASHI
CI-ASHI
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa Rotenone results in increased expression of NDUFB8 mRNA increases expression
mRNA 18191903
D012402 4724 NDUFS4
AQDQ
CI-18
NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) Rotenone results in increased expression of NDUFS4 mRNA increases expression
mRNA 18191903
D012402 4726 NDUFS6
CI-13kA
CI-13kD-A
CI13KDA
NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase) (EC:1.6.5.3 1.6.99.3) Rotenone results in increased expression of NDUFS6 mRNA increases expression
mRNA 18191903
D012402 4728 NDUFS8
CI-23k
CI23KD
TYKY
NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase) (EC:1.6.5.3 1.6.99.3) Rotenone results in increased expression of NDUFS8 mRNA increases expression
mRNA 18191903
D012402 10725 NFAT5
NF-AT5
NFATL1
NFATZ
OREBP
TONEBP
nuclear factor of activated T-cells 5, tonicity-responsive Rotenone inhibits the reaction [Sodium Chloride results in increased activity of NFAT5 protein] decreases reaction
/ increases activity
protein 16303854
D012402 4772 NFATC1
NF-ATC
NFAT2
NFATc
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 Rotenone inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA] decreases reaction
/ increases expression
mRNA 19900598
D012402 4772 NFATC1
NF-ATC
NFAT2
NFATc
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 Rotenone inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein] decreases reaction
/ increases expression
protein 19900598
D012402 4780 NFE2L2
NRF2
nuclear factor, erythroid 2-like 2 NFE2L2 protein results in decreased susceptibility to Rotenone decreases response to substance
protein 17360324
D012402 4790 NFKB1
EBP-1
KBF1
NF-kB1
NF-kappa-B
NF-kappaB
NFKB-p105
NFKB-p50
NFkappaB
p105
p50
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 Rotenone inhibits the reaction [Oxygen deficiency promotes the reaction [RELA protein binds to NFKB1 protein]] affects binding
/ decreases reaction
/ increases reaction
protein 11950692
D012402 4846 NOS3
ECNOS
eNOS
nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) Rotenone inhibits the reaction [Equol results in increased phosphorylation of and results in increased activity of NOS3 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 21300668
D012402 4879 NPPB
BNP
natriuretic peptide B Rotenone inhibits the reaction [Oxygen deficiency results in increased secretion of NPPB protein] decreases reaction
/ increases secretion
protein 19542490
D012402 4521 NUDT1
MTH1
nudix (nucleoside diphosphate linked moiety X)-type motif 1 (EC:3.6.1.55 3.6.1.56) Rotenone results in increased expression of NUDT1 mRNA increases expression
mRNA 18191903
D012402 4953 ODC1
ODC
ornithine decarboxylase 1 (EC:4.1.1.17) Rotenone inhibits the reaction [Estradiol results in increased activity of ODC1 protein] decreases reaction
/ increases activity
protein 9834970
D012402 4953 ODC1
ODC
ornithine decarboxylase 1 (EC:4.1.1.17) Rotenone inhibits the reaction [IGF1 protein results in increased activity of ODC1 protein] decreases reaction
/ increases activity
protein 9834970
D012402 4953 ODC1
ODC
ornithine decarboxylase 1 (EC:4.1.1.17) Rotenone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of ODC1 protein] decreases reaction
/ increases activity
protein 9834970
D012402 4953 ODC1
ODC
ornithine decarboxylase 1 (EC:4.1.1.17) Rotenone results in increased activity of ODC1 protein increases activity
protein 9834970
D012402 4976 OPA1
MGM1
NPG
NTG
largeG
optic atrophy 1 (autosomal dominant) (EC:3.6.5.5) Rotenone results in increased expression of OPA1 protein increases expression
protein 21223980
D012402 126014 OSCAR
PIGR3
PIgR-3
osteoclast associated, immunoglobulin-like receptor Rotenone inhibits the reaction [TNFSF11 protein results in increased expression of OSCAR mRNA] decreases reaction
/ increases expression
mRNA 19900598
D012402 5071 PARK2
AR-JP
LPRS2
PDJ
PRKN
parkin RBR E3 ubiquitin protein ligase PARK2 gene mutant form results in increased susceptibility to Rotenone increases response to substance
gene 17687034
D012402 5071 PARK2
AR-JP
LPRS2
PDJ
PRKN
parkin RBR E3 ubiquitin protein ligase PARK2 protein affects the susceptibility to Rotenone affects response to substance
protein 20940149
D012402 5071 PARK2
AR-JP
LPRS2
PDJ
PRKN
parkin RBR E3 ubiquitin protein ligase PARK2 protein inhibits the reaction [LRRK2 gene polymorphism results in increased susceptibility to Rotenone] decreases reaction
/ increases response to substance
protein 19741132
D012402 5071 PARK2
AR-JP
LPRS2
PDJ
PRKN
parkin RBR E3 ubiquitin protein ligase PARK2 protein results in decreased susceptibility to Rotenone decreases response to substance
protein 17687034
19741132
D012402 11315 PARK7
