PCIDB

KNApSAcK Metabolite C00001232

Metabolite

KNApSAcK Entry

id C00001232
Name Oleic acid / (Z)-9-Octadecenoic acid
CAS RN 112-80-1
Standard InChI InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/b10-9-
Standard InChI (Main Layer) InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)

Cluster

Phytochemical cluster No. 68
KCF-S cluster No. 184

Link

ChEMBL

By standard InChI CHEMBL8659
By standard InChI Main Layer CHEMBL8659 CHEMBL460657

KEGG

By LinkDB C00712

CTD

By CAS RN D019301

Species

Summary

Plant class

class name count
rosids 12
asterids 4
eudicotyledons 3
Liliopsida 2
Embryophyta 1

Family (Top 10)

family name count
Rosaceae 3
Brassicaceae 3
Calophyllaceae 2
Zingiberaceae 1
Apiaceae 1
Saxifragaceae 1
Malvaceae 1
Fabaceae 1
Caryophyllaceae 1
Euphorbiaceae 1

List (24)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Alpinia oxyphylla 125261 Zingiberaceae Liliopsida Viridiplantae
Aphanamixis polystachya 201010 Meliaceae rosids Viridiplantae
Arabidopsis thaliana 3702 Brassicaceae rosids Viridiplantae
Brassica hirta 3728 Brassicaceae rosids Viridiplantae
Calophyllum calaba 883767 Calophyllaceae rosids Viridiplantae
Calophyllum inophyllum 158927 Calophyllaceae rosids Viridiplantae
Clitoria ternata 43365 Fabaceae rosids Viridiplantae
Drymaria cordata 191453 Caryophyllaceae eudicotyledons Viridiplantae
Erycibe expansa 197385 Convolvulaceae asterids Viridiplantae
Escherichia coli 562 Enterobacteriaceae Bacteria
Ferula assa-foetida 52471 Apiaceae asterids Viridiplantae
Frullania incumbens 642320 Frullaniaceae Embryophyta Viridiplantae
Iris soforana 26339 Iridaceae Liliopsida Viridiplantae
Isatis tinctoria 161756 Brassicaceae rosids Viridiplantae
Jatropha curcus 3995 Euphorbiaceae rosids Viridiplantae
Justicia heterocarpa T.ANDERS 4190 Acanthaceae asterids Viridiplantae
Mandragora autumnalis 389206 Solanaceae asterids Viridiplantae
Potentilla asiatica 23204 Rosaceae rosids Viridiplantae
Potentilla desertorum 667246 Rosaceae rosids Viridiplantae
Potentilla orientalis 23204 Rosaceae rosids Viridiplantae
Poterium polygamum
Saxifraga stolonifera Meerb. 3798 Saxifragaceae eudicotyledons Viridiplantae
Scurrula atropurpurea 1146880 Loranthaceae eudicotyledons Viridiplantae
Tilia cordata Mill. 172266 Malvaceae rosids Viridiplantae

