PCIDB

KNApSAcK Metabolite C00002413

Metabolite

KNApSAcK Entry

id C00002413
Name Usnic acid
CAS RN 125-46-2
Standard InChI InChI=1S/C18H16O7/c1-6-14(22)12(8(3)20)16-13(15(6)23)18(4)10(25-16)5-9(21)11(7(2)19)17(18)24/h5,21-23H,1-4H3/t18-/m1/s1
Standard InChI (Main Layer) InChI=1S/C18H16O7/c1-6-14(22)12(8(3)20)16-13(15(6)23)18(4)10(25-16)5-9(21)11(7(2)19)17(18)24/h5,21-23H,1-4H3

Cluster

Phytochemical cluster
KCF-S cluster No. 3171

Link

ChEMBL

By standard InChI CHEMBL461903
By standard InChI Main Layer CHEMBL367881 CHEMBL242022 CHEMBL461903

KEGG

By LinkDB C10101

CTD

By CAS RN C073339

Human Protein / Gene in interaction

2 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr CHEMBL367881 CHEMBL968638 (1)
0 / 0
P09467 Fructose-1,6-bisphosphatase 1 Enzyme CHEMBL242022 CHEMBL1106396 (1)
1 / 1

CTD interaction (5)

compound gene gene name gene description interaction interaction type form reference
pmid
C073339 581 BAX
BCL2L4
BCL2-associated X protein usnic acid results in decreased expression of BAX protein decreases expression
protein 22285236
C073339 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 usnic acid results in decreased expression of BCL2 protein decreases expression
protein 22285236
C073339 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) usnic acid results in increased activity of CASP3 protein increases activity
protein 22285236
C073339 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 usnic acid results in decreased expression of TP53 protein decreases expression
protein 22285236
C073339 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 usnic acid results in increased expression of TP53 protein increases expression
protein 22285236

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (1)

OMIM preferred title UniProt
#229700 Fructose-1,6-bisphosphatase deficiency P09467

KEGG DISEASE (1)

KEGG disease name UniProt
H00114 Fructose-1,6-bisphosphatase deficiency P09467 (related)

Diseases related to CTD interactions

3 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D007249 C073339 Inflammation therapeutic
22186154
D009369 C073339 Neoplasms therapeutic
22186154
22285236
D013276 C073339 Stomach Ulcer therapeutic
16169175