PCIDB

KNApSAcK Metabolite C00002962

Metabolite

KNApSAcK Entry

id C00002962
Name Aphloiol / Mangiferin / 2-beta-D-Glucopyranosyl-1,3,6,7-tetrahydroxy xanthone
CAS RN 4773-96-0
Standard InChI InChI=1S/C19H18O11/c20-4-11-15(25)17(27)18(28)19(30-11)12-8(23)3-10-13(16(12)26)14(24)5-1-6(21)7(22)2-9(5)29-10/h1-3,11,15,17-23,25-28H,4H2/t11?,15-,17+,18?,19+/m1/s1
Standard InChI (Main Layer) InChI=1S/C19H18O11/c20-4-11-15(25)17(27)18(28)19(30-11)12-8(23)3-10-13(16(12)26)14(24)5-1-6(21)7(22)2-9(5)29-10/h1-3,11,15,17-23,25-28H,4H2

Cluster

Phytochemical cluster No. 15
KCF-S cluster No. 22

Link

ChEMBL

By standard InChI
By standard InChI Main Layer CHEMBL1329826

KEGG

By LinkDB C10077

CTD

By CAS RN C013592

Human Protein / Gene in interaction

27 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein CHEMBL1329826 CHEMBL1738312 (1)
0 / 0
P29466 Caspase-1 C14 CHEMBL1329826 CHEMBL1614158 (1)
0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme CHEMBL1329826 CHEMBL1794585 (1)
0 / 0
Q9Y5X4 Photoreceptor-specific nuclear receptor NR2E3 CHEMBL1329826 CHEMBL1613893 (1)
2 / 2
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL1329826 CHEMBL1614458 (1)
0 / 0
O75496 Geminin Unclassified protein CHEMBL1329826 CHEMBL2114780 (1)
0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor CHEMBL1329826 CHEMBL2114788 (1)
0 / 0
Q9Y253 DNA polymerase eta Enzyme CHEMBL1329826 CHEMBL1794569 (1)
1 / 1
P09923 Intestinal-type alkaline phosphatase Enzyme CHEMBL1329826 CHEMBL1738087 (1) CHEMBL1738192 (1)
0 / 0
P05186 Alkaline phosphatase, tissue-nonspecific isozyme Enzyme CHEMBL1329826 CHEMBL1738634 (1)
3 / 1
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein CHEMBL1329826 CHEMBL1614280 (1)
0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein CHEMBL1329826 CHEMBL1794401 (1)
0 / 0
P10696 Alkaline phosphatase, placental-like Enzyme CHEMBL1329826 CHEMBL1738576 (1)
0 / 1
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme CHEMBL1329826 CHEMBL1613910 (1)
3 / 3
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme CHEMBL1329826 CHEMBL1614038 (1)
2 / 2
P55210 Caspase-7 C14 CHEMBL1329826 CHEMBL1613779 (1)
0 / 0
Q9UNA4 DNA polymerase iota Enzyme CHEMBL1329826 CHEMBL1794483 (1)
0 / 0
O75164 Lysine-specific demethylase 4A Enzyme CHEMBL1329826 CHEMBL1737991 (1)
0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme CHEMBL1329826 CHEMBL1614466 (1) CHEMBL1614211 (1)
0 / 0
Q9UBT6 DNA polymerase kappa Enzyme CHEMBL1329826 CHEMBL1794536 (2)
0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL1329826 CHEMBL1613914 (1)
0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL1329826 CHEMBL1738442 (1)
0 / 0
Q13951 Core-binding factor subunit beta Unclassified protein CHEMBL1329826 CHEMBL1613933 (1)
0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein CHEMBL1329826 CHEMBL1613933 (1)
1 / 6
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 CHEMBL1329826 CHEMBL1614465 (1)
5 / 3
Q9Y618 Nuclear receptor corepressor 2 Unclassified protein CHEMBL1329826 CHEMBL1614465 (1)
0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme CHEMBL1329826 CHEMBL2114738 (1)
0 / 0