DJ-1
DJ1
parkinson protein 7 4-phenylbutyric acid inhibits the reaction [Rotenone results in increased expression of PARK7 protein] decreases reaction
/ increases expression
protein 17459145
D012402 11315 PARK7
DJ-1
DJ1
parkinson protein 7 Acetylcysteine inhibits the reaction [Rotenone results in increased expression of PARK7 protein] decreases reaction
/ increases expression
protein 18377993
D012402 11315 PARK7
DJ-1
DJ1
parkinson protein 7 alpha-Tocopherol inhibits the reaction [Rotenone affects the localization of PARK7 protein] affects localization
/ decreases reaction
protein 16439141
D012402 11315 PARK7
DJ-1
DJ1
parkinson protein 7 PARK7 protein affects the susceptibility to Rotenone affects response to substance
protein 20940149
D012402 11315 PARK7
DJ-1
DJ1
parkinson protein 7 PARK7 protein results in decreased susceptibility to Rotenone decreases response to substance
protein 18331584
18377993
D012402 11315 PARK7
DJ-1
DJ1
parkinson protein 7 Rotenone affects the localization of PARK7 protein affects localization
protein 16439141
18377993
D012402 11315 PARK7
DJ-1
DJ1
parkinson protein 7 Rotenone results in increased expression of PARK7 mRNA increases expression
mRNA 18377993
D012402 11315 PARK7
DJ-1
DJ1
parkinson protein 7 Rotenone results in increased expression of PARK7 protein increases expression
protein 17459145
18377993
D012402 142 PARP1
ADPRT
ADPRT_1
ADPRT1
ARTD1
PARP
PARP-1
PPOL
pADPRT-1
poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [Rotenone results in increased cleavage of PARP1 protein] decreases reaction
/ increases cleavage
protein 19777565
D012402 142 PARP1
ADPRT
ADPRT_1
ADPRT1
ARTD1
PARP
PARP-1
PPOL
pADPRT-1
poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) aspartyl-glutamyl-valyl-aspartal inhibits the reaction [Rotenone results in increased cleavage of PARP1 protein] decreases reaction
/ increases cleavage
protein 14976342
D012402 142 PARP1
ADPRT
ADPRT_1
ADPRT1
ARTD1
PARP
PARP-1
PPOL
pADPRT-1
poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) ATG5 protein affects the reaction [Sirolimus inhibits the reaction [Rotenone results in increased cleavage of PARP1 protein]] affects reaction
/ decreases reaction
/ increases cleavage
protein 19682553
D012402 142 PARP1
ADPRT
ADPRT_1
ADPRT1
ARTD1
PARP
PARP-1
PPOL
pADPRT-1
poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) Ranitidine inhibits the reaction [Rotenone results in increased cleavage of PARP1 protein] decreases reaction
/ increases cleavage
protein 19723537
D012402 142 PARP1
ADPRT
ADPRT_1
ADPRT1
ARTD1
PARP
PARP-1
PPOL
pADPRT-1
poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) Rotenone results in increased cleavage of PARP1 protein increases cleavage
protein 14976342
19539006
19682553
19723537
19777565
D012402 142 PARP1
ADPRT
ADPRT_1
ADPRT1
ARTD1
PARP
PARP-1
PPOL
pADPRT-1
poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) SB 203580 inhibits the reaction [Rotenone results in increased cleavage of PARP1 protein] decreases reaction
/ increases cleavage
protein 19777565
D012402 142 PARP1
ADPRT
ADPRT_1
ADPRT1
ARTD1
PARP
PARP-1
PPOL
pADPRT-1
poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) Sirolimus inhibits the reaction [Rotenone results in increased cleavage of PARP1 protein] decreases reaction
/ increases cleavage
protein 19682553
D012402 142 PARP1
ADPRT
ADPRT_1
ADPRT1
ARTD1
PARP
PARP-1
PPOL
pADPRT-1
poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) Tranexamic Acid inhibits the reaction [Rotenone results in increased cleavage of PARP1 protein] decreases reaction
/ increases cleavage
protein 19539006
D012402 5162 PDHB
PDHBD
PDHE1-B
PHE1B
pyruvate dehydrogenase (lipoamide) beta (EC:1.2.4.1) Rotenone results in increased expression of PDHB protein increases expression
protein 19763263
D012402 5163 PDK1
pyruvate dehydrogenase kinase, isozyme 1 (EC:2.7.11.2) [Rotenone co-treated with Thenoyltrifluoroacetone] inhibits the reaction [Oxygen deficiency results in increased expression of PDK1 mRNA] affects cotreatment
/ decreases reaction
/ increases expression
mRNA 17671207
D012402 65018 PINK1
BRPK
PARK6
PTEN induced putative kinase 1 (EC:2.7.11.1) PINK1 protein affects the susceptibility to Rotenone affects response to substance
protein 16226715
20940149
D012402 65018 PINK1
BRPK
PARK6
PTEN induced putative kinase 1 (EC:2.7.11.1) PINK1 protein results in decreased susceptibility to Rotenone decreases response to substance
protein 19492085
D012402 5422 POLA1
POLA
p180
polymerase (DNA directed), alpha 1, catalytic subunit (EC:2.7.7.7) Rotenone results in increased expression of POLA1 mRNA increases expression
mRNA 18191903
D012402 5427 POLE2
DPE2
