PCIDB

KNApSAcK Metabolite C00001071

Metabolite

KNApSAcK Entry

id C00001071
Name Myricetin
CAS RN 529-44-2
Standard InChI InChI=1S/C15H10O8/c16-6-3-7(17)11-10(4-6)23-15(14(22)13(11)21)5-1-8(18)12(20)9(19)2-5/h1-4,16-20,22H
Standard InChI (Main Layer) InChI=1S/C15H10O8/c16-6-3-7(17)11-10(4-6)23-15(14(22)13(11)21)5-1-8(18)12(20)9(19)2-5/h1-4,16-20,22H

Cluster

Phytochemical cluster No. 15
KCF-S cluster No. 3

Link

ChEMBL

By standard InChI CHEMBL164
By standard InChI Main Layer CHEMBL164

KEGG

By LinkDB C10107

CTD

By CAS RN C040015

Species

Summary

Plant class

class name count
rosids 66
asterids 3
eudicotyledons 2
Spermatophyta 1
Magnoliophyta 1
Liliopsida 1

Family (Top 10)

family name count
Fabaceae 49
Myrtaceae 5
Anacardiaceae 3
Myricaceae 2
Elaeagnaceae 1
Nymphaeaceae 1
Pinaceae 1
Xanthoceraceae 1
Phyllanthaceae 1
Cunoniaceae 1

List (75)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Acacia aroma 207708 Fabaceae rosids Viridiplantae
Acacia cyanophylla 420411 Fabaceae rosids Viridiplantae
Acacia dealbata 205042 Fabaceae rosids Viridiplantae
Ardisia colorata 1009002 Primulaceae asterids Viridiplantae
Astragalus complanatus 47064 Fabaceae rosids Viridiplantae
Bridelia ferruginea 319147 Phyllanthaceae rosids Viridiplantae
Caragana frutex 47643 Fabaceae rosids Viridiplantae
Davidsonia pruriens 60422 Cunoniaceae rosids Viridiplantae
Diploknema butyracea 233684 Sapotaceae asterids Viridiplantae
Eskemukerjea megacarpum HARA 3615 Polygonaceae eudicotyledons Viridiplantae
Eucalyptus globulus 34317 Myrtaceae rosids Viridiplantae
Eugenia jambolana 260142 Myrtaceae rosids Viridiplantae
Halophila johnsonii 180125 Hydrocharitaceae Liliopsida Viridiplantae
Haplopappus canescens 71051 Asteraceae asterids Viridiplantae
Hippophae rhamnoides 193516 Elaeagnaceae rosids Viridiplantae
Hypericum scabrum 1137022 Hypericaceae rosids Viridiplantae
Hypocalyptus sophoroides 140923 Fabaceae rosids Viridiplantae
Intsia bijuga 162812 Fabaceae rosids Viridiplantae
Intsia palembanica 576999 Fabaceae rosids Viridiplantae
Kunzea ericoides 106044 Myrtaceae rosids Viridiplantae
Lathyrus aphaca 3854 Fabaceae rosids Viridiplantae
Lathyrus spp. 3853 Fabaceae rosids Viridiplantae
Lotus maritimus 118937 Fabaceae rosids Viridiplantae
Medicago arabica 70936 Fabaceae rosids Viridiplantae
Medicago blancheana 70938 Fabaceae rosids Viridiplantae
Medicago cancellata 66809 Fabaceae rosids Viridiplantae
Medicago cretacea 66812 Fabaceae rosids Viridiplantae
Medicago doliata 70944 Fabaceae rosids Viridiplantae
Medicago falcata 3878 Fabaceae rosids Viridiplantae
Medicago glomerata 66813 Fabaceae rosids Viridiplantae
Medicago hybrida 66814 Fabaceae rosids Viridiplantae
Medicago intertexta 70950 Fabaceae rosids Viridiplantae
Medicago laciniata 70952 Fabaceae rosids Viridiplantae
Medicago lupulina 47085 Fabaceae rosids Viridiplantae
Medicago monantha 70958 Fabaceae rosids Viridiplantae
Medicago monspeliaca 70959 Fabaceae rosids Viridiplantae
Medicago murex 75627 Fabaceae rosids Viridiplantae
Medicago orbicularis 70962 Fabaceae rosids Viridiplantae
Medicago polyceratia 70965 Fabaceae rosids Viridiplantae
Medicago polymorpha 47084 Fabaceae rosids Viridiplantae
Medicago radiata 70968 Fabaceae rosids Viridiplantae
Medicago rotata 70971 Fabaceae rosids Viridiplantae
Medicago sativa 3879 Fabaceae rosids Viridiplantae
Medicago scutellata 36901 Fabaceae rosids Viridiplantae
Medicago truncatula 3880 Fabaceae rosids Viridiplantae
Melilotus italica 78528 Fabaceae rosids Viridiplantae
Melilotus messanensis 1279044 Fabaceae rosids Viridiplantae
Melilotus officinalis 47083 Fabaceae rosids Viridiplantae
Melilotus sulcatus 861159 Fabaceae rosids Viridiplantae
Melilotus wolgicus 47081 Fabaceae rosids Viridiplantae
Millettia racemosa 53625 Fabaceae rosids Viridiplantae
Myrica nagi 262756 Myricaceae rosids Viridiplantae
Myrica rubra 262757 Myricaceae rosids Viridiplantae
Nothofagus antarctica 28933 Nothofagaceae rosids Viridiplantae
Nymphaea odorata 4419 Nymphaeaceae Magnoliophyta Viridiplantae
Oxycoccus quadripetalis
Peltophorum africanum 321567 Fabaceae rosids Viridiplantae
Pimenta dioica 375272 Myrtaceae rosids Viridiplantae
Plinia pinnata 3931 Myrtaceae rosids Viridiplantae
Prosopis reptans 207717 Fabaceae rosids Viridiplantae
Pseudolarix amabilis 3355 Pinaceae Spermatophyta Viridiplantae
Rhus parviflora 4012 Anacardiaceae rosids Viridiplantae
Rhus wallichi 4012 Anacardiaceae rosids Viridiplantae
Sedum takesimense Nakai 904691 Crassulaceae eudicotyledons Viridiplantae
Semecarpus vitiensis 173682 Anacardiaceae rosids Viridiplantae
Soymida febrifuga 43707 Meliaceae rosids Viridiplantae
Trifolium repens 3899 Fabaceae rosids Viridiplantae
Trigonella balansae 200961 Fabaceae rosids Viridiplantae
Trigonella calliceras 119381 Fabaceae rosids Viridiplantae
Trigonella cretica 78533 Fabaceae rosids Viridiplantae
Trigonella geminiflora 78532 Fabaceae rosids Viridiplantae
Vicia bithynica 84681 Fabaceae rosids Viridiplantae
Vicia faba 3906 Fabaceae rosids Viridiplantae
Vicia johannis 85131 Fabaceae rosids Viridiplantae
Xanthoceras sorbifolia 99658 Xanthoceraceae rosids Viridiplantae

