PCIDB

KNApSAcK Metabolite C00003410

Metabolite

KNApSAcK Entry

id C00003410
Name Carnosol
CAS RN 5957-80-2
Standard InChI InChI=1S/C20H26O4/c1-10(2)11-8-12-13-9-14-19(3,4)6-5-7-20(14,18(23)24-13)15(12)17(22)16(11)21/h8,10,13-14,21-22H,5-7,9H2,1-4H3/t13-,14-,20+/m0/s1
Standard InChI (Main Layer) InChI=1S/C20H26O4/c1-10(2)11-8-12-13-9-14-19(3,4)6-5-7-20(14,18(23)24-13)15(12)17(22)16(11)21/h8,10,13-14,21-22H,5-7,9H2,1-4H3

Cluster

Phytochemical cluster No. 40
KCF-S cluster No. 734

Link

ChEMBL

By standard InChI CHEMBL218693
By standard InChI Main Layer CHEMBL218693 CHEMBL1514916

KEGG

By LinkDB C09069

CTD

By CAS RN C068623

Human Protein / Gene in interaction

17 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
Q99700 Ataxin-2 Unclassified protein CHEMBL1514916 CHEMBL2114784 (1)
1 / 1
P49798 Regulator of G-protein signaling 4 Unclassified protein CHEMBL1514916 CHEMBL1794499 (1)
2 / 0
Q9Y5X4 Photoreceptor-specific nuclear receptor NR2E3 CHEMBL1514916 CHEMBL2114728 (1)
2 / 2
P37840 Alpha-synuclein Unclassified protein CHEMBL1514916 CHEMBL2354282 (1)
4 / 2
P11473 Vitamin D3 receptor NR1I1 CHEMBL1514916 CHEMBL1794311 (1)
2 / 3
P39748 Flap endonuclease 1 Enzyme CHEMBL1514916 CHEMBL1794486 (1)
0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme CHEMBL1514916 CHEMBL1738606 (1)
0 / 0
P11413 Glucose-6-phosphate 1-dehydrogenase Enzyme CHEMBL1514916 CHEMBL1737961 (1)
1 / 2
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein CHEMBL1514916 CHEMBL1794584 (1)
2 / 0
O75496 Geminin Unclassified protein CHEMBL1514916 CHEMBL2114843 (1) CHEMBL2114780 (1)
0 / 0
P16233 Pancreatic triacylglycerol lipase Hydrolase CHEMBL218693 CHEMBL925170 (1)
0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein CHEMBL1514916 CHEMBL1794401 (1)
0 / 0
Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G Enzyme CHEMBL1514916 CHEMBL1963863 (1)
0 / 0
O75164 Lysine-specific demethylase 4A Enzyme CHEMBL1514916 CHEMBL1737991 (1)
0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL1514916 CHEMBL1738442 (1)
0 / 0
O00255 Menin Unclassified protein CHEMBL1514916 CHEMBL1614257 (1)
2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL1514916 CHEMBL1614257 (1)
1 / 3

CTD interaction (51)