Human Protein / Gene in interaction

30 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P35610 Sterol O-acyltransferase 1 Enzyme CHEMBL8659 CHEMBL874435 (1) CHEMBL828068 (1)
0 / 0
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) CHEMBL8659 CHEMBL1614446 (1)
2 / 2
P15090 Fatty acid-binding protein, adipocyte Other cytosolic protein CHEMBL8659 CHEMBL460657 CHEMBL641280 (1) CHEMBL887934 (1)
CHEMBL1120071 (1) CHEMBL1120072 (1)
0 / 0
P17252 Protein kinase C alpha type Alpha CHEMBL8659 CHEMBL768406 (1)
0 / 0
P05413 Fatty acid-binding protein, heart Other cytosolic protein CHEMBL8659 CHEMBL887935 (1)
0 / 0
Q13315 Serine-protein kinase ATM Atypical serine/threonine protein kinase PIKK subfamily CHEMBL8659 CHEMBL1614153 (1)
1 / 4
P54132 Bloom syndrome protein Enzyme CHEMBL8659 CHEMBL1614067 (1)
1 / 2
P11387 DNA topoisomerase 1 Isomerase CHEMBL8659 CHEMBL460657 CHEMBL1008110 (2)
0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme CHEMBL8659 CHEMBL1738606 (1)
0 / 0
O75496 Geminin Unclassified protein CHEMBL8659 CHEMBL2114843 (1) CHEMBL2114780 (1)
0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase CHEMBL8659 CHEMBL991179 (1)
0 / 0
O00519 Fatty-acid amide hydrolase 1 Enzyme CHEMBL8659 CHEMBL938648 (1)
0 / 0
Q9UGP5 DNA polymerase lambda Enzyme CHEMBL8659 CHEMBL1921596 (1) CHEMBL1920071 (1)
0 / 0
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL8659 CHEMBL1614410 (1)
1 / 3
P83916 Chromobox protein homolog 1 Unclassified protein CHEMBL8659 CHEMBL1794401 (1)
0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme CHEMBL8659 CHEMBL1794467 (1)
0 / 0
P11511 Cytochrome P450 19A1 Cytochrome P450 19A1 CHEMBL8659 CHEMBL976708 (1) CHEMBL976710 (1)
CHEMBL976711 (1)
2 / 2
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 CHEMBL8659 CHEMBL1794510 (1)
5 / 3
P13726 Tissue factor Membrane receptor CHEMBL8659 CHEMBL995691 (1)
0 / 0
Q96RI1 Bile acid receptor NR1H4 CHEMBL8659 CHEMBL1794437 (1)
0 / 0
Q01469 Fatty acid-binding protein, epidermal Other cytosolic protein CHEMBL8659 CHEMBL887936 (1)
0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme CHEMBL8659 CHEMBL1613910 (1) CHEMBL1614227 (1)
3 / 3
P07148 Fatty acid-binding protein, liver Unclassified protein CHEMBL8659 CHEMBL964796 (1) CHEMBL964797 (1)
0 / 0
P51449 Nuclear receptor ROR-gamma Nuclear hormone receptor subfamily 1 group F member 3 CHEMBL8659 CHEMBL2114842 (1)
0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein CHEMBL8659 CHEMBL1738588 (1)
0 / 0
O75164 Lysine-specific demethylase 4A Enzyme CHEMBL8659 CHEMBL1737991 (1)
0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme CHEMBL8659 CHEMBL1614211 (1)
0 / 0
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL8659 CHEMBL1614421 (1)
4 / 3
Q07869 Peroxisome proliferator-activated receptor alpha NR1C1 CHEMBL8659 CHEMBL2114915 (2)
0 / 0
Q9UBT6 DNA polymerase kappa Enzyme CHEMBL8659 CHEMBL1794536 (1) CHEMBL1921592 (1)
CHEMBL1921595 (1)
0 / 0

CTD interaction (72)