Human Protein / Gene in interaction

78 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL164 CHEMBL1614110 (1) CHEMBL1741321 (2)
1 / 0
P42345 Serine/threonine-protein kinase mTOR Enzyme CHEMBL164 CHEMBL1613805 (1) CHEMBL1614293 (1)
0 / 0
P33527 Multidrug resistance-associated protein 1 drugs CHEMBL164 CHEMBL1062294 (1) CHEMBL1062295 (1)
CHEMBL2077005 (1)
0 / 0
P31941 DNA dC->dU-editing enzyme APOBEC-3A Enzyme CHEMBL164 CHEMBL1737903 (1)
0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein CHEMBL164 CHEMBL1738312 (1)
0 / 0
Q99700 Ataxin-2 Unclassified protein CHEMBL164 CHEMBL1794367 (1) CHEMBL2114784 (2)
1 / 1
P49798 Regulator of G-protein signaling 4 Unclassified protein CHEMBL164 CHEMBL1794499 (2)
2 / 0
P21728 D(1A) dopamine receptor Dopamine receptor CHEMBL164 CHEMBL1738565 (1)
0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase CHEMBL164 CHEMBL1014033 (1) CHEMBL1014036 (1)
0 / 3
P06746 DNA polymerase beta Enzyme CHEMBL164 CHEMBL1614079 (1)
0 / 0
P04062 Glucosylceramidase Enzyme CHEMBL164 CHEMBL1613818 (2)
6 / 4
P42336 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Enzyme CHEMBL164 CHEMBL1942593 (1) CHEMBL1942598 (1)
9 / 1
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme CHEMBL164 CHEMBL1738600 (1) CHEMBL1794585 (1)
0 / 0
P28907 ADP-ribosyl cyclase 1 Enzyme CHEMBL164 CHEMBL1799589 (1)
0 / 1
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme CHEMBL164 CHEMBL1614331 (1) CHEMBL1613927 (1)
0 / 0
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase CHEMBL164 CHEMBL1023248 (1)
1 / 1
P11309 Serine/threonine-protein kinase pim-1 Pim CHEMBL164 CHEMBL862675 (1) CHEMBL862676 (1)
CHEMBL926333 (1)
0 / 0
P04798 Cytochrome P450 1A1 Cytochrome P450 1A1 CHEMBL164 CHEMBL1780345 (1)
0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL164 CHEMBL1614027 (3) CHEMBL1741325 (2)
0 / 1
P54132 Bloom syndrome protein Enzyme CHEMBL164 CHEMBL1614522 (1) CHEMBL1614067 (4)
1 / 2
Q9HC97 G-protein coupled receptor 35 Kynurenic acid receptor CHEMBL164 CHEMBL2039370 (1) CHEMBL2039371 (1)
CHEMBL2039372 (1) CHEMBL2039375 (1)
CHEMBL2039376 (1) CHEMBL2039377 (1)
CHEMBL2039379 (1)
0 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein CHEMBL164 CHEMBL1614166 (1)
1 / 0
P11387 DNA topoisomerase 1 Isomerase CHEMBL164 CHEMBL987597 (1)
0 / 0
P11388 DNA topoisomerase 2-alpha Isomerase CHEMBL164 CHEMBL1014686 (1) CHEMBL1014697 (1)
CHEMBL1014698 (1) CHEMBL1014699 (1)
CHEMBL1014700 (1) CHEMBL987598 (1)
0 / 0
P11473 Vitamin D3 receptor NR1I1 CHEMBL164 CHEMBL1794311 (2)
2 / 3
Q15746 Myosin light chain kinase, smooth muscle Mlck CHEMBL164 CHEMBL971891 (1)
1 / 1
Q9Y3R4 Sialidase-2 Enzyme CHEMBL164 CHEMBL1100507 (1)
0 / 0
O15296 Arachidonate 15-lipoxygenase B Enzyme CHEMBL164 CHEMBL1613800 (3)
0 / 0
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL164 CHEMBL1614458 (3)
0 / 0
P36888 Receptor-type tyrosine-protein kinase FLT3 Pdgfr CHEMBL164 CHEMBL2342404 (1)
1 / 1
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor CHEMBL164 CHEMBL1614456 (1) CHEMBL1613803 (1)
0 / 0
P39748 Flap endonuclease 1 Enzyme CHEMBL164 CHEMBL1613922 (1) CHEMBL1794486 (5)
0 / 0
P15121 Aldose reductase Enzyme CHEMBL164 CHEMBL936594 (1)
0 / 0
Q14790 Caspase-8 C14 CHEMBL164 CHEMBL2014551 (1)
2 / 1
Q9Y253 DNA polymerase eta Enzyme CHEMBL164 CHEMBL1794569 (2)
1 / 1
P09923 Intestinal-type alkaline phosphatase Enzyme CHEMBL164 CHEMBL1738315 (1)
0 / 0
P05186 Alkaline phosphatase, tissue-nonspecific isozyme Enzyme CHEMBL164 CHEMBL1738602 (1)
3 / 1
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein CHEMBL164 CHEMBL1614280 (1) CHEMBL1794529 (1)
0 / 0