polymerase (DNA directed), epsilon 2, accessory subunit (EC:2.7.7.7) Rotenone results in increased expression of POLE2 mRNA increases expression
mRNA 18191903
D012402 5481 PPID
CYP-40
CYPD
peptidylprolyl isomerase D (EC:5.2.1.8) Rotenone results in increased expression of PPID mRNA increases expression
mRNA 18614807
D012402 5481 PPID
CYP-40
CYPD
peptidylprolyl isomerase D (EC:5.2.1.8) Rotenone results in increased expression of PPID protein increases expression
protein 18614807
D012402 5562 PRKAA1
AMPK
AMPKa1
protein kinase, AMP-activated, alpha 1 catalytic subunit (EC:2.7.11.1 2.7.11.26 2.7.11.27 2.7.11.31) Rotenone results in increased expression of PRKAA1 mRNA increases expression
mRNA 17651460
D012402 8842 PROM1
AC133
CD133
CORD12
MCDR2
PROML1
RP41
STGD4
prominin 1 Rotenone results in increased expression of PROM1 protein increases expression
protein 18985161
D012402 5810 RAD1
HRAD1
REC1
RAD1 homolog (S. pombe) (EC:3.1.11.2) Rotenone results in increased expression of RAD1 mRNA increases expression
mRNA 18191903
D012402 5884 RAD17
CCYC
HRAD17
R24L
RAD17SP
RAD24
RAD17 homolog (S. pombe) Rotenone results in increased expression of RAD17 mRNA increases expression
mRNA 18191903
D012402 56852 RAD18
RNF73
RAD18 homolog (S. cerevisiae) Rotenone results in increased expression of RAD18 mRNA increases expression
mRNA 18191903
D012402 10111 RAD50
NBSLD
RAD502
hRad50
RAD50 homolog (S. cerevisiae) Rotenone results in increased expression of RAD50 mRNA increases expression
mRNA 18191903
D012402 5888 RAD51
BRCC5
HRAD51
HsRad51
HsT16930
MRMV2
RAD51A
RECA
RAD51 recombinase Rotenone results in increased expression of RAD51 mRNA increases expression
mRNA 18191903
D012402 10635 RAD51AP1
PIR51
RAD51 associated protein 1 Rotenone results in increased expression of RAD51AP1 mRNA increases expression
mRNA 18191903
D012402 25788 RAD54B
RDH54
RAD54 homolog B (S. cerevisiae) Rotenone results in increased expression of RAD54B mRNA increases expression
mRNA 18191903
D012402 5883 RAD9A
RAD9
RAD9 homolog A (S. pombe) (EC:3.1.11.2) Rotenone results in increased expression of RAD9A mRNA increases expression
mRNA 18191903
D012402 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A Rotenone inhibits the reaction [Oxygen deficiency promotes the reaction [RELA protein binds to NFKB1 protein]] affects binding
/ decreases reaction
/ increases reaction
protein 11950692
D012402 5984 RFC4
A1
RFC37
replication factor C (activator 1) 4, 37kDa Rotenone results in increased expression of RFC4 mRNA increases expression
mRNA 18191903
D012402 5985 RFC5
RFC36
replication factor C (activator 1) 5, 36.5kDa Rotenone results in increased expression of RFC5 mRNA increases expression
mRNA 18191903
D012402 6513 SLC2A1
DYT17
DYT18
DYT9
EIG12
GLUT
GLUT1
GLUT1DS
HTLVR
PED
solute carrier family 2 (facilitated glucose transporter), member 1 Rotenone inhibits the reaction [Oxygen deficiency results in increased expression of SLC2A1 mRNA] decreases reaction
/ increases expression
mRNA 19091749
D012402 6513 SLC2A1
DYT17
DYT18
DYT9
EIG12
GLUT
GLUT1
GLUT1DS
HTLVR
PED
solute carrier family 2 (facilitated glucose transporter), member 1 SLC2A1 protein inhibits the reaction [Rotenone results in increased activity of MAPK8 protein] decreases reaction
/ increases activity
protein 10780954
D012402 6513 SLC2A1
DYT17
DYT18
DYT9
EIG12
GLUT
GLUT1
GLUT1DS
HTLVR
PED
solute carrier family 2 (facilitated glucose transporter), member 1 SLC2A1 protein results in decreased susceptibility to Rotenone decreases response to substance
protein 10780954
D012402 6539 SLC6A12
BGT-1
BGT1
GAT2
solute carrier family 6 (neurotransmitter transporter), member 12 Rotenone inhibits the reaction [Sodium Chloride results in increased expression of SLC6A12 mRNA] decreases reaction
/ increases expression
mRNA 16303854
D012402 6531 SLC6A3
DAT
DAT1
PKDYS
solute carrier family 6 (neurotransmitter transporter), member 3 SLC6A3 protein results in increased susceptibility to Rotenone increases response to substance
protein 18206288
D012402 6606 SMN1
BCD541
GEMIN1
SMA
SMA1
SMA2
SMA3
SMA4
SMA@
SMN
SMNT
T-BCD541
TDRD16A
survival of motor neuron 1, telomeric Rotenone results in increased expression of SMN1 mRNA alternative form increases expression
mRNA 17064354
D012402 6615 SNAI1
SLUGH2
SNA
SNAH
SNAIL
SNAIL1
dJ710H13.1
snail family zinc finger 1 Rotenone inhibits the reaction [Aldosterone results in increased expression of SNAI1 mRNA] decreases reaction
/ increases expression
mRNA 17596522
D012402 6622 SNCA
NACP
PARK1
PARK4
PD1
synuclein, alpha (non A4 component of amyloid precursor) 3-Hydroxybutyric Acid inhibits the reaction [SNCA protein results in increased susceptibility to Rotenone] decreases reaction
