KNApSAcK Metabolite C00001906
Metabolite
KNApSAcK Entry
| id | C00001906 |
|---|---|
| Name | Fumarin / Biflorine / Protopine / Fumarine / Corydinine |
| CAS RN | 130-86-9 |
| Standard InChI | InChI=1S/C20H19NO5/c1-21-5-4-13-7-18-19(25-10-24-18)8-14(13)16(22)6-12-2-3-17-20(15(12)9-21)26-11-23-17/h2-3,7-8H,4-6,9-11H2,1H3 |
| Standard InChI (Main Layer) | InChI=1S/C20H19NO5/c1-21-5-4-13-7-18-19(25-10-24-18)8-14(13)16(22)6-12-2-3-17-20(15(12)9-21)26-11-23-17/h2-3,7-8H,4-6,9-11H2,1H3 |
Cluster
| Phytochemical cluster | No. 4 |
|---|---|
| KCF-S cluster | No. 820 |
Link
ChEMBL
| By standard InChI | CHEMBL453019 |
|---|---|
| By standard InChI Main Layer | CHEMBL453019 |
KEGG
| By LinkDB | C05189 |
|---|
CTD
| By CAS RN | C009093 |
|---|
Species
Summary
Plant class
| class name | count |
|---|---|
| eudicotyledons | 78 |
| asterids | 2 |
Family
| family name | count |
|---|---|
| Papaveraceae | 75 |
| Ranunculaceae | 3 |
| Rubiaceae | 2 |
List (82)
* NCBI
Human Protein / Gene in interaction
5 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | CHEMBL453019 |
CHEMBL1614110
(1)
|
1 / 0 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | CHEMBL453019 |
CHEMBL1614281
(1)
CHEMBL1614361
(1)
|
3 / 2 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | CHEMBL453019 |
CHEMBL1613777
(1)
|
1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | CHEMBL453019 |
CHEMBL1614108
(1)
CHEMBL1613886
(1)
|
0 / 1 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | CHEMBL453019 |
CHEMBL1613914
(1)
|
0 / 0 |
CTD interaction (2)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| C009093 | 1543 |
CYP1A1
AHH AHRR CP11 CYP1 P1-450 P450-C P450DX |
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) | protopine results in increased expression of CYP1A1 mRNA |
increases expression
|
mRNA |
21419197
|
| C009093 | 1544 |
CYP1A2
CP12 P3-450 P450(PA) |
cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) | protopine results in increased expression of CYP1A2 mRNA |
increases expression
|
mRNA |
21419197
|
Related Disease
Diseases related to proteins in ChEMBL interactions
OMIM (5)
| OMIM | preferred title | UniProt |
|---|---|---|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|