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL164 CHEMBL1614257 (4) CHEMBL1614410 (1)
CHEMBL1614531 (4)
1 / 3
P83916 Chromobox protein homolog 1 Unclassified protein CHEMBL164 CHEMBL1738610 (1) CHEMBL1794401 (1)
0 / 0
Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G Enzyme CHEMBL164 CHEMBL1738408 (1)
0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme CHEMBL164 CHEMBL1794467 (2)
0 / 0
P06213 Insulin receptor TK tyrosine-protein kinase INSR subfamily CHEMBL164 CHEMBL941409 (1)
5 / 4
P11511 Cytochrome P450 19A1 Cytochrome P450 19A1 CHEMBL164 CHEMBL987970 (1)
2 / 2
Q16678 Cytochrome P450 1B1 Cytochrome P450 1B1 CHEMBL164 CHEMBL1780346 (1)
4 / 4
P06276 Cholinesterase Hydrolase CHEMBL164 CHEMBL1045780 (1) CHEMBL1045783 (1)
0 / 0
P04745 Alpha-amylase 1 Enzyme CHEMBL164 CHEMBL964479 (2)
0 / 0
P18054 Arachidonate 12-lipoxygenase, 12S-type Enzyme CHEMBL164 CHEMBL1614252 (1)
2 / 0
P10696 Alkaline phosphatase, placental-like Enzyme CHEMBL164 CHEMBL1738514 (1)
0 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL164 CHEMBL1741322 (2)
0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme CHEMBL164 CHEMBL1613910 (3) CHEMBL1614227 (3)
3 / 3
Q92887 Canalicular multispecific organic anion transporter 1 Unclassified protein CHEMBL164 CHEMBL1062296 (1)
1 / 1
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme CHEMBL164 CHEMBL1614038 (3)
2 / 2
Q01453 Peripheral myelin protein 22 Unclassified protein CHEMBL164 CHEMBL1614171 (1)
5 / 2
P22303 Acetylcholinesterase Hydrolase CHEMBL164 CHEMBL1045781 (1)
1 / 0
Q02880 DNA topoisomerase 2-beta Isomerase CHEMBL164 CHEMBL687375 (1)
0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme CHEMBL164 CHEMBL1614240 (3)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL164 CHEMBL1613777 (3) CHEMBL1741323 (2)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL164 CHEMBL1614108 (3) CHEMBL1613886 (3)
CHEMBL1741324 (2)
0 / 1
Q9UNA4 DNA polymerase iota Enzyme CHEMBL164 CHEMBL1794483 (5)
0 / 0
Q15046 Lysine--tRNA ligase Enzyme CHEMBL164 CHEMBL2173401 (1) CHEMBL2173408 (1)
2 / 1
O75164 Lysine-specific demethylase 4A Enzyme CHEMBL164 CHEMBL1737991 (1)
0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme CHEMBL164 CHEMBL1614283 (1) CHEMBL1614466 (1)
CHEMBL1614211 (4)
0 / 0
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL164 CHEMBL1614250 (2) CHEMBL1614421 (2)
CHEMBL1614502 (2)
4 / 3
Q99549 M-phase phosphoprotein 8 Unclassified protein CHEMBL164 CHEMBL1738402 (2)
0 / 0
Q04760 Lactoylglutathione lyase Enzyme CHEMBL164 CHEMBL967534 (1) CHEMBL1913551 (1)
0 / 0
Q9UBT6 DNA polymerase kappa Enzyme CHEMBL164 CHEMBL1794536 (8)
0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL164 CHEMBL1613914 (3) CHEMBL1798570 (1)
0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme CHEMBL164 CHEMBL1614330 (1) CHEMBL1613829 (4)
0 / 0
P40225 Thrombopoietin Unclassified protein CHEMBL164 CHEMBL1614086 (1) CHEMBL1614034 (1)
1 / 1
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL164 CHEMBL1738442 (4)
0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme CHEMBL164 CHEMBL1614364 (4)
1 / 1
O00255 Menin Unclassified protein CHEMBL164 CHEMBL1614257 (4) CHEMBL1614531 (4)
2 / 5
Q13951 Core-binding factor subunit beta Unclassified protein CHEMBL164 CHEMBL1613933 (2)
0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein CHEMBL164 CHEMBL1613933 (2)
1 / 6
O94925 Glutaminase kidney isoform, mitochondrial Enzyme CHEMBL164 CHEMBL2114738 (1)
0 / 0
Q14191 Werner syndrome ATP-dependent helicase Enzyme CHEMBL164 CHEMBL2114796 (1)
2 / 1
Q9HCT0 Fibroblast growth factor 22 Unclassified protein CHEMBL164 CHEMBL2354256 (1)
0 / 0

