KNApSAcK Metabolite C00002837
Metabolite
KNApSAcK Entry
| id | C00002837 |
|---|---|
| Name | Lawsone |
| CAS RN | 83-72-7 |
| Standard InChI | InChI=1S/C10H6O3/c11-8-5-9(12)10(13)7-4-2-1-3-6(7)8/h1-5,12H |
| Standard InChI (Main Layer) | InChI=1S/C10H6O3/c11-8-5-9(12)10(13)7-4-2-1-3-6(7)8/h1-5,12H |
Cluster
| Phytochemical cluster | No. 80 |
|---|---|
| KCF-S cluster | No. 1047 |
Link
ChEMBL
| By standard InChI | CHEMBL240963 |
|---|---|
| By standard InChI Main Layer | CHEMBL240963 |
KEGG
| By LinkDB | C10368 |
|---|
CTD
| By CAS RN | C005090 |
|---|
Species
Summary
Family
| family name | count |
|---|---|
| Lythraceae | 2 |
| Balsaminaceae | 1 |
List (3)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Impatiens balsamina | 63779 | Balsaminaceae | asterids | Viridiplantae |
| Lawsonia alba | 3928 | Lythraceae | rosids | Viridiplantae |
| Lawsonia inermis | 141191 | Lythraceae | rosids | Viridiplantae |
Human Protein / Gene in interaction
16 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| P09917 | Arachidonate 5-lipoxygenase | Oxidoreductase | CHEMBL240963 |
CHEMBL1664429
(1)
|
0 / 0 |
| P22894 | Neutrophil collagenase | M10A | CHEMBL240963 |
CHEMBL1664434
(1)
|
0 / 0 |
| P14780 | Matrix metalloproteinase-9 | M10A | CHEMBL240963 |
CHEMBL1664435
(1)
|
2 / 2 |
| P11473 | Vitamin D3 receptor | NR1I1 | CHEMBL240963 |
CHEMBL1794311
(2)
|
2 / 3 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | CHEMBL240963 |
CHEMBL1614458
(2)
|
0 / 0 |
| P14902 | Indoleamine 2,3-dioxygenase 1 | Enzyme | CHEMBL240963 |
CHEMBL935410
(1)
|
0 / 0 |
| P03956 | Interstitial collagenase | M10A | CHEMBL240963 |
CHEMBL1664431
(1)
|
0 / 1 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | CHEMBL240963 |
CHEMBL1794467
(1)
|
0 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | CHEMBL240963 |
CHEMBL1613808
(1)
|
0 / 0 |
| P08253 | 72 kDa type IV collagenase | M10A | CHEMBL240963 |
CHEMBL1664432
(1)
|
1 / 3 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | CHEMBL240963 |
CHEMBL1614038
(1)
|
2 / 2 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | CHEMBL240963 |
CHEMBL1614108
(1)
CHEMBL1613886
(1)
|
0 / 1 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | CHEMBL240963 |
CHEMBL1614250
(1)
CHEMBL1614421
(2)
|
4 / 3 |
| P08254 | Stromelysin-1 | M10A | CHEMBL240963 |
CHEMBL1664433
(1)
|
1 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | CHEMBL240963 |
CHEMBL1794536
(1)
|
0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | CHEMBL240963 |
CHEMBL1613914
(2)
|
0 / 0 |
CTD interaction (1)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| C005090 | 196 |
AHR
bHLHe76 |
aryl hydrocarbon receptor | lawsone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein] |
decreases reaction
/ increases activity |
protein |
19269596
|
Related Disease
Diseases related to proteins in ChEMBL interactions
OMIM (12)
| OMIM | preferred title | UniProt |
|---|---|---|
| #614466 | Coronary heart disease, susceptibility to, 6; chds6 |
P08254
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #603932 | Intervertebral disc disease; idd |
P14780
|
| #613073 | Metaphyseal anadysplasia 2; mandp2 |
P14780
|
| #259600 | Multicentric osteolysis, nodulosis, and arthropathy; mona |
P08253
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
KEGG DISEASE (13)
| KEGG | disease name | UniProt |
|---|---|---|
| H00028 | Choriocarcinoma |
P03956
(related)
P08253 (related) |
| H00025 | Penile cancer |
P08253
(related)
P14780 (related) |
| H00472 | Torg-Winchester syndrome |
P08253
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H00479 | Metaphyseal dysplasias |
P14780
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|