compound gene gene name gene description interaction interaction type form reference
pmid
D019301 19 ABCA1
ABC-1
ABC1
CERP
HDLDT1
TGD
ATP-binding cassette, sub-family A (ABC1), member 1 Oleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Cholesterol]] affects reaction
/ decreases reaction
/ increases transport
protein 16118212
D019301 19 ABCA1
ABC-1
ABC1
CERP
HDLDT1
TGD
ATP-binding cassette, sub-family A (ABC1), member 1 Oleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Phospholipids]] affects reaction
/ decreases reaction
/ increases transport
protein 16118212
D019301 19 ABCA1
ABC-1
ABC1
CERP
HDLDT1
TGD
ATP-binding cassette, sub-family A (ABC1), member 1 Oleic Acid results in increased degradation of ABCA1 protein increases degradation
protein 16118212
D019301 19 ABCA1
ABC-1
ABC1
CERP
HDLDT1
TGD
ATP-binding cassette, sub-family A (ABC1), member 1 Oleic Acid results in increased phosphorylation of ABCA1 protein increases phosphorylation
protein 16118212
D019301 9619 ABCG1
ABC8
WHITE1
ATP-binding cassette, sub-family G (WHITE), member 1 Oleic Acid results in decreased expression of ABCG1 mRNA decreases expression
mRNA 16730733
D019301 9619 ABCG1
ABC8
WHITE1
ATP-binding cassette, sub-family G (WHITE), member 1 Oleic Acid results in decreased expression of ABCG1 protein decreases expression
protein 16730733
D019301 9429 ABCG2
ABC15
ABCP
BCRP
BCRP1
BMDP
CD338
CDw338
EST157481
GOUT1
MRX
MXR
MXR1
UAQTL1
ATP-binding cassette, sub-family G (WHITE), member 2 Oleic Acid results in increased expression of ABCG2 mRNA increases expression
mRNA 22819932
D019301 213 ALB
PRO0883
PRO0903
PRO1341
albumin Oleic Acid results in decreased secretion of ALB protein decreases secretion
protein 23348005
D019301 213 ALB
PRO0883
PRO0903
PRO1341
albumin Quercetin inhibits the reaction [Oleic Acid results in decreased secretion of ALB protein] decreases reaction
/ decreases secretion
protein 23348005
D019301 213 ALB
PRO0883
PRO0903
PRO1341
albumin Silymarin inhibits the reaction [Oleic Acid results in decreased secretion of ALB protein] decreases reaction
/ decreases secretion
protein 23348005
D019301 213 ALB
PRO0883
PRO0903
PRO1341
albumin Vitamin E inhibits the reaction [Oleic Acid results in decreased secretion of ALB protein] decreases reaction
/ decreases secretion
protein 23348005
D019301 335 APOA1
apolipoprotein A-I Oleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Cholesterol]] affects reaction
/ decreases reaction
/ increases transport
protein 16118212
D019301 335 APOA1
apolipoprotein A-I Oleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Phospholipids]] affects reaction
/ decreases reaction
/ increases transport
protein 16118212
D019301 338 APOB
FLDB
LDLCQ4
apolipoprotein B Bezafibrate inhibits the reaction [Oleic Acid results in increased expression of APOB protein] decreases reaction
/ increases expression
protein 12048068
D019301 338 APOB
FLDB
LDLCQ4
apolipoprotein B [Eicosapentaenoic Acid co-treated with Docosahexaenoic Acids co-treated with Oleic Acid co-treated with Folic Acid co-treated with Vitamin B 6 co-treated with Vitamin E] results in decreased expression of APOB protein affects cotreatment
/ decreases expression
protein 17237316
D019301 338 APOB
FLDB
LDLCQ4
apolipoprotein B Oleic Acid inhibits the reaction [Glucosamine results in decreased secretion of APOB protein] decreases reaction
/ decreases secretion
protein 15618547
D019301 338 APOB
FLDB
LDLCQ4
apolipoprotein B Oleic Acid results in increased expression of and results in increased secretion of APOB protein increases expression
/ increases secretion
protein 19383982
D019301 338 APOB
FLDB
LDLCQ4
apolipoprotein B Oleic Acid results in increased expression of APOB protein increases expression
protein 12048068
D019301 847 CAT
catalase (EC:1.11.1.6) Oleic Acid results in decreased activity of CAT protein decreases activity
protein 23348005
D019301 847 CAT
catalase (EC:1.11.1.6) Quercetin inhibits the reaction [Oleic Acid results in decreased activity of CAT protein] decreases activity
/ decreases reaction
protein 23348005
D019301 847 CAT
catalase (EC:1.11.1.6) Silymarin inhibits the reaction [Oleic Acid results in decreased activity of CAT protein] decreases activity
/ decreases reaction
protein 23348005
D019301 847 CAT
catalase (EC:1.11.1.6) Vitamin E inhibits the reaction [Oleic Acid results in decreased activity of CAT protein] decreases activity
/ decreases reaction
protein 23348005
D019301 1401 CRP
PTX1
C-reactive protein, pentraxin-related [Eicosapentaenoic Acid co-treated with Docosahexaenoic Acids co-treated with Oleic Acid co-treated with Folic Acid co-treated with Vitamin B 6 co-treated with Vitamin E] results in decreased expression of CRP protein affects cotreatment
/ decreases expression
protein 17237316
D019301 1869 E2F1
E2F-1
RBAP1
RBBP3
RBP3
E2F transcription factor 1 Oleic Acid results in decreased expression of E2F1 protein decreases expression
protein 16027227
D019301 1906 EDN1
ET1
HDLCQ7
PPET1
endothelin 1 Oleic Acid results in decreased expression of EDN1 mRNA decreases expression
mRNA 16895544
D019301 1906 EDN1