/ increases response to substance
protein 16239214
D012402 6622 SNCA
NACP
PARK1
PARK4
PD1
synuclein, alpha (non A4 component of amyloid precursor) 3-Hydroxybutyric Acid promotes the reaction [tauroursodeoxycholic acid inhibits the reaction [SNCA protein results in increased susceptibility to Rotenone]] decreases reaction
/ increases reaction
/ increases response to substance
protein 16239214
D012402 6622 SNCA
NACP
PARK1
PARK4
PD1
synuclein, alpha (non A4 component of amyloid precursor) [Acetylcarnitine co-treated with Thioctic Acid] inhibits the reaction [Rotenone results in increased expression of SNCA protein] affects cotreatment
/ decreases reaction
/ increases expression
protein 20414966
D012402 6622 SNCA
NACP
PARK1
PARK4
PD1
synuclein, alpha (non A4 component of amyloid precursor) Acetylcarnitine inhibits the reaction [Rotenone results in increased expression of SNCA protein] decreases reaction
/ increases expression
protein 20414966
D012402 6622 SNCA
NACP
PARK1
PARK4
PD1
synuclein, alpha (non A4 component of amyloid precursor) alpha-Tocopherol inhibits the reaction [Rotenone results in increased expression of SNCA protein] decreases reaction
/ increases expression
protein 16439141
D012402 6622 SNCA
NACP
PARK1
PARK4
PD1
synuclein, alpha (non A4 component of amyloid precursor) Probucol inhibits the reaction [SNCA protein results in increased susceptibility to Rotenone] decreases reaction
/ increases response to substance
protein 16239214
D012402 6622 SNCA
NACP
PARK1
PARK4
PD1
synuclein, alpha (non A4 component of amyloid precursor) Rotenone affects the localization of SNCA protein affects localization
protein 19628769
D012402 6622 SNCA
NACP
PARK1
PARK4
PD1
synuclein, alpha (non A4 component of amyloid precursor) Rotenone affects the localization of SNCA protein mutant form affects localization
protein 19628769
D012402 6622 SNCA
NACP
PARK1
PARK4
PD1
synuclein, alpha (non A4 component of amyloid precursor) Rotenone promotes the reaction [SNCA protein binds to SNCA protein] affects binding
/ increases reaction
protein 23244436
D012402 6622 SNCA
NACP
PARK1
PARK4
PD1
synuclein, alpha (non A4 component of amyloid precursor) Rotenone promotes the reaction [SNCA protein binds to YWHAB protein] affects binding
/ increases reaction
protein 15280438
D012402 6622 SNCA
NACP
PARK1
PARK4
PD1
synuclein, alpha (non A4 component of amyloid precursor) Rotenone results in increased expression of SNCA mRNA alternative form increases expression
mRNA 19857570
D012402 6622 SNCA
NACP
PARK1
PARK4
PD1
synuclein, alpha (non A4 component of amyloid precursor) Rotenone results in increased expression of SNCA protein increases expression
protein 12177198
15114628
15280438
16439141
17131421
19114014
20414966
D012402 6622 SNCA
NACP
PARK1
PARK4
PD1
synuclein, alpha (non A4 component of amyloid precursor) SNCA protein results in decreased susceptibility to Rotenone decreases response to substance
protein 16239214
17041725
D012402 6622 SNCA
NACP
PARK1
PARK4
PD1
synuclein, alpha (non A4 component of amyloid precursor) SNCA protein results in increased susceptibility to Rotenone increases response to substance
protein 12151787
18514418
D012402 6622 SNCA
NACP
PARK1
PARK4
PD1
synuclein, alpha (non A4 component of amyloid precursor) [Staurosporine co-treated with Rotenone] promotes the reaction [SNCA protein binds to SNCA protein] affects binding
/ affects cotreatment
/ increases reaction
protein 19114014
D012402 6622 SNCA
NACP
PARK1
PARK4
PD1
synuclein, alpha (non A4 component of amyloid precursor) tauroursodeoxycholic acid inhibits the reaction [SNCA protein results in increased susceptibility to Rotenone] decreases reaction
/ increases response to substance
protein 16239214
D012402 6622 SNCA
NACP
PARK1
PARK4
PD1
synuclein, alpha (non A4 component of amyloid precursor) Thioctic Acid inhibits the reaction [Rotenone results in increased expression of SNCA protein] decreases reaction
/ increases expression
protein 20414966
D012402 6648 SOD2
IPOB
MNSOD
MVCD6
superoxide dismutase 2, mitochondrial (EC:1.15.1.1) Acetylcysteine inhibits the reaction [Rotenone results in increased expression of and results in increased activity of SOD2 protein] decreases reaction
/ increases activity
/ increases expression
protein 15904944
D012402 6648 SOD2
IPOB
MNSOD
MVCD6
superoxide dismutase 2, mitochondrial (EC:1.15.1.1) fraxetin inhibits the reaction [Rotenone results in increased expression of and results in increased activity of SOD2 protein] decreases reaction
/ increases activity
/ increases expression
protein 15904944
D012402 6648 SOD2
IPOB
MNSOD
MVCD6