CTD interaction (64)

compound gene gene name gene description interaction interaction type form reference
pmid
C040015 4363 ABCC1
ABC29
ABCC
GS-X
MRP
MRP1
ATP-binding cassette, sub-family C (CFTR/MRP), member 1 myricetin inhibits the reaction [ABCC1 protein affects the export of and results in decreased susceptibility to Vincristine] affects export
/ decreases reaction
/ decreases response to substance
protein 15896345
C040015 4363 ABCC1
ABC29
ABCC
GS-X
MRP
MRP1
ATP-binding cassette, sub-family C (CFTR/MRP), member 1 myricetin inhibits the reaction [ABCC1 protein affects the export of Vincristine] affects export
/ decreases reaction
protein 15896345
C040015 4363 ABCC1
ABC29
ABCC
GS-X
MRP
MRP1
ATP-binding cassette, sub-family C (CFTR/MRP), member 1 myricetin inhibits the reaction [ABCC1 protein results in decreased susceptibility to Vincristine] decreases reaction
/ decreases response to substance
protein 15896345
C040015 4363 ABCC1
ABC29
ABCC
GS-X
MRP
MRP1
ATP-binding cassette, sub-family C (CFTR/MRP), member 1 myricetin results in decreased activity of ABCC1 protein decreases activity
protein 15670588
C040015 1244 ABCC2
ABC30
CMOAT
DJS
MRP2
cMRP
ATP-binding cassette, sub-family C (CFTR/MRP), member 2 myricetin inhibits the reaction [ABCC2 protein affects the export of and results in decreased susceptibility to Vincristine] affects export
/ decreases reaction
/ decreases response to substance
protein 15896345
C040015 1244 ABCC2
ABC30
CMOAT
DJS
MRP2
cMRP
ATP-binding cassette, sub-family C (CFTR/MRP), member 2 myricetin inhibits the reaction [ABCC2 protein affects the export of Vincristine] affects export
/ decreases reaction
protein 15896345
C040015 1244 ABCC2
ABC30
CMOAT
DJS
MRP2
cMRP
ATP-binding cassette, sub-family C (CFTR/MRP), member 2 myricetin inhibits the reaction [ABCC2 protein results in decreased susceptibility to Vincristine] decreases reaction
/ decreases response to substance
protein 15896345
C040015 1244 ABCC2
ABC30
CMOAT
DJS
MRP2
cMRP
ATP-binding cassette, sub-family C (CFTR/MRP), member 2 myricetin results in decreased activity of ABCC2 protein decreases activity
protein 15670588
C040015 397 ARHGDIB
D4
GDIA2
GDID4
LYGDI
Ly-GDI
RAP1GN1
RhoGDI2
Rho GDP dissociation inhibitor (GDI) beta myricetin results in increased cleavage of ARHGDIB protein increases cleavage
protein 15748703
C040015 581 BAX
BCL2L4
BCL2-associated X protein myricetin results in decreased expression of BAX protein decreases expression
protein 15748703
C040015 581 BAX
BCL2L4
BCL2-associated X protein Tetradecanoylphorbol Acetate inhibits the reaction [myricetin results in decreased expression of BAX protein] decreases expression
/ decreases reaction
protein 15748703
C040015 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 myricetin results in decreased expression of BCL2 protein decreases expression
protein 15748703
C040015 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 Tetradecanoylphorbol Acetate inhibits the reaction [myricetin results in decreased expression of BCL2 protein] decreases expression
/ decreases reaction
protein 15748703
C040015 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) myricetin results in increased activity of CASP3 protein increases activity
protein 15748703
C040015 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) myricetin results in increased cleavage of CASP3 protein increases cleavage
protein 19397994
C040015 842 CASP9
APAF-3
APAF3
ICE-LAP6
MCH6
PPP1R56
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) myricetin results in increased activity of CASP9 protein increases activity
protein 15748703
C040015 847 CAT
catalase (EC:1.11.1.6) myricetin inhibits the reaction [Rotenone results in increased activity of CAT protein] decreases reaction
/ increases activity
protein 15904944
C040015 891 CCNB1
CCNB
cyclin B1 myricetin results in decreased expression of CCNB1 mRNA decreases expression
mRNA 19397994
C040015 891 CCNB1
CCNB
cyclin B1 myricetin results in decreased expression of CCNB1 protein decreases expression
protein 19397994
C040015 1026 CDKN1A
CAP20
CDKN1
CIP1
MDA-6
P21
SDI1
WAF1
p21CIP1
cyclin-dependent kinase inhibitor 1A (p21, Cip1) myricetin results in increased expression of CDKN1A mRNA increases expression
mRNA 19397994
C040015 1026 CDKN1A
CAP20
CDKN1
CIP1
MDA-6
P21
SDI1
WAF1
p21CIP1
cyclin-dependent kinase inhibitor 1A (p21, Cip1) myricetin results in increased expression of CDKN1A protein increases expression
protein 19397994
C040015 1031 CDKN2C
INK4C