CTD interaction (69)

compound gene gene name gene description interaction interaction type form reference
pmid
C013592 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) Dichlororibofuranosylbenzimidazole inhibits the reaction [mangiferin results in increased expression of ABCB1 protein] decreases reaction
/ increases expression
protein 20513373
C013592 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) mangiferin results in increased expression of ABCB1 mRNA increases expression
mRNA 20513373
C013592 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) mangiferin results in increased expression of ABCB1 protein increases expression
protein 20513373
C013592 25 ABL1
ABL
JTK7
bcr/abl
c-ABL
p150
v-abl
c-abl oncogene 1, non-receptor tyrosine kinase (EC:2.7.10.2) mangiferin results in decreased expression of ABL1 mRNA decreases expression
mRNA 15498116
C013592 213 ALB
PRO0883
PRO0903
PRO1341
albumin mangiferin binds to ALB protein affects binding
protein 19157745
C013592 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 mangiferin inhibits the reaction [TNF protein results in increased expression of BCL2 mRNA] decreases reaction
/ increases expression
mRNA 21420233
C013592 598 BCL2L1
BCL-XL/S
BCL2L
BCLX
BCLXL
BCLXS
Bcl-X
PPP1R52
bcl-xL
bcl-xS
BCL2-like 1 mangiferin results in decreased expression of BCL2L1 protein decreases expression
protein 21547680
C013592 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) mangiferin results in increased activity of CASP3 protein increases activity
protein 21547680
C013592 847 CAT
catalase (EC:1.11.1.6) mangiferin inhibits the reaction [Mercuric Chloride results in decreased expression of CAT protein] decreases expression
/ decreases reaction
protein 20629087
C013592 847 CAT
catalase (EC:1.11.1.6) mangiferin results in increased activity of CAT protein increases activity
protein 15161907
C013592 891 CCNB1
CCNB
cyclin B1 mangiferin results in increased expression of CCNB1 mRNA increases expression
mRNA 20518311
C013592 983 CDK1
CDC2
CDC28A
P34CDC2
cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22) mangiferin results in increased expression of CDK1 mRNA increases expression
mRNA 20518311
C013592 1147 CHUK
IKBKA
IKK-alpha
IKK1
IKKA
NFKBIKA
TCF16
conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) mangiferin inhibits the reaction [TNF protein results in increased phosphorylation of CHUK protein] decreases reaction
/ increases phosphorylation
protein 21420233
C013592 7852 CXCR4
CD184
D2S201E
FB22
HM89
HSY3RR
LAP3
LCR1
LESTR
NPY3R
NPYR
NPYRL
NPYY3R
WHIM
chemokine (C-X-C motif) receptor 4 mangiferin inhibits the reaction [TNF protein results in increased expression of CXCR4 mRNA] decreases reaction
/ increases expression
mRNA 21420233
C013592 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) mangiferin results in increased expression of CYP1A1 mRNA increases expression
mRNA 22815239
C013592 1544 CYP1A2
CP12
P3-450
P450(PA)
cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) mangiferin results in decreased activity of CYP1A2 protein decreases activity
protein 22815239
C013592 1544 CYP1A2
CP12
P3-450
P450(PA)
cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) mangiferin results in increased expression of CYP1A2 mRNA increases expression
mRNA 22815239
C013592 1548 CYP2A6
CPA6
CYP2A
CYP2A3
CYPIIA6
P450C2A
P450PB
cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1) mangiferin results in decreased activity of CYP2A6 protein decreases activity
protein 22815239
C013592 1559 CYP2C9
CPC9
CYP2C
CYP2C10
CYPIIC9
P450IIC9
cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) mangiferin results in decreased activity of CYP2C9 protein decreases activity
protein 22815239
C013592 1565 CYP2D6
CPD6
CYP2D
CYP2D7AP
CYP2D7BP
CYP2D7P2
CYP2D8P2
CYP2DL1
CYPIID6
P450-DB1
P450C2D
P450DB1
cytochrome P450, family 2, subfamily D, polypeptide 6 (EC:1.14.14.1) mangiferin results in decreased activity of CYP2D6 protein decreases activity
protein 22815239
C013592 1576 CYP3A4
CP33
CP34
CYP3A
CYP3A3
CYPIIIA3
CYPIIIA4
HLP
NF-25
P450C3
P450PCN1
cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) mangiferin results in decreased activity of CYP3A4 protein decreases activity
protein 22815239
C013592 355 FAS
ALPS1A
APO-1
APT1
CD95
FAS1
FASTM
TNFRSF6
Fas cell surface death receptor mangiferin results in increased expression of FAS protein increases expression
protein 17634039
C013592 3383 ICAM1
BB2
CD54
P3.58
intercellular adhesion molecule 1 mangiferin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA] decreases reaction
/ increases expression
mRNA 15161907
C013592 3551 IKBKB
IKK-beta
IKK2
IKKB
NFKBIKB
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) mangiferin inhibits the reaction [TNF protein results in increased phosphorylation of IKBKB protein] decreases reaction
/ increases phosphorylation
protein 21420233
C013592 3569 IL6
BSF2
HGF
HSF
IFNB2
IL-6
