KNApSAcK Metabolite C00031697
Metabolite
KNApSAcK Entry
| id | C00031697 |
|---|---|
| Name | Cryptotanshinone |
| CAS RN | 35825-57-1 |
| Standard InChI | InChI=1S/C19H20O3/c1-10-9-22-18-12-6-7-13-11(5-4-8-19(13,2)3)15(12)17(21)16(20)14(10)18/h6-7,10H,4-5,8-9H2,1-3H3/t10-/m0/s1 |
| Standard InChI (Main Layer) | InChI=1S/C19H20O3/c1-10-9-22-18-12-6-7-13-11(5-4-8-19(13,2)3)15(12)17(21)16(20)14(10)18/h6-7,10H,4-5,8-9H2,1-3H3 |
Cluster
| Phytochemical cluster | |
|---|---|
| KCF-S cluster | No. 5489 |
Link
ChEMBL
| By standard InChI | CHEMBL187460 |
|---|---|
| By standard InChI Main Layer | CHEMBL187460 CHEMBL1518673 |
KEGG
| By LinkDB |
|---|
CTD
| By CAS RN | C037886 |
|---|
Species
Summary
List (7)
* NCBI
Human Protein / Gene in interaction
45 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | CHEMBL187460 |
CHEMBL1738312
(1)
|
0 / 0 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | CHEMBL187460 |
CHEMBL1794499
(1)
|
2 / 0 |
| P06746 | DNA polymerase beta | Enzyme | CHEMBL187460 |
CHEMBL1614079
(1)
|
0 / 0 |
| O00748 | Cocaine esterase | Enzyme | CHEMBL187460 |
CHEMBL2341911
(1)
CHEMBL2341914
(1)
CHEMBL2341915 (1) |
0 / 0 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | CHEMBL187460 |
CHEMBL1614554
(1)
|
3 / 1 |
| P54132 | Bloom syndrome protein | Enzyme | CHEMBL1518673 |
CHEMBL1614067
(1)
|
1 / 2 |
| Q9NR56 | Muscleblind-like protein 1 | Unclassified protein | CHEMBL187460 |
CHEMBL1614166
(1)
|
1 / 0 |
| P11473 | Vitamin D3 receptor | NR1I1 | CHEMBL187460 CHEMBL1518673 |
CHEMBL1794311
(4)
CHEMBL1963865
(3)
CHEMBL1963915 (1) CHEMBL1963934 (3) CHEMBL1963947 (3) |
2 / 3 |
| O15296 | Arachidonate 15-lipoxygenase B | Enzyme | CHEMBL1518673 |
CHEMBL1613800
(1)
|
0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | CHEMBL187460 CHEMBL1518673 |
CHEMBL1614458
(3)
|
0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | CHEMBL187460 |
CHEMBL1794486
(1)
|
0 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | CHEMBL187460 CHEMBL1518673 |
CHEMBL1738606
(4)
|
0 / 0 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | CHEMBL187460 |
CHEMBL1794584
(1)
|
2 / 0 |
| O75496 | Geminin | Unclassified protein | CHEMBL187460 |
CHEMBL2114843
(1)
CHEMBL2114780
(1)
|
0 / 0 |
| P40763 | Signal transducer and activator of transcription 3 | Transcription Factor | CHEMBL187460 |
CHEMBL2175173
(1)
|
1 / 2 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | CHEMBL187460 |
CHEMBL2114788
(1)
|
0 / 0 |
| Q9Y253 | DNA polymerase eta | Enzyme | CHEMBL187460 |
CHEMBL1794569
(1)
|
1 / 1 |
| Q9Y468 | Lethal(3)malignant brain tumor-like protein 1 | Unclassified protein | CHEMBL187460 |
CHEMBL1614280
(1)
|
0 / 0 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | CHEMBL187460 CHEMBL1518673 |
CHEMBL1614257
(4)
CHEMBL1614410
(1)
CHEMBL1614531 (1) |
1 / 3 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | CHEMBL187460 |
CHEMBL1794401
(1)
|
0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | CHEMBL1518673 |
CHEMBL1794467
(1)
|
0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | CHEMBL1518673 |
CHEMBL1613910
(1)
|
3 / 3 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | CHEMBL1518673 |
CHEMBL1614038
(2)
|
2 / 2 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | CHEMBL187460 |
CHEMBL1738588
(1)
|
0 / 0 |
| P22303 | Acetylcholinesterase | Hydrolase | CHEMBL187460 |
CHEMBL2341912
(1)
CHEMBL2341913
(1)
|
1 / 0 |
| P55210 | Caspase-7 | C14 | CHEMBL1518673 |
CHEMBL1613779
(1)
|
0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | CHEMBL1518673 |
CHEMBL1614108
(1)
CHEMBL1613886
(1)
|
0 / 1 |
| Q9UNA4 | DNA polymerase iota | Enzyme | CHEMBL187460 |
CHEMBL1794483
(1)
|
0 / 0 |
| Q6W5P4 | Neuropeptide S receptor | Neuropeptide receptor | CHEMBL187460 |
CHEMBL1614052
(1)
|
1 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | CHEMBL187460 |
CHEMBL1737991
(1)
|
0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | CHEMBL1518673 |
CHEMBL1614211
(1)
|
0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | CHEMBL187460 CHEMBL1518673 |