compound gene gene name gene description interaction interaction type form reference
pmid
C068623 196 AHR
bHLHe76
aryl hydrocarbon receptor carnosol results in decreased expression of AHR protein decreases expression
protein 22374940
C068623 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) carnosol inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA] decreases reaction
/ increases expression
mRNA 22374940
C068623 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) carnosol inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein] decreases reaction
/ increases expression
protein 22374940
C068623 1545 CYP1B1
CP1B
CYPIB1
GLC3A
P4501B1
cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) carnosol inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 mRNA] decreases reaction
/ increases expression
mRNA 22374940
C068623 1545 CYP1B1
CP1B
CYPIB1
GLC3A
P4501B1
cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) carnosol inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 protein] decreases reaction
/ increases expression
protein 22374940
C068623 2729 GCLC
GCL
GCS
GLCL
GLCLC
glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2) carnosol results in increased expression of GCLC mRNA increases expression
mRNA 20116392
C068623 2730 GCLM
GLCLR
glutamate-cysteine ligase, modifier subunit (EC:6.3.2.2) carnosol results in increased expression of GCLM mRNA increases expression
mRNA 20116392
C068623 3162 HMOX1
HMOX1D
HO-1
HSP32
bK286B10
heme oxygenase (decycling) 1 (EC:1.14.99.3) carnosol results in increased expression of HMOX1 protein increases expression
protein 20116392
C068623 3162 HMOX1
HMOX1D
HO-1
HSP32
bK286B10
heme oxygenase (decycling) 1 (EC:1.14.99.3) HMOX1 mutant form inhibits the reaction [carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]] affects localization
/ decreases reaction
mutant form 20116392
C068623 3162 HMOX1
HMOX1D
HO-1
HSP32
bK286B10
heme oxygenase (decycling) 1 (EC:1.14.99.3) [HMOX1 mutant form inhibits the reaction [carnosol results in increased expression of HMOX1 protein]] which results in increased expression of ICAM1 protein decreases reaction
/ increases expression
mutant form / protein 20116392
C068623 3162 HMOX1
HMOX1D
HO-1
HSP32
bK286B10
heme oxygenase (decycling) 1 (EC:1.14.99.3) HMOX1 mutant form inhibits the reaction [carnosol results in increased glutathionylation of RELA protein] decreases reaction
/ increases glutathionylation
mutant form 20116392
C068623 3162 HMOX1
HMOX1D
HO-1
HSP32
bK286B10
heme oxygenase (decycling) 1 (EC:1.14.99.3) NFE2L2 mutant form inhibits the reaction [carnosol results in increased expression of HMOX1 protein] decreases reaction
/ increases expression
protein 20116392
C068623 3162 HMOX1
HMOX1D
HO-1
HSP32
bK286B10
heme oxygenase (decycling) 1 (EC:1.14.99.3) [NFE2L2 mutant form inhibits the reaction [carnosol results in increased expression of HMOX1 protein]] which results in increased expression of ICAM1 protein decreases reaction
/ increases expression
protein 20116392
C068623 3383 ICAM1
BB2
CD54
P3.58
intercellular adhesion molecule 1 Buthionine Sulfoximine inhibits the reaction [carnosol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]] decreases reaction
/ increases expression
protein 20116392
C068623 3383 ICAM1
BB2
CD54
P3.58
intercellular adhesion molecule 1 carnosol inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA] decreases reaction
/ increases expression
mRNA 20116392
C068623 3383 ICAM1
BB2
CD54
P3.58
intercellular adhesion molecule 1 carnosol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] decreases reaction
/ increases expression
protein 20116392
C068623 3383 ICAM1
BB2
CD54
P3.58
intercellular adhesion molecule 1 [HMOX1 mutant form inhibits the reaction [carnosol results in increased expression of HMOX1 protein]] which results in increased expression of ICAM1 protein decreases reaction
/ increases expression
protein 20116392
C068623 3383 ICAM1
BB2
CD54
P3.58
intercellular adhesion molecule 1 NFE2L2 mutant form inhibits the reaction [carnosol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]] decreases reaction
/ increases expression
protein 20116392
C068623 3383 ICAM1
BB2
CD54
P3.58
intercellular adhesion molecule 1 [NFE2L2 mutant form inhibits the reaction [carnosol results in increased expression of HMOX1 protein]] which results in increased expression of ICAM1 protein decreases reaction
/ increases expression
protein 20116392
C068623 3551 IKBKB
IKK-beta
IKK2
IKKB
NFKBIKB
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) carnosol inhibits the reaction [TNF protein results in increased phosphorylation of IKBKB protein] decreases reaction
/ increases phosphorylation
protein 20116392
C068623 4780 NFE2L2
NRF2
nuclear factor, erythroid 2-like 2 carnosol results in increased localization of NFE2L2 protein increases localization
protein 20116392
C068623 4780 NFE2L2
NRF2
nuclear factor, erythroid 2-like 2 NFE2L2 mutant form inhibits the reaction [carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]] affects localization
/ decreases reaction
mutant form 20116392
C068623 4780 NFE2L2
NRF2
nuclear factor, erythroid 2-like 2 NFE2L2 mutant form inhibits the reaction [carnosol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]] decreases reaction
/ increases expression
mutant form 20116392
C068623 4780 NFE2L2
NRF2
nuclear factor, erythroid 2-like 2 NFE2L2 mutant form inhibits the reaction [carnosol results in increased expression of HMOX1 protein] decreases reaction
/ increases expression
mutant form 20116392
C068623 4780 NFE2L2
NRF2
nuclear factor, erythroid 2-like 2 [NFE2L2 mutant form inhibits the reaction [carnosol results in increased expression of HMOX1 protein]] which results in increased expression of ICAM1 protein decreases reaction
/ increases expression
mutant form 20116392
C068623 4780 NFE2L2
NRF2
nuclear factor, erythroid 2-like 2 NFE2L2 mutant form inhibits the reaction [carnosol results in increased glutathionylation of RELA protein] decreases reaction
/ increases glutathionylation
mutant form 20116392
C068623 4792 NFKBIA
IKBA
MAD-3
NFKBI
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha carnosol inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein] decreases reaction
/ increases degradation
/ increases phosphorylation
protein 20116392
C068623 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A Buthionine Sulfoximine inhibits the reaction [carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]] affects localization