superoxide dismutase 2, mitochondrial (EC:1.15.1.1) [Rotenone results in increased abundance of Superoxides] which results in increased expression of SOD2 protein increases abundance
/ increases expression
protein 16179351
D012402 6648 SOD2
IPOB
MNSOD
MVCD6
superoxide dismutase 2, mitochondrial (EC:1.15.1.1) Rotenone results in increased expression of and results in increased activity of SOD2 protein increases activity
/ increases expression
protein 15904944
D012402 6648 SOD2
IPOB
MNSOD
MVCD6
superoxide dismutase 2, mitochondrial (EC:1.15.1.1) SOD2 protein inhibits the reaction [Rotenone results in increased expression of BECN1 protein] decreases reaction
/ increases expression
protein 18032788
D012402 6648 SOD2
IPOB
MNSOD
MVCD6
superoxide dismutase 2, mitochondrial (EC:1.15.1.1) SOD2 protein results in decreased susceptibility to Rotenone decreases response to substance
protein 18032788
D012402 8878 SQSTM1
A170
OSIL
PDB3
ZIP3
p60
p62
p62B
sequestosome 1 SQSTM1 protein results in decreased susceptibility to Rotenone decreases response to substance
protein 17360324
D012402 6720 SREBF1
SREBP-1c
SREBP1
bHLHd1
sterol regulatory element binding transcription factor 1 Rotenone results in increased expression of SREBF1 mRNA increases expression
mRNA 17651460
D012402 6742 SSBP1
Mt-SSB
SOSS-B1
SSBP
mtSSB
single-stranded DNA binding protein 1, mitochondrial Rotenone results in increased expression of SSBP1 protein increases expression
protein 21223980
D012402 6772 STAT1
CANDF7
ISGF-3
STAT91
signal transducer and activator of transcription 1, 91kDa Rotenone inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT1 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 15748169
D012402 6772 STAT1
CANDF7
ISGF-3
STAT91
signal transducer and activator of transcription 1, 91kDa Rotenone inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein] decreases reaction
/ increases phosphorylation
protein 19635391
D012402 6772 STAT1
CANDF7
ISGF-3
STAT91
signal transducer and activator of transcription 1, 91kDa Rotenone inhibits the reaction [IFNG protein affects the localization of STAT1 protein] affects localization
/ decreases reaction
protein 15748169
D012402 6772 STAT1
CANDF7
ISGF-3
STAT91
signal transducer and activator of transcription 1, 91kDa Rotenone inhibits the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of STAT1 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 15748169
D012402 6772 STAT1
CANDF7
ISGF-3
STAT91
signal transducer and activator of transcription 1, 91kDa Rotenone promotes the reaction [Nitrofurantoin inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT1 protein]] decreases reaction
/ increases activity
/ increases phosphorylation
/ increases reaction
protein 15748169
D012402 6772 STAT1
CANDF7
ISGF-3
STAT91
signal transducer and activator of transcription 1, 91kDa Thioctic Acid inhibits the reaction [Rotenone inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]] decreases reaction
/ increases phosphorylation
protein 19635391
D012402 6774 STAT3
APRF
HIES
signal transducer and activator of transcription 3 (acute-phase response factor) Rotenone inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT3 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 15748169
D012402 6774 STAT3
APRF
HIES
signal transducer and activator of transcription 3 (acute-phase response factor) Rotenone inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein] decreases reaction
/ increases phosphorylation
protein 19635391
D012402 6774 STAT3
APRF
HIES
signal transducer and activator of transcription 3 (acute-phase response factor) Rotenone promotes the reaction [Nitrofurantoin inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT3 protein]] decreases reaction
/ increases activity
/ increases phosphorylation
/ increases reaction
protein 15748169
D012402 6774 STAT3
APRF
HIES
signal transducer and activator of transcription 3 (acute-phase response factor) Thioctic Acid inhibits the reaction [Rotenone inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]] decreases reaction
/ increases phosphorylation
protein 19635391
D012402 7084 TK2
MTDPS2
MTTK
thymidine kinase 2, mitochondrial (EC:2.7.1.21) Rotenone results in increased expression of TK2 protein increases expression
protein 16565515
D012402 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Rotenone inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species] decreases reaction
/ increases abundance
protein 10973919
D012402 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Rotenone inhibits the reaction [TNF protein results in increased cleavage of CASP3 protein] decreases reaction
/ increases cleavage
protein 10973919
D012402 4982 TNFRSF11B
OCIF
OPG
TR1
