KNApSAcK Metabolite C00025953
Metabolite
KNApSAcK Entry
| id | C00025953 |
|---|---|
| Name | Nantenine / Domestine / (+)-Domestine / (+)-Nantenine / O-Methyldomesticine |
| CAS RN | 2565-1-7 |
| Standard InChI | InChI=1S/C20H21NO4/c1-21-5-4-11-7-17(22-2)20(23-3)19-13-9-16-15(24-10-25-16)8-12(13)6-14(21)18(11)19/h7-9,14H,4-6,10H2,1-3H3/t14-/m0/s1 |
| Standard InChI (Main Layer) | InChI=1S/C20H21NO4/c1-21-5-4-11-7-17(22-2)20(23-3)19-13-9-16-15(24-10-25-16)8-12(13)6-14(21)18(11)19/h7-9,14H,4-6,10H2,1-3H3 |
Cluster
| Phytochemical cluster | No. 4 |
|---|---|
| KCF-S cluster | No. 20 |
Link
ChEMBL
| By standard InChI | CHEMBL179440 |
|---|---|
| By standard InChI Main Layer | CHEMBL179440 CHEMBL467094 |
KEGG
| By LinkDB | C19985 |
|---|
CTD
| By CAS RN |
|---|
Species
Summary
Plant class
| class name | count |
|---|---|
| eudicotyledons | 1 |
Family
| family name | count |
|---|---|
| Menispermaceae | 1 |
List (1)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Stephania tetrandra S.Moore | 425106 | Menispermaceae | eudicotyledons | Viridiplantae |
Human Protein / Gene in interaction
38 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| P21728 | D(1A) dopamine receptor | Dopamine receptor | CHEMBL467094 |
CHEMBL1066742
(1)
|
0 / 0 |
| Q9Y5N1 | Histamine H3 receptor | Histamine receptor | CHEMBL467094 |
CHEMBL1066755
(1)
|
0 / 0 |
| P07550 | Beta-2 adrenergic receptor | Adrenergic receptor | CHEMBL467094 |
CHEMBL1066740
(1)
|
0 / 1 |
| P25021 | Histamine H2 receptor | Histamine receptor | CHEMBL467094 |
CHEMBL1066754
(1)
|
0 / 0 |
| P28222 | 5-hydroxytryptamine receptor 1B | Serotonin receptor | CHEMBL467094 |
CHEMBL1066723
(1)
|
0 / 0 |
| P35367 | Histamine H1 receptor | Histamine receptor | CHEMBL467094 |
CHEMBL1066753
(1)
|
0 / 0 |
| Q01959 | Sodium-dependent dopamine transporter | Dopamine | CHEMBL467094 |
CHEMBL1066747
(1)
|
1 / 0 |
| P18825 | Alpha-2C adrenergic receptor | Adrenergic receptor | CHEMBL467094 |
CHEMBL1066738
(1)
|
0 / 0 |
| P21918 | D(1B) dopamine receptor | Dopamine receptor | CHEMBL467094 |
CHEMBL1066746
(1)
|
1 / 0 |
| P13945 | Beta-3 adrenergic receptor | Adrenergic receptor | CHEMBL467094 |
CHEMBL1066741
(1)
|
0 / 0 |
| P34969 | 5-hydroxytryptamine receptor 7 | Serotonin receptor | CHEMBL467094 |
CHEMBL1066732
(1)
|
0 / 0 |
| P47898 | 5-hydroxytryptamine receptor 5A | Serotonin receptor | CHEMBL467094 |
CHEMBL1066730
(1)
|
0 / 0 |
| P14416 | D(2) dopamine receptor | Dopamine receptor | CHEMBL467094 |
CHEMBL1066743
(1)
|
2 / 0 |
| P41145 | Kappa-type opioid receptor | Opioid receptor | CHEMBL467094 |
CHEMBL1066751
(1)
|
0 / 0 |
| P28566 | 5-hydroxytryptamine receptor 1E | Serotonin receptor | CHEMBL467094 |
CHEMBL1066725
(1)
|
0 / 0 |
| P08913 | Alpha-2A adrenergic receptor | Adrenergic receptor | CHEMBL467094 |
CHEMBL1066736
(1)
|
0 / 0 |
| P21917 | D(4) dopamine receptor | Dopamine receptor | CHEMBL467094 |
CHEMBL1066745
(1)
|
0 / 0 |
| P35348 | Alpha-1A adrenergic receptor | Adrenergic receptor | CHEMBL179440 CHEMBL467094 |
