PCIDB

KNApSAcK Metabolite C00027150

Metabolite

KNApSAcK Entry

id C00027150
Name Nantenine / (+)-Domestine / (+)-Nantenine
CAS RN 2565-01-7
Standard InChI InChI=1S/C20H21NO4/c1-21-5-4-11-7-17(22-2)20(23-3)19-13-9-16-15(24-10-25-16)8-12(13)6-14(21)18(11)19/h7-9,14H,4-6,10H2,1-3H3/t14-/m0/s1
Standard InChI (Main Layer) InChI=1S/C20H21NO4/c1-21-5-4-11-7-17(22-2)20(23-3)19-13-9-16-15(24-10-25-16)8-12(13)6-14(21)18(11)19/h7-9,14H,4-6,10H2,1-3H3

Cluster

Phytochemical cluster No. 4
KCF-S cluster No. 20

Link

ChEMBL

By standard InChI CHEMBL179440
By standard InChI Main Layer CHEMBL179440 CHEMBL467094

KEGG

By LinkDB C19985

CTD

By CAS RN C041615

Human Protein / Gene in interaction

38 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P21728 D(1A) dopamine receptor Dopamine receptor CHEMBL467094 CHEMBL1066742 (1)
0 / 0
Q9Y5N1 Histamine H3 receptor Histamine receptor CHEMBL467094 CHEMBL1066755 (1)
0 / 0
P07550 Beta-2 adrenergic receptor Adrenergic receptor CHEMBL467094 CHEMBL1066740 (1)
0 / 1
P25021 Histamine H2 receptor Histamine receptor CHEMBL467094 CHEMBL1066754 (1)
0 / 0
P28222 5-hydroxytryptamine receptor 1B Serotonin receptor CHEMBL467094 CHEMBL1066723 (1)
0 / 0
P35367 Histamine H1 receptor Histamine receptor CHEMBL467094 CHEMBL1066753 (1)
0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine CHEMBL467094 CHEMBL1066747 (1)
1 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor CHEMBL467094 CHEMBL1066738 (1)
0 / 0
P21918 D(1B) dopamine receptor Dopamine receptor CHEMBL467094 CHEMBL1066746 (1)
1 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor CHEMBL467094 CHEMBL1066741 (1)
0 / 0
P34969 5-hydroxytryptamine receptor 7 Serotonin receptor CHEMBL467094 CHEMBL1066732 (1)
0 / 0
P47898 5-hydroxytryptamine receptor 5A Serotonin receptor CHEMBL467094 CHEMBL1066730 (1)
0 / 0
P14416 D(2) dopamine receptor Dopamine receptor CHEMBL467094 CHEMBL1066743 (1)
2 / 0
P41145 Kappa-type opioid receptor Opioid receptor CHEMBL467094 CHEMBL1066751 (1)
0 / 0
P28566 5-hydroxytryptamine receptor 1E Serotonin receptor CHEMBL467094 CHEMBL1066725 (1)
0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor CHEMBL467094 CHEMBL1066736 (1)
0 / 0
P21917 D(4) dopamine receptor Dopamine receptor CHEMBL467094 CHEMBL1066745 (1)
0 / 0
P35348 Alpha-1A adrenergic receptor Adrenergic receptor CHEMBL179440 CHEMBL467094 CHEMBL829974 (1) CHEMBL1066733 (1)
CHEMBL1831390 (1)
0 / 0
P35462 D(3) dopamine receptor Dopamine receptor CHEMBL467094 CHEMBL1066744 (1)
1 / 0
P41143 Delta-type opioid receptor Opioid receptor CHEMBL467094 CHEMBL1066750 (1)
0 / 0
P46098 5-hydroxytryptamine receptor 3A NS CHEMBL467094 CHEMBL1066729 (1)
0 / 0
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor CHEMBL467094 CHEMBL1066727 (1)
0 / 0
Q9H3N8 Histamine H4 receptor Histamine receptor CHEMBL467094 CHEMBL1066756 (1)
0 / 0
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor CHEMBL467094 CHEMBL1066758 (1)
2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor CHEMBL467094 CHEMBL1066757 (1)
0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin CHEMBL467094 CHEMBL1066748 (1)
2 / 0
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor CHEMBL467094 CHEMBL1066759 (1)
1 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor CHEMBL467094 CHEMBL1066731 (1)
0 / 0
P08588 Beta-1 adrenergic receptor Adrenergic receptor CHEMBL467094 CHEMBL1066739 (1)
1 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor CHEMBL467094 CHEMBL980679 (1) CHEMBL1066726 (1)
CHEMBL1251998 (1)
0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor CHEMBL467094 CHEMBL1066728 (1)
0 / 0
P35372 Mu-type opioid receptor Opioid receptor CHEMBL467094 CHEMBL1066752 (1)
0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor CHEMBL467094 CHEMBL1066760 (1)
0 / 0
P23975 Sodium-dependent noradrenaline transporter Norepinephrine CHEMBL467094 CHEMBL1066749 (1)
1 / 1
P25100 Alpha-1D adrenergic receptor Adrenergic receptor CHEMBL467094 CHEMBL1066735 (1)
0 / 0
P28221 5-hydroxytryptamine receptor 1D Serotonin receptor CHEMBL467094 CHEMBL1066724 (1)
0 / 0
P35368 Alpha-1B adrenergic receptor Adrenergic receptor CHEMBL467094 CHEMBL1066734 (1)
0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor CHEMBL467094 CHEMBL1066737 (1)
0 / 0

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (10)

OMIM preferred title UniProt
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#103780 Alcohol dependence P08172
P14416
P31645
#606798 Blepharospasm, benign essential P21918
#608516 Major depressive disorder; mdd P08172
#159900 Myoclonic dystonia P14416
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#607276 Resting heart rate, variation in P08588
#190300 Tremor, hereditary essential, 1; etm1 P35462

KEGG DISEASE (2)

KEGG disease name UniProt
H00079 Asthma P07550 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)