interleukin 6 (interferon, beta 2) mangiferin inhibits the reaction [TNF protein results in increased expression of IL6 mRNA] decreases reaction
/ increases expression
mRNA 21420233
C013592 3569 IL6
BSF2
HGF
HSF
IFNB2
IL-6
interleukin 6 (interferon, beta 2) mangiferin inhibits the reaction [TNF protein results in increased secretion of IL6 protein] decreases reaction
/ increases secretion
protein 21420233
C013592 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 mangiferin inhibits the reaction [TNF protein results in increased expression of IL8 mRNA] decreases reaction
/ increases expression
mRNA 21420233
C013592 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 mangiferin inhibits the reaction [TNF protein results in increased secretion of IL8 protein] decreases reaction
/ increases secretion
protein 21420233
C013592 4023 LPL
HDLCQ11
LIPD
lipoprotein lipase (EC:3.1.1.34) L 663536 inhibits the reaction [mangiferin results in increased activity of LPL protein] decreases reaction
/ increases activity
protein 15975614
C013592 4023 LPL
HDLCQ11
LIPD
lipoprotein lipase (EC:3.1.1.34) L 663536 inhibits the reaction [mangiferin results in increased expression of LPL mRNA] decreases reaction
/ increases expression
mRNA 15975614
C013592 4023 LPL
HDLCQ11
LIPD
lipoprotein lipase (EC:3.1.1.34) mangiferin results in increased activity of LPL protein increases activity
protein 15975614
C013592 4023 LPL
HDLCQ11
LIPD
lipoprotein lipase (EC:3.1.1.34) mangiferin results in increased expression of LPL mRNA increases expression
mRNA 15975614
C013592 4790 NFKB1
EBP-1
KBF1
NF-kB1
NF-kappa-B
NF-kappaB
NFKB-p105
NFKB-p50
NFkappaB
p105
p50
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 mangiferin inhibits the reaction [TNF protein affects the localization of and results in increased activity of NFKB1 protein] affects localization
/ decreases reaction
/ increases activity
protein 15161907
C013592 4792 NFKBIA
IKBA
MAD-3
NFKBI
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha mangiferin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein] decreases reaction
/ increases degradation
/ increases phosphorylation
protein 15161907
C013592 4793 NFKBIB
IKBB
TRIP9
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta mangiferin inhibits the reaction [TNF protein results in increased degradation of NFKBIB protein] decreases reaction
/ increases degradation
protein 21420233
C013592 4803 NGF
Beta-NGF
HSAN5
NGFB
nerve growth factor (beta polypeptide) mangiferin results in increased secretion of NGF protein increases secretion
protein 20303935
C013592 5320 PLA2G2A
MOM1
PLA2
PLA2B
PLA2L
PLA2S
PLAS1
sPLA2
phospholipase A2, group IIA (platelets, synovial fluid) (EC:3.1.1.4) mangiferin results in decreased activity of PLA2G2A protein decreases activity
protein 15177302
C013592 5465 PPARA
NR1C1
PPAR
PPARalpha
hPPAR
peroxisome proliferator-activated receptor alpha L 663536 inhibits the reaction [mangiferin results in increased activity of PPARA protein] decreases reaction
/ increases activity
protein 15975614
C013592 5465 PPARA
NR1C1
PPAR
PPARalpha
hPPAR
peroxisome proliferator-activated receptor alpha mangiferin results in increased activity of PPARA protein increases activity
protein 15975614
C013592 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) mangiferin inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA] decreases reaction
/ increases expression
mRNA 15161907
21420233
C013592 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A mangiferin inhibits the reaction [TNF protein affects the localization of and results in increased phosphorylation of and results in increased activity of RELA protein] affects localization
/ decreases reaction
/ increases activity
/ increases phosphorylation
protein 15161907
C013592 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A mangiferin results in decreased localization of RELA protein decreases localization
protein 21547680
C013592 6716 SRD5A2
steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) (EC:1.3.1.22) mangiferin results in decreased activity of SRD5A2 protein decreases activity
protein 20823678
C013592 7015 TERT
CMM9
DKCA2
DKCB4
EST2
PFBMFT1
TCS1
TP2
TRT
hEST2
hTRT
telomerase reverse transcriptase (EC:2.7.7.49) mangiferin results in decreased activity of TERT protein decreases activity
protein 17634039
C013592 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor mangiferin inhibits the reaction [TNF protein affects the localization of and results in increased activity of NFKB1 protein] affects localization
/ decreases reaction
/ increases activity
protein 15161907
C013592 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor mangiferin inhibits the reaction [TNF protein affects the localization of and results in increased phosphorylation of and results in increased activity of RELA protein] affects localization
/ decreases reaction
/ increases activity
