PCIDB

KNApSAcK Metabolite C00001092

Metabolite

KNApSAcK Entry

id C00001092
Name Robinetin
CAS RN 490-31-3
Standard InChI InChI=1S/C15H10O7/c16-7-1-2-8-11(5-7)22-15(14(21)12(8)19)6-3-9(17)13(20)10(18)4-6/h1-5,16-18,20-21H
Standard InChI (Main Layer) InChI=1S/C15H10O7/c16-7-1-2-8-11(5-7)22-15(14(21)12(8)19)6-3-9(17)13(20)10(18)4-6/h1-5,16-18,20-21H

Cluster

Phytochemical cluster No. 15
KCF-S cluster No. 3

Link

ChEMBL

By standard InChI CHEMBL170405
By standard InChI Main Layer CHEMBL170405

KEGG

By LinkDB C10177

CTD

By CAS RN C040014

Human Protein / Gene in interaction

10 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P33527 Multidrug resistance-associated protein 1 drugs CHEMBL170405 CHEMBL1062293 (1)
0 / 0
P28907 ADP-ribosyl cyclase 1 Enzyme CHEMBL170405 CHEMBL1799589 (1)
0 / 1
P11473 Vitamin D3 receptor NR1I1 CHEMBL170405 CHEMBL1794311 (1)
2 / 3
Q92830 Histone acetyltransferase KAT2A Enzyme CHEMBL170405 CHEMBL1738606 (1)
0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme CHEMBL170405 CHEMBL1614211 (1)
0 / 0
Q9UBT6 DNA polymerase kappa Enzyme CHEMBL170405 CHEMBL1794536 (1)
0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme CHEMBL170405 CHEMBL1613829 (1)
0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme CHEMBL170405 CHEMBL1614364 (1)
1 / 1
O00255 Menin Unclassified protein CHEMBL170405 CHEMBL1614257 (1) CHEMBL1614531 (1)
2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL170405 CHEMBL1614257 (1) CHEMBL1614531 (1)
1 / 3

CTD interaction (4)

compound gene gene name gene description interaction interaction type form reference
pmid
C040014 4363 ABCC1
ABC29
ABCC
GS-X
MRP
MRP1
ATP-binding cassette, sub-family C (CFTR/MRP), member 1 robinetin inhibits the reaction [ABCC1 protein affects the export of fluorexon] affects export
/ decreases reaction
protein 15670588
C040014 4363 ABCC1
ABC29
ABCC
GS-X
MRP
MRP1
ATP-binding cassette, sub-family C (CFTR/MRP), member 1 robinetin results in decreased activity of ABCC1 protein decreases activity
protein 15670588
C040014 1244 ABCC2
ABC30
CMOAT
DJS
MRP2
cMRP
ATP-binding cassette, sub-family C (CFTR/MRP), member 2 robinetin inhibits the reaction [ABCC2 protein affects the export of fluorexon] affects export
/ decreases reaction
protein 15670588
C040014 1244 ABCC2
ABC30
CMOAT
DJS
MRP2
cMRP
ATP-binding cassette, sub-family C (CFTR/MRP), member 2 robinetin results in decreased activity of ABCC2 protein decreases activity
protein 15670588

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (6)

OMIM preferred title UniProt
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (12)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00005 Chronic lymphocytic leukemia (CLL) P28907 (marker)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)