p18
p18-INK4C
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) myricetin results in increased expression of CDKN2C mRNA increases expression
mRNA 18331776
C040015 1312 COMT
catechol-O-methyltransferase (EC:2.1.1.6) [myricetin co-treated with COMT protein] results in decreased activity of DNMT1 protein affects cotreatment
/ decreases activity
protein 16037419
C040015 1499 CTNNB1
CTNNB
MRD19
armadillo
catenin (cadherin-associated protein), beta 1, 88kDa myricetin results in decreased expression of CTNNB1 protein decreases expression
protein 22245592
C040015 1499 CTNNB1
CTNNB
MRD19
armadillo
catenin (cadherin-associated protein), beta 1, 88kDa [myricetin results in increased activity of SIRT1 protein] which results in decreased expression of CTNNB1 protein decreases expression
/ increases activity
protein 22245592
C040015 54205 CYCS
CYC
HCS
THC4
cytochrome c, somatic myricetin affects the localization of CYCS protein affects localization
protein 15748703
C040015 54205 CYCS
CYC
HCS
THC4
cytochrome c, somatic Tetradecanoylphorbol Acetate inhibits the reaction [myricetin affects the localization of CYCS protein] affects localization
/ decreases reaction
protein 15748703
C040015 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) myricetin results in decreased activity of CYP1A1 protein decreases activity
protein 16271822
21482471
C040015 1545 CYP1B1
CP1B
CYPIB1
GLC3A
P4501B1
cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) myricetin results in decreased activity of CYP1B1 protein decreases activity
protein 16271822
21482471
C040015 1786 DNMT1
ADCADN
AIM
CXXC9
DNMT
HSN1E
MCMT
DNA (cytosine-5-)-methyltransferase 1 (EC:2.1.1.37) [myricetin co-treated with COMT protein] results in decreased activity of DNMT1 protein affects cotreatment
/ decreases activity
protein 16037419
C040015 1786 DNMT1
ADCADN
AIM
CXXC9
DNMT
HSN1E
MCMT
DNA (cytosine-5-)-methyltransferase 1 (EC:2.1.1.37) myricetin results in decreased activity of DNMT1 protein decreases activity
protein 16037419
C040015 54583 EGLN1
C1orf12
ECYT3
HIF-PH2
HIFPH2
HPH-2
HPH2
PHD2
SM20
ZMYND6
egl-9 family hypoxia-inducible factor 1 (EC:1.14.11.29) myricetin results in decreased expression of EGLN1 protein decreases expression
protein 22245592
C040015 54583 EGLN1
C1orf12
ECYT3
HIF-PH2
HIFPH2
HPH-2
HPH2
PHD2
SM20
ZMYND6
egl-9 family hypoxia-inducible factor 1 (EC:1.14.11.29) [myricetin results in increased activity of SIRT1 protein] which results in decreased expression of EGLN1 protein decreases expression
/ increases activity
protein 22245592
C040015 2203 FBP1
FBP
fructose-1,6-bisphosphatase 1 (EC:3.1.3.11) myricetin results in decreased expression of FBP1 mRNA decreases expression
mRNA 18331776
C040015 3082 HGF
DFNB39
F-TCF
HGFB
HPTA
SF
hepatocyte growth factor (hepapoietin A; scatter factor) myricetin inhibits the reaction [HGF protein results in increased phosphorylation of MET protein] decreases reaction
/ increases phosphorylation
protein 19244381
C040015 3091 HIF1A
HIF-1A
HIF-1alpha
HIF1
HIF1-ALPHA
MOP1
PASD8
bHLHe78
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) [myricetin results in increased activity of SIRT1 protein] which results in increased expression of HIF1A protein increases activity
/ increases expression
protein 22245592
C040015 3091 HIF1A
HIF-1A
HIF-1alpha
HIF1
HIF1-ALPHA
MOP1
PASD8
bHLHe78
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) myricetin results in increased expression of HIF1A protein increases expression
protein 22245592
C040015 3162 HMOX1
HMOX1D
HO-1
HSP32
bK286B10
heme oxygenase (decycling) 1 (EC:1.14.99.3) myricetin results in increased expression of HMOX1 protein increases expression
protein 16799064
C040015 3569 IL6
BSF2
HGF
HSF
IFNB2
IL-6
interleukin 6 (interferon, beta 2) myricetin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased secretion of IL6 protein] affects cotreatment
/ decreases reaction
/ increases secretion
protein 18958421
C040015 4233 MET
AUTS9
HGFR
RCCP2
c-Met
met proto-oncogene (EC:2.7.10.1) myricetin inhibits the reaction [HGF protein results in increased phosphorylation of MET protein] decreases reaction
/ increases phosphorylation
protein 19244381
C040015 4318 MMP9
CLG4B
GELB
MANDP2
MMP-9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) myricetin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP9 protein] decreases reaction
/ increases activity
protein 19804834
C040015 4609 MYC
MRTL
MYCC
bHLHe39
c-Myc