/ increases phosphorylation
protein 15161907
C013592 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor mangiferin inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species] decreases reaction
/ increases abundance
protein 15161907
C013592 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor mangiferin inhibits the reaction [TNF protein results in increased degradation of NFKBIB protein] decreases reaction
/ increases degradation
protein 21420233
C013592 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor mangiferin inhibits the reaction [TNF protein results in increased expression of BCL2 mRNA] decreases reaction
/ increases expression
protein 21420233
C013592 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor mangiferin inhibits the reaction [TNF protein results in increased expression of CXCR4 mRNA] decreases reaction
/ increases expression
protein 21420233
C013592 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor mangiferin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA] decreases reaction
/ increases expression
protein 15161907
C013592 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor mangiferin inhibits the reaction [TNF protein results in increased expression of IL6 mRNA] decreases reaction
/ increases expression
protein 21420233
C013592 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor mangiferin inhibits the reaction [TNF protein results in increased expression of IL8 mRNA] decreases reaction
/ increases expression
protein 21420233
C013592 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor mangiferin inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA] decreases reaction
/ increases expression
protein 15161907
21420233
C013592 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor mangiferin inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA] decreases reaction
/ increases expression
protein 21420233
C013592 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor mangiferin inhibits the reaction [TNF protein results in increased expression of XIAP mRNA] decreases reaction
/ increases expression
protein 21420233
C013592 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor mangiferin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein] decreases reaction
/ increases degradation
/ increases phosphorylation
protein 15161907
C013592 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor mangiferin inhibits the reaction [TNF protein results in increased phosphorylation of CHUK protein] decreases reaction
/ increases phosphorylation
protein 21420233
C013592 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor mangiferin inhibits the reaction [TNF protein results in increased phosphorylation of IKBKB protein] decreases reaction
/ increases phosphorylation
protein 21420233
C013592 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor mangiferin inhibits the reaction [TNF protein results in increased secretion of IL6 protein] decreases reaction
/ increases secretion
protein 21420233
C013592 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor mangiferin inhibits the reaction [TNF protein results in increased secretion of IL8 protein] decreases reaction
/ increases secretion
protein 21420233
C013592 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor mangiferin results in increased secretion of TNF protein increases secretion
protein 20303935
C013592 54658 UGT1A1
BILIQTL1
GNT1
HUG-BR1
UDPGT
UDPGT_1-1
UGT1
UGT1A
UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) mangiferin results in decreased activity of UGT1A1 protein decreases activity
protein 22815239
C013592 54658 UGT1A1
BILIQTL1
GNT1
HUG-BR1
UDPGT
UDPGT_1-1
UGT1
UGT1A
UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) mangiferin results in increased expression of UGT1A1 mRNA increases expression
mRNA 22815239
C013592 54600 UGT1A9
HLUGP4
LUGP4
UDPGT
UDPGT_1-9
UGT-1I
UGT1-09
UGT1-9
UGT1.9
UGT1AI
UGT1I
UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) mangiferin results in increased expression of UGT1A9 mRNA increases expression
mRNA 22815239
C013592 7364 UGT2B7
UDPGT_2B9
UDPGT2B7
UDPGTH2
UGT2B9
UDP glucuronosyltransferase 2 family, polypeptide B7 (EC:2.4.1.17) mangiferin results in decreased activity of UGT2B7 protein decreases activity
protein 22815239
C013592 7422 VEGFA
MVCD1
VEGF
VPF
vascular endothelial growth factor A mangiferin inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA] decreases reaction
/ increases expression
mRNA 21420233
C013592 331 XIAP
API3
BIRC4
IAP-3
ILP1
MIHA
XLP2
hIAP-3
hIAP3
X-linked inhibitor of apoptosis mangiferin inhibits the reaction [TNF protein results in increased expression of XIAP mRNA] decreases reaction
/ increases expression
mRNA 21420233
C013592 331 XIAP
API3
BIRC4
IAP-3
ILP1
MIHA
XLP2
hIAP-3
hIAP3
X-linked inhibitor of apoptosis mangiferin results in decreased expression of XIAP protein decreases expression
protein 21547680

