PCIDB

KNApSAcK Metabolite C00001872

Metabolite

KNApSAcK Entry

id C00001872
Name Isocorydine / (+)-Isocorydine / L-(+)-Isocorydine / (S)-(+)-Isocorydine
CAS RN 475-67-2
Standard InChI InChI=1S/C20H23NO4/c1-21-8-7-12-10-15(24-3)20(25-4)18-16(12)13(21)9-11-5-6-14(23-2)19(22)17(11)18/h5-6,10,13,22H,7-9H2,1-4H3/t13-/m0/s1
Standard InChI (Main Layer) InChI=1S/C20H23NO4/c1-21-8-7-12-10-15(24-3)20(25-4)18-16(12)13(21)9-11-5-6-14(23-2)19(22)17(11)18/h5-6,10,13,22H,7-9H2,1-4H3

Cluster

Phytochemical cluster No. 4
KCF-S cluster No. 20

Link

ChEMBL

By standard InChI CHEMBL489525
By standard InChI Main Layer CHEMBL489525 CHEMBL1376826

KEGG

By LinkDB C09549

CTD

By CAS RN

Species

Summary

Plant class

class name count
eudicotyledons 31
Magnoliophyta 17
rosids 1

Family

family name count
Papaveraceae 18
Lauraceae 8
Annonaceae 8
Menispermaceae 6
Berberidaceae 4
Ranunculaceae 3
Siparunaceae 1
Euphorbiaceae 1

List (51)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Annona cherimola 49314 Annonaceae Magnoliophyta Viridiplantae
Annona glabra 301703 Annonaceae Magnoliophyta Viridiplantae
Annona purpurea 1123437 Annonaceae Magnoliophyta Viridiplantae
Annona senegalensis 306945 Annonaceae Magnoliophyta Viridiplantae
Artabotrys suaveolens 225832 Annonaceae Magnoliophyta Viridiplantae
Artabotrys uncinatus 225832 Annonaceae Magnoliophyta Viridiplantae
Berberis densiflora 22774 Berberidaceae eudicotyledons Viridiplantae
Berberis heterobotrys 22774 Berberidaceae eudicotyledons Viridiplantae
Berberis oblonga 22774 Berberidaceae eudicotyledons Viridiplantae
Berberis vulgaris 258209 Berberidaceae eudicotyledons Viridiplantae
Corydalis cava 3463 Papaveraceae eudicotyledons Viridiplantae
Corydalis lutea 54436 Papaveraceae eudicotyledons Viridiplantae
Corydalis ochroleuca 3463 Papaveraceae eudicotyledons Viridiplantae
Corydalis solida 38914 Papaveraceae eudicotyledons Viridiplantae
Croton hemiargyreus 765397 Euphorbiaceae rosids Viridiplantae
Dactylocapnos torulosa
Dehaasia incrassata 128613 Lauraceae Magnoliophyta Viridiplantae
Dehaasia triandra 128612 Lauraceae Magnoliophyta Viridiplantae
Dicentra canadensis 581247 Papaveraceae eudicotyledons Viridiplantae
Glaucium corniculatum 56852 Papaveraceae eudicotyledons Viridiplantae
Glaucium fimbrilligerum 56852 Papaveraceae eudicotyledons Viridiplantae
Glaucium flavum 56853 Papaveraceae eudicotyledons Viridiplantae
Glaucium spp. 56852 Papaveraceae eudicotyledons Viridiplantae
Guatteria oliviformis 295178 Annonaceae Magnoliophyta Viridiplantae
Hypecoum procumbens 391933 Papaveraceae eudicotyledons Viridiplantae
Isopyrum thalictroides 432643 Ranunculaceae eudicotyledons Viridiplantae
Litsea deccanensis 22042 Lauraceae Magnoliophyta Viridiplantae
Miliusa velutina 235758 Annonaceae Magnoliophyta Viridiplantae
Ocotea benesii 63801 Lauraceae Magnoliophyta Viridiplantae
Ocotea holdrigeana 63801 Lauraceae Magnoliophyta Viridiplantae
Ocotea holdrigeiana 63801 Lauraceae Magnoliophyta Viridiplantae
Ocotea vellosiana 63801 Lauraceae Magnoliophyta Viridiplantae
Papaver confine 3468 Papaveraceae eudicotyledons Viridiplantae
Papaver pinnatifidum 3468 Papaveraceae eudicotyledons Viridiplantae
Papaver rhoeas 33128 Papaveraceae eudicotyledons Viridiplantae
Papaver rhopalothece 3468 Papaveraceae eudicotyledons Viridiplantae
Papaver spp. 3468 Papaveraceae eudicotyledons Viridiplantae
Papaver stevenianum 3468 Papaveraceae eudicotyledons Viridiplantae
Phoebe clemensii 128686 Lauraceae Magnoliophyta Viridiplantae
Sarcocapnos enneaphylla 38924 Papaveraceae eudicotyledons Viridiplantae
Sarcocapnos saetabensis 107196 Papaveraceae eudicotyledons Viridiplantae
Siparuna griseo-flavescens 63803 Siparunaceae Magnoliophyta Viridiplantae
Stephania cepharantha 147243 Menispermaceae eudicotyledons Viridiplantae
Stephania dinklaget 147243 Menispermaceae eudicotyledons Viridiplantae
Stephania lincangensis 147243 Menispermaceae eudicotyledons Viridiplantae
Stephania macrantha 147243 Menispermaceae eudicotyledons Viridiplantae
Stephania officinarum 147243 Menispermaceae eudicotyledons Viridiplantae
Stephania pierii 147243 Menispermaceae eudicotyledons Viridiplantae
Thalictrum delavayi 1084667 Ranunculaceae eudicotyledons Viridiplantae
Thalictrum pedunculatum 46968 Ranunculaceae eudicotyledons Viridiplantae
Xanthoxylum brachyacanthum

Human Protein / Gene in interaction

14 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL489525 CHEMBL1376826 CHEMBL1614110 (1) CHEMBL1741321 (1)
1 / 0
P24941 Cyclin-dependent kinase 2 Cdc2 CHEMBL489525 CHEMBL1067148 (1)
0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL489525 CHEMBL1614027 (1) CHEMBL1741325 (1)
0 / 1
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL1376826 CHEMBL1614458 (1)
0 / 0
O75496 Geminin Unclassified protein CHEMBL489525 CHEMBL2114780 (1)
0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL489525 CHEMBL1741322 (1)
0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme CHEMBL489525 CHEMBL1613910 (1)
3 / 3
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL489525 CHEMBL1741323 (1)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL489525 CHEMBL1614108 (1) CHEMBL1613886 (1)
CHEMBL1741324 (1)
0 / 1
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL489525 CHEMBL1376826 CHEMBL1613914 (3)
0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme CHEMBL489525 CHEMBL2354311 (1)
1 / 0
Q13951 Core-binding factor subunit beta Unclassified protein CHEMBL489525 CHEMBL1613933 (1)
0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein CHEMBL489525 CHEMBL1613933 (1)
1 / 6
O94925 Glutaminase kidney isoform, mitochondrial Enzyme CHEMBL489525 CHEMBL2114738 (1)
0 / 0

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (7)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#137800 Glioma susceptibility 1; glm1 O75874
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196

KEGG DISEASE (10)

KEGG disease name UniProt
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)