CHEMBL1614250
(3)
CHEMBL1614421
(3)
CHEMBL1614502 (2) |
4 / 3 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | CHEMBL187460 |
CHEMBL1738184
(1)
|
0 / 0 |
| P23141 | Liver carboxylesterase 1 | Enzyme | CHEMBL187460 |
CHEMBL2341916
(1)
|
0 / 0 |
| O14746 | Telomerase reverse transcriptase | Enzyme | CHEMBL187460 |
CHEMBL2160257
(1)
|
5 / 5 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | CHEMBL187460 CHEMBL1518673 |
CHEMBL1794536
(4)
|
0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | CHEMBL187460 CHEMBL1518673 |
CHEMBL1613914
(2)
|
0 / 0 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | CHEMBL187460 CHEMBL1518673 |
CHEMBL1613829
(2)
CHEMBL1613928
(1)
|
0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | CHEMBL1518673 |
CHEMBL1738442
(1)
|
0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | CHEMBL187460 CHEMBL1518673 |
CHEMBL1614364
(3)
|
1 / 1 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | CHEMBL187460 |
CHEMBL1964002
(1)
CHEMBL2354311
(1)
|
1 / 0 |
| O00255 | Menin | Unclassified protein | CHEMBL187460 CHEMBL1518673 |
CHEMBL1614257
(4)
CHEMBL1614531
(1)
|
2 / 5 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | CHEMBL187460 |
CHEMBL1613933
(2)
|
0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | CHEMBL187460 |
CHEMBL1613933
(2)
|
1 / 6 |
| Q14191 | Werner syndrome ATP-dependent helicase | Enzyme | CHEMBL187460 |
CHEMBL2114796
(1)
|
2 / 1 |
CTD interaction (17)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| C037886 | 43 |
ACHE
ACEE ARACHE N-ACHE YT |
acetylcholinesterase (EC:3.1.1.7) | cryptotanshinone binds to and results in decreased activity of ACHE protein |
affects binding
/ decreases activity |
protein |
20350537
|
| C037886 | 196 |
AHR
bHLHe76 |
aryl hydrocarbon receptor | cryptotanshinone promotes the reaction [beta-Naphthoflavone results in increased expression of AHR mRNA] |
increases expression
/ increases reaction |
mRNA |
21262253
|
| C037886 | 590 |
BCHE
CHE1 CHE2 E1 |
butyrylcholinesterase (EC:3.1.1.8) | cryptotanshinone binds to and results in decreased activity of BCHE protein |
affects binding
/ decreases activity |
protein |
20350537
|
| C037886 | 1543 |
CYP1A1
AHH AHRR CP11 CYP1 P1-450 P450-C P450DX |
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) | cryptotanshinone promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA] |
increases expression
/ increases reaction |
mRNA |
21262253
|
| C037886 | 1543 |
CYP1A1
AHH AHRR CP11 CYP1 P1-450 P450-C P450DX |
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) | cryptotanshinone promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein] |
increases expression
/ increases reaction |
protein |
21262253
|
| C037886 | 1543 |
CYP1A1
AHH AHRR CP11 CYP1 P1-450 P450-C P450DX |
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) | cryptotanshinone results in increased expression of CYP1A1 mRNA |
increases expression
|
mRNA |
21262253
|
| C037886 | 1543 |
CYP1A1
AHH AHRR CP11 CYP1 P1-450 P450-C P450DX |
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) | cryptotanshinone results in increased expression of CYP1A1 protein |
increases expression
|
protein |
21262253
|
| C037886 | 1543 |
CYP1A1
AHH AHRR CP11 CYP1 P1-450 P450-C P450DX |
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) | Dactinomycin inhibits the reaction [cryptotanshinone results in increased expression of CYP1A1 mRNA] |
decreases reaction
/ increases expression |
mRNA |
21262253
|
| C037886 | 1543 |
CYP1A1
AHH AHRR CP11 CYP1 P1-450 P450-C P450DX |
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) | resveratrol inhibits the reaction [cryptotanshinone results in increased expression of CYP1A1 mRNA] |
decreases reaction
/ increases expression |
mRNA |
21262253
|
| C037886 | 1544 |
CYP1A2
CP12 P3-450 P450(PA) |
cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) | cryptotanshinone promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA] |
increases expression
/ increases reaction |
mRNA |
21262253
|
| C037886 | 1544 |