ET1
HDLCQ7
PPET1
endothelin 1 Oleic Acid results in decreased expression of EDN1 protein decreases expression
protein 16895544
D019301 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 Oleic Acid results in increased expression of IL8 protein increases expression
protein 23348005
D019301 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 Quercetin inhibits the reaction [Oleic Acid results in increased expression of IL8 protein] decreases reaction
/ increases expression
protein 23348005
D019301 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 Silymarin inhibits the reaction [Oleic Acid results in increased expression of IL8 protein] decreases reaction
/ increases expression
protein 23348005
D019301 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 Vitamin E inhibits the reaction [Oleic Acid results in increased expression of IL8 protein] decreases reaction
/ increases expression
protein 23348005
D019301 3630 INS
IDDM2
ILPR
IRDN
MODY10
insulin Bezafibrate inhibits the reaction [[Oleic Acid co-treated with INS protein] results in increased expression of SERPINE1 mRNA] affects cotreatment
/ decreases reaction
/ increases expression
protein 11292061
D019301 3630 INS
IDDM2
ILPR
IRDN
MODY10
insulin Bezafibrate inhibits the reaction [[Oleic Acid co-treated with INS protein] results in increased expression of SERPINE1 protein] affects cotreatment
/ decreases reaction
/ increases expression
protein 11292061
D019301 3630 INS
IDDM2
ILPR
IRDN
MODY10
insulin [Oleic Acid co-treated with INS protein] results in increased expression of SERPINE1 mRNA affects cotreatment
/ increases expression
protein 11292061
D019301 3630 INS
IDDM2
ILPR
IRDN
MODY10
insulin [Oleic Acid co-treated with INS protein] results in increased expression of SERPINE1 protein affects cotreatment
/ increases expression
protein 11292061
D019301 3630 INS
IDDM2
ILPR
IRDN
MODY10
insulin troglitazone promotes the reaction [[Oleic Acid co-treated with INS protein] results in increased expression of SERPINE1 mRNA] affects cotreatment
/ increases expression
/ increases reaction
protein 11292061
D019301 3630 INS
IDDM2
ILPR
IRDN
MODY10
insulin troglitazone promotes the reaction [[Oleic Acid co-treated with INS protein] results in increased expression of SERPINE1 protein] affects cotreatment
/ increases expression
/ increases reaction
protein 11292061
D019301 4846 NOS3
ECNOS
eNOS
nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) Oleic Acid results in decreased expression of NOS3 mRNA decreases expression
mRNA 16895544
D019301 142 PARP1
ADPRT
ADPRT_1
ADPRT1
ARTD1
PARP
PARP-1
PPOL
pADPRT-1
poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) Oleic Acid results in increased cleavage of PARP1 protein increases cleavage
protein 21132278
D019301 5444 PON1
ESA
MVCD5
PON
paraoxonase 1 (EC:3.1.1.2 3.1.8.1 3.1.1.81) [Calcium co-treated with Oleic Acid] results in increased stability of PON1 protein affects cotreatment
/ increases stability
protein 12871208
D019301 5444 PON1
ESA
MVCD5
PON
paraoxonase 1 (EC:3.1.1.2 3.1.8.1 3.1.1.81) Calcium promotes the reaction [Oleic Acid inhibits the reaction [4-hydroxymercuribenzoate results in decreased activity of PON1 protein]] decreases activity
/ decreases reaction
/ increases reaction
protein 12871208
D019301 5444 PON1
ESA
MVCD5
PON
paraoxonase 1 (EC:3.1.1.2 3.1.8.1 3.1.1.81) Oleic Acid inhibits the reaction [4-hydroxymercuribenzoate results in decreased activity of PON1 protein] decreases activity
/ decreases reaction
protein 12871208
D019301 5444 PON1
ESA
MVCD5
PON
paraoxonase 1 (EC:3.1.1.2 3.1.8.1 3.1.1.81) Oleic Acid inhibits the reaction [[Ascorbic Acid co-treated with Copper Sulfate] results in decreased activity of PON1 protein] affects cotreatment
/ decreases activity
/ decreases reaction
protein 12871208
D019301 5444 PON1
ESA
MVCD5
PON
paraoxonase 1 (EC:3.1.1.2 3.1.8.1 3.1.1.81) Oleic Acid inhibits the reaction [Copper promotes the reaction [Ascorbic Acid results in decreased activity of PON1 protein]] decreases activity
/ decreases reaction
/ increases reaction
protein 15104111
D019301 5444 PON1
ESA
MVCD5
PON
paraoxonase 1 (EC:3.1.1.2 3.1.8.1 3.1.1.81) Oleic Acid inhibits the reaction [Hydrogen Peroxide results in decreased activity of PON1 protein] decreases activity
/ decreases reaction
protein 12871208
D019301 5444 PON1
ESA
MVCD5
PON
paraoxonase 1 (EC:3.1.1.2 3.1.8.1 3.1.1.81) Oleic Acid inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon] decreases reaction
/ increases hydrolysis
protein 15375178
D019301 5444 PON1
ESA
MVCD5
PON
paraoxonase 1 (EC:3.1.1.2 3.1.8.1 3.1.1.81) Oleic Acid results in decreased activity of PON1 protein decreases activity
protein 15375178
D019301 778733 Oleic Acid results in decreased expression of PPAR mRNA decreases expression
mRNA 15949695
D019301 5465 PPARA
NR1C1
PPAR
PPARalpha
hPPAR
peroxisome proliferator-activated receptor alpha Oleic Acid binds to and results in increased activity of PPARA protein affects binding
/ increases activity
protein 10403814
15491415
16731579
D019301 100136658 Oleic Acid binds to and results in increased activity of PPARB protein affects binding
