PCIDB

KNApSAcK Metabolite C00026982

Metabolite

KNApSAcK Entry

id C00026982
Name Indirubin / Indigo red / Couroupitine B / Indigopurpurin
CAS RN 479-41-4
Standard InChI InChI=1S/C16H10N2O2/c19-15-10-6-2-4-8-12(10)17-14(15)13-9-5-1-3-7-11(9)18-16(13)20/h1-8,17H,(H,18,20)/b14-13+
Standard InChI (Main Layer) InChI=1S/C16H10N2O2/c19-15-10-6-2-4-8-12(10)17-14(15)13-9-5-1-3-7-11(9)18-16(13)20/h1-8,17H,(H,18,20)

Cluster

Phytochemical cluster
KCF-S cluster No. 4840

Link

ChEMBL

By standard InChI CHEMBL259664
By standard InChI Main Layer CHEMBL259664 CHEMBL1276127

KEGG

By LinkDB

CTD

By CAS RN C027185

Human Protein / Gene in interaction

16 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
Q16637 Survival motor neuron protein Unclassified protein CHEMBL1276127 CHEMBL1613842 (1)
4 / 2
P24941 Cyclin-dependent kinase 2 Cdc2 CHEMBL259664 CHEMBL660705 (1)
0 / 0
P06493 Cyclin-dependent kinase 1 Cdc2 CHEMBL259664 CHEMBL660807 (1) CHEMBL666598 (1)
CHEMBL1815312 (1)
0 / 0
Q00535 Cyclin-dependent kinase 5 Cdk5 CHEMBL259664 CHEMBL663602 (1) CHEMBL663605 (1)
CHEMBL867889 (1)
0 / 0
Q15078 Cyclin-dependent kinase 5 activator 1 REG serine/threonine protein kinase family CHEMBL259664 CHEMBL663602 (1) CHEMBL663605 (1)
CHEMBL867889 (1)
0 / 0
P11473 Vitamin D3 receptor NR1I1 CHEMBL1276127 CHEMBL1794311 (1)
2 / 3
P17538 Chymotrypsinogen B S1A CHEMBL259664 CHEMBL661258 (1)
0 / 0
P36888 Receptor-type tyrosine-protein kinase FLT3 Pdgfr CHEMBL259664 CHEMBL1106056 (1)
1 / 1
P21980 Protein-glutamine gamma-glutamyltransferase 2 Enzyme CHEMBL259664 CHEMBL1771981 (1)
0 / 0
P12931 Proto-oncogene tyrosine-protein kinase Src Src CHEMBL259664 CHEMBL806344 (1)
0 / 0
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL1276127 CHEMBL1614421 (3) CHEMBL1614502 (2)
4 / 3
O95067 G2/mitotic-specific cyclin-B2 Other cytosolic protein CHEMBL259664 CHEMBL660807 (1) CHEMBL666598 (1)
0 / 0
P14635 G2/mitotic-specific cyclin-B1 Other cytosolic protein CHEMBL259664 CHEMBL660807 (1) CHEMBL666598 (1)
0 / 0
Q8WWL7 G2/mitotic-specific cyclin-B3 Other cytosolic protein CHEMBL259664 CHEMBL660807 (1) CHEMBL666598 (1)
0 / 0
P49840 Glycogen synthase kinase-3 alpha Gsk CHEMBL259664 CHEMBL683003 (1) CHEMBL683005 (1)
CHEMBL867890 (1)
0 / 0
P49841 Glycogen synthase kinase-3 beta Gsk CHEMBL259664 CHEMBL683003 (1) CHEMBL683005 (1)
CHEMBL867890 (1)
0 / 0

CTD interaction (48)