v-myc avian myelocytomatosis viral oncogene homolog myricetin results in decreased expression of MYC protein decreases expression
protein 22245592
C040015 4609 MYC
MRTL
MYCC
bHLHe39
c-Myc
v-myc avian myelocytomatosis viral oncogene homolog [myricetin results in increased activity of SIRT1 protein] which results in decreased expression of MYC protein decreases expression
/ increases activity
protein 22245592
C040015 4780 NFE2L2
NRF2
nuclear factor, erythroid 2-like 2 myricetin results in increased expression of NFE2L2 protein increases expression
protein 16799064
C040015 8505 PARG
PARG99
poly (ADP-ribose) glycohydrolase (EC:3.2.1.143) myricetin results in decreased activity of PARG protein decreases activity
protein 19840838
C040015 142 PARP1
ADPRT
ADPRT_1
ADPRT1
ARTD1
PARP
PARP-1
PPOL
pADPRT-1
poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) myricetin results in decreased activity of PARP1 protein decreases activity
protein 17884996
C040015 142 PARP1
ADPRT
ADPRT_1
ADPRT1
ARTD1
PARP
PARP-1
PPOL
pADPRT-1
poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) myricetin results in increased cleavage of PARP1 protein increases cleavage
protein 15748703
C040015 8000 PSCA
PRO232
prostate stem cell antigen myricetin results in decreased expression of PSCA mRNA decreases expression
mRNA 18331776
C040015 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) myricetin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein] decreases reaction
/ increases expression
protein 19804834
C040015 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A myricetin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] affects the localization of and results in increased activity of RELA protein] affects cotreatment
/ affects localization
/ decreases reaction
/ increases activity
protein 18958421
C040015 23411 SIRT1
SIR2L1
sirtuin 1 myricetin results in increased activity of SIRT1 protein increases activity
protein 22245592
C040015 23411 SIRT1
SIR2L1
sirtuin 1 [myricetin results in increased activity of SIRT1 protein] which results in decreased expression of CTNNB1 protein decreases expression
/ increases activity
protein 22245592
C040015 23411 SIRT1
SIR2L1
sirtuin 1 [myricetin results in increased activity of SIRT1 protein] which results in decreased expression of EGLN1 protein decreases expression
/ increases activity
protein 22245592
C040015 23411 SIRT1
SIR2L1
sirtuin 1 [myricetin results in increased activity of SIRT1 protein] which results in decreased expression of MYC protein decreases expression
/ increases activity
protein 22245592
C040015 23411 SIRT1
SIR2L1
sirtuin 1 [myricetin results in increased activity of SIRT1 protein] which results in increased expression of HIF1A protein increases activity
/ increases expression
protein 22245592
C040015 23411 SIRT1
SIR2L1
sirtuin 1 myricetin results in increased expression of SIRT1 protein increases expression
protein 22245592
C040015 6513 SLC2A1
DYT17
DYT18
DYT9
EIG12
GLUT
GLUT1
GLUT1DS
HTLVR
PED
solute carrier family 2 (facilitated glucose transporter), member 1 myricetin inhibits the reaction [SLC2A1 protein affects the transport of Glucose] affects transport
/ decreases reaction
protein 14642735
C040015 6513 SLC2A1
DYT17
DYT18
DYT9
EIG12
GLUT
GLUT1
GLUT1DS
HTLVR
PED
solute carrier family 2 (facilitated glucose transporter), member 1 myricetin results in decreased activity of SLC2A1 protein decreases activity
protein 14642735
C040015 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor myricetin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased secretion of TNF protein] affects cotreatment
/ decreases reaction
/ increases secretion
protein 18958421
C040015 7153 TOP2A
TOP2
TP2A
topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3) myricetin results in decreased activity of TOP2A protein decreases activity
protein 16536579
C040015 9540 TP53I3
PIG3
tumor protein p53 inducible protein 3 myricetin results in increased expression of TP53I3 mRNA increases expression
mRNA 19397994
C040015 9540 TP53I3
PIG3
tumor protein p53 inducible protein 3 myricetin results in increased expression of TP53I3 protein increases expression
protein 19397994
C040015 8626 TP63
AIS
B(p51A)
B(p51B)
EEC3
KET
LMS
NBP
OFC8
RHS
SHFM4
TP53CP
TP53L
TP73L
p40
p51
p53CP
p63
p73H
p73L
tumor protein p63 myricetin results in increased expression of TP63 protein increases expression
protein 19397994
C040015 7161 TP73
P73
tumor protein p73 myricetin results in increased expression of TP73 protein increases expression
protein 19397994