tumor necrosis factor receptor superfamily, member 11b Rotenone results in decreased expression of TNFRSF11B mRNA decreases expression
mRNA 17651460
D012402 4982 TNFRSF11B
OCIF
OPG
TR1
tumor necrosis factor receptor superfamily, member 11b Rotenone results in decreased expression of TNFRSF11B protein decreases expression
protein 17651460
D012402 4982 TNFRSF11B
OCIF
OPG
TR1
tumor necrosis factor receptor superfamily, member 11b Rotenone results in decreased secretion of TNFRSF11B protein decreases secretion
protein 17651460
D012402 8600 TNFSF11
CD254
ODF
OPGL
OPTB2
RANKL
TRANCE
hRANKL2
sOdf
tumor necrosis factor (ligand) superfamily, member 11 Rotenone inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA] decreases reaction
/ increases expression
protein 19900598
D012402 8600 TNFSF11
CD254
ODF
OPGL
OPTB2
RANKL
TRANCE
hRANKL2
sOdf
tumor necrosis factor (ligand) superfamily, member 11 Rotenone inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA] decreases reaction
/ increases expression
protein 19900598
D012402 8600 TNFSF11
CD254
ODF
OPGL
OPTB2
RANKL
TRANCE
hRANKL2
sOdf
tumor necrosis factor (ligand) superfamily, member 11 Rotenone inhibits the reaction [TNFSF11 protein results in increased expression of FOS protein] decreases reaction
/ increases expression
protein 19900598
D012402 8600 TNFSF11
CD254
ODF
OPGL
OPTB2
RANKL
TRANCE
hRANKL2
sOdf
tumor necrosis factor (ligand) superfamily, member 11 Rotenone inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA] decreases reaction
/ increases expression
protein 19900598
D012402 8600 TNFSF11
CD254
ODF
OPGL
OPTB2
RANKL
TRANCE
hRANKL2
sOdf
tumor necrosis factor (ligand) superfamily, member 11 Rotenone inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein] decreases reaction
/ increases expression
protein 19900598
D012402 8600 TNFSF11
CD254
ODF
OPGL
OPTB2
RANKL
TRANCE
hRANKL2
sOdf
tumor necrosis factor (ligand) superfamily, member 11 Rotenone inhibits the reaction [TNFSF11 protein results in increased expression of OSCAR mRNA] decreases reaction
/ increases expression
protein 19900598
D012402 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 Rotenone affects the localization of TP53 protein affects localization
protein 21223980
D012402 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 Rotenone results in increased expression of and results in increased phosphorylation of TP53 protein increases expression
/ increases phosphorylation
protein 21223980
D012402 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 Rotenone results in increased expression of TP53 mRNA increases expression
mRNA 18191903
D012402 25828 TXN2
MT-TRX
MTRX
TRX2
thioredoxin 2 Rotenone results in increased oxidation of TXN2 protein increases oxidation
protein 17018646
D012402 25828 TXN2
MT-TRX
MTRX
TRX2
thioredoxin 2 TXN2 protein results in increased susceptibility to Rotenone increases response to substance
protein 12080052
D012402 7334 UBE2N
UBC13
UbcH-ben
UbcH13
ubiquitin-conjugating enzyme E2N (EC:6.3.2.19) Rotenone results in increased expression of UBE2N mRNA increases expression
mRNA 18191903
D012402 7381 UQCRB
MC3DN3
QCR7
QP-C
QPC
UQBC
UQBP
UQCR6
UQPC
ubiquinol-cytochrome c reductase binding protein (EC:1.10.2.2) Rotenone results in increased expression of UQCRB mRNA increases expression
mRNA 18191903
D012402 7384 UQCRC1
D3S3191
QCR1
UQCR1
ubiquinol-cytochrome c reductase core protein I (EC:1.10.2.2) Rotenone results in increased expression of UQCRC1 mRNA increases expression
mRNA 18191903
D012402 7416 VDAC1
PORIN
VDAC-1
voltage-dependent anion channel 1 asiatic acid inhibits the reaction [Rotenone results in increased expression of VDAC1 mRNA] decreases reaction
/ increases expression
mRNA 18802751
D012402 7416 VDAC1
PORIN
VDAC-1
voltage-dependent anion channel 1 asiatic acid inhibits the reaction [Rotenone results in increased expression of VDAC1 protein] decreases reaction
/ increases expression
protein 18802751
D012402 7416 VDAC1
PORIN
VDAC-1
voltage-dependent anion channel 1 Rotenone results in increased expression of VDAC1 mRNA increases expression
mRNA 18802751
D012402 7416 VDAC1
PORIN
VDAC-1
voltage-dependent anion channel 1 Rotenone results in increased expression of VDAC1 protein increases expression
protein 18802751
D012402 7421 VDR
NR1I1
vitamin D (1,25- dihydroxyvitamin D3) receptor Rotenone results in increased activity of VDR protein increases activity
protein 20143881
D012402 7422 VEGFA
MVCD1
VEGF
VPF
vascular endothelial growth factor A [Rotenone co-treated with Thenoyltrifluoroacetone] inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA] affects cotreatment
/ decreases reaction
/ increases expression
mRNA 17671207
D012402 7422 VEGFA
MVCD1
VEGF
VPF
