KNApSAcK Metabolite C00030400
Metabolite
KNApSAcK Entry
| id | C00030400 |
|---|---|
| Name | Ginsenoside Rg3 |
| CAS RN | 14197-60-5 |
| Standard InChI | InChI=1S/C42H72O13/c1-21(2)10-9-14-42(8,51)22-11-16-41(7)29(22)23(45)18-27-39(5)15-13-28(38(3,4)26(39)12-17-40(27,41)6)54-37-35(33(49)31(47)25(20-44)53-37)55-36-34(50)32(48)30(46)24(19-43)52-36/h10,22-37,43-51H,9,11-20H2,1-8H3/t22-,23+,24+,25+,26-,27+,28-,29-,30+,31+,32-,33-,34+,35+,36-,37-,39-,40+,41+,42-/m0/s1 |
| Standard InChI (Main Layer) | InChI=1S/C42H72O13/c1-21(2)10-9-14-42(8,51)22-11-16-41(7)29(22)23(45)18-27-39(5)15-13-28(38(3,4)26(39)12-17-40(27,41)6)54-37-35(33(49)31(47)25(20-44)53-37)55-36-34(50)32(48)30(46)24(19-43)52-36/h10,22-37,43-51H,9,11-20H2,1-8H3 |
Cluster
| Phytochemical cluster | No. 51 |
|---|---|
| KCF-S cluster | No. 32 |
Link
ChEMBL
| By standard InChI | CHEMBL398412 |
|---|---|
| By standard InChI Main Layer | CHEMBL398412 CHEMBL1095008 CHEMBL1735785 CHEMBL2151041 |
KEGG
| By LinkDB |
|---|
CTD
| By CAS RN | C097367 |
|---|
Species
Summary
Plant class
| class name | count |
|---|---|
| asterids | 2 |
Family
| family name | count |
|---|---|
| Araliaceae | 2 |
List (2)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Panax ginseng C.A.Meyer | 4053 | Araliaceae | asterids | Viridiplantae |
| Panax notoginseng | 44586 | Araliaceae | asterids | Viridiplantae |
Human Protein / Gene in interaction
2 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| P11387 | DNA topoisomerase 1 | Isomerase | CHEMBL398412 CHEMBL1095008 |
CHEMBL1111926
(2)
|
0 / 0 |
| P11388 | DNA topoisomerase 2-alpha | Isomerase | CHEMBL398412 CHEMBL1095008 |
CHEMBL1111927
(2)
|
0 / 0 |
CTD interaction (8)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| C097367 | 367 |
AR
AIS DHTR HUMARA HYSP1 KD NR3C4 SBMA SMAX1 TFM |
androgen receptor | ginsenoside Rg3 inhibits the reaction [Testosterone results in increased expression of AR protein] |
decreases reaction
/ increases expression |
protein |
22101440
|
| C097367 | 367 |
AR
AIS DHTR HUMARA HYSP1 KD NR3C4 SBMA SMAX1 TFM |
androgen receptor | ginsenoside Rg3 results in increased degradation of AR protein |
increases degradation
|
protein |
22101440
|
| C097367 | 332 |
BIRC5
API4 EPR-1 |
baculoviral IAP repeat containing 5 | ginsenoside Rg3 results in decreased expression of BIRC5 mRNA |
decreases expression
|
mRNA |
19778801
|
| C097367 | 332 |
BIRC5
API4 EPR-1 |
baculoviral IAP repeat containing 5 | ginsenoside Rg3 results in decreased expression of BIRC5 protein |
decreases expression
|
protein |
19778801
|
| C097367 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | ginsenoside Rg3 results in increased cleavage of CASP3 protein |
increases cleavage
|
protein |
22101440
|
| C097367 | 354 |
KLK3
APS KLK2A1 PSA hK3 |
kallikrein-related peptidase 3 (EC:3.4.21.77) | ginsenoside Rg3 inhibits the reaction [Testosterone results in increased expression of KLK3 mRNA] |
decreases reaction
/ increases expression |
mRNA |
22101440
|
| C097367 | 354 |
KLK3
APS KLK2A1 PSA hK3 |
kallikrein-related peptidase 3 (EC:3.4.21.77) | ginsenoside Rg3 inhibits the reaction [Testosterone results in increased expression of KLK3 protein] |
decreases reaction
/ increases expression |
protein |
22101440
|
| C097367 | 142 |
PARP1
ADPRT ADPRT_1 ADPRT1 ARTD1 PARP PARP-1 PPOL pADPRT-1 |
poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) | ginsenoside Rg3 results in increased cleavage of PARP1 protein |
increases cleavage
|
protein |
22101440
|