/ increases activity
protein 16731579
D019301 5467 PPARD
FAAR
NR1C2
NUC1
NUCI
NUCII
PPARB
peroxisome proliferator-activated receptor delta Oleic Acid results in increased expression of PPARD mRNA increases expression
mRNA 11172467
D019301 5468 PPARG
CIMT1
GLM1
NR1C3
PPARG1
PPARG2
PPARgamma
peroxisome proliferator-activated receptor gamma Oleic Acid results in increased expression of PPARG mRNA increases expression
mRNA 11172467
D019301 5468 PPARG
CIMT1
GLM1
NR1C3
PPARG1
PPARG2
PPARgamma
peroxisome proliferator-activated receptor gamma Oleic Acid results in increased expression of PPARG protein increases expression
protein 11172467
D019301 5925 RB1
OSRC
RB
p105-Rb
pRb
pp110
retinoblastoma 1 Oleic Acid results in decreased phosphorylation of RB1 protein decreases phosphorylation
protein 16027227
D019301 6256 RXRA
NR2B1
retinoid X receptor, alpha Oleic Acid binds to and results in increased activity of RXRA protein affects binding
/ increases activity
protein 16731579
D019301 5054 SERPINE1
PAI
PAI-1
PAI1
PLANH1
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 Bezafibrate inhibits the reaction [[Oleic Acid co-treated with INS protein] results in increased expression of SERPINE1 mRNA] affects cotreatment
/ decreases reaction
/ increases expression
mRNA 11292061
D019301 5054 SERPINE1
PAI
PAI-1
PAI1
PLANH1
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 Bezafibrate inhibits the reaction [[Oleic Acid co-treated with INS protein] results in increased expression of SERPINE1 protein] affects cotreatment
/ decreases reaction
/ increases expression
protein 11292061
D019301 5054 SERPINE1
PAI
PAI-1
PAI1
PLANH1
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 [Oleic Acid co-treated with INS protein] results in increased expression of SERPINE1 mRNA affects cotreatment
/ increases expression
mRNA 11292061
D019301 5054 SERPINE1
PAI
PAI-1
PAI1
PLANH1
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 [Oleic Acid co-treated with INS protein] results in increased expression of SERPINE1 protein affects cotreatment
/ increases expression
protein 11292061
D019301 5054 SERPINE1
PAI
PAI-1
PAI1
PLANH1
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 troglitazone promotes the reaction [[Oleic Acid co-treated with INS protein] results in increased expression of SERPINE1 mRNA] affects cotreatment
/ increases expression
/ increases reaction
mRNA 11292061
D019301 5054 SERPINE1
PAI
PAI-1
PAI1
PLANH1
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 troglitazone promotes the reaction [[Oleic Acid co-treated with INS protein] results in increased expression of SERPINE1 protein] affects cotreatment
/ increases expression
/ increases reaction
protein 11292061
D019301 6514 SLC2A2
GLUT2
solute carrier family 2 (facilitated glucose transporter), member 2 Bezafibrate inhibits the reaction [Oleic Acid results in increased expression of SLC2A2 mRNA] decreases reaction
/ increases expression
mRNA 12048068
D019301 6514 SLC2A2
GLUT2
solute carrier family 2 (facilitated glucose transporter), member 2 Oleic Acid results in increased expression of SLC2A2 mRNA increases expression
mRNA 12048068
D019301 6720 SREBF1
SREBP-1c
SREBP1
bHLHd1
sterol regulatory element binding transcription factor 1 Oleic Acid results in decreased expression of SREBF1 mRNA decreases expression
mRNA 15949695
D019301 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Oleic Acid results in decreased susceptibility to TNF protein decreases response to substance
protein 22683933
D019301 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Oleic Acid results in increased expression of TNF mRNA increases expression
mRNA 23348005
D019301 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Oleic Acid results in increased expression of TNF protein increases expression
protein 23348005
D019301 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Quercetin inhibits the reaction [Oleic Acid results in increased expression of TNF mRNA] decreases reaction
/ increases expression
mRNA 23348005
D019301 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Quercetin inhibits the reaction [Oleic Acid results in increased expression of TNF protein] decreases reaction
/ increases expression
protein 23348005
D019301 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Silymarin inhibits the reaction [Oleic Acid results in increased expression of TNF mRNA] decreases reaction
/ increases expression
mRNA 23348005
D019301 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Silymarin inhibits the reaction [Oleic Acid results in increased expression of TNF protein] decreases reaction
/ increases expression
protein 23348005
D019301 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Vitamin E inhibits the reaction [Oleic Acid results in increased expression of TNF mRNA] decreases reaction
/ increases expression
mRNA 23348005
D019301 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Vitamin E inhibits the reaction [Oleic Acid results in increased expression of TNF protein] decreases reaction
/ increases expression
protein 23348005