compound gene gene name gene description interaction interaction type form reference
pmid
C027185 36 ACADSB
2-MEBCAD
ACAD7
SBCAD
acyl-CoA dehydrogenase, short/branched chain (EC:1.3.8.5) indirubin results in decreased expression of ACADSB mRNA decreases expression
mRNA 15056799
C027185 196 AHR
bHLHe76
aryl hydrocarbon receptor indirubin binds to AHR protein affects binding
protein 15056799
C027185 196 AHR
bHLHe76
aryl hydrocarbon receptor indirubin binds to and results in increased activity of AHR protein affects binding
/ increases activity
protein 11425848
15001395
19299563
19860415
C027185 196 AHR
bHLHe76
aryl hydrocarbon receptor indirubin results in increased activity of AHR protein increases activity
protein 12972062
C027185 378 ARF4
ARF2
ADP-ribosylation factor 4 indirubin results in decreased expression of ARF4 mRNA decreases expression
mRNA 15056799
C027185 405 ARNT
HIF-1-beta
HIF-1beta
HIF1-beta
HIF1B
HIF1BETA
TANGO
bHLHe2
aryl hydrocarbon receptor nuclear translocator indirubin results in increased activity of ARNT protein increases activity
protein 12972062
C027185 10575 CCT4
CCT-DELTA
Cctd
SRB
chaperonin containing TCP1, subunit 4 (delta) indirubin results in decreased expression of CCT4 mRNA decreases expression
mRNA 15056799
C027185 1000 CDH2
CD325
CDHN
CDw325
NCAD
cadherin 2, type 1, N-cadherin (neuronal) indirubin results in decreased expression of CDH2 mRNA decreases expression
mRNA 15056799
C027185 983 CDK1
CDC2
CDC28A
P34CDC2
cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22) indirubin results in decreased expression of CDK1 mRNA decreases expression
mRNA 15056799
C027185 1017 CDK2
p33(CDK2)
cyclin-dependent kinase 2 (EC:2.7.11.22) indirubin inhibits the reaction [CDK2 protein results in increased phosphorylation of RB1 protein] decreases reaction
/ increases phosphorylation
protein 16115123
C027185 1017 CDK2
p33(CDK2)
cyclin-dependent kinase 2 (EC:2.7.11.22) indirubin results in decreased activity of CDK2 protein decreases activity
protein 16115123
C027185 1195 CLK1
CLK
CLK/STY
STY
CDC-like kinase 1 (EC:2.7.12.1) indirubin results in decreased expression of CLK1 mRNA decreases expression
mRNA 15056799
C027185 9318 COPS2
ALIEN
CSN2
SGN2
TRIP15
COP9 signalosome subunit 2 indirubin results in decreased expression of COPS2 mRNA decreases expression
mRNA 15056799
C027185 1441 CSF3R
CD114
GCSFR
colony stimulating factor 3 receptor (granulocyte) indirubin results in increased expression of CSF3R protein increases expression
protein 16115123
C027185 3577 CXCR1
C-C
C-C-CKR-1
CD128
CD181
CDw128a
CKR-1
CMKAR1
IL8R1
IL8RA
IL8RBA
chemokine (C-X-C motif) receptor 1 indirubin results in increased expression of CXCR1 protein increases expression
protein 16115123
C027185 1588 CYP19A1
ARO
ARO1
CPV1
CYAR
CYP19
CYPXIX
P-450AROM
cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1) indirubin results in increased expression of CYP19A1 mRNA increases expression
mRNA 15056799
C027185 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) CYP1A1 protein results in increased metabolism of indirubin increases metabolic processing
protein 14637189
15056799
C027185 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) indirubin binds to and results in decreased activity of CYP1A1 protein affects binding
/ decreases activity
protein 15056799
C027185 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) indirubin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] decreases reaction
/ increases activity
protein 18493746
C027185 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) indirubin results in increased activity of CYP1A1 protein increases activity
protein 14637189
18493746
C027185 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) indirubin results in increased expression of CYP1A1 mRNA increases expression
mRNA 14637189
15056799
C027185 1544 CYP1A2
CP12
P3-450
P450(PA)
cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) indirubin results in increased expression of CYP1A2 mRNA increases expression
mRNA 15056799
C027185 1545 CYP1B1
CP1B
CYPIB1
GLC3A
P4501B1
cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) CYP1B1 protein results in increased metabolism of indirubin increases metabolic processing
protein 14637189
C027185 1545 CYP1B1
CP1B
CYPIB1
GLC3A
P4501B1
cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) indirubin results in increased expression of CYP1B1 mRNA increases expression
mRNA 14637189
C027185 3491 CYR61
CCN1
GIG1
IGFBP10
cysteine-rich, angiogenic inducer, 61 indirubin results in increased expression of CYR61 mRNA increases expression
mRNA 15056799