vascular endothelial growth factor A Rotenone inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA] decreases reaction
/ increases expression
mRNA 19091749
D012402 7422 VEGFA
MVCD1
VEGF
VPF
vascular endothelial growth factor A Rotenone inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein] decreases reaction
/ increases expression
protein 19091749
D012402 7422 VEGFA
MVCD1
VEGF
VPF
vascular endothelial growth factor A Rotenone inhibits the reaction [Oxygen deficiency results in increased secretion of VEGFA protein] decreases reaction
/ increases secretion
protein 19091749
19542490
D012402 7498 XDH
XO
XOR
xanthine dehydrogenase (EC:1.17.1.4 1.17.3.2) Rotenone results in decreased activity of XDH protein decreases activity
protein 21570952
D012402 7529 YWHAB
GW128
HS1
KCIP-1
YWHAA
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide Rotenone promotes the reaction [SNCA protein binds to YWHAB protein] affects binding
/ increases reaction
protein 15280438
D012402 7532 YWHAG
14-3-3GAMMA
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide YWHAG protein results in decreased susceptibility to Rotenone decreases response to substance
protein 22490660

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (92)

OMIM preferred title UniProt
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#103780 Alcohol dependence P08172
P14416
P31645
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#608584 Asthma-related traits, susceptibility to, 2 Q6W5P4
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#210900 Bloom syndrome; blm P54132
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
%606641 Body mass index; bmi P37231
#300615 Brunner syndrome P21397
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#609338 Carotid intimal medial thickness 1 P37231
#118300 Charcot-marie-tooth disease and deafness Q01453
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#118220 Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a Q01453
#162800 Cyclic neutropenia P08246
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#237500 Dubin-johnson syndrome; djs Q92887
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#133239 Esophageal cancer P04637
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#137800 Glioma susceptibility 1; glm1 P04626
P37231
#139393 Guillain-barre syndrome, familial; gbs Q01453
#610140 Heart-hand syndrome, slovenian type P02545
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#145900 Hypertrophic neuropathy of dejerine-sottas Q01453
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#603932 Intervertebral disc disease; idd P14780
#535000 Leber optic atrophy P03905
#500001 Leber optic atrophy and dystonia P03905
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
P04637
#608516 Major depressive disorder; mdd P08172
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
%300852 Mental retardation, x-linked 88; mrx88 P50052
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#540000 Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes; melas P03905
#126200 Multiple sclerosis, susceptibility to; ms P08575
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#159900 Myoclonic dystonia P14416
#162500 Neuropathy, hereditary, with liability to pressure palsies; hnpp Q01453
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#257220 Niemann-pick disease, type c1; npc1 O15118
#601665 Obesity P32245
P37231
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#260500 Papilloma of choroid plexus; cpp P04637
#260540 Parkinson-dementia syndrome P10636
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#172700 Pick disease of brain P10636
#607276 Resting heart rate, variation in P08588
#275210 Restrictive dermopathy, lethal P02545
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#187950 Thrombocythemia 1; thcyt1 P40225
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#190300 Tremor, hereditary essential, 1; etm1 P35462
#610379 West nile virus, susceptibility to P51681
#112100 Yt blood group antigen P22303

KEGG DISEASE (86)

KEGG disease name UniProt
H00136 Niemann-Pick disease type C (NPC) O15118 (related)
H00016 Oral cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P00533 (related)
P04637 (related)
P04637 (marker)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
P04637 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
P04637 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
P04637 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
Q01453 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
P37231 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
P04637 (related)
Q92731 (marker)
H00068 Leber optic atrophy P03905 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00019 Pancreatic cancer P04626 (related)