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (19)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#613546 Aromatase deficiency P11511
#139300 Aromatase excess syndrome; aexs P11511
#208900 Ataxia-telangiectasia; at Q13315
#210900 Bloom syndrome; blm P54132
%606641 Body mass index; bmi P37231
#609338 Carotid intimal medial thickness 1 P37231
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 P37231
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#613688 Long qt syndrome 2; lqt2 Q12809
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#601665 Obesity P37231
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#609620 Short qt syndrome 1; sqt1 Q12809
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636

KEGG DISEASE (20)

KEGG disease name UniProt
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P11511 (related)
H00794 Aromatase excess syndrome P11511 (related)
H00032 Thyroid cancer P37231 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00420 Familial partial lipodystrophy (FPL) P37231 (related)
H00094 DNA repair defects P54132 (related)
Q13315 (related)
H00296 Defects in RecQ helicases P54132 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00005 Chronic lymphocytic leukemia (CLL) Q13315 (related)
H00064 Ataxia telangiectasia (AT) Q13315 (related)
H00848 Ataxia with ocular apraxia (AOA) Q13315 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)

Diseases related to CTD interactions

9 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D055371 D019301 Acute Lung Injury marker/mechanism
3789173
D000860 D019301 Anoxia marker/mechanism
15090967
D003072 D019301 Cognition Disorders marker/mechanism
18398226
D005234 D019301 Fatty Liver marker/mechanism
12048068
23348005
D006520 D019301 Hepatitis, Animal marker/mechanism
18559427
D007333 D019301 Insulin Resistance marker/mechanism
23348005
D055370 D019301 Lung Injury marker/mechanism
15090967
D011654 D019301 Pulmonary Edema marker/mechanism
6881582
7294408
15090967
D012128 D019301 Respiratory Distress Syndrome, Adult marker/mechanism
18549715