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (70)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#613780 Aortic aneurysm, familial thoracic 7; aat7 Q15746
#613546 Aromatase deficiency P11511
#139300 Aromatase excess syndrome; aexs P11511
#210900 Bloom syndrome; blm P54132
#114480 Breast cancer P42336
#607271 Caspase 8 deficiency Q14790
#118300 Charcot-marie-tooth disease and deafness Q01453
#118220 Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a Q01453
#613641 Charcot-marie-tooth disease, recessive intermediate b; cmtrib Q15046
#114500 Colorectal cancer; crc P18054
P42336
Q14191
#612918 Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi P42336
#615108 Cowden syndrome 5; cws5 P42336
#613916 Deafness, autosomal recessive 89; dfnb89 Q15046
#610549 Diabetes mellitus, insulin-resistant, with acanthosis nigricans P06213
#125853 Diabetes mellitus, noninsulin-dependent; niddm P06213
#119900 Digital clubbing, isolated congenital P15428
#246200 Donohue syndrome P06213
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#237500 Dubin-johnson syndrome; djs Q92887
#133239 Esophageal cancer P18054
#600274 Frontotemporal dementia; ftd P10636
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#137750 Glaucoma 1, open angle, a; glc1a Q16678
#231300 Glaucoma 3, primary congenital, a; glc3a Q16678
#137760 Glaucoma, primary open angle; poag Q16678
#139393 Guillain-barre syndrome, familial; gbs Q01453
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#114550 Hepatocellular carcinoma P42336
#609968 Hyperinsulinemic hypoglycemia, familial, 5; hhf5 P06213
#145000 Hyperparathyroidism 1; hrpt1 O00255
#145900 Hypertrophic neuropathy of dejerine-sottas Q01453
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#146300 Hypophosphatasia, adult P05186
#241510 Hypophosphatasia, childhood P05186
#241500 Hypophosphatasia, infantile P05186
#182000 Keratosis, seborrheic P42336
#601626 Leukemia, acute myeloid; aml P36888
#211980 Lung cancer Q14790
#602501 Megalencephaly-capillary malformation-polymicrogyria syndrome; mcap P42336
#603387 Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome; mpph P42336
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#162500 Neuropathy, hereditary, with liability to pressure palsies; hnpp Q01453
#167000 Ovarian cancer P42336
#168600 Parkinson disease, late-onset; pd P04062
#260540 Parkinson-dementia syndrome P10636
#604229 Peters anomaly Q16678
#172700 Pick disease of brain P10636
#262190 Pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities P06213
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#187950 Thrombocythemia 1; thcyt1 P40225
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#277700 Werner syndrome; wrn Q14191
#278300 Xanthinuria, type i P47989
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253
#112100 Yt blood group antigen P22303