P04637 (related)
P04637 (marker)
H00027 Ovarian cancer P04626 (related)
P04637 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
P04637 (related)
H00046 Cholangiocarcinoma P04626 (related)
P04637 (related)
P35354 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00025 Penile cancer P04637 (related)
P04637 (marker)
P14780 (related)
P35354 (related)
H00029 Vulvar cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
P37231 (related)
H00033 Adrenal carcinoma P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00044 Cancer of the anal canal P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00079 Asthma P07550 (related)
H00100 Neutropenic disorders P08246 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H01205 Coumarin resistance P11712 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00548 Brunner syndrome P21397 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00227 Congenital amegakaryocytic thrombocytopenia (CAMT) P40225 (marker)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
H01296 Hereditary neuropathy with liability to pressure palsies (HNPP) Q01453 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
Q16637 (related)
H00208 Hyperbilirubinemia Q92887 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)

Diseases related to CTD interactions

42 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D001766 D012402 Blindness marker/mechanism
20628600
D001862 D012402 Bone Resorption therapeutic
19900598
D001930 D012402 Brain Injuries marker/mechanism
12504863
14645467
14766796
15635186
15854587
16118017
16219024
17459145
18197244
18289173
18803299
19385059
19626387
D002375 D012402 Catalepsy marker/mechanism
12385818
15635186
16118017
18308296
18817789
19616571
21807080
D002561 D012402 Cerebrovascular Disorders marker/mechanism
19276049
D003643 D012402 Death marker/mechanism
22521218
D004195 D012402 Disease Models, Animal marker/mechanism
18155613
18308296
18817789
19385059
20628600
21807080
D056486 D012402 Drug-Induced Liver Injury marker/mechanism
22331495
D020820 D012402 Dyskinesias marker/mechanism
21807080
D004421 D012402 Dystonia marker/mechanism
14766796
16219024
D005767 D012402 Gastrointestinal Diseases marker/mechanism
14766796
D005911 D012402 Gliosis marker/mechanism
17367952
D006470 D012402 Hemorrhage marker/mechanism
19276049
D006930 D012402 Hyperalgesia therapeutic
16472913
D018476 D012402 Hypokinesia marker/mechanism
11100151
14766796
15635186
16219024
18289173
18308296
18817789
19385059
19616571
D007249 D012402 Inflammation therapeutic
15720824
D020961 D012402 Lewy Body Disease marker/mechanism
15280438
D028361 D012402 Mitochondrial Diseases marker/mechanism
20414966
D016472 D012402 Motor Neuron Disease marker/mechanism
17367952
D009069 D012402 Movement Disorders marker/mechanism
15574749
17459145
17520785
18803299
D009127 D012402 Muscle Rigidity marker/mechanism
11100151
18817789
19385059
D009336 D012402 Necrosis marker/mechanism
therapeutic
7931358
10486581
16580092
D009410 D012402 Nerve Degeneration marker/mechanism
7824183
11826108
14766796
15280438
15574749
15790535
16490285
17356569
18206288
18619942
18804145
19580850
21807080
D009437 D012402 Neuralgia therapeutic
16472913
D019636 D012402 Neurodegenerative Diseases marker/mechanism
12558969
D020879 D012402 Neuromuscular Manifestations marker/mechanism
20371261
D020258 D012402 Neurotoxicity Syndromes marker/mechanism
14741061
19744517
22521218
D029242 D012402 Optic Atrophy, Hereditary, Leber marker/mechanism
20628600
D009901 D012402 Optic Nerve Diseases marker/mechanism
19384599
D010190 D012402 Pancreatic Neoplasms therapeutic
17040906
D010300 D012402 Parkinson Disease marker/mechanism
11445065
11535288
15280438
15451049
16140633
16412576
18191903
18619942
19114014
19232380
19276049
19385059
19681169
21269927
21807080
D010302 D012402 Parkinson Disease, Secondary marker/mechanism
18817789
19909981
D020734 D012402 Parkinsonian Disorders marker/mechanism
12177198
15574749
15635186
15790535
15795934
15927086
16115015
16490285
18155613
18197244
18308296
18579341
20143419
21383081
21524431
D015427 D012402 Reperfusion Injury therapeutic
15720824
D012162 D012402 Retinal Degeneration marker/mechanism
19384599
D012798 D012402 Sialorrhea marker/mechanism
21807080
D012818 D012402 Signs and Symptoms, Respiratory marker/mechanism
21807080
D012893 D012402 Sleep Disorders marker/mechanism
15854587
17520785
D020955 D012402 Striatonigral Degeneration marker/mechanism
11100151
18155613
D024801 D012402 Tauopathies marker/mechanism
16219024
D014786 D012402 Vision Disorders marker/mechanism
19384599
D015431 D012402 Weight Loss marker/mechanism
21807080