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (17)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
%606641 Body mass index; bmi P37231
#609338 Carotid intimal medial thickness 1 P37231
#119900 Digital clubbing, isolated congenital P15428
#268100 Enhanced s-cone syndrome; escs Q9Y5X4
#137800 Glioma susceptibility 1; glm1 P37231
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#146300 Hypophosphatasia, adult P05186
#241510 Hypophosphatasia, childhood P05186
#241500 Hypophosphatasia, infantile P05186
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#601665 Obesity P37231
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#611131 Retinitis pigmentosa 37; rp37 Q9Y5X4
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (17)

KEGG disease name UniProt
H00213 Hypophosphatasia P05186 (related)
H00023 Testicular cancer P10696 (marker)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00032 Thyroid cancer P37231 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00420 Familial partial lipodystrophy (FPL) P37231 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)
H00527 Retinitis pigmentosa (RP) Q9Y5X4 (related)
H00805 Vitreoretinal degeneration Q9Y5X4 (related)

Diseases related to CTD interactions

41 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D016301 C013592 Alveolar Bone Loss therapeutic
19026997
D000707 C013592 Anaphylaxis therapeutic
14669257
16536907
D050197 C013592 Atherosclerosis therapeutic
18450471
D001847 C013592 Bone Diseases therapeutic
20683903
D001862 C013592 Bone Resorption therapeutic
9881647
D003248 C013592 Constipation therapeutic
20699592
D003457 C013592 Cryptosporidiosis therapeutic
16547730
D003921 C013592 Diabetes Mellitus, Experimental therapeutic
12093613
19028559
D003924 C013592 Diabetes Mellitus, Type 2 therapeutic
9881663
11315760
D003928 C013592 Diabetic Nephropathies therapeutic
19706694
19960420
D056486 C013592 Drug-Induced Liver Injury therapeutic
22310181
D005234 C013592 Fatty Liver therapeutic
15975614
D006331 C013592 Heart Diseases therapeutic
12093613
D006561 C013592 Herpes Simplex therapeutic
10715843
D015658 C013592 HIV Infections therapeutic
21610656
D006946 C013592 Hyperinsulinism therapeutic
9881663
11315760
D006949 C013592 Hyperlipidemias therapeutic
15975614
D006967 C013592 Hypersensitivity therapeutic
16536907
D033461 C013592 Hyperuricemia therapeutic
21348301
D007154 C013592 Immune System Diseases therapeutic
16076520
D007249 C013592 Inflammation therapeutic
15222974
21837981
D007333 C013592 Insulin Resistance therapeutic
11315760
D007511 C013592 Ischemia therapeutic
16806951
D007674 C013592 Kidney Diseases therapeutic
12093613
D007859 C013592 Learning Disorders therapeutic
19182383
D015464 C013592 Leukemia, Myelogenous, Chronic, BCR-ABL Positive therapeutic
15498116
D015470 C013592 Leukemia, Myeloid, Acute therapeutic
21547680
D008175 C013592 Lung Neoplasms therapeutic
18520028
18569708
18816296
D008569 C013592 Memory Disorders therapeutic
19182383
D008630 C013592 Mercury Poisoning therapeutic
20629087
D009203 C013592 Myocardial Infarction therapeutic
16538859
16584858
16697266
17052832
19172585
D009336 C013592 Necrosis therapeutic
22310181
D009410 C013592 Nerve Degeneration therapeutic
17433543
D009437 C013592 Neuralgia therapeutic
21150823
D010300 C013592 Parkinson Disease therapeutic
17433543
D010518 C013592 Periodontitis therapeutic
19026997
21194846
D011470 C013592 Prostatic Hyperplasia therapeutic
20823678
D011833 C013592 Radiation Injuries, Experimental therapeutic
15830843
D012772 C013592 Shock, Septic therapeutic
15177305
D013276 C013592 Stomach Ulcer therapeutic
17918041
D014235 C013592 Trichinellosis therapeutic
14669257