/ decreases reaction
protein 20116392
C068623 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A Buthionine Sulfoximine inhibits the reaction [carnosol results in increased glutathionylation of RELA protein] decreases reaction
/ increases glutathionylation
protein 20116392
C068623 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A carnosol inhibits the reaction [TNF protein affects the localization of RELA protein] affects localization
/ decreases reaction
protein 20116392
C068623 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A [carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]] which results in increased glutathionylation of RELA protein affects localization
/ decreases reaction
/ increases glutathionylation
protein 20116392
C068623 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A carnosol results in increased glutathionylation of RELA protein increases glutathionylation
protein 20116392
C068623 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A diethyl maleate inhibits the reaction [carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]] affects localization
/ decreases reaction
protein 20116392
C068623 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A diethyl maleate inhibits the reaction [[carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]] which results in increased glutathionylation of RELA protein] affects localization
/ decreases reaction
/ increases glutathionylation
protein 20116392
C068623 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A HMOX1 mutant form inhibits the reaction [carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]] affects localization
/ decreases reaction
protein 20116392
C068623 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A HMOX1 mutant form inhibits the reaction [carnosol results in increased glutathionylation of RELA protein] decreases reaction
/ increases glutathionylation
protein 20116392
C068623 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A NFE2L2 mutant form inhibits the reaction [carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]] affects localization
/ decreases reaction
protein 20116392
C068623 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A NFE2L2 mutant form inhibits the reaction [carnosol results in increased glutathionylation of RELA protein] decreases reaction
/ increases glutathionylation
protein 20116392
C068623 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Buthionine Sulfoximine inhibits the reaction [carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]] affects localization
/ decreases reaction
protein 20116392
C068623 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Buthionine Sulfoximine inhibits the reaction [carnosol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]] decreases reaction
/ increases expression
protein 20116392
C068623 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor carnosol inhibits the reaction [TNF protein affects the localization of RELA protein] affects localization
/ decreases reaction
protein 20116392
C068623 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor [carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]] which results in increased glutathionylation of RELA protein affects localization
/ decreases reaction
/ increases glutathionylation
protein 20116392
C068623 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor carnosol inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA] decreases reaction
/ increases expression
protein 20116392
C068623 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor carnosol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] decreases reaction
/ increases expression
protein 20116392
C068623 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor carnosol inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein] decreases reaction
/ increases degradation
/ increases phosphorylation
protein 20116392
C068623 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor carnosol inhibits the reaction [TNF protein results in increased phosphorylation of IKBKB protein] decreases reaction
/ increases phosphorylation
protein 20116392
C068623 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor diethyl maleate inhibits the reaction [carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]] affects localization
/ decreases reaction
protein 20116392
C068623 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor diethyl maleate inhibits the reaction [[carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]] which results in increased glutathionylation of RELA protein] affects localization
/ decreases reaction
/ increases glutathionylation
protein 20116392
C068623 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor HMOX1 mutant form inhibits the reaction [carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]] affects localization
/ decreases reaction
protein 20116392
C068623 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor NFE2L2 mutant form inhibits the reaction [carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]] affects localization
/ decreases reaction
protein 20116392
C068623 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor NFE2L2 mutant form inhibits the reaction [carnosol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]] decreases reaction
/ increases expression
protein 20116392

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (17)

OMIM preferred title UniProt
#300908 Anemia, nonspherocytic hemolytic, due to g6pd deficiency P11413
#114500 Colorectal cancer; crc P84022
#127750 Dementia, lewy body; dlb P37840
#268100 Enhanced s-cone syndrome; escs Q9Y5X4
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#168601 Parkinson disease 1, autosomal dominant; park1 P37840
#605543 Parkinson disease 4, autosomal dominant; park4 P37840
#168600 Parkinson disease, late-onset; pd P37840
#611131 Retinitis pigmentosa 37; rp37 Q9Y5X4
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (17)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00101 Other phagocyte defects P11413 (related)
H00668 Anemia due to disorders of glutathione metabolism P11413 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00057 Parkinson's disease (PD) P37840 (related)
H00066 Lewy body dementia (LBD) P37840 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
H00527 Retinitis pigmentosa (RP) Q9Y5X4 (related)
H00805 Vitreoretinal degeneration Q9Y5X4 (related)