CYP1A2
CP12 P3-450 P450(PA) |
cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) | cryptotanshinone promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 protein] |
increases expression
/ increases reaction |
protein |
21262253
|
| C037886 | 1544 |
CYP1A2
CP12 P3-450 P450(PA) |
cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) | cryptotanshinone results in increased expression of CYP1A2 mRNA |
increases expression
|
mRNA |
21262253
|
| C037886 | 1544 |
CYP1A2
CP12 P3-450 P450(PA) |
cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) | cryptotanshinone results in increased expression of CYP1A2 protein |
increases expression
|
protein |
21262253
|
| C037886 | 1544 |
CYP1A2
CP12 P3-450 P450(PA) |
cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) | Dactinomycin inhibits the reaction [cryptotanshinone results in increased expression of CYP1A2 mRNA] |
decreases reaction
/ increases expression |
mRNA |
21262253
|
| C037886 | 1544 |
CYP1A2
CP12 P3-450 P450(PA) |
cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) | resveratrol inhibits the reaction [cryptotanshinone results in increased expression of CYP1A2 mRNA] |
decreases reaction
/ increases expression |
mRNA |
21262253
|
| C037886 | 1576 |
CYP3A4
CP33 CP34 CYP3A CYP3A3 CYPIIIA3 CYPIIIA4 HLP NF-25 P450C3 P450PCN1 |
cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) | cryptotanshinone results in increased expression of CYP3A4 protein |
increases expression
|
protein |
18805405
|
| C037886 | 8856 |
NR1I2
BXR ONR1 PAR PAR1 PAR2 PARq PRR PXR SAR SXR |
nuclear receptor subfamily 1, group I, member 2 | cryptotanshinone results in increased activity of NR1I2 protein |
increases activity
|
protein |
18805405
|
Related Disease
Diseases related to proteins in ChEMBL interactions
OMIM (36)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #609135 | Aplastic anemia |
O14746
|
| #608584 | Asthma-related traits, susceptibility to, 2 |
Q6W5P4
|
| #210900 | Bloom syndrome; blm |
P54132
|
| #114500 | Colorectal cancer; crc |
P84022
Q14191 |
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #613989 | Dyskeratosis congenita, autosomal dominant, 2; dkca2 |
O14746
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #137800 | Glioma susceptibility 1; glm1 |
O75874
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #147060 | Hyper-ige recurrent infection syndrome, autosomal dominant |
P40763
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #615134 | Melanoma, cutaneous malignant, susceptibility to, 9; cmm9 |
O14746
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #160900 | Myotonic dystrophy 1; dm1 |
Q9NR56
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #614742 | Pulmonary fibrosis and/or bone marrow failure, telomere-related, 1; pfbmft1 |
O14746
|
| #178500 | Pulmonary fibrosis, idiopathic; ipf |
O14746
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
| #277700 | Werner syndrome; wrn |
Q14191
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
| #112100 | Yt blood group antigen |
P22303
|
KEGG DISEASE (34)
| KEGG | disease name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00764 | Cri du chat syndrome |
O14746
(related)
|
| H01132 | Aplastic anemia (AA) |
O14746
(related)
|
| H01299 | Idiopathic pulmonary fibrosis |
O14746
(related)
|
| H00022 | Bladder cancer |
O14746
(marker)
|
| H00024 | Prostate cancer |
O14746
(marker)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00016 | Oral cancer |
P40763
(related)
|
| H00107 | Other well-defined immunodeficiency syndromes |
P40763
(related)
|
| H00094 | DNA repair defects |
P54132
(related)
|
| H00296 | Defects in RecQ helicases |
P54132
(related)
Q14191 (related) |
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) Q03164 (related) Q03164 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00004 | Chronic myeloid leukemia (CML) |
Q01196
(related)
|
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q9NUW8
(related)
|
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|