CHEMBL829974
(1)
CHEMBL1066733
(1)
CHEMBL1831390 (1) |
0 / 0 |
| P35462 | D(3) dopamine receptor | Dopamine receptor | CHEMBL467094 |
CHEMBL1066744
(1)
|
1 / 0 |
| P41143 | Delta-type opioid receptor | Opioid receptor | CHEMBL467094 |
CHEMBL1066750
(1)
|
0 / 0 |
| P46098 | 5-hydroxytryptamine receptor 3A | NS | CHEMBL467094 |
CHEMBL1066729
(1)
|
0 / 0 |
| P41595 | 5-hydroxytryptamine receptor 2B | Serotonin receptor | CHEMBL467094 |
CHEMBL1066727
(1)
|
0 / 0 |
| Q9H3N8 | Histamine H4 receptor | Histamine receptor | CHEMBL467094 |
CHEMBL1066756
(1)
|
0 / 0 |
| P08172 | Muscarinic acetylcholine receptor M2 | Acetylcholine receptor | CHEMBL467094 |
CHEMBL1066758
(1)
|
2 / 0 |
| P11229 | Muscarinic acetylcholine receptor M1 | Acetylcholine receptor | CHEMBL467094 |
CHEMBL1066757
(1)
|
0 / 0 |
| P31645 | Sodium-dependent serotonin transporter | Serotonin | CHEMBL467094 |
CHEMBL1066748
(1)
|
2 / 0 |
| P20309 | Muscarinic acetylcholine receptor M3 | Acetylcholine receptor | CHEMBL467094 |
CHEMBL1066759
(1)
|
1 / 0 |
| P50406 | 5-hydroxytryptamine receptor 6 | Serotonin receptor | CHEMBL467094 |
CHEMBL1066731
(1)
|
0 / 0 |
| P08588 | Beta-1 adrenergic receptor | Adrenergic receptor | CHEMBL467094 |
CHEMBL1066739
(1)
|
1 / 0 |
| P28223 | 5-hydroxytryptamine receptor 2A | Serotonin receptor | CHEMBL467094 |
CHEMBL980679
(1)
CHEMBL1066726
(1)
CHEMBL1251998 (1) |
0 / 0 |
| P28335 | 5-hydroxytryptamine receptor 2C | Serotonin receptor | CHEMBL467094 |
CHEMBL1066728
(1)
|
0 / 0 |
| P35372 | Mu-type opioid receptor | Opioid receptor | CHEMBL467094 |
CHEMBL1066752
(1)
|
0 / 0 |
| P08173 | Muscarinic acetylcholine receptor M4 | Acetylcholine receptor | CHEMBL467094 |
CHEMBL1066760
(1)
|
0 / 0 |
| P23975 | Sodium-dependent noradrenaline transporter | Norepinephrine | CHEMBL467094 |
CHEMBL1066749
(1)
|
1 / 1 |
| P25100 | Alpha-1D adrenergic receptor | Adrenergic receptor | CHEMBL467094 |
CHEMBL1066735
(1)
|
0 / 0 |
| P28221 | 5-hydroxytryptamine receptor 1D | Serotonin receptor | CHEMBL467094 |
CHEMBL1066724
(1)
|
0 / 0 |
| P35368 | Alpha-1B adrenergic receptor | Adrenergic receptor | CHEMBL467094 |
CHEMBL1066734
(1)
|
0 / 0 |
| P18089 | Alpha-2B adrenergic receptor | Adrenergic receptor | CHEMBL467094 |
CHEMBL1066737
(1)
|
0 / 0 |
Related Disease
Diseases related to proteins in ChEMBL interactions
OMIM (10)
| OMIM | preferred title | UniProt |
|---|---|---|
| #100100 | Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism |
P20309
|
| #103780 | Alcohol dependence |
P08172
P14416 P31645 |
| #606798 | Blepharospasm, benign essential |
P21918
|
| #608516 | Major depressive disorder; mdd |
P08172
|
| #159900 | Myoclonic dystonia |
P14416
|
| #164230 | Obsessive-compulsive disorder; ocd |
P31645
|
| #604715 | Orthostatic intolerance |
P23975
|
| #613135 | Parkinsonism-dystonia, infantile; pkdys |
Q01959
|
| #607276 | Resting heart rate, variation in |
P08588
|
| #190300 | Tremor, hereditary essential, 1; etm1 |
P35462
|