C027185 1869 E2F1
E2F-1
RBAP1
RBBP3
RBP3
E2F transcription factor 1 indirubin results in decreased expression of E2F1 mRNA decreases expression
mRNA 15056799
C027185 2950 GSTP1
DFN7
FAEES3
GST3
GSTP
PI
glutathione S-transferase pi 1 (EC:2.5.1.18) indirubin results in increased expression of GSTP1 mRNA increases expression
mRNA 15056799
C027185 3281 HSBP1
NPC-A-13
heat shock factor binding protein 1 indirubin results in decreased expression of HSBP1 mRNA decreases expression
mRNA 15056799
C027185 3329 HSPD1
CPN60
GROEL
HLD4
HSP-60
HSP60
HSP65
HuCHA60
SPG13
heat shock 60kDa protein 1 (chaperonin) indirubin results in decreased expression of HSPD1 mRNA decreases expression
mRNA 15056799
C027185 10808 HSPH1
HSP105
HSP105A
HSP105B
NY-CO-25
heat shock 105kDa/110kDa protein 1 indirubin results in decreased expression of HSPH1 mRNA decreases expression
mRNA 15056799
C027185 3458 IFNG
IFG
IFI
interferon, gamma indirubin results in decreased expression of IFNG protein decreases expression
protein 11134660
C027185 3484 IGFBP1
AFBP
IBP1
IGF-BP25
PP12
hIGFBP-1
insulin-like growth factor binding protein 1 indirubin results in increased expression of IGFBP1 mRNA increases expression
mRNA 15056799
C027185 3554 IL1R1
CD121A
D2S1473
IL-1R-alpha
IL1R
IL1RA
P80
interleukin 1 receptor, type I indirubin results in decreased expression of IL1R1 mRNA decreases expression
mRNA 15056799
C027185 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 indirubin results in increased secretion of IL8 protein increases secretion
protein 16115123
C027185 3608 ILF2
NF45
PRO3063
interleukin enhancer binding factor 2 indirubin results in decreased expression of ILF2 mRNA decreases expression
mRNA 15056799
C027185 3688 ITGB1
CD29
FNRB
GPIIA
MDF2
MSK12
VLA-BETA
VLAB
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) indirubin results in decreased expression of ITGB1 mRNA decreases expression
mRNA 15056799
C027185 3689 ITGB2
CD18
LAD
LCAMB
LFA-1
MAC-1
MF17
MFI7
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) indirubin results in increased expression of ITGB2 protein increases expression
protein 16115123
C027185 4258 MGST2
GST2
MGST-II
microsomal glutathione S-transferase 2 (EC:2.5.1.18) indirubin results in decreased expression of MGST2 mRNA decreases expression
mRNA 15056799
C027185 4436 MSH2
COCA1
FCC1
HNPCC
HNPCC1
LCFS2
mutS homolog 2 indirubin results in decreased expression of MSH2 mRNA decreases expression
mRNA 15056799
C027185 653361 NCF1
NCF1A
NOXO2
SH3PXD1A
p47phox
neutrophil cytosolic factor 1 indirubin results in increased expression of NCF1 protein increases expression
protein 16115123
C027185 4864 NPC1
NPC
Niemann-Pick disease, type C1 indirubin results in increased expression of NPC1 mRNA increases expression
mRNA 15056799
C027185 5925 RB1
OSRC
RB
p105-Rb
pRb
pp110
retinoblastoma 1 indirubin inhibits the reaction [CDK2 protein results in increased phosphorylation of RB1 protein] decreases reaction
/ increases phosphorylation
protein 16115123
C027185 4735 SEPT2
DIFF6
NEDD-5
NEDD5
Pnutl3
hNedd5
septin 2 indirubin results in decreased expression of SEPT2 mRNA decreases expression
mRNA 15056799
C027185 6514 SLC2A2
GLUT2
solute carrier family 2 (facilitated glucose transporter), member 2 indirubin results in decreased expression of SLC2A2 mRNA decreases expression
mRNA 15056799
C027185 6688 SPI1
OF
PU.1
SFPI1
SPI-1
SPI-A
spleen focus forming virus (SFFV) proviral integration oncogene indirubin results in increased activity of SPI1 protein increases activity
protein 16115123
C027185 6938 TCF12
CRS3
HEB
HTF4
HsT17266
bHLHb20
transcription factor 12 indirubin results in decreased expression of TCF12 mRNA decreases expression
mRNA 15056799
C027185 7150 TOP1
TOPI
topoisomerase (DNA) I (EC:5.99.1.2) indirubin results in decreased expression of TOP1 mRNA decreases expression
mRNA 15056799
C027185 7153 TOP2A
TOP2
TP2A
topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3) indirubin results in decreased expression of TOP2A mRNA decreases expression
mRNA 15056799

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (11)

OMIM preferred title UniProt
#600274 Frontotemporal dementia; ftd P10636
#601626 Leukemia, acute myeloid; aml P36888
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (8)

KEGG disease name UniProt
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00003 Acute myeloid leukemia (AML) P36888 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
Q16637 (related)

Diseases related to CTD interactions

1 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D006968 C027185 Hypersensitivity, Delayed therapeutic
11275354