KEGG DISEASE (56)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00213 Hypophosphatasia P05186 (related)
H00719 Leprechaunism P06213 (related)
H00942 Rabson-Mendenhall syndrome P06213 (related)
H01228 Insulin-resistant diabetes mellitus with acanthosis nigricans (IRAN) P06213 (related)
H01267 Familial hyperinsulinemic hypoglycemia (HHF) P06213 (related)
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00023 Testicular cancer P10696 (marker)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P11511 (related)
H00794 Aromatase excess syndrome P11511 (related)
H01205 Coumarin resistance P11712 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00005 Chronic lymphocytic leukemia (CLL) P28907 (marker)
H01171 Poor drug metabolism (PM) P33261 (related)
H00017 Esophageal cancer P35354 (related)
H00025 Penile cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)
H00003 Acute myeloid leukemia (AML) P36888 (related)
Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00227 Congenital amegakaryocytic thrombocytopenia (CAMT) P40225 (marker)
H00027 Ovarian cancer P42336 (related)
H00192 Xanthinuria P47989 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
Q14191 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00264 Charcot-Marie-Tooth disease (CMT) Q01453 (related)
Q15046 (related)
H01296 Hereditary neuropathy with liability to pressure palsies (HNPP) Q01453 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00108 Autoimmune lymphoproliferative syndromes (ALPS) Q14790 (related)
H00801 Familial thoracic aortic aneurysm and dissection (TAAD) Q15746 (related)
H00612 Primary open angle glaucoma Q16678 (related)
H01075 Peters anomaly Q16678 (related)
H01159 Anterior segment dysgenesis (ASD) Q16678 (related)
H01203 Primary congenital glaucoma (PCG) Q16678 (related)
H00208 Hyperbilirubinemia Q92887 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

2 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D005909 C040015 Glioblastoma therapeutic
19804834
D009203 C040015 Myocardial